tributyl citrate

1,2,3-propanetricarboxylic acid, 2-hydroxy-, tributyl ester

CAS: 77-94-1 C18 H32 O7 MW: 360.44744000

Identification

Nametributyl citrate
IUPACtributyl 2-hydroxypropane-1,2,3-tricarboxylate
CAS Number77-94-1
EINECS201-071-2
FDA UNII827D5B1B6S
Molecular FormulaC18 H32 O7
Molecular Weight360.44744000
MDL NumberMFCD00027217
Nikkaji NumberJ4.216A
Beilstein1806072

Regulatory

FDA Mainterm (IAUFC)77-94-1 ; TRIBUTYL CITRATE

Physical Properties

Appearance colorless clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.03704 to 1.04700 @ 25.00 °C.
Pounds per Gallon - (est). 8.629 to 8.712
Refractive Index 1.44300 @ 25.00 °C.
Melting Point -20.00 °C. @ 760.00 mm Hg
Boiling Point 170.00 °C. @ 1.00 mm Hg
Vapor Pressure 1.000000 mmHg @ 170.00 °C.
Vapor Density 12.4 ( Air = 1 )
Flash Point 285.00 °F. TCC ( 140.56 °C. )
logP (o/w) 4.324 (est)
Soluble in alcohol
Insoluble in water
Stability will not support fungous grouth in resins

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfilm formers

Organoleptic Properties

Odor Strength low
Substantivity 400 Hour(s)
Odor Description at 100.00 %.

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 2900 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysolvents
Recommendation for tributyl citrate usage levels up tonot for fragrance use.
Recommendation for tributyl citrate flavor usage levels up tonot for flavor use.

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Potential Uses

solvents

Natural Occurrence

not found in nature

Synonyms

citric acid tri-N-butyl ester citric acid, tributyl ester citroflex 4 dibutyl 3-(butoxycarbonyl)-3-hydroxypentane-1,5-dioate 2- hydroxy-1,2,3-propanetricarboxylate de tributyle 2- hydroxy-1,2,3-propanetricarboxylic acid, tributyl ester 1,2,3- propanetricarboxylic acid, 2-hydroxy-, tributyl ester tri-N-butyl citrate tributyl 2-hydroxy-1,2,3-propanetricarboxylate tributyl 2-hydroxypropane-1,2,3-tricarboxylate 1,2,3- tributyl 2-hydroxypropane-1,2,3-tricarboxylate tributylcitrate PubMed: Biocompatibility of wollastonite-poly(N-butyl-2-cyanoacrylate) composites. PubMed: Local demixion in plasticized polylactide probed by electron spin resonance. PubMed: The effect of plasticizers on the erosion and mechanical properties of polymeric films. PubMed: Optimization of focused ultrasonic extraction of propellant components determined by gas chromatography/mass spectrometry. PubMed: Improved mechanical property and water resistance of zein films by plasticization with tributyl citrate. PubMed: [Survey of plasticizers in polyvinyl chloride toys]. PubMed: Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion. PubMed: Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome p450 3a through steroid and xenobiotic receptor. PubMed: Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan. PubMed: Effect of ionising radiation treatment on the specific migration characteristics of packaging-food simulant combinations: effect of type and dose of radiation. PubMed: Development of a gas chromatographic/mass spectrometric method for determination of phthalates in oily foods. PubMed: Migration and hydrolysis of hydrophobic polylactide plasticizer. PubMed: Occurrence of extractable ink residuals in packaging materials used in the Czech Republic. PubMed: Guided tissue regeneration with bioabsorbable barriers III 10-year results in infrabony defects. PubMed: Design and characterization of an adhesive matrix based on a poly(ethyl acrylate, methyl methacrylate). PubMed: Fabrication and characterization of poly(lactic acid)/acetyl tributyl citrate/carbon black as conductive polymer composites. PubMed: Determination of diethylhexyladipate and acetyltributylcitrate in aqueous extracts after cloud point extraction coupled with microwave assisted back extraction and gas chromatographic separation. PubMed: Temporary restorative resins using non-phthalate ester plasticizers. PubMed: Molecular biomarkers and adaptation to environmental stress in moon jelly (Aurelia spp.). PubMed: Preparation and properties of plasticized poly(lactic acid) films. PubMed: Controlled release of atenolol from the ethylene-vinyl acetate matrix. PubMed: [Examination of sex-hormonal activity of some additives for PVDC film]. PubMed: Enhanced bioavailability of atenolol by transdermal administration of the ethylene-vinyl acetate matrix in rabbits. PubMed: [Material labeling of soft plastic toys and plasticizers in polyvinyl chloride products]. PubMed: Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan. PubMed: [Contents of plasticizers in cap-sealing for bottled food and their migration into food]. PubMed: Polymerized rosin: novel film forming polymer for drug delivery. PubMed: Final report on the safety assessment of acetyl triethyl citrate, acetyl tributyl citrate, acetyl trihexyl citrate, and acetyl trioctyl citrate. PubMed: Cytocompatibility of new phthalate ester-free tissue conditioners in vitro. PubMed: Self-adhesive thin films for topical delivery of 5-aminolevulinic acid. PubMed: Influence of curing on the adhesive and thermomechanical properties of an applied acrylic polymer. PubMed: Organic esters of plasticizers affecting the water absorption, adhesive property, glass transition temperature and plasticizer permanence of eudragit acrylic films. PubMed: Guided tissue regeneration with bioabsorbable barriers: intrabony defects and class II furcations. PubMed: The effects of plasticizers on the release of metoprolol tartrate from granules coated with a polymethacrylate film. PubMed: Influence of surfactants in aqueous-based polymeric dispersions on the thermomechanical and adhesive properties of acrylic films. PubMed: Diffusion-controlled drug delivery systems: calculation of the required composition to achieve desired release profiles. PubMed: Tackiness of acrylic and cellulosic polymer films used in the coating of solid dosage forms. PubMed: Effect of high-dose electron beam irradiation on the migration of DOA and ATBC plasticizers from food-grade PVC and PVDC/PVC films, respectively, into olive oil. PubMed: Calculation of the dimensions of drug-polymer devices based on diffusion parameters. PubMed: Acetyl tributyl citrate and dibutyl sebacate inhibit the growth of cultured mammalian cells. PubMed: Variables that affect the mechanism of drug release from osmotic pumps coated with acrylate/methacrylate copolymer latexes. PubMed: Processing considerations for an EC latex coating system: influence of curing time and temperature. PubMed: Migration from plasticized films into foods. 3. Migration of phthalate, sebacate, citrate and phosphate esters from films used for retail food packaging. PubMed: [Control of drug release from coated parenteral matrix-retard tablets using softening agents]. PubMed: In vitro release of therapeutically active ingredients from polymer matrixes. PubMed: Pharmacological properties of the plasticizer, acetyl N-tributyl citrate, and its extraction from poly(vinyl chloride) tubing. PubMed: Toxicology of the citric acid esters: tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate.