sodium ferulate

sodium 3-methoxy-4-hydroxycinnamate

CAS: 24276-84-4 C10 H10 O4 Na MW: 217.17626928 spicy

Identification

Namesodium ferulate
IUPACsodium (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
CAS Number24276-84-4
FDA UNIIOIS7F1IRQK
Molecular FormulaC10 H10 O4 Na
Molecular Weight217.17626928

Regulatory

JECFA Food Flavoring2014 sodium 3-methoxy-4-hydroxycinnamate
FEMA Number3812
FDANo longer provide for the use of these seven synthetic flavoring substances

Physical Properties

Appearance pale yellow powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 371.00 to 372.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.000003 mmHg @ 25.00 °C. (est)
Flash Point 302.00 °F. TCC ( 150.00 °C. )
logP (o/w) 1.641 (est)
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

Organoleptic Properties

Odor Description at 100.00 %.

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for sodium ferulate usage levels up tonot for fragrance use.
Structure ClassI
baked goods100.00000
beverages(nonalcoholic)400.00000
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings100.00000
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes2000.00000
sweet sauces300.00000

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Chemical sources Association Inc

Exchange of knowledge

Need This Item for Flavor? You can contact the Chemical Sources Association.

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

cinnamic acid, 4-hydroxy-3-methoxy-, monosodium salt ferulic acid sodium salt 3-(4- hydroxy-3-methoxyphenyl) propenoic acid sodium salt 3-(4- hydroxy-3-methoxyphenyl)-2-propenoic acid monosodium salt (2E)-3-(4- hydroxy-3-methoxyphenyl)prop-2-enoic acid, sodium salt 2- propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, monosodium salt 2- propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, sodium salt, (2E)- (1:1) sodium (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate sodium (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate sodium (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate mono sodium 3-(4-hydroxy-3-methoxyphenyl)-2-propenoate sodium 3-methoxy-4-hydroxycinnamate mono sodium 4-hydroxy-3-methoxycinnamate PubMed: Sodium Ferulate Prevents Daunorubicin - Induced Apoptosis in H9c2 Cells via Inhibition of the ERKs Pathway. PubMed: [Sodium Ferulate Attenuates Oxidative Stress Induced Inflammation via Suppressing NALP3 and NF-κB Signal Pathway]. PubMed: [Sodium ferulate protects against daunorubicin-induced cardiotoxicity in juvenile rats]. PubMed: The Protective Effect of Sodium Ferulate and Oxymatrine Combination on Paraquat-induced Lung Injury. PubMed: Sodium Ferulate Reduces Portal Pressure Through Inhibition of RhoA/Rho-Kinase and Activation of Endothelial Nitric Oxide Synthase in Cirrhotic Rats. PubMed: HMGB1 Silencing Potentiates the Anti-inflammatory Effects of Sodium Ferulate in ox-LDL-Stimulated Vascular Smooth Muscle Cells. PubMed: Angelica sinensis and osteoarthritis: a natural therapeutic link? PubMed: Sodium ferulate lowers portal pressure in rats with secondary biliary cirrhosis through the RhoA/Rho-kinase signaling pathway: a preliminary study. PubMed: Effect of sodium ferulate on delayed rectifier K(+) currents in PC12 cells. PubMed: Protective effects of the combination of sodium ferulate and oxymatrine on cecal ligation and puncture-induced sepsis in mice. PubMed: Sodium ferulate inhibits neointimal hyperplasia in rat balloon injury model. PubMed: The protective effects of the combination of sodium ferulate and oxymatrine on ethanol-induced liver damage in mice. PubMed: [Protective effect of sodium ferulate magnetic nanoparticle in septic kidney injury rats]. PubMed: Sodium ferulate protects against daunorubicin-induced cardiotoxicity by inhibition of mitochondrial apoptosis in juvenile rats. PubMed: Exogenous and endogenous therapeutic effects of combination Sodium Ferulate and bone marrow stromal cells (BMSCs) treatment enhance neurogenesis after rat focal cerebral ischemia. PubMed: Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate. PubMed: Synchronous fluorescence determination of ferulic acid with Ce(IV) and sodium tripolyphosphate. PubMed: Response to 'TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro'--authors' reply. PubMed: Response to 'TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro'. PubMed: Effects of sodium ferulate on preventing steroid-induced femoral head