sedanenolide
(-)-3-butyl-4,5-dihydro-1(3H)-isobenzofuranone
Identification
| Name | sedanenolide |
| IUPAC | 3-butyl-4,5-dihydro-3H-2-benzofuran-1-one |
| CAS Number | 62006-39-7 |
| FDA UNII | Search |
| Molecular Formula | C12 H16 O2 |
| Molecular Weight | 192.25792000 |
| Nikkaji Number | J981.167B |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
| Boiling Point | 367.00 to 368.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.000013 mmHg @ 25.00 °C. (est) |
| Flash Point | 309.00 °F. TCC ( 153.89 °C. ) |
| logP (o/w) | 1.775 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Organoleptic Properties
| Odor Description | at 1.00 % in propylene glycol. |
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for sedanenolide usage levels up to | not for fragrance use. |
| Recommendation for sedanenolide flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(-)-3-
butyl-4,5-dihydro-1(3H)-isobenzofuranone
3-
butyl-4,5-dihydro-3H-2-benzofuran-1-one
3-N-
butyl-4,5-dihydrophthalide
3-N-
butyl-4,5-dihydrophthalide (S)-isomer
senkyunolide
senkyunolide A
PubMed:
Development of an analytical method coupling cell membrane chromatography with gas chromatography-mass spectrometry via microextraction by packed sorbent and its application in the screening of volatile active compounds in natural products.
J-Stage:
Asymmetric Synthesis and Sensory Evaluation of Sedanenolide
PubMed:
Evaluation of the influence of sulfur fumigation on the pharmacokinetics of four active ingredients in Si Wu Tang.
PubMed:
[Quantitative determination of 5 active ingredients in different harvest periods of Ligusticum chuanxiong by HPLC].
PubMed:
Comparative analysis of main aromatic acids and phthalides in Angelicae Sinensis Radix, Chuanxiong Rhizoma, and Fo-Shou-San by a validated UHPLC-TQ-MS/MS.
PubMed:
Multi-component analysis in sun-dried and sulfur-fumigated Angelicae Sinensis Radix by single marker quantitation and chemometric discrimination.
PubMed:
Analysis of the Correlation between Commodity Grade and Quality of Angelica sinensis by Determination of Active Compounds Using Ultraperformance Liquid Chromatography Coupled with Chemometrics.
PubMed:
Optimization of high-pressure ultrasonic-assisted simultaneous extraction of six major constituents from Ligusticum chuanxiong rhizome using response surface methodology.
PubMed:
[Optimization of supercritical fluid extraction of bioactive components in Ligusticum chuanxiong by orthogonal array design].
PubMed:
Chemistry, technology, and nutraceutical functions of celery (Apium graveolens L.): an overview.
PubMed:
[Study on the constituents of essential oil of Shunaoxin dropping pills by GC-MS].
PubMed:
[Chemical change of chuanxiong raw materials during storage].
PubMed:
Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry.
PubMed:
Utilization of gene expression signature for quality control of traditional Chinese medicine formula Si-Wu-Tang.
PubMed:
Online isolation and purification of four phthalide compounds from Chuanxiong rhizoma using high-speed counter-current chromatography coupled with semi-preparative liquid chromatography.
PubMed:
[Analysis of chemical constituents of chuanxiong rhizoma absorbed into rat brain tissues by UPLC-Q-TOF-MS].
PubMed:
Chemical and biological assessment of angelica roots from different cultivated regions in a chinese herbal decoction danggui buxue tang.
PubMed:
Isolation of the volatile fraction from Apium graveolens L. (Apiaceae) by supercritical carbon dioxide extraction and hydrodistillation: chemical composition and antifungal activity.
PubMed:
Chemometric classification of morphologically similar Umbelliferae medicinal herbs by DART-TOF-MS fingerprint.
PubMed:
Identification of the absorbed components and metabolites in rat plasma after oral administration of Rhizoma Chuanxiong decoction by HPLC-ESI-MS/MS.
PubMed:
[Studies on the chemical constituents of Ligusticum sinense].
PubMed:
Asymmetric synthesis and sensory evaluation of sedanenolide.
PubMed:
A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to Si Wu Tang.
PubMed:
Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia.
PubMed:
[Analysis of volatile oils of Ligusticum chuanxiong Hort. from different geographical origins by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry].
PubMed:
Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.
PubMed:
Simultaneous determination of phenolic acids and phthalide compounds by liquid chromatography for quality assessment of Rhizoma cnidii.
PubMed:
Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry.
PubMed:
Identification and determination of the major constituents in Traditional Chinese Medicinal formula Danggui-Shaoyao-San by HPLC-DAD-ESI-MS/MS.
PubMed:
GC-MS fingerprints for discrimination of Ligusticum chuanxiong from Angelica.
PubMed:
Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells.
PubMed:
Flavor enhancement of chicken broth from boiled celery constituents.
PubMed:
Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC.
PubMed:
Comparative analysis of Ligusticum chuanxiong and related umbelliferous medicinal plants by high performance liquid chromatography-electrospray ionization mass spectrometry.
PubMed:
Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in Rhizoma Chuanxiong, in the rat.
PubMed:
Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta.
PubMed:
Post-harvest alteration of the main chemical ingredients in Ligusticum chuanxiong Hort. (Rhizoma Chuanxiong).
PubMed:
Screening and analysis of the multiple absorbed bioactive components and metabolites of Dangguibuxue decoction by the metabolic fingerprinting technique and liquid chromatography/diode-array detection mass spectrometry.
PubMed:
Potent odorants characterize the aroma quality of leaves and stalks in raw and boiled celery.
PubMed:
Time-course accumulation of main bioactive components in the rhizome of Ligusticum chuanxiong.
PubMed:
[Determination of lactone components in chuanxiong by reversed-phase high performance liquid chromatography].
PubMed:
Identification and comparative determination of senkyunolide A in traditional Chinese medicinal plants Ligusticum chuanxiong and Angelica sinensis by HPLC coupled with DAD and ESI-MS.
PubMed:
Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation.
PubMed:
Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs.
PubMed:
HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong.
PubMed:
[Study on fingerprint of rhizoma chuanxiong by HPLC-DAD-MS].
PubMed:
Phytochemical analysis of anti-atherogenic constituents of Xue-Fu-Zhu-Yu-Tang using HPLC-DAD-ESI-MS.
PubMed:
Simultaneous analysis of seventeen chemical ingredients of Ligusticum chuanxiong by on-line high performance liquid chromatography-diode array detector-mass spectrometry.
PubMed:
Separation and identification of the phthalic anhydride derivatives of Liqusticum Chuanxiong Hort by GC-MS, TLC, HPLC-DAD, and HPLC-MS.
PubMed:
Phthalide-based host-plant resistance toSpodoptera exigua andTrichoplusia ni inApium graveolens.
PubMed:
Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells.
PubMed:
Antiproliferative effects of the traditional Chinese medicine shimotsu-to, its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells.