finasteride

(1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide

CAS: 98319-26-7 C23 H36 N2 O2 MW: 372.55232000

Identification

Namefinasteride
IUPAC(1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert-butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
CAS Number98319-26-7
FDA UNII57GNO57U7G
Molecular FormulaC23 H36 N2 O2
Molecular Weight372.55232000
MDL NumberMFCD00869737
Nikkaji NumberJ367.472J
Beilstein4269024
XlogP33.00 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 252.00 °C. @ 760.00 mm Hg
Boiling Point 576.61 °C. @ 760.00 mm Hg (est)
Flash Point 351.00 °F. TCC ( 177.40 °C. ) (est)
logP (o/w) 3.030
Soluble in water, 11.68 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-dog LD50 > 1000 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 > 2000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for finasteride usage levels up tonot for fragrance use.
Recommendation for finasteride flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

(1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-tert- butyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide Info: Finasteride PubMed: Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction. PubMed: The dark side of 5α-reductase inhibitors' therapy: sexual dysfunction, high Gleason grade prostate cancer and depression. PubMed: Androgenetic alopecia (male pattern hair loss) in the United States: what treatments should primary care providers recommend? PubMed: New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line. PubMed: Effect of Phellius linteus water extract on benign prostatic hyperplasia. PubMed: Male breast cancer and 5α-reductase inhibitors finasteride and dutasteride. PubMed: Current status of 5α-reductase inhibitors in prostate disease management. PubMed: Actos, slings, finasteride, and the vaccine compensation solution. PubMed: Role of 5α-reductase inhibitors in androgen-stimulated skin disorders. PubMed: Prevention strategies for prostate cancer. PubMed: Prostate, baldness drugs linked to sexual dysfunction. PubMed: [Prevention of uro-oncological diseases]. PubMed: Fraction of macroporous resin from Smilax china L. inhibits testosterone propionate-induced prostatic hyperplasia in castrated rats. PubMed: Effect of treatment with 5-α reductase inhibitors on progression in monitored men with favourable-risk prostate cancer. PubMed: The effect of finasteride and dutasteride on the growth of WPE1-NA22 prostate cancer xenografts in nude mice. PubMed: [Primary prevention of urologic tumors: prostate cancer]. PubMed: 5-α reductase inhibitors and prostate cancer prevention: where do we turn now? PubMed: Effects of in utero exposure to D-004, a lipid extract from Roystonea regia fruits, in the male rat: a comparison with finasteride. PubMed: The risks and benefits of 5α-reductase inhibitors for prostate-cancer prevention. PubMed: Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. PubMed: Update on the pathogenesis, genetics and medical treatment of patterned hair loss. PubMed: Types of hair loss and treatment options, including the novel low-level light therapy and its proposed mechanism. PubMed: Selenium, but not lycopene or vitamin E, decreases growth of transplantable dunning R3327-H rat prostate tumors. PubMed: Synergistic disruption of external male sex organ development by a mixture of four antiandrogens. PubMed: An overview on 5alpha-reductase inhibitors. PubMed: PCOS. PubMed: Hypersensitivity to intravenous ondansetron: a case report. PubMed: Preventing prostate cancer: new analyses put finasteride back on the map. PubMed: Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. PubMed: Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase. PubMed: [Chemoprevention of prostate cancer. Current status]. PubMed: Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas. PubMed: Oral testosterone in oil: pharmacokinetic effects of 5alpha reduction by finasteride or dutasteride and food intake in men. PubMed: Psychological effect, pathophysiology, and management of androgenetic alopecia in men. PubMed: Preventing diseases of the prostate in the elderly using hormones and nutriceuticals. PubMed: Clinical trials in cancer prevention: current results and perspectives for the future. PubMed: Alfuzosin hydrochloride for the treatment of benign prostatic hyperplasia. PubMed: Common hair loss disorders. PubMed: The potential role of minoxidil in the hair transplantation setting. PubMed: Dietary supplement use in the Prostate Cancer Prevention Trial: implications for prevention trials. PubMed: Prostate cancer prevention agent development: Criteria and pipeline for candidate chemoprevention agents. PubMed: Executive Summary of the National Cancer Institute Workshop: Highlights and recommendations. PubMed: Bioequivalence study of finasteride. Determination in human plasma by high-pressure liquid chromatography coupled to tandem mass spectrometry. PubMed: Continuous haemodynamic monitoring in an unusual case of swallow induced syncope. PubMed: Planning and analysis of repeated measures at key time-points in clinical trials sponsored by pharmaceutical companies. PubMed: Study of the Food and Drug Administration files on Propecia: dosages, side effects, and recommendations. PubMed: Gone today, hair tomorrow? PubMed: Clinical pharmacokinetics and pharmacodynamics of finasteride. PubMed: [Chemoprevention of cancer of the prostate]. PubMed: New drugs from 1991-1992. PubMed: From the Food and Drug Administration.