osteonecrosis in rabbits. PubMed: TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro. PubMed: The effects of sodium ferulate on the pharmacokinetics of bupropion and its active metabolite in healthy men. PubMed: Cardioprotective effect of sodium ferulate in diabetic rats. PubMed: Hypnic headache responsive to sodium ferulate in 2 new cases. PubMed: Sodium Ferulate combined with bone marrow stromal cell treatment ameliorating rat brain ischemic injury after stroke. PubMed: Protective effect of sodium ferulate on acetaldehyde-treated precision-cut rat liver slices. PubMed: The effects of the combination of sodium ferulate and oxymatrine on lipopolysaccharide-induced acute lung injury in mice. PubMed: Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure. PubMed: The synergistic anti-inflammatory effect of the combination of sodium ferulate and oxymatrine and its modulation on inflammation-associated mediators in RAW 264.7 cells. PubMed: P2X receptors and modulation of pain transmission: focus on effects of drugs and compounds used in traditional Chinese medicine. PubMed: The orally combined neuroprotective effects of sodium ferulate and borneol against transient global ischaemia in C57 BL/6J mice. PubMed: The analgesic effect and mechanism of the combination of sodium ferulate and oxymatrine. PubMed: [Effect of Ligusticum and its two main components on muscle atrophy in a hind limb unloaded rat model]. PubMed: [Systematic review on sodium ferulate for treatment of diabetic nephropathy]. PubMed: Effect of sodium ferulate on the hyperalgesia mediated by P2X3 receptor in the neuropathic pain rats. PubMed: [Sodium ferulate treatment and interventional mechanism reverse erectile dysfunction in streptozotocin-induced diabetic rats]. PubMed: Sodium ferulate modified gene expression profile of oxidized low-density lipoprotein-stimulated human umbilical vein endothelial cells. PubMed: Mannose 6-phosphate-modified bovine serum albumin nanoparticles for controlled and targeted delivery of sodium ferulate for treatment of hepatic fibrosis. PubMed: Effects of sodium ferulate on human osteoarthritic chondrocytes and osteoarthritis in rats. PubMed: [Clinical study on sodium ferulate for intracerebral hemorrhage in early stage]. PubMed: Sodium ferulate attenuates anoxia/reoxygenation-induced calcium overload in neonatal rat cardiomyocytes by NO/cGMP/PKG pathway. PubMed: Endothelium-independent vasorelaxant effect of sodium ferulate on rat thoracic aorta. PubMed: Neuroprotective effect of sodium ferulate and signal transduction mechanisms in the aged rat hippocampus. PubMed: [Effect of sodium ferulate on hemodynamics in hepatic cirrhosis patients with portal hypertension]. PubMed: Role of sodium ferulate in the nociceptive sensory facilitation of neuropathic pain injury mediated by P2X(3) receptor. PubMed: Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. PubMed: Neuroprotection by sodium ferulate against glutamate-induced apoptosis is mediated by ERK and PI3 kinase pathways. PubMed: Study on effect and mechanism of sodium ferulate in preventing and treating ozone induced lung injury in mice. PubMed: Preparation and characterization of sodium ferulate entrapped bovine serum albumin nanoparticles for liver targeting. PubMed: Protection against oxidative stress in diabetic rats by wheat bran feruloyl oligosaccharides. PubMed: Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury. PubMed: A novel controlled porosity osmotic pump system for sodium ferulate. PubMed: [Preliminary study on effects of sodium ferulate in treating diabetic nephropathy]. PubMed: High-performance liquid chromatography-electrospray ionization mass spectrometry determination of sodium ferulate in human plasma. PubMed: Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus. PubMed: Development of a gradient reversed-phase HPLC method for the determination of sodium ferulate in beagle dog plasma. PubMed: In vitro controlled release of sodium ferulate from Compritol 888 ATO-based matrix tablets. PubMed: [Cardioprotective effects of sodium ferulate mediated by nitric oxide on ischemia-reperfusion injured myocardium: experiment with isolated rat hearts]. PubMed: Potent protection of ferulic acid against excitotoxic effects of maternal intragastric administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain. PubMed: Differentiation of human bone marrow stromal cells into neural-like cells