Identification

Nameglyceryl tributyrate
IUPAC1,3-di(butanoyloxy)propan-2-yl butanoate
CAS Number60-01-5
EINECS200-451-5
FDA UNIIS05LZ624MF
Molecular FormulaC15 H26 O6
Molecular Weight302.36742000
MDL NumberMFCD00009392
Nikkaji NumberJ4.798H
Beilstein1714746
CoE Number747

Regulatory

JECFA Food Flavoring922 tributyrin
DG SANTE Food Flavourings09.211 glyceryl tributyrate
FEMA Number2223
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)60-01-5 ; GLYCEROL TRIBUTYRATE
FDA RegulationFDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE

Physical Properties

Appearance colorless clear oily liquid (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.03300 to 1.03600 @ 20.00 °C.
Pounds per Gallon - (est). 8.606 to 8.631
Refractive Index 1.43500 to 1.43800 @ 20.00 °C.
Melting Point -75.00 °C. @ 760.00 mm Hg
Boiling Point 287.00 to 288.00 °C. @ 760.00 mm Hg, 190.00 °C. @ 15.00 mm Hg
Acid Value 5.00 max. KOH/g
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Flash Point 345.00 °F. TCC ( 173.89 °C. )
logP (o/w) 2.951 (est)
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Odor Description
at 100.00 %.
Cheese, waxy, fatty, acidic
caramel; creamy; fatty
CHEESE, WAXY, CREAMY, FATTY
Taste Description at 30.00 ppm.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 3200 mg/kg
Dermal ToxicityNot determined
Inhalation Toxicityinhalation-rat LC > 75 ppm/6H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents and adjuvants
Recommendation for glyceryl tributyrate usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)27.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)2.00 (μg/capita/day)
Structure ClassI
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils2.00000
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy0.33000
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

CJ Latta & Associates, LLC

Extensive Line

Aromatic Chemicals and Organic Acids.

View All Website (630) 240-8079 chiplatta@msn.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Prodasynth

PRODUCTEUR PAR ESSENCE

Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry.

View All Website (33) 4 93 09 00 11 info@prodasynth.com

Sigma-Aldrich

Complete Supply Chain

The perfect blend of products and services that bring your creativity to life.

View All Website 800-244-1173 ff@sial.com

Synerzine, Inc.

Innovation. Customization. Aroma Ingredients.

Synerzine is a leading supplier of flavor and fragrance ingredients.

View All Website (404) 524-6744 info@synerzine.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

