Identification

Nameguaiacyl acetate
IUPAC(2-methoxyphenyl) acetate
CAS Number613-70-7
EINECS210-350-8
FDA UNIIK5YN7743HC
Molecular FormulaC9 H10 O3
Molecular Weight166.17630000
MDL NumberMFCD00017221
Nikkaji NumberJ31.560E
CoE Number552
XlogP31.40 (est)

Regulatory

JECFA Food Flavoring718 guaiacyl acetate
DG SANTE Food Flavourings09.174 2-methoxyphenyl acetate
FEMA Number3687
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)613-70-7 ; GUAIACYL ACETATE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.13600 to 1.13800 @ 20.00 °C.
Pounds per Gallon - (est). 9.464 to 9.480
Refractive Index 1.51300 to 1.51500 @ 20.00 °C.
Melting Point 31.00 to 32.00 °C. @ 760.00 mm Hg
Boiling Point 122.00 to 124.00 °C. @ 18.00 mm Hg, 239.00 to 241.00 °C. @ 760.00 mm Hg
Acid Value 1.00 max. KOH/g
Vapor Pressure 0.042000 mmHg @ 25.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 1.380
Shelf Life 24.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Description
at 100.00 %.
at 5.00 %.
Odor sample from Fritzsche Dodge & Olcott, Inc.
Taste Description at 50.00 ppm.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for guaiacyl acetate usage levels up to2.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)0.10 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

BOC Sciences

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Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

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Fleurchem, Inc.

Have A Flavorful Day

A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.

View All Website 845-341-2100 info@fleurchem.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Synerzine, Inc.

Innovation. Customization. Aroma Ingredients.

Synerzine is a leading supplier of flavor and fragrance ingredients.

View All Website (404) 524-6744 info@synerzine.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

The John D. Walsh Company, Inc

Suppliers Since 1942

Supplying the fragrance and flavor industry with high quality products.

View All Website 973-962-1400 info@johndwalsh.com

Potential Uses

FR acacia FR allspice FR almond FR alpine bouquet FR amber FR ambreine FR animal FR autumn FR azalea FR balsam FL barley FR bayberry FR beeswax absolute replacer FR bouquet FR boxwood berry FR cabreuva wood FR calamus oil replacer FR carnation FR cassia FR cassia blossom FR castoreum FR champaca FL cheese FR chestnut blossom FL chocolate cocoa FR christmas FR cigar FL/FR cistus FR clove FR clove blossom FL cookie FL/FR copaiba balsam FR coronilla FR country meadow FR cyclamen FR deertongue absolute replacer FR dogwood FR fern FR fig FR flouve FR flouve blossom FR forest FR ginger white ginger FL/FR guaiacwood FR gurjun balsam FR habuba FR hawthorn FR hay new mown hay FR heather FR hinoki oil replacer FR hugonia FR incense FR iris blossom FR jonquil FR labdanum FL meat smoked meat FR millefleurs FR moss FR musk FR opoponax FR oriental FR orris FR osmanthus FR petunia FR phlox FR pinion FL praline FR rose FR rose moss rose FR rose tea rose FR rose white rose FR sherry FL smoke FR spice FR sweet grass FL tea tea china FR tobacco FR tonka bean FL/FR valerian FR vanilla FR wine FR woodruff FR woody FL/FR yerba mate

Natural Occurrence

not found in nature

Synonyms

acetic acid 2-methoxyphenyl ester 1- acetoxy-2-methoxybenzene 2- acetoxyanisole o- acetoxyanisole ortho- acetoxyanisole acetyl guaiacol o- acetyl guaiacol ortho- acetyl guaiacol o- anisyl acetate ortho- anisyl acetate eucol guaiacol acetate guaiacyl acetate 2- methoxyphenol acetate 2- methoxyphenyl acetate o- methoxyphenyl acetate ortho- methoxyphenyl acetate (2- methoxyphenyl) acetate phenol, 2-methoxy-, acetate phenol, o-methoxy-, acetate PubMed: Volatile fingerprint of Brazilian defective coffee seeds: corroboration of potential marker compounds and identification of new low quality indicators. J-Stage: Microbial Enantioselective Ester Hydrolysis for the Preparation of Optically Active 4,1-Benzoxazepine-3-acetic Acid Derivatives as Squalene Synthase Inhibitors PubMed: Aromatic profile of ciders by chemical quantitative, gas chromatography-olfactometry, and sensory analysis. PubMed: [Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS]. 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PubMed: Immunolocalization of 8-5' and 8-8' linked structures of lignin in cell walls of Chamaecyparis obtusa using monoclonal antibodies. PubMed: Understanding changes in lignin of Panicum virgatum and Eucalyptus globulus as a function of ionic liquid pretreatment. PubMed: Evaluation of a potential starter culture for enhance quality of coffee fermentation. PubMed: Amperometric determination of total phenolic content in wine by laccase immobilized onto silver nanoparticles/zinc oxide nanoparticles modified gold electrode. PubMed: Depolymerization of oak wood lignin under mild conditions using the acidic ionic liquid 1-H-3-methylimidazolium chloride as both solvent and catalyst. PubMed: Comparative study of organosolv lignin extracted from prairie cordgrass, switchgrass and corn stover. PubMed: Development of an amperometric polyphenol biosensor based on fungal laccase immobilized on nitrocellulose membrane. PubMed: An amperometric biosensor based on laccase immobilized onto MnO2NPs/cMWCNT/PANI modified Au electrode. PubMed: Simultaneous determination of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: application to a bioequivalence study. PubMed: Quality evaluation of olive oil by statistical analysis of multicomponent stable isotope dilution assay data of aroma active compounds. PubMed: Extraction of lignins from aqueous-ionic liquid mixtures by organic solvents. PubMed: Fabrication of polyphenol biosensor based on laccase immobilized on copper nanoparticles/chitosan/multiwalled carbon nanotubes/polyaniline-modified gold electrode. PubMed: Polyphenol biosensor based on laccase immobilized onto silver nanoparticles/multiwalled carbon nanotube/polyaniline gold electrode. PubMed: Phenol Glycosides with In Vitro anti-Helicobacter pylori Activity from Hypericum erectum Thunb. PubMed: Modulating the synthetase activity of penicillin G acylase in organic media by addition of N-methylimidazole: using vinyl acetate as activated acyl donor. PubMed: A hydrogel-based enzyme-loaded polymersome reactor. PubMed: Effects of foliar fertilization and arbuscular mycorrhizal colonization on Salvia officinalis L. growth, antioxidant capacity, and essential oil composition. PubMed: Fate of key odorants in Sauternes wines through aging. PubMed: A sensitive liquid chromatography-electrospray ionization-mass spectrometry method for the simultaneous determination of pentoxyverine citrate and guaifenesin in human plasma---application to pharmacokinetic and bioequivalence studies. PubMed: Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. PubMed: Highly acylated (acetylated and/or p-coumaroylated) native lignins from diverse herbaceous plants. PubMed: Rapid headspace solid-phase microextraction/gas chromatographic/mass spectrometric assay for the quantitative determination of some of the main odorants causing off-flavours in wine. PubMed: Aroma extraction dilution analysis of Sauternes wines. Key role of polyfunctional thiols. PubMed: Effect of essential oil active compounds on rumen microbial fermentation and nutrient flow in in vitro systems. PubMed: Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity. PubMed: Theoretical prediction of the relationship between phenol function and COX-2/AP-1 inhibition for ferulic acid-related compounds. PubMed: Structure and function of the antennal sensilla of the palm weevil Rhynchophorus palmarum (Coleoptera, Curculionidae). PubMed: Simultaneous determination of some active ingredients in cough and cold preparations by gas chromatography, and method validation. PubMed: Use of ozone and/or UV in the treatment of effluents from board paper industry. PubMed: Inhibitory effect on activator protein-1, nuclear factor-kappaB, and cell transformation by extracts of strawberries (Fragaria x ananassa Duch.). PubMed: Perceptual interactions in odour mixtures: odour quality in binary mixtures of woody and fruity wine odorants. PubMed: Screening for key odorants in Moroccan green olives by gas chromatography-olfactometry/aroma extract dilution analysis. PubMed: Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger. PubMed: Purification of the precursor for the automated radiosynthesis of [18F]FCWAY by counter-current chromatography. PubMed: Gas chromatography-olfactometry and chemical quantitative study of the aroma of six premium quality spanish aged red wines. PubMed: Characterization of odor-active compounds in Californian chardonnay wines using GC-olfactometry and GC-mass spectrometry. PubMed: Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae). PubMed: Gateways to Clinical Trials. June 2002. PubMed: Effects of yakuchinone A and yakuchinone B on the phorbol ester-induced expression of COX-2 and iNOS and activation of NF-kappaB in mouse skin. PubMed: Microbial enantioselective ester hydrolysis for the preparation of optically active 4,1-benzoxazepine-3-acetic acid derivatives as squalene synthase inhibitors. PubMed: Aromatase inhibitors from Broussonetia papyrifera. PubMed: Antioxidative and antitumor promoting effects of [6]-paradol and its homologs. PubMed: Synthesis of (+)-lariciresinol 3a-acetate, a lignan from Aglaia elaeagnoidea. PubMed: Measurement of urinary methoxyphenols and their use for biological monitoring of wood smoke exposure. PubMed: Determination of 1-(2-methoxyphenyl)piperazine derivatives of isocyanates at low concentrations by temperature-programmed miniaturized liquid chromatography. PubMed: Diarylheptanoids suppress expression of leukocyte adhesion molecules on human vascular endothelial cells. PubMed: Biosynthesis, molecular structure, and domain architecture of potato suberin: a (13)C NMR study using isotopically labeled precursors. PubMed: Effects of the sniffing port air makeup in gas chromatography-olfactometry. PubMed: The mechanism of action of amtolmetin guacyl, a new gastroprotective nonsteroidal anti-inflammatory drug. PubMed: Anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin. PubMed: [Chemical constituents of the leaves of Ginkgo biloba]. PubMed: [Substituted methoxyphenol with antioxidative activity: correlation between physicochemical and biological results]. PubMed: Studies on the preparation of bioactive lignans by oxidative coupling reaction. III. Synthesis of polyphenolic benzofuran and coumestan derivatives by oxidative coupling reaction of methyl (E)-3-(4-hydroxy-2-methoxyphenyl)propenoate and their inhibitory effect on lipid peroxidation. PubMed: Immunostimulation of tiger shrimp (Penaeus monodon) hemocytes for generation of microbicidal substances: analysis of reactive oxygen species. PubMed: Development and validation of a high-performance liquid chromatographic method for the determination of methocarbamol in human plasma. PubMed: Enzymatic reduction of xenobiotic alpha,beta-unsaturated ketones: formation of allyl alcohol metabolites from shogaol and dehydroparadol. PubMed: Effects of glucocorticoids on 5-HT1A presynaptic function in the mouse. PubMed: [A bioequivalence study in man of tablet and capsule formulations of the nonsteroidal anti-inflammatory compound 2-methoxyphenyl 1-methyl-5-(p-methylbenzoylpyrrol)-2-acetamidoacetate]. PubMed: [A bioequivalence study of tablet and powder formulations of the nonsteroidal anti-inflammatory drug 2-methoxyphenyl 1-methyl-5-(p-methylbenzoylpyrrol)-2-acetamidoacetate]. PubMed: Studies to demonstrate inhibition of functional activity of neutrophil lysosomal enzymes with ANCA. PubMed: A liquid chromatographic assay using a high-speed column for the determination of lamotrigine, a new antiepileptic drug, in human plasma. PubMed: High-performance liquid chromatographic analysis of methocarbamol enantiomers in biological fluids. PubMed: The effects of corticosterone on 5-HT receptor function in rodents. PubMed: Design and evaluation of a solid sampler for the monitoring of airborne 1,6-hexamethylene diisocyanate (HDI) and its prepolymers in two-component spray painting. PubMed: Analysis of carbohydrate residues on human thyroid peroxidase (TPO) and thyroglobulin (Tg) and effects of deglycosylation, reduction and unfolding on autoantibody binding. PubMed: Degradation of synthetic lignins and some lignin monomers by the yeastRhodotorula glutinis. PubMed: [An application of electrochemical detector to dental pharmacology]. PubMed: Biomimetic oxidation of nonphenolic lignin models by Mn(III): new observations on the oxidizability of guaiacyl and syringyl substructures. PubMed: Antioxidant properties of conjugated bilirubin and biliverdin: biologically relevant scavenging of hypochlorous acid. PubMed: Inhibition of peroxidase-catalyzed reactions by deferoxamine. PubMed: Radiochemical detection of dihydrodiol dehydrogenase: distribution of the enzyme in male Sprague-Dawley rat tissues and its sensitivity to inhibition by indomethacin and 6-medroxyprogesterone acetate. PubMed: Cytochrome c/H2O2-mediated one electron oxidation of carcinogenic N-fluorenylacetohydroxamic acids to nitroxyl free radicals. PubMed: Aromatic retinoic acid analogues. 2. Synthesis and pharmacological activity. PubMed: Constituents of essential oil of Aframomum giganteum. PubMed: [Experimental studies on the sealing properties of various kind of root canal sealers and pastes in vitro, with special reference to non-eugenol preparations (author's transl)]. PubMed: [The alleged antagonism to vitamin E of phenolic esters, particulary of guaiacol acetate].