dextromethorphan hydrobromide monohydrate

morphinan, 3-methoxy-17-methyl-, (9a,13a,14a)-, hydrobromide, hydrate (1:1:2)

CAS: 6700-34-1 C18 H30 Br N O3 MW: 388.34570000

Identification

Namedextromethorphan hydrobromide monohydrate
CAS Number6700-34-1
FDA UNII9D2RTI9KYH
Molecular FormulaC18 H30 Br N O3
Molecular Weight388.34570000
MDL NumberMFCD02173901
Beilstein6453793

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 543.80 °C. @ 760.00 mm Hg (est)
Flash Point 541.00 °F. TCC ( 282.70 °C. ) (est)
logP (o/w) 1.351 (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for dextromethorphan hydrobromide monohydrate usage levels up tonot for fragrance use.
Recommendation for dextromethorphan hydrobromide monohydrate flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

Consistent sources

North American supplier for globally sourced ingredients.

View All Website (800) 238-0001 info@aicma.com

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

dextromethorphan hydrobromide drixoral cough endotussin-NN pediatric (9a,13a,14a)-3- methoxy-17-methylmorphinan hydrobromide dihydrate morphinan, 3-methoxy-17-methyl-, (9a,13a,14a)-, hydrobromide, hydrate (1:1:2) pediacare 1 robitussin cough calmers robitussin maximum strength cough robitussin pediatric cough SAM001247062 st. joseph cough syrup tylenol cough liquid PubMed: Dextromethorphan/quinidine for the treatment of pseudobulbar affect. PubMed: Pseudobulbar affect: prevalence and management. PubMed: Selective inhibition of the cytochrome P450 isoform by hyperoside and its potent inhibition of CYP2D6. PubMed: Effects of Ougan juice on P450 activities using a cocktail method. PubMed: Randomized open-label drug-drug interaction trial of dextromethorphan/quinidine and paroxetine in healthy volunteers. PubMed: Therapeutic options for acute cough due to upper respiratory infections in children. PubMed: Suppressive effect of the ethanolic extract of adlay bran on cytochrome P-450 enzymes in rat liver and lungs. PubMed: Advisers vote against declaring dextromethorphan a controlled substance. PubMed: Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages. PubMed: Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. PubMed: Postherpetic neuralgia. PubMed: (13)C breath tests in personalized medicine: fiction or reality? PubMed: Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. PubMed: Involuntary emotional expression disorder in Alzheimer's disease - psychopharmacotherapy aspects. PubMed: Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles. PubMed: Overdose in infant caused by over-the-counter cough medicine. PubMed: Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design. PubMed: Dextromethorphan/quinidine sulfate for pseudobulbar affect. PubMed: Central mechanisms IV: conscious control of cough and the placebo effect. PubMed: Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants. PubMed: Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver. PubMed: Cough and cold medication use by US children, 1999-2006: results from the slone survey. PubMed: Unexpected infant deaths associated with use of cough and cold medications. PubMed: The causes and treatment of pseudobulbar affect in ischemic stroke. PubMed: The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes. PubMed: The effect of dextromethorphan in preventing cholecalciferol-induced poison shyness and sickness-induced anorexia in the laboratory Norway rat. PubMed: FDA halts sales of some anti-vomiting suppositories...and are cough medications effective in children? PubMed: Involuntary emotional expression disorder: treating the untreated. PubMed: Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. PubMed: A real reason for patients with pseudobulbar affect to smile. PubMed: Postherpetic neuralgia. PubMed: Effects of dextromethorphan on rats' acquisition of responding with delayed reinforcement. PubMed: Review of pseudobulbar affect including a novel and potential therapy. PubMed: Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification. PubMed: Dextromethorphan-induced delirium and possible methadone interaction. PubMed: Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats. PubMed: Fast screening method for the analysis of total flavonoid content in plants and foodstuffs by high-performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry with polarity switching. PubMed: Down-regulation of hepatic CYP3A in chronic renal insufficiency. PubMed: Clinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterial. PubMed: Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. PubMed: Dietary levels of quinine in tonic water do not inhibit CYP2D6 in vivo. PubMed: Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. PubMed: Clinical pharmacokinetics of tegaserod, a serotonin 5-HT(4) receptor partial agonist with promotile activity. PubMed: The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein. PubMed: Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine. PubMed: Cardiovascular sympathomimetic amine interactions in rats treated with monoamine oxidase inhibitors and the novel oxazolidinone antibiotic linezolid. PubMed: Cytochrome P450 expression and related metabolism in human buccal mucosa. PubMed: Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression. PubMed: Phencyclidine-induced discriminative stimulus is mediated via phencyclidine binding sites on the N-methyl-D-aspartate receptor-ion channel complex, not via sigma(1) receptors. PubMed: Dextromethorphan alters methamphetamine self-administration in the rat. PubMed: Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail". PubMed: MorphiDex pharmacokinetic studies and single-dose analgesic efficacy studies in patients with postoperative pain. PubMed: Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase. PubMed: Evaluation of the reinforcing properties and phencyclidine-like discriminative stimulus effects of dextromethorphan and dextrorphan in rats and rhesus monkeys. PubMed: [Non-ketotic hyperglycinemia: clinical and therapeutic course in three patients]. PubMed: The stimulus properties of two common over-the-counter drug mixtures: dextromethorphan + ephedrine and dextromethorphan + diphenhydramine. PubMed: A massive outbreak of food poisoning--a reminder of the importance of proper toxic waste control. PubMed: Discriminative stimulus properties of dextromethorphan in rats. PubMed: Hazards of nonprescription medications. PubMed: Pharmacological specificity of the discriminative stimulus properties of 2-amino-4,5-(1,2-cyclohexyl)-7-phosphono-heptanoic acid (NPC 12626), a competitive N-methyl-D-aspartate receptor antagonist. PubMed: Polymorphisms in oxidative drug metabolism: relationship to food preference. PubMed: Subsensitivity to the cough-depressant effects of opioid and nonopioid antitussives in morphine-dependent rats: relationship to central serotonin function. PubMed: Discriminative stimulus effects of dextrorphan in pigeons. PubMed: Discriminative stimulus effects of pentobarbital in rhesus monkeys: tests of stimulus generalization and duration of action.