tributyl citrate
1,2,3-propanetricarboxylic acid, 2-hydroxy-, tributyl ester
Identification
| Name | tributyl citrate |
| IUPAC | tributyl 2-hydroxypropane-1,2,3-tricarboxylate |
| CAS Number | 77-94-1 |
| EINECS | 201-071-2 |
| FDA UNII | 827D5B1B6S |
| Molecular Formula | C18 H32 O7 |
| Molecular Weight | 360.44744000 |
| MDL Number | MFCD00027217 |
| Nikkaji Number | J4.216A |
| Beilstein | 1806072 |
Regulatory
| FDA Mainterm (IAUFC) | 77-94-1 ; TRIBUTYL CITRATE |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.03704 to 1.04700 @ 25.00 °C. |
| Pounds per Gallon - (est). | 8.629 to 8.712 |
| Refractive Index | 1.44300 @ 25.00 °C. |
| Melting Point | -20.00 °C. @ 760.00 mm Hg |
| Boiling Point | 170.00 °C. @ 1.00 mm Hg |
| Vapor Pressure | 1.000000 mmHg @ 170.00 °C. |
| Vapor Density | 12.4 ( Air = 1 ) |
| Flash Point | 285.00 °F. TCC ( 140.56 °C. ) |
| logP (o/w) | 4.324 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
| Stability | will not support fungous grouth in resins |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | film formers |
Organoleptic Properties
| Odor Strength | low |
| Substantivity | 400 Hour(s) |
| Odor Description | at 100.00 %. |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 2900 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | solvents |
| Recommendation for tributyl citrate usage levels up to | not for fragrance use. |
| Recommendation for tributyl citrate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
citric acid tri-N-butyl ester
citric acid, tributyl ester
citroflex 4
dibutyl 3-(butoxycarbonyl)-3-hydroxypentane-1,5-dioate
2-
hydroxy-1,2,3-propanetricarboxylate de tributyle
2-
hydroxy-1,2,3-propanetricarboxylic acid, tributyl ester
1,2,3-
propanetricarboxylic acid, 2-hydroxy-, tributyl ester
tri-N-butyl citrate
tributyl 2-hydroxy-1,2,3-propanetricarboxylate
tributyl 2-hydroxypropane-1,2,3-tricarboxylate
1,2,3-
tributyl 2-hydroxypropane-1,2,3-tricarboxylate
tributylcitrate
PubMed:
Biocompatibility of wollastonite-poly(N-butyl-2-cyanoacrylate) composites.
PubMed:
Local demixion in plasticized polylactide probed by electron spin resonance.
PubMed:
The effect of plasticizers on the erosion and mechanical properties of polymeric films.
PubMed:
Optimization of focused ultrasonic extraction of propellant components determined by gas chromatography/mass spectrometry.
PubMed:
Improved mechanical property and water resistance of zein films by plasticization with tributyl citrate.
PubMed:
[Survey of plasticizers in polyvinyl chloride toys].
PubMed:
Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion.
PubMed:
Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome p450 3a through steroid and xenobiotic receptor.
PubMed:
Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan.
PubMed:
Effect of ionising radiation treatment on the specific migration characteristics of packaging-food simulant combinations: effect of type and dose of radiation.
PubMed:
Development of a gas chromatographic/mass spectrometric method for determination of phthalates in oily foods.
PubMed:
Migration and hydrolysis of hydrophobic polylactide plasticizer.
PubMed:
Occurrence of extractable ink residuals in packaging materials used in the Czech Republic.
PubMed:
Guided tissue regeneration with bioabsorbable barriers III 10-year results in infrabony defects.
PubMed:
Design and characterization of an adhesive matrix based on a poly(ethyl acrylate, methyl methacrylate).
PubMed:
Fabrication and characterization of poly(lactic acid)/acetyl tributyl citrate/carbon black as conductive polymer composites.
PubMed:
Determination of diethylhexyladipate and acetyltributylcitrate in aqueous extracts after cloud point extraction coupled with microwave assisted back extraction and gas chromatographic separation.
PubMed:
Temporary restorative resins using non-phthalate ester plasticizers.
PubMed:
Molecular biomarkers and adaptation to environmental stress in moon jelly (Aurelia spp.).
PubMed:
Preparation and properties of plasticized poly(lactic acid) films.
PubMed:
Controlled release of atenolol from the ethylene-vinyl acetate matrix.
PubMed:
[Examination of sex-hormonal activity of some additives for PVDC film].
PubMed:
Enhanced bioavailability of atenolol by transdermal administration of the ethylene-vinyl acetate matrix in rabbits.
PubMed:
[Material labeling of soft plastic toys and plasticizers in polyvinyl chloride products].
PubMed:
Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan.
PubMed:
[Contents of plasticizers in cap-sealing for bottled food and their migration into food].
PubMed:
Polymerized rosin: novel film forming polymer for drug delivery.
PubMed:
Final report on the safety assessment of acetyl triethyl citrate, acetyl tributyl citrate, acetyl trihexyl citrate, and acetyl trioctyl citrate.
PubMed:
Cytocompatibility of new phthalate ester-free tissue conditioners in vitro.
PubMed:
Self-adhesive thin films for topical delivery of 5-aminolevulinic acid.
PubMed:
Influence of curing on the adhesive and thermomechanical properties of an applied acrylic polymer.
PubMed:
Organic esters of plasticizers affecting the water absorption, adhesive property, glass transition temperature and plasticizer permanence of eudragit acrylic films.
PubMed:
Guided tissue regeneration with bioabsorbable barriers: intrabony defects and class II furcations.
PubMed:
The effects of plasticizers on the release of metoprolol tartrate from granules coated with a polymethacrylate film.
PubMed:
Influence of surfactants in aqueous-based polymeric dispersions on the thermomechanical and adhesive properties of acrylic films.
PubMed:
Diffusion-controlled drug delivery systems: calculation of the required composition to achieve desired release profiles.
PubMed:
Tackiness of acrylic and cellulosic polymer films used in the coating of solid dosage forms.
PubMed:
Effect of high-dose electron beam irradiation on the migration of DOA and ATBC plasticizers from food-grade PVC and PVDC/PVC films, respectively, into olive oil.
PubMed:
Calculation of the dimensions of drug-polymer devices based on diffusion parameters.
PubMed:
Acetyl tributyl citrate and dibutyl sebacate inhibit the growth of cultured mammalian cells.
PubMed:
Variables that affect the mechanism of drug release from osmotic pumps coated with acrylate/methacrylate copolymer latexes.
PubMed:
Processing considerations for an EC latex coating system: influence of curing time and temperature.
PubMed:
Migration from plasticized films into foods. 3. Migration of phthalate, sebacate, citrate and phosphate esters from films used for retail food packaging.
PubMed:
[Control of drug release from coated parenteral matrix-retard tablets using softening agents].
PubMed:
In vitro release of therapeutically active ingredients from polymer matrixes.
PubMed:
Pharmacological properties of the plasticizer, acetyl N-tributyl citrate, and its extraction from poly(vinyl chloride) tubing.
PubMed:
Toxicology of the citric acid esters: tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate.