bicyclogermacrene
Identification
| Name | bicyclogermacrene |
| IUPAC | (4E,8E)-4,8,11,11-tetramethylbicyclo[8.1.0]undeca-4,8-diene |
| CAS Number | 24703-35-3 |
| FDA UNII | Search |
| Molecular Formula | C15 H24 |
| Molecular Weight | 204.35628000 |
Regulatory
Physical Properties
| Appearance | colorless to pale yellow clear liquid (est) |
| Assay | 96.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 267.00 to 268.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.013000 mmHg @ 25.00 °C. (est) |
| Flash Point | 220.00 °F. TCC ( 104.44 °C. ) |
| logP (o/w) | 6.498 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Organoleptic Properties
| Odor Description | at 100.00 %. |
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for bicyclogermacrene usage levels up to | not for fragrance use. |
| Recommendation for bicyclogermacrene flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
(+)-
bicyclogermacrene
(4E,8E)-4,8,11,11-
tetramethylbicyclo[8.1.0]undeca-4,8-diene
PubMed:
Chemical composition, antioxidant activity and antibacterial effect of essential oil of the aerial parts of Salvia sclareoides.
PubMed:
Chemical Composition, Modulatory Bacterial Resistance and Antimicrobial Activity of Essential Oil the Hyptis martiusii Benth by Direct and Gaseous Contact.
PubMed:
Essential oils from Schinus species of northwest Argentina: Composition and antifungal activity.
PubMed:
Evolutionary and Mechanistic Insights from the Reconstruction of α-Humulene Synthases from a Modern (+)-Germacrene A Synthase.
PubMed:
Evaluation of the anti-inflammatory and antinociceptive effects of the essential oil from leaves of Xylopia laevigata in experimental models.
PubMed:
Essential-oil composition of the needles collected from natural populations of Macedonian pine (Pinus peuce Griseb.) from the Scardo-Pindic mountain system.
PubMed:
Chemogeography and antimicrobial activity of essential oils from Geijera parviflora and Geijera salicifolia (Rutaceae): two traditional Australian medicinal plants.
PubMed:
Biomimetic synthesis of (+)-ledene, (+)-viridiflorol, (-)-palustrol, (+)-spathulenol, and psiguadial A, C, and D via the platform terpene (+)-bicyclogermacrene.
PubMed:
Chemical composition of essential oils from four Vietnamese species of piper (piperaceae).
PubMed:
Composition and activity against oral pathogens of the essential oil of Melampodium divaricatum (Rich.) DC.
PubMed:
Terpene constituents of the leaves of five Vietnamese species of Clausena (Rutaceae).
PubMed:
Chemical composition of essential oils from the leaves and stem barks of Vietnamese species of Polyalthia harmandii, Polyalthia jucunda and Polyalthia thorelii.
PubMed:
Chemical composition of the essential oil from the leaves of Carapa guianensis collected from Venezuelan Guayana and the antimicrobial activity of the oil and crude extracts.
PubMed:
The seasonal variation of the chemical composition of essential oils from Porcelia macrocarpa R.E. Fries (Annonaceae) and their antimicrobial activity.
PubMed:
Essential oil compositions of Alphonsea philastreana (Pierre) Pierre ex Finet & Gagnep. and Alphonsea gaudichaudiana (Baill.) Finet & Gagnep. from Vietnam.
PubMed:
Antitumour properties of the leaf essential oil of Xylopia frutescens Aubl. (Annonaceae).
PubMed:
Chemical composition and anti-Trypanosoma cruzi activity of essential oils obtained from leaves of Xylopia frutescens and X. laevigata (Annonaceae).
PubMed:
Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae).
PubMed:
Chemical constituents and cytotoxic evaluation of essential oils from leaves of Porcelia macrocarpa (Annonaceae).
PubMed:
Essential oils from five species of Annonaceae from Vietnam.
PubMed:
Chemical composition of Hypericum richeri subsp. grisebachii essential oil from Croatia.
PubMed:
Chemical diversity among the essential oils of wild populations of Stachys lavandulifolia VAHL (Lamiaceae) from Iran.
PubMed:
Acaricidal activity of essential oils from five endemic conifers of New Caledonia on the cattle tick Rhipicephalus (Boophilus) microplus.
PubMed:
Chemical constituents and anticancer effects of the essential oil from leaves of Xylopia laevigata.
PubMed:
Antimicrobial activity of selected essential oils against cariogenic bacteria.
PubMed:
Composition of the essential oil of Buddleja thyrsoides Lam. leaves from Brazil.
PubMed:
Chemical composition of Hypericum rumeliacum Boiss. essential oil. A new chemotype of this pharmacologically valuable species?
PubMed:
Analysis of the essential oil of large cardamom (Amomum subulatum Roxb.) growing in different agro-climatic zones of Himachal Pradesh, India.
PubMed:
Chemical composition, antibacterial and antifungal activities of essential oil from Cordia verbenacea DC leaves.
PubMed:
Essential oils from Schinus terebinthifolius leaves - chemical composition and in vitro cytotoxicity evaluation.
PubMed:
Molecular cloning and characterization of (+)-epi-α-bisabolol synthase, catalyzing the first step in the biosynthesis of the natural sweetener, hernandulcin, in Lippia dulcis.
PubMed:
Differences in the volatile compositions of ginseng species (Panax sp.).
PubMed:
Chemical composition and antibacterial activity of the essential oil of Espeletia nana.
PubMed:
In vitro bioactivity of essential oils and methanol extracts of Salvia reuterana from Iran.
PubMed:
Chemical classification of the essential oils of the Iranian Salvia species in comparison with their botanical taxonomy.
PubMed:
Chemical diversity of volatiles of Teucrium orientale L. var. orientale, var. puberulens, and var. glabrescens determined by simultaneous GC-FID and GC/MS techniques.
PubMed:
Fragrant volatile oil composition of Nutmeg Geranium (PelargoniumâÃâfragrans Willd.) from India.
PubMed:
Chemical composition of the essential oils of Annona pickelii and Annona salzmannii (Annonaceae), and their antitumour and trypanocidal activities.
PubMed:
Chemical composition and amoebicidal activity of Croton pallidulus, Croton ericoides, and Croton isabelli (Euphorbiaceae) essential oils.
PubMed:
Chemical composition and synergistic interaction between aminoglycosides antibiotics and essential oil of Lantana montevidensis Briq.
PubMed:
Essential oil from the leaves of Annona vepretorum: chemical composition and bioactivity.
PubMed:
The leaf essential oils of five Vietnamese Desmos species (Annonaceae).
PubMed:
Composition of the essential oil of Pogostemon travancoricus var. travancoricus.
PubMed:
Analysis of the essential oil of Teucrium polium ssp. capitatum from the Balkan Peninsula.
PubMed:
Essential oil of three Uvaria species from Ivory Coast.
PubMed:
Chemical composition of leaf and root essential oils of Boenninghausenia albiflora Reichb. from northern India.
PubMed:
Volatile constituents of Origanum vulgare L., 'thymol' chemotype: variability in North India during plant ontogeny.
PubMed:
Helichrysum gymnocephalum essential oil: chemical composition and cytotoxic, antimalarial and antioxidant activities, attribution of the activity origin by correlations.
PubMed:
Antibacterial activity and GC/MS analysis of the essential oils from flower, leaf and stem of Origanum vulgare ssp. viride growing wild in north-west Iran.
PubMed:
Chemical composition and antioxidant, antimicrobial, and larvicidal activities of the essential oils of Annona salzmannii and A. pickelii (Annonaceae).
PubMed:
Essential oil composition of three species of Scutellaria from Turkey.
PubMed:
Antimicrobial activity and chemical constituents of the essential oils from flower, leaf and stem of Gypsophila bicolor from Iran.
PubMed:
Comparative volatile oil composition of four Ocimum species from northern India.
PubMed:
Chemical composition of the essential oil from Carramboa littlei (Asteraceae).
PubMed:
Variation in volatile leaf oils of seven eucalyptus species harvested from Zerniza arboreta (Tunisia).
PubMed:
Chemical constituents and larvicidal activity of Hymenaea courbaril fruit peel.
PubMed:
Essential oil composition of three Australian endemic species of Darwinia (Myrtaceae).
PubMed:
Chemical composition and resistance-modifying effect of the essential oil of Lantana camara Linn.
PubMed:
A study of the larvicidal activity of two Croton species from northeastern Brazil against Aedes aegypti.
PubMed:
The volatile constituents of Salvia leucantha.
PubMed:
Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol.
PubMed:
The intrasectional chemotaxonomic placement of Hypericum elegans Stephan ex Willd. Inferred from the essential-oil chemical composition.
PubMed:
Extraction, separation and isolation of volatiles from Vitex agnus-castus L. (Verbenaceae) wild species of Sardinia, Italy, by supercritical CO2.
PubMed:
Croton sonderianus essential oil samples distinctly affect rat airway smooth muscle.
PubMed:
Essential oils from two Lantana species with antimycobacterial activity.
PubMed:
[Study on the volatile oil of Murraya exotica].
PubMed:
Chemical composition and antibacterial activity of the essential oil of Cordia verbenacea from the Venezuelan Andes.
PubMed:
Composition and antibacterial activity of essential oils from leaf, stem and root of Chrysanthemum parthenium (L.) Bernh. from Iran.
PubMed:
Chemical composition and cytotoxic, mutagenic and genotoxic activities of the essential oil from Pipergaudichaudianum Kunth leaves.
PubMed:
Composition and antimicrobial activity of Marrubium incanum Desr. (Lamiaceae) essential oil.
PubMed:
Essential oil compositions of three Lantana species from Monteverde, Costa Rica.
PubMed:
Chemical composition and antibacterial activity of essential oils of Eugenia species.
PubMed:
Furanocembranoids from the soft corals Sinularia asterolobata and Litophyton arboreum.
PubMed:
Chemical composition and antibacterial activity of essential oils from leaves, stems and flowers of Salvia reuterana Boiss. grown in Iran.
PubMed:
Antifungal activity of essential oils of Croton species from the Brazilian Caatinga biome.
PubMed:
Variability in essential-oil composition of Piper marginatum sensu lato.
PubMed:
Chemical composition and larvicidal properties of the essential oils from Drimys brasiliensis Miers (Winteraceae) on the cattle tick Rhipicephalus (Boophilus) microplus and the brown dog tick Rhipicephalus sanguineus.
PubMed:
Bioactivity and chemical composition of the leaf essential oils of Zanthoxylum rhoifolium and Zanthoxylum setulosum from Monteverde, Costa Rica.
PubMed:
Studies on the antioxidant activity of the essential oil and methanol extract of Marrubium globosum subsp. globosum (lamiaceae) by three different chemical assays.
PubMed:
Essential oil composition of Hypericum triquetrifolium Turra. aerial parts.
PubMed:
Antinociceptive effect and acute toxicity of the essential oil of Hyptis fruticosa in mice.
PubMed:
Analysis by gas chromatography-mass spectrometry of essential oil from seeds and aerial parts of Ferulago angulata (Schlecht.) Boiss gathered in Nevakoh and Shahoo, Zagross mountain, West of Iran.
PubMed:
Qualitative and quantitative analysis of the active components of the essential oil from Brickellia veronicaefolia by nuclear magnetic resonance spectroscopy.
PubMed:
Isolation of Seseli bocconi Guss., subsp. praecox Gamisans (Apiaceae) volatile oil by supercritical carbon dioxide extraction.
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Comparative analysis of the oil and supercritical CO(2) extract of Artemisia arborescens L. and Helichrysum splendidum (Thunb.) Less.
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Response of economically important aphids to components of Hemizygia petiolata essential oil.
PubMed:
Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw.
PubMed:
Essential oil composition of the different parts of Eryngium bourgatii Gouan from Spain.
PubMed:
Chemical composition and larvicidal activity of the essential oils from Eupatorium betonicaeforme (D.C.) Baker (Asteraceae).
PubMed:
Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil.
PubMed:
Essential oils from the leaves of three New Zealand species of Pseudopanax (Araliaceae).
PubMed:
Essential oils of the leaves of the Raukaua genus (Araliaceae).
PubMed:
Composition and antibacterial activity of the essential oils from Zanthoxylum rhoifolium.
PubMed:
Insecticidal activity and chemical composition of volatile oils from Hyptis martiusii Benth.
PubMed:
Volatile constituents of Aristolochia argentina.
PubMed:
Aroma compound analysis of Piper nigrum and Piper guineense essential oils from Cameroon using solid-phase microextraction-gas chromatography, solid-phase microextraction-gas chromatography-mass spectrometry and olfactometry.
PubMed:
Microbial conversion of partheniol by Calonectria decora.
PubMed:
Phytotoxicity and volatile constituents from leaves of Callicarpa japonica Thunb.
PubMed:
Quinoline alkaloids, coumarins and volatile constituents of Helietta longifoliata.
PubMed:
Microbial metabolism of partheniol by Mucor circinelloides.
PubMed:
Essential oils from Piper cernuum and Piper regnellii: antimicrobial activities and analysis by GC/MS and 13C-NMR.
PubMed:
Chemical variability in the essential oil of Hyptis suaveolens.
PubMed:
Identification of volatile constituents of Tambourissa leptophylla.
PubMed:
Chemical variability of the volatile metabolites from the Caribbean corals of the genus Gorgonia.
PubMed:
The steam volatile oil of Wollemia nobilis and its comparison with other members of the Araucariaceae (Agathis and Araucaria).
PubMed:
Solid phase microextraction of volatile constituents from individual fresh Eucalyptus leaves of three species.
PubMed:
Influence of plant growth stage on the essential oil content and composition in Davana (Artemisia pallens wall.).
PubMed:
[Miscellaneous contributions to the essential oils of plants from various territories. LI. On the components of essential oils of Torilis japonica (Houtt.) DC].
PubMed:
Growth and sesquiterpenoid production by Calypogeia granulata inoue cells in suspension culture.