gedunin
gedunine
Identification
| Name | gedunin |
| CAS Number | 2753-30-2 |
| FDA UNII | Search |
| Molecular Formula | C28 H34 O7 |
| Molecular Weight | 482.57338000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 594.29 °C. @ 760.00 mm Hg (est) |
| Flash Point | 596.00 °F. TCC ( 313.20 °C. ) (est) |
| logP (o/w) | 3.201 (est) |
| Soluble in | water, 0.9604 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for gedunin usage levels up to | not for fragrance use. |
| Recommendation for gedunin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
gedunine
PubMed:
Stimulation of erythrocyte cell membