4-hydroxyflavanone
4H-1-benzopyran-4-one, 2,3-dihydro-2-(4-hydroxyphenyl)-
Identification
| Name | 4-hydroxyflavanone |
| IUPAC | 2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one |
| CAS Number | 6515-37-3 |
| FDA UNII | 5K6L8O868Y |
| Molecular Formula | C15 H12 O3 |
| Molecular Weight | 240.25824000 |
| MDL Number | MFCD00017705 |
| Nikkaji Number | J285.123G |
| XlogP3 | 2.80 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 447.53 °C. @ 760.00 mm Hg (est) |
| Flash Point | 345.00 °F. TCC ( 174.00 °C. ) (est) |
| logP (o/w) | 2.720 (est) |
| Soluble in | water, 416.5 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 4-hydroxyflavanone usage levels up to | not for fragrance use. |
| Recommendation for 4-hydroxyflavanone flavor usage levels up to | not for flavor use. |
Penta International Corporation
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Potential Uses
Natural Occurrence
Synonyms
4H-1-
benzopyran-4-one, 2,3-dihydro-2-(4-hydroxyphenyl)-
2,3-
dihydro-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
4'-
hydroxy flavanone
2-(4-
hydroxy-phenyl)-chroman-4-one
4'-
hydroxyflavanone
2-(4-
hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
2-(4-
hydroxyphenyl)-2,3-dihydrochromen-4-one
2-(4-
hydroxyphenyl)chroman-4-one
PubMed:
Regiospecificity of human UDP-glucuronosyltransferase isoforms in chalcone and flavanone glucuronidation determined by metal complexation and tandem mass spectrometry.
PubMed:
Three new phenolic compounds from the roots of Glycyrrhiza yunnanensis.
PubMed:
Bioconversion of 7-hydroxyflavanone: isolation, characterization and bioactivity evaluation of twenty-one phase I and phase II microbial metabolites.
PubMed:
Evaluation of novel amylose and cellulose-based chiral stationary phases for the stereoisomer separation of flavanones by means of nano-liquid chromatography.
PubMed:
4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis.
PubMed:
Microbial metabolism. Part 12. Isolation, characterization and bioactivity evaluation of eighteen microbial metabolites of 4'-hydroxyflavanone.
PubMed:
Optical isomer separation of flavanones and flavanone glycosides by nano-liquid chromatography using a phenyl-carbamate-propyl-beta-cyclodextrin chiral stationary phase.
PubMed:
[Studies on chemical constituents from seed of Psoralea corylifolia].
PubMed:
Chiral separation of hydroxyflavanones in cyclodextrin-modified capillary zone electrophoresis using sulfated cyclodextrins as chiral selectors.
PubMed:
[Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].
PubMed:
Synthesis and immunosuppressive activity of L-rhamnopyranosyl flavonoids.
PubMed:
Effect of different flavonoids on collagen synthesis in human fibroblasts.
PubMed:
Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels.
PubMed:
Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences.
PubMed:
Synthesis and anti-inflammatory effect of chalcones and related compounds.
PubMed:
Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-alpha in L-929 tumor cells.
PubMed:
Aromatase inhibition by flavonoids.
PubMed:
Microbiological transformation of (+/-)-flavanone and (+/-)-isoflavanone.