solasonine
b-D-galactopyranoside, (3b,22a,25R)-spirosol-5-en-3-yl O-6-deoxy-a-L-mannopyranosyl-(1->;2)-O-[b-D-glucopyranosyl-(1->3)]-
Identification
| Name | solasonine |
| CAS Number | 19121-58-5 |
| EINECS | 242-826-6 |
| FDA UNII | TR60638HXL |
| Molecular Formula | C45 H73 N O16 |
| Molecular Weight | 884.07101000 |
| Nikkaji Number | J13.552F |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | 4.350 (est) |
| Soluble in | water, 0.9627 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 77300 ug/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for solasonine usage levels up to | not for fragrance use. |
| Recommendation for solasonine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
b-D-
galactopyranoside, (3b,22a,25R)-spirosol-5-en-3-yl O-6-deoxy-a-L-mannopyranosyl-(1->;2)-O-[b-D-glucopyranosyl-(1->3)]-
purapurine
solamargine
solanine-S
PubMed:
In vitro and in vivo evaluation of the delivery of topical formulations containing glycoalkaloids of Solanum lycocarpum fruits.
PubMed:
Purification, antitumor activity in vitro of steroidal glycoalkaloids from black nightshade (Solanum nigrum L.).
PubMed:
In vitro leishmanicidal and cytotoxic activities of the glycoalkaloids from Solanum lycocarpum (Solanaceae) fruits.
PubMed:
Antiproliferative activity of Solanum lycocarpum alkaloidic extract and their constituents, solamargine and solasonine, in tumor cell lines.
PubMed:
Biosynthesis of steroidal alkaloids in Solanaceae plants: involvement of an aldehyde intermediate during C-26 amination.
PubMed:
A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids in Solanum lycocarpum and Its Extracts.
PubMed:
Antihepatitis B virus constituents of Solanum erianthum.
PubMed:
Evaluation of the schistosomicidal activity of the steroidal alkaloids from Solanum lycocarpum fruits.
PubMed:
[Simultaneous determination of three steroidal alkaloids from Solanum Nigrum by RP-HPLC].
PubMed:
Antimutagenic potential of Solanum lycocarpum against induction of chromosomal aberrations in V79 cells and micronuclei in mice by doxorubicin.
PubMed:
Simultaneous determination of three steroidal glycoalkaloids in Solanum xanthocarpum by high performance thin layer chromatography.
PubMed:
In vivo antimalarial activities of glycoalkaloids isolated from Solanaceae plants.
PubMed:
Effects of glycoalkaloids from Solanum plants on cucumber root growth.
PubMed:
Characterization of health-related compounds in eggplant (Solanum melongena L.) lines derived from introgression of allied species.
PubMed:
Alpha-solasonine and alpha-solamargine contents of gboma (Solanum macrocarpon L.) and scarlet (Solanum aethiopicum L.) eggplants.
PubMed:
pH-Zone-refining centrifugal partition chromatography for preparative isolation and purification of steroidal glycoalkaloids from Solanum xanthocarpum.
PubMed:
Solanaceous steroidal glycoalkaloids and poisoning by Solanum torvum, the normally edible susumber berry.
PubMed:
Phytochemical study of Solanum lycocarpum (St. Hil) unripe fruit and its effects on rat gestation.
PubMed:
Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.
PubMed:
Efficacy and mechanisms of alpha-solasonine-and alpha-solamargine-induced cytolysis on two strains of Trypanosoma cruzi.
PubMed:
Rats exposed to Solanum lycocarpum fruit in utero and during lactation: neurochemical, behavioral and histopathological effects.
PubMed:
Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells.
PubMed:
Liquid chromatographic determination of alpha-solasonine in frozen green peas as an indicator of the presence of nightshade berries.
PubMed:
Monitoring changes in anthocyanin and steroid alkaloid glycoside content in lines of transgenic potato plants using liquid chromatography/mass spectrometry.
PubMed:
Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice.
PubMed:
Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions.
PubMed:
Membrane disruption and enzyme inhibition by naturally-occurring and modified chacotriose-containing Solanum steroidal glycoalkaloids.
PubMed:
Absence of interceptive effect in rats treated with Solanum lycocarpum (St. Hil).
PubMed:
Developmental toxicology of solamargine and solasonine glycoalkaloids in frog embryos.
PubMed:
Inhibition of Trypanosoma cruzi growth in vitro by Solanum alkaloids: a comparison with ketoconazole.
PubMed:
The effect of some Solanum steroidal alkaloids and glycoalkaloids on larvae of the red flour beetle, Tribolium castaneum, and the tobacco hornworm, Manduca sexta.
PubMed:
Steroidal alkaloid glycosides from Solanum suaveolens.
PubMed:
Steroid alkaloid glycosides from Solanum coccineum.
PubMed:
Feeding of potato, tomato and eggplant alkaloids affects food consumption and body and liver weights in mice.
PubMed:
Solasodine glycosides of Solanum unguiculatum (A.) Rich.
PubMed:
Steroid alkaloid glycosides from Solanum robustum.
PubMed:
Production of monoclonal antibodies and development of an ELISA for solamargine.
PubMed:
Interactions between the glycoalkaloids solasonine and solamargine in relation to inhibition of fungal growth.
PubMed:
1H- and 13C-nmr assignments and structural determination of a novel glycoalkaloid from Solanum platanifolium.
PubMed:
Analysis of glycoalkaloids from potato shoots and tomatoes by four-sector tandem mass spectrometry with scanning-array detection: comparison of positive ion and negative ion methods.
PubMed:
Isolation of steroidal glycoalkaloids from Solanum incanum by two countercurrent chromatographic methods.
PubMed:
Solasodine glycosides. Selective cytotoxicity for cancer cells and inhibition of cytotoxicity by rhamnose in mice with sarcoma 180.
PubMed:
HPLC of Glycoalkaloids from Solanum sodomaeum.
PubMed:
The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids.
PubMed:
Molluscicidal steroid glycoalkaloids possessing stereoisomeric spirosolane structures.
PubMed:
[Isolation of solasonine from glucoalkaloid mixtures by fungal fermentation.].
PubMed:
Some pharmacological actions of solasonine.