ephedrine sulfate
benzenemethanol, a-(1-(methylamino)ethyl)-, (R-(R*,S*))-, sulfate (2:1) (salt)
Identification
| Name | ephedrine sulfate |
| IUPAC | (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;sulfuric acid |
| CAS Number | 134-72-5 |
| EINECS | 205-154-4 |
| FDA UNII | U6X61U5ZEG |
| Molecular Formula | C20 H32 N2 O6 S |
| Molecular Weight | 428.54924000 |
Regulatory
Physical Properties
| Appearance | white microcrystalline powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 38.10 °C. @ 760.00 mm Hg (est) |
| Boiling Point | 255.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.008650 mmHg @ 25.00 °C. (est) |
| Flash Point | 186.00 °F. TCC ( 85.60 °C. ) (est) |
| logP (o/w) | 1.054 (est) |
| Soluble in | water, 7.148e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intravenous-cat LDLo 75 mg/kg |
| Dermal Toxicity | subcutaneous-guinea pig LDLo 425 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION\nCARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for ephedrine sulfate usage levels up to | not for fragrance use. |
| Recommendation for ephedrine sulfate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzenemethanol, a-((1S)-1-(methylamino)ethyl)-, (aR)-,sulfate (2:1) (salt)
benzenemethanol, a-(1-(methylamino)ethyl)-, (theta-(theta,S))-, sulfate (2:1) (salt)
benzenemethanol, a-(1-(methylamino)ethyl)-, (R-(R*,S*))-, sulfate (2:1) (salt)
benzenemethanol, a-[(1S)-1-(methylamino)ethyl]-, (aR)-, sulfate (2:1) (salt)
(-)-
ephedrine sulfate
(-)-
ephedrine sulphate
iso
fedrol
bis((R-(R*,S*))-b-
hydroxy-a-methylphenethyl)methylammonium sulfate
bis((R-(R*,S*))-beta-
hydroxy-alpha-methyl phenethyl)methyl ammonium) sulfate
(1R,2S)-2-
methylamino-1-phenylpropan-1-ol; sulfuric acid
(1R,2S)-2-(
methylamino)-1-phenyl-1-propanol sulfate (2:1)
(1R,2S)-2-(
methylamino)-1-phenylpropan-1-ol sulfate (2:1)
(aR)-a-((1S)-1-(
methylamino)ethyl)benzenemethanol sulfate (2:1) (salt)
1-a-(1-(
methylamino)ethyl)benzyl alcohol sulfate
pazo ointment
pazo suppositories
1-
phenyl-2-(methylamino)propanol sulfate
1-
phenyl-2-methylamine-propanol-1-sulfate
(1R,2S)-1-
phenyl-2-methylaminopropanol-1 sulfate
PubMed:
Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis.
PubMed:
Labeling for bronchodilators to treat asthma; cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use. Final rule.
PubMed:
Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms.
PubMed:
Separation of cold medicine ingredients using a precise MEKC method at elevated pH.
PubMed:
Comparison of the acute pharmacodynamic responses after single doses of ephedrine or sibutramine in healthy, overweight volunteers.
PubMed:
Stability of Ephedrine Sulfate at Ambient Temperature and 4 deg C in Polypropylene Syringes.
PubMed:
Ephedrine-activated physiological sexual arousal in women.
PubMed:
Neurochemical mechanisms of nitroglycerin-induced neuronal activation in rat brain: a pharmacological investigation.
PubMed:
Prevention of maternal hypotension by epidural administration of ephedrine sulfate during lumbar epidural anesthesia for cesarean section.
PubMed:
Determination of ephedrine, pseudoephedrine, and norephedrine in mixtures (bulk and dosage forms) by proton nuclear magnetic resonance spectroscopy.
PubMed:
Atropine and ephedrine adsorption to syringe plastic.
PubMed:
Retrograde ejaculation and loss of emission: possibilities of conservative treatment.
PubMed:
Nonprescription drugs and hypertension. Which ones affect blood pressure?
PubMed:
NTP Toxicology and Carcinogenesis Studies of Ephedrine Sulfate (CAS No. 134-72-5) in F344/N Rats and B6C3F1 Mice (Feed Studies).
PubMed:
Prophylaxis against repeated radiocontrast media reactions in 857 cases. Adverse experience with cimetidine and safety of beta-adrenergic antagonists.
PubMed:
Acute angle-closure glaucoma associated with surgical anesthesia.
PubMed:
Central nervous system lesion causing urethral instability and urinary incontinence.
PubMed:
Experience with the classification, diagnosis, and therapy of nonejaculatory intercourse.
PubMed:
Prophylactic intravenous ephedrine infusion during spinal anesthesia for cesarean section.
PubMed:
Experimental motion sickness: efficacy of transdermal scopolamine plus ephedrine.
PubMed:
The alpha-adrenergic blocking action of prazosin hydrochloride on the canine urethra.
PubMed:
On-calcium periodate reaction method for analysis of ephedrine sulfate in solid dosage forms: collaborative study.
PubMed:
Arrhythmogenic effects of orally administered bronchodilators.
PubMed:
A comparative study of bronchodilator effects of carbuterol and ephedrine.
PubMed:
Physical properties and dissolution profiles of ephedrine sulfate and nicotinic acid tablets made from water soluble vehicles.
PubMed:
[Reaction kinetic studies on the formation of n-nitrosoephedrine in vitro and in vivo (author's transl)].
PubMed:
Double-blind trial of oral carbuterol in bronchial asthma.
PubMed:
Ephedrine therapy in asthmatic children. Clinical tolerance and absence of side effects.
PubMed:
Subject expectancy and environmental factors as determinants of psychedelic flashback experiences.
PubMed:
Human assay of antimotion sickness drugs.
PubMed:
Collaborative study of an on-column periodate reaction method for the determination of ephedrine sulfate in sirups.
PubMed:
Ephedrine in treatment of urinary incontinence.
PubMed:
Cholinergic and adrenergic neuroreceptors in urinary tract of female dogs. Evaluation of function with pharmacodynamics.
PubMed:
Subsensitivity to epinephrine following the administration of epinephrine and ephedrine to normal individuals.
PubMed:
Urinary excretion of ephedrine in man without pH control following oral administration of three commercial ephedrine sulfate preparations.
PubMed:
A note on the quantitative determination of ephedrine sulfate when compounded with phenobarbital elixir U.S.P.
PubMed:
Failure to produce polycythemia in man, dog and rabbit by daily administration of ephedrine sulfate.
PubMed:
A comparative study of intrathecal ephedrine sulfate, intrathecal pontocaine, and inhalation anesthesia for obstetrical delivery.
PubMed:
Prolonged spinal anesthesia using ephedrine sulfate intrathecally.
PubMed:
The use of ephedrine sulfate in the control of enuresis in schizophrenic regression.
PubMed:
The Spinal Anaesthetic Effects of Ephedrine Sulfate: A Preliminary Report.
PubMed:
Influence of ephedrine sulfate on blood pressure in hypertensive rats.
PubMed:
EPHEDRINE sulfate and phenobarbital capsules.
PubMed:
Influence of ephedrine sulfate on blood pressure in hypertensive rats.