ephedrine sulfate

benzenemethanol, a-(1-(methylamino)ethyl)-, (R-(R*,S*))-, sulfate (2:1) (salt)

CAS: 134-72-5 C20 H32 N2 O6 S MW: 428.54924000

Identification

Nameephedrine sulfate
IUPAC(1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;sulfuric acid
CAS Number134-72-5
EINECS205-154-4
FDA UNIIU6X61U5ZEG
Molecular FormulaC20 H32 N2 O6 S
Molecular Weight428.54924000

Regulatory

Physical Properties

Appearance white microcrystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 38.10 °C. @ 760.00 mm Hg (est)
Boiling Point 255.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.008650 mmHg @ 25.00 °C. (est)
Flash Point 186.00 °F. TCC ( 85.60 °C. ) (est)
logP (o/w) 1.054 (est)
Soluble in water, 7.148e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral Toxicityintravenous-cat LDLo 75 mg/kg
Dermal Toxicitysubcutaneous-guinea pig LDLo 425 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION\nCARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for ephedrine sulfate usage levels up tonot for fragrance use.
Recommendation for ephedrine sulfate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

benzenemethanol, a-((1S)-1-(methylamino)ethyl)-, (aR)-,sulfate (2:1) (salt) benzenemethanol, a-(1-(methylamino)ethyl)-, (theta-(theta,S))-, sulfate (2:1) (salt) benzenemethanol, a-(1-(methylamino)ethyl)-, (R-(R*,S*))-, sulfate (2:1) (salt) benzenemethanol, a-[(1S)-1-(methylamino)ethyl]-, (aR)-, sulfate (2:1) (salt) (-)- ephedrine sulfate (-)- ephedrine sulphate iso fedrol bis((R-(R*,S*))-b- hydroxy-a-methylphenethyl)methylammonium sulfate bis((R-(R*,S*))-beta- hydroxy-alpha-methyl phenethyl)methyl ammonium) sulfate (1R,2S)-2- methylamino-1-phenylpropan-1-ol; sulfuric acid (1R,2S)-2-( methylamino)-1-phenyl-1-propanol sulfate (2:1) (1R,2S)-2-( methylamino)-1-phenylpropan-1-ol sulfate (2:1) (aR)-a-((1S)-1-( methylamino)ethyl)benzenemethanol sulfate (2:1) (salt) 1-a-(1-( methylamino)ethyl)benzyl alcohol sulfate pazo ointment pazo suppositories 1- phenyl-2-(methylamino)propanol sulfate 1- phenyl-2-methylamine-propanol-1-sulfate (1R,2S)-1- phenyl-2-methylaminopropanol-1 sulfate PubMed: Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis. PubMed: Labeling for bronchodilators to treat asthma; cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use. Final rule. PubMed: Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms. PubMed: Separation of cold medicine ingredients using a precise MEKC method at elevated pH. PubMed: Comparison of the acute pharmacodynamic responses after single doses of ephedrine or sibutramine in healthy, overweight volunteers. PubMed: Stability of Ephedrine Sulfate at Ambient Temperature and 4 deg C in Polypropylene Syringes. PubMed: Ephedrine-activated physiological sexual arousal in women. PubMed: Neurochemical mechanisms of nitroglycerin-induced neuronal activation in rat brain: a pharmacological investigation. PubMed: Prevention of maternal hypotension by epidural administration of ephedrine sulfate during lumbar epidural anesthesia for cesarean section. PubMed: Determination of ephedrine, pseudoephedrine, and norephedrine in mixtures (bulk and dosage forms) by proton nuclear magnetic resonance spectroscopy. PubMed: Atropine and ephedrine adsorption to syringe plastic. PubMed: Retrograde ejaculation and loss of emission: possibilities of conservative treatment. PubMed: Nonprescription drugs and hypertension. Which ones affect blood pressure? PubMed: NTP Toxicology and Carcinogenesis Studies of Ephedrine Sulfate (CAS No. 134-72-5) in F344/N Rats and B6C3F1 Mice (Feed Studies). PubMed: Prophylaxis against repeated radiocontrast media reactions in 857 cases. Adverse experience with cimetidine and safety of beta-adrenergic antagonists. PubMed: Acute angle-closure glaucoma associated with surgical anesthesia. PubMed: Central nervous system lesion causing urethral instability and urinary incontinence. PubMed: Experience with the classification, diagnosis, and therapy of nonejaculatory intercourse. PubMed: Prophylactic intravenous ephedrine infusion during spinal anesthesia for cesarean section. PubMed: Experimental motion sickness: efficacy of transdermal scopolamine plus ephedrine. PubMed: The alpha-adrenergic blocking action of prazosin hydrochloride on the canine urethra. PubMed: On-calcium periodate reaction method for analysis of ephedrine sulfate in solid dosage forms: collaborative study. PubMed: Arrhythmogenic effects of orally administered bronchodilators. PubMed: A comparative study of bronchodilator effects of carbuterol and ephedrine. PubMed: Physical properties and dissolution profiles of ephedrine sulfate and nicotinic acid tablets made from water soluble vehicles. PubMed: [Reaction kinetic studies on the formation of n-nitrosoephedrine in vitro and in vivo (author's transl)]. PubMed: Double-blind trial of oral carbuterol in bronchial asthma. PubMed: Ephedrine therapy in asthmatic children. Clinical tolerance and absence of side effects. PubMed: Subject expectancy and environmental factors as determinants of psychedelic flashback experiences. PubMed: Human assay of antimotion sickness drugs. PubMed: Collaborative study of an on-column periodate reaction method for the determination of ephedrine sulfate in sirups. PubMed: Ephedrine in treatment of urinary incontinence. PubMed: Cholinergic and adrenergic neuroreceptors in urinary tract of female dogs. Evaluation of function with pharmacodynamics. PubMed: Subsensitivity to epinephrine following the administration of epinephrine and ephedrine to normal individuals. PubMed: Urinary excretion of ephedrine in man without pH control following oral administration of three commercial ephedrine sulfate preparations. PubMed: A note on the quantitative determination of ephedrine sulfate when compounded with phenobarbital elixir U.S.P. PubMed: Failure to produce polycythemia in man, dog and rabbit by daily administration of ephedrine sulfate. PubMed: A comparative study of intrathecal ephedrine sulfate, intrathecal pontocaine, and inhalation anesthesia for obstetrical delivery. PubMed: Prolonged spinal anesthesia using ephedrine sulfate intrathecally. PubMed: The use of ephedrine sulfate in the control of enuresis in schizophrenic regression. PubMed: The Spinal Anaesthetic Effects of Ephedrine Sulfate: A Preliminary Report. PubMed: Influence of ephedrine sulfate on blood pressure in hypertensive rats. PubMed: EPHEDRINE sulfate and phenobarbital capsules. PubMed: Influence of ephedrine sulfate on blood pressure in hypertensive rats.