FL butterscotch FL caramel FL cheese

Natural Occurrence

not found in nature

Synonyms

butanoic acid 1,2,3-propane triyl ester butanoic acid 1,2,3-propanetriyl ester butanoic acid, 1,2,3-propanetriyl ester butyric acid 2-butyryloxy-1-butyryloxymethyl-ethyl ester butyric acid triester with glycerin butyrin butyryl triglyceride 1,3- di(butanoyloxy)propan-2-yl butanoate glycerin tributyrate glycerol tributanoate glycerol tributyrate glycerol tributyrin propane-1,2,3-triyl tributanoate 1,2,3- propanetriyl tributanoate 1,2,3- propanetriyl tributyrate tri-N-butyrin tributyrin tributyrl glyceride 1,2,3- tributyrylglycerol PubMed: Production and characterization of a tributyrin esterase from Lactobacillus plantarum suitable for cheese lipolysis. J-Stage: A Novel Alkaline Esterase from Sporosarcina sp. nov. Strain eSP04 Catalyzing the Hydrolysis of a Wide Variety of Aryl-carboxylic Acid Esters PubMed: A novel esterase gene cloned from a metagenomic library from neritic sediments of the South China Sea. PubMed: Purification and characterization of a pregastric esterase from a hygienized kid rennet paste. PubMed: Purification and partial characterization of psychrotrophic Serratia marcescens lipase. PubMed: Comparative proteome profiling of bovine and human Staphylococcus epidermidis strains for screening specifically expressed virulence and adaptation proteins. PubMed: Preparation of low calorie structured lipids catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene(TBD)-functionalized mesoporous SBA-15 silica in a heterogeneous manner. PubMed: The chemopreventive activity of the histone deacetylase inhibitor tributyrin in colon carcinogenesis involves the induction of apoptosis and reduction of DNA damage. PubMed: Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid. PubMed: Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. PubMed: Encapsulation of mixtures of tuna oil, tributyrin and resveratrol in a spray dried powder formulation. PubMed: Isolation and biochemical characterization of Bacillus pumilus lipases from the Antarctic. PubMed: The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway. PubMed: Lipolysis within single culture and co-culture biofilms of dairy origin. PubMed: Molecular cloning of a novel bioH gene from an environmental metagenome encoding a carboxylesterase with exceptional tolerance to organic solvents. PubMed: Anticarcinogenic actions of tributyrin, a butyric acid prodrug. PubMed: Biotechnological and safety characterization of Enterococcus lactis, a recently described species of dairy origin. PubMed: [Gene cloning, expression and characterization of two cold-adapted lipases from Penicillium sp. XMZ-9]. PubMed: Cloning, sequencing, and characterization of lipase genes from a polyhydroxyalkanoate (PHA)-synthesizing Pseudomonas resinovorans. PubMed: Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice. PubMed: Characterization of lipases from Staphylococcus aureus and Staphylococcus epidermidis isolated from human facial sebaceous skin. PubMed: Enzymatically catalyzed synthesis of low-calorie structured lipid in a solvent-free system: optimization by response surface methodology. PubMed: Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats. PubMed: Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system. PubMed: Construction of the yeast whole-cell Rhizopus oryzae lipase biocatalyst with high activity. PubMed: Changes in psychrotrophic microbial populations during milk creaming to produce Grana Trentino cheese. PubMed: Site-specific saturation mutagenesis on residues 132 and 450 of Candida rugosa LIP2 enhances catalytic efficiency and alters substrate specificity in various chain lengths of triglycerides and esters. PubMed: Preparation of a whole-cell biocatalyst of Aspergillus niger lipase and its practical properties. PubMed: Design of nano-laminated coatings to control bioavailability of lipophilic food components. PubMed: SOA genes encode proteins controlling lipase expression in response to triacylglycerol utilization in the yeast Yarrowia lipolytica. PubMed: Emulsion-based delivery systems for tributyrin, a potential colon cancer preventative agent. PubMed: Development of an indirect method for measuring porcine pancreatic lipase in human duodenal fluid. PubMed: Quantitative determination of alpha-tocopherol distribution in a tributyrin/Brij 30/water model food emulsion. PubMed: Characterization and selection of autochthonous lactic acid bacteria isolated from traditional Iberian dry-fermented salchichón and chorizo sausages. PubMed: Importance of the residue Asp 290 on chain length selectivity and catalytic efficiency of recombinant Staphylococcus simulans lipase expressed in E. coli. PubMed: Characterization of new biosurfactant produced by Klebsiella sp. Y6-1 isolated from waste soybean oil. PubMed: Altering the substrate specificity of Candida rugosa LIP4 by engineering the substrate-binding sites. PubMed: Supplementary biochemical tests useful for the differentiation of oxidase positive staphylococci. PubMed: Phospholipid-based microemulsions suitable for use in foods. PubMed: Lipolytic activity and radial daily growth rate changes during incubation of thermomyces lanuginosus on natural and synthetic fatty substrates. PubMed: Technological properties of Enterococcus faecium isolated from ewe's milk and cheese with importance for flavour development. PubMed: Kinetic studies of lycopene isomerization in a tributyrin model system at gastric pH. PubMed: Screening of Korean medicinal plants for lipase inhibitory activity. PubMed: Purification and characterization of a pregastric esterase from a hygienized kid rennet paste. PubMed: Degradation of African locust bean oil by Bacillus subtilis and Bacillus pumilus isolated from soumbala, a fermented African locust bean condiment. PubMed: Purification and partial characterization of psychrotrophic Serratia marcescens lipase. PubMed: Esterolytic and lipolytic activities of lactic acid bacteria isolated from ewe's milk and cheese. PubMed: Enzymes from isolates of Pseudomonas fluorescens involved in food spoilage. PubMed: Early weaning of calves using feedstuffs. A rationalization based on inhibition of lipolysis. PubMed: Influence of solvent absorption on the migration of Irganox 1076 from LDPE. PubMed: [Quantitative occurrence of lipolytic and proteolytic enzymes in food of animal origin]. PubMed: Taxonomical and technological characteristics of Saccharomyces spp. associated with blue veined cheese. PubMed: Fatty acid steryl, stanyl, and steroid esters by esterification and transesterification in vacuo using Candida rugosa lipase as catalyst. PubMed: Presence and changes in populations of yeasts on raw and processed poultry products stored at refrigeration temperature. PubMed: Biochemical properties of Streptococcus macedonicus strains isolated from Greek Kasseri cheese. PubMed: Cloning, characterization, controlled overexpression, and inactivation of the major tributyrin esterase gene of Lactococcus lactis. PubMed: The effects of environmental conditions on the lipolytic activity of strains of Penicillium roqueforti. PubMed: Regulation of intestinal peptidases by nutrients in human fetuses and children. PubMed: Butyric acid and tributyrin induce apoptosis in human hepatic tumour cells. PubMed: Initiation of growth arrest and apoptosis of MCF-7 mammary carcinoma cells by tributyrin, a triglyceride analogue of the short-chain fatty acid butyrate, is associated with mitochondrial activity. PubMed: Isolation and characterization of a tributyrin esterase from Lactobacillus plantarum 2739. PubMed: Method for the rapid quantitative detection of lipolytic activity among food fermenting microorganisms. PubMed: Optimized enzymatic synthesis of geranyl butyrate with lipase AY from Candida rugosa. PubMed: Regulation of food intake by metabolic fuels in white-crowned sparrows. PubMed: Proteolytic and lipolytic activities of Micrococcus roseus (65), Halomonas elongata (16) and Vibrio sp. (168) isolated from Danish bacon curing brines. PubMed: Lipolytic activity and degradation of rapeseed oil and rapeseed by spoilage fungi. PubMed: Study of surface yeast flora of Roquefort cheese. PubMed: The effect of triacylglycerol chain length on food intake in domestic fowl. PubMed: Various dietary fibers have different effects on lipase-catalyzed hydrolysis of tributyrin in vitro. PubMed: Factors affecting growth and lipase production by meat lactobacilli strains and Brochothrix thermosphacta. PubMed: [Lipolytic activity from milk isolated strains of the species Thermoactinomyces vulgaris, Tsiklinsky 1899 (author's transl)]. PubMed: Simple media containing stabilized tributyrin for demonstrating lipolytic bacteria in foods and soils. PubMed: Assay for lipolytic and proteolytic activity using marine substrates.