moskene (Givaudan)
1H-indene, 2,3-dihydro-1,1,3,3,5-pentamethyl-4,6-dinitro-
Identification
| Name | moskene (Givaudan) |
| IUPAC | 1,1,3,3,5-pentamethyl-4,6-dinitro-2H-indene |
| CAS Number | 116-66-5 |
| EINECS | 204-149-4 |
| FDA UNII | 1Q49IC9FAW |
| Molecular Formula | C14 H20 N2 O4 |
| Molecular Weight | 280.32420000 |
| MDL Number | MFCD00021242 |
| Nikkaji Number | J10.095A |
| Beilstein | 2163411 |
Regulatory
Physical Properties
| Appearance | yellow powder (est) |
| Assay | 97.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 131.00 °C. @ 760.00 mm Hg |
| Boiling Point | 350.00 to 353.00 °C. @ 760.00 mm Hg |
| Congealing Point | 132.00 °C. |
| Vapor Pressure | 0.000084 mmHg @ 25.00 °C. (est) |
| Flash Point | > 200.00 °F. TCC ( > 93.33 °C. ) |
| logP (o/w) | 4.839 (est) |
| Soluble in | 1.05 gms to 100 gms alcohol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | not used anymore |
Organoleptic Properties
| Odor Strength | medium , |
| Substantivity | 400 hour(s) at 20.00 % |
| Odor Description | at 10.00 % in benzyl benzoate. |
| Odor sample from | Givaudan Corporation |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 > 5000 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 > 5000 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| IFRA Critical Effect | Insufficient data |
| Recommendation for moskene (Givaudan) usage levels up to | PROHIBITED: Should not be used as a fragrance ingredient. |
| Recommendation for moskene (Givaudan) flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1-tert-
butyl-3,5-dinitro-1-isopropyl-4-methylbenzene
4,6-
dinitro-1,1,3,3,5-pentamethyl indan
4,6-
dinitro-1,1,3,3,5-pentamethylindan
4,6-
dinitro-1,1,3,3,5-pentamethylindane
indan, 1,1,3,3,5-pentamethyl-4,6-dinitro-
indan, 4,6-dinitro-1,1,3,3,5-pentamethyl-
1H-
indene, 2,3-dihydro-1,1,3,3,5-pentamethyl-4,6-dinitro-
moskene (Givaudan)
musk moskene
1,1,3,3,5-
pentamethyl-4,6-dinitro-2,3-dihydro-1H-indene
1,1,3,3,5-
pentamethyl-4,6-dinitro-2H-indene
1,2,3,3,5-
pentamethyl-4,6-dinitro-indan
1,1,3,3,5-
pentamethyl-4,6-dinitroindan
1,1,3,3,5-
pentamethyl-4,6-dinitroindane
1,1,3,3,5-
pentamethyl-4,6-dinitrolindan
PubMed:
Headspace stir bar sorptive extraction followed by thermal desorption and gas chromatography with mass spectrometry to determine musk fragrances in sludge samples without sample pretreatment.
PubMed:
Analysis of 7 synthetic musks in cream by supported liquid extraction and solid phase extraction followed by GC-MS/MS.
PubMed:
Determination of polycyclic and nitro musks in environmental water samples by means of microextraction by packed sorbents coupled to large volume injection-gas chromatography-mass spectrometry analysis.
PubMed:
[Determination of synthetic nitro-musks in cosmetics by gas chromatography coupled with negative chemical ionization-triple quadrupole mass spectrometry].
PubMed:
Fully automated ionic liquid-based headspace single drop microextraction coupled to GC-MS/MS to determine musk fragrances in environmental water samples.
PubMed:
Determination of synthetic musk compounds in indoor house dust by gas chromatography-ion trap mass spectrometry.
PubMed:
Multicomponent analytical methodology to control phthalates, synthetic musks, fragrance allergens and preservatives in perfumes.
PubMed:
High-sensitivity analysis of six synthetic musks by ultra-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry.
PubMed:
Occurrence of synthetic musks in indoor dust from China and implications for human exposure.
PubMed:
Optimization of a sensitive method for the determination of nitro musk fragrances in waters by solid-phase microextraction and gas chromatography with micro electron capture detection using factorial experimental design.
PubMed:
Analysis of neutral nitromusks in incenses by capillary electrophoresis in organic solvents and gas chromatography-mass spectrometry.
PubMed:
Simultaneous congener-specific determination of selected organochlorine compounds and nitro musks in human whole blood samples by solid-phase extraction and capillary gas chromatography with electron capture detection.
PubMed:
Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks.
PubMed:
Further solid-phase microextraction-gas chromatography-mass spectrometry applications: "on-fibre" and aqueous photodegradation of nitro musks.
PubMed:
Determination of musk compounds in sewage treatment plant sludge samples by solid-phase microextraction.
PubMed:
Nitromusk compounds in women with gynecological and endocrine dysfunction.
PubMed:
Analysis of nitro musk compounds and their amino metabolites in liquid sewage sludges using NMR and mass spectrometry.
PubMed:
Kinetics of nitromusk compounds degradation in water by ultraviolet radiation and hydrogen peroxide.
PubMed:
Nitro musks, nitro musk amino metabolites and polycyclic musks in sewage sludges. Quantitative determination by HRGC-ion-trap-MS/MS and mass spectral characterization of the amino metabolites.
PubMed:
Interactions of nitromusk parent compounds and their amino-metabolites with the estrogen receptors of rainbow trout (Oncorhynchus mykiss) and the South African clawed frog (Xenopus laevis).
PubMed:
Toxicity of nitromusks in early lifestages of South African clawed frog (Xenopus laevis) and zebrafish (Danio rerio).
PubMed:
Contact allergy to musk moskene in a perfumed moisturizing cream.
PubMed:
Genotoxicity of nitro musks in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line Hep G2.
PubMed:
Nitro musk compounds genotoxic activity : Genotoxicity testing of nitro musks with the SOS-chromotest and the sister-chromatid exchange test.
PubMed:
Occurrence of nitro and non-nitro benzenoid musk compounds in human adipose tissue.
PubMed:
A comparative study of five nitro musk compounds for genotoxicity in the SOS chromotest and Salmonella mutagenicity.
PubMed:
[Mutagenicity, genotoxicity and cogenotoxicity of environmentally relevant nitro musk compounds].
PubMed:
[Nitro-musk compounds in breast milk].
PubMed:
Pigmented contact dermatitis due to musk moskene.
PubMed:
90-day dermal toxicity study and neurotoxicity evaluation of nitromusks in the albino rat.
PubMed:
Photoallergic potential in the guinea-pig of the nitromusk perfume ingredients musk ambrette, musk moskene, musk xylene, musk ketone, and musk tibetene.
PubMed:
Contact and photocontact allergy to musk ambrette.
PubMed:
Phototoxicity, photoallergy, and contact sensitization of nitro musk perfume raw materials.
PubMed:
Contact allergy to photoproducts of musk ambrette.
PubMed:
Thin layer chromatography and high pressure liquid chromatography of musk ambrette and other nitromusk compounds including photopatch studies.
PubMed:
Photosensitivity to musk ambrette.