induced by sodium ferulate in vitro. PubMed: Neuroprotective effect of sodium ferulate on transient focal cerebral ischemia by weakening activation of postsynaptic density-95 in rats. PubMed: Effect of sodium ferulate on human colonic anion secretion and the underlying signaling mechanism. PubMed: Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus. PubMed: Pharmacological actions of sodium ferulate in cardiovascular system. PubMed: [Preliminary clinical observation on effect of soduim ferulate in treating diabetic nephropathy]. PubMed: [Study on the pharmacological mechanism of sodium ferulate for anti-asthmatic effect in guinea pigs]. PubMed: [Mechanisms of sodium ferulate inhibition of collagen synthesis in hepatic stellate cells]. PubMed: [Description of the release of sodium ferulate from hydroxypropyl methylcellulose based matrix tablets in vitro]. PubMed: [Protective effect and mechanism of pharmacologic preconditioning induced by sodium ferulate on primary cultured myocardial cell injury by anoxia/reoxygenation]. PubMed: [Renal protective effect and its mechanism of sodium ferulate in diabetic rats]. PubMed: Sodium ferulate inhibits atherosclerogenesis in hyperlipidemia rabbits. PubMed: [Antagonistic effect of sodium ferulate on glycerol-induced renal oxidative injury in mice]. PubMed: [Effect of sodium ferulate on activation of extracellular signal regulated kinase after cerebral ischemia/reperfusion injury in rats]. PubMed: Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats. PubMed: [Effect of sodium ferulate on leucocyte spontaneous activation and surface adhesion molecule expression in arteriosclerosis obliterans patients]. PubMed: Influence of Angelicae sinensis extract on lipid accumulation in rabbit aortic smooth muscle cells induced by oxidized LDL. PubMed: [Effect of sodium ferulate on proliferation of rabbit aortic smooth muscle cells induced by oxidized LDL]. PubMed: [The effect of antioxidant sodium ferulate on human lymphocytes apoptosis induced by H2O2]. PubMed: [Antagonizing effect of sodium ferulate on the changes of hepatic antioxidative function induced by ethanol in mice]. PubMed: [Mechanism of inhibitory action of sodium ferulate on liver lipid peroxidation in mice]. PubMed: Effects of tetramethylpyrazine phosphate and sodium ferulate alone or in combination on hemodynamics in anesthetized dog. PubMed: [Sodium ferulate alleviates prednisolone induced liver toxicity in mice]. PubMed: [Protective effect of sodium ferulate on damage of the rat liver mitochondria induced by oxygen free radicals]. PubMed: [Sodium ferulate alleviated paracetamol-induced liver toxicity in mice]. PubMed: [Effects of paracetamol on glutathione S-transferase activity in mice]. PubMed: Effect of hydroxyl radical on Na(+)-K(+)-ATPase activity of the brain microsomal membranes. PubMed: [The influence of sodium ferulate on hypotensive effect and urinary excretion of TXB2 after captopril in essential hypertensive patients]. PubMed: [Protection of biomembrane fatty acids by antioxidants studied with gas chromatography]. PubMed: [Scavenging effects of sodium ferulate and 18 beta-glycyrrhetic acid on oxygen free radicals]. PubMed: [Effect of sodium ferulate on arachidonic acid metabolism]. PubMed: [Effect of sodium ferulate on C14-arachidonic acid metabolism in rabbit platelets]. PubMed: [Experimental study on the effect of sodium ferulate in protecting acute oxygen intoxication and lipid peroxidation]. PubMed: [Sodium ferulate is an inhibitor of thromboxane A2 synthetase]. PubMed: [Effects of sodium ferulate on platelet aggregation and platelet thromboxane A2 in patients with coronary heart disease]. PubMed: [Hemospasia therapy and sodium ferulate intravenous dripping in the treatment of cor pulmonale]. PubMed: [Effect of sodium ferulate on malondialdehyde production from the platelets of rats]. PubMed: [The effect of sodium ferulate on complement-activated hemolysis]. PubMed: [The effect of sodium ferulate on lipid peroxidation of the erythrocyte membrane]. PubMed: [Effects of sodium ferulate combined with acetylsalicylic acid on rat platelet aggregation and on modulation of PGI2-TXA2 balance]. PubMed: [Studies on mechanism of the antiplatelet effect of sodium ferulate--effect on TXA2/PGI2 balance]. PubMed: [Antithrombotic effect of sodium ferulate in rats (author's transl)]. PubMed: Effect of sodium glycolate and sodium ferulate on renal functions in dog.