dextro,laevo-muscone
3-methyl-1-cyclopentadecanone
Identification
| Name | dextro,laevo-muscone |
| IUPAC | 3-methylcyclopentadecan-1-one |
| CAS Number | 541-91-3 |
| EINECS | 208-795-8 |
| FDA UNII | 5JO79R7S9R |
| Molecular Formula | C16 H30 O |
| Molecular Weight | 238.41430000 |
| MDL Number | MFCD00211114 |
| Nikkaji Number | J6.397E |
| CoE Number | 11135 |
Regulatory
| JECFA Food Flavoring | 1402 3-methyl-1-cyclopentadecanone |
| FEMA Number | 3434 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 541-91-3 ; 3-METHYL-1-CYCLOPENTADECANONE |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 97.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.91800 to 0.92500 @ 25.00 °C. |
| Pounds per Gallon - (est). | 7.639 to 7.697 |
| Refractive Index | 1.47700 to 1.48100 @ 20.00 °C. |
| Melting Point | 8.60 °C. @ 760.00 mm Hg |
| Boiling Point | 320.00 to 329.00 °C. @ 760.00 mm Hg, 130.00 °C. @ 0.50 mm Hg |
| Acid Value | 1.00 max. KOH/g |
| Vapor Pressure | 0.000176 mmHg @ 25.00 °C. (est) |
| Flash Point | > 212.00 °F. TCC ( > 100.00 °C. ) |
| logP (o/w) | 6.100 (est) |
| Shelf Life | 24.00 month(s) or longer if stored properly. |
| Storage | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in | alcohol |
| Stability | APC: - |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | perfuming agents |
Organoleptic Properties
| Odor Strength | high , |
| Substantivity | 400 hour(s) at 100.00 % |
| Odor Description |
at 10.00 % in dipropylene glycol. at 0.20 %. A very soft, sweet, musky odor with a warm animal tonality, reminiscent of the natural Tonkin musk Musk, powdery, soft, animalic. Exalting. Fixative Soft, sweet, musky with animalic tonalities trong aroma of Thonky musk, which has good diffusion musk animal powdery
|
| Odor sample from | Firmenich Inc. |
| Taste Description | at 1.00 ppm. |
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Human Experience | 30 % solution: no irritation or sensitization. |
| Oral/Parenteral Toxicity | oral-rat LD50 [sex: M,F] > 5000 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 > 5000 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD\nLUNGS, THORAX, OR RESPIRATION: OTHER CHANGES\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']
Safety in Use
| Category | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment | Search |
| Recommendation for dextro,laevo-muscone usage levels up to | 2.0000 % in the fragrance concentrate. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 0.37 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA) | 0.009 (μg/capita/day) |
| Structure Class | II |
| baked goods | - |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | - |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | - |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
ACS International GmbH
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Augustus Oils Ltd
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Azelis UK Ltd.
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Indukern, S.A. F&F Ingredients Division
Commitment to quality
Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients.
Lluch Essence S.L.
A family company dedicated to sales and distribution
Flexibility, availability, price and quality.
M&U International LLC
Steady supply & demand
Meeting customers increasing demands at home as well as abroad.
Pell Wall Perfumes
Hand-made fragrances
Pell Wall maintains a broad palette of ingredients & in order to keep stocks fresh & the options wide we also sell from our own stock.
Penta International Corporation
Chemistry innovation
At Penta, our products and services help businesses do business better.
Prodasynth
PRODUCTEUR PAR ESSENCE
Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry.
Tianjin Danjun International Trade Co., LTD.
Quality Products
We know the Chinese chemical market well.
Vigon International
Passion for Simplicity
Manufacturer and supplier of high quality flavor and fragrance ingredients.
Potential Uses
Natural Occurrence
Synonyms
cyclopentadecanone, 3-methyl-
3-
methyl cyclopentadecan-1-one
3-
methyl cyclopentadecanone
methyl exaltone
3-
methyl-1-cyclopentadecanone
3-
methyl-cyclopentadecanone
3-
methylcyclopentadecan-1-one
3-
methylcyclopentadecanone
methylexaltone
moschus ketone
dextro,laevo-
muscone
DL-
muscone
muscone (Firmenich)
muscor (IFF)
muskone
Info:
Muscone
PubMed:
Administration of BMSCs with Muscone in Rats with Gentamicin-Induced AKI Improves Their Therapeutic Efficacy.
PubMed:
Beneficial effects of muscone on cardiac remodeling in a mouse model of myocardial infarction.
PubMed:
Chinese herbs and their active ingredients for activatingâxueâ(blood)âpromote the proliferation and differentiation of neural stem cells and mesenchymal stem cells.
PubMed:
Neuroprotective effect of muscone on glutamate-induced apoptosis in PC12 cells via antioxidant and Ca(2+) antagonism.
PubMed:
Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors.
PubMed:
Anti-inflammatory effects of 4-methylcyclopentadecanone on edema models in mice.
PubMed:
Effects of Qishe Pill, a compound traditional Chinese herbal medicine, on cervical radiculopathy: study protocol for a randomized controlled trial.
PubMed:
Influence of borneol and muscone on geniposide transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model.
PubMed:
Metabolomic strategy for studying the intervention and the synergistic effects of the shexiang baoxin pill for treating myocardial infarction in rats.
PubMed:
Fast and direct quantification of underivatized muscone by ultra performance liquid chromatography coupled with evaporative light scattering detection.
PubMed:
[Effect of borneol on intestinal absorption of muscone in rats].
PubMed:
[Analysis of muscone from serum and cerebrospinal fluid of rabbits after intragastric administration of tongqiao huoxue granules].
PubMed:
[Determination method of muscone in rat intestinal perfusate by GC-MS/MS and its intestinal absorption kinetic characteristics in rats].
PubMed:
Muscone exerts neuroprotection in an experimental model of stroke via inhibition of the fas pathway.
PubMed:
Efficient macrocyclization by a novel oxy-oxonia-Cope reaction: synthesis and olfactory properties of new macrocyclic musks.
PubMed:
Protective effects of muscone on ischemia-reperfusion injury in cardiac myocytes.
PubMed:
Fragrance material review on 3-methyl-1-cyclopentadecanone.
PubMed:
Catalytic asymmetric Michael reactions of α,β-unsaturated ketones with sulfonyl-containing nucleophiles: chiral synthesis of (R)-muscone and (S)-celery ketone.
PubMed:
Dynamic octopus amphiphiles as powerful activators of DNA transporters: differential fragrance sensing and beyond.
PubMed:
Synthesis of omega-hydroxy carboxylic acids and alpha,omega-dimethyl ketones using alpha,omega-diols as alkylating agents.
PubMed:
(+)-(R,Z)-5-Muscenone and (-)-(R)-muscone by enantioselective aldol reaction and Grob fragmentation.
PubMed:
[Protective effects and machanism of muskone on pheochromocytoma cell injure induced by glutamate].
PubMed:
Muscone protects vertebral end-plate degeneration by antiinflammatory property.
PubMed:
Efficient formation of ring structures utilizing multisite activation by indium catalysis.
PubMed:
Comparison of the therapeutic effects of different compositions of muskone in the treatment of experimental myocardial infarct in rats and analgesia in mice.
PubMed:
Synthesis of l-muscone by asymmetric methylation via enol esters.
PubMed:
Synthetic applications of enantioselective protonation and case study for (S)-alpha-damascone.
PubMed:
A three-carbon (n+1+2) ring expansion method for the synthesis of macrocyclic enones. Application to muscone synthesis.
PubMed:
[Effects of series of Muskone on heart hemodynamics and myocardial consumption of oxygen in experimental dogs].
PubMed:
[Study on therapeutic effects of series of muskone on myocardial infarction canines].
PubMed:
Enantioselective intramolecular aldol addition/dehydration reaction of a macrocyclic diketone: synthesis of the musk odorants (R)-muscone and (R,Z)-5-muscenone.
PubMed:
[Study on comparative pharmacology of series of Muskone].
PubMed:
Normal-phase chiral liquid chromatography-mass spectrometry of non-UV-active compounds: applications for pharmaceutically relevant racemates.
PubMed:
[Determination of muscone in Xingnaojing injection by gas chromatography with solid phase microextraction].
PubMed:
CpRu(PN) complex-catalyzed isomerization of allylic alcohols and its application to the asymmetric synthesis of muscone.
PubMed:
Ti-crossed-Claisen condensation between carboxylic esters and acid chlorides or acids: a highly selective and general method for the preparation of various beta-keto esters.
PubMed:
[Study of diffusion of muscone in different inclusion complexes and liposome through mouse (correction of rat) skin in vitro].
PubMed:
Characterization of allegedly musk-containing medicinal products in Taiwan.
PubMed:
[An experimental study on distribution of musk into the brain through blood brain barrier].
PubMed:
Solid-phase extraction of L-muscone from aqueous samples with Amberlite XAD-4 for gas chromatographic assay.
PubMed:
Psychological effects of musky compounds: comparison of androstadienone with androstenol and muscone.
PubMed:
Estrogenic activity of musk fragrances detected by the E-screen assay using human mcf-7 cells.
PubMed:
Synthesis of (R)- and (S)- muscone.
PubMed:
Solid phase synthesis of complex natural products and libraries thereof.
PubMed:
Enantioselectivity of the musk odor sensation.
PubMed:
[Quantitative analysis of muscone in shexiang baoxin pills by gas chromatography].
PubMed:
[Pharmacokinetics of muscone in rats, rabbits and dogs].
PubMed:
[Determination of major volatile components in suhexiang wan (storax pill) using analytical supercritical fluid extraction (SFE)].
PubMed:
[A preliminary research on the quality of musk].
PubMed:
Characterization of liver microsomal cytochrome P450 from rats treated with muscone (3-methylcyclopentadecanone).
PubMed:
[Analysis of musk rheumatic oil by GC/FTIR].
PubMed:
[Method of analysis for musk, artificially bred musk and original musk by HPLC].
PubMed:
Induction of cytochrome P-450 and related drug-oxidizing activities in muscone (3-methylcyclopentadecanone)-treated rats.
PubMed:
[Determination of muscone contents in Chinese drug preparations containing Moschus by the TLC scanning method].
PubMed:
Musk deer (Moschus moschiferus): Reinvestigation of main lipid components from preputial gland secretion.
PubMed:
Pharmacological properties of musk.
PubMed:
Induction of rat liver microsomal cytochrome P-450 by muscone (3-methylcyclopentadecanone).
PubMed:
[Mass spectrography analysis on the components of a substance obtained from the male musk-rat].
PubMed:
[Quantitative analysis of muscone in musk by GC].
PubMed:
[The analysis of synthetic muscone (DL-3-methylcyclopentadecanone) and its impurities (author's transl)].
PubMed:
Insect and mammalian pheromones.
PubMed:
Many-membered carbon rings; a new synthesis of civetone and dl-muscone.
PubMed:
[Not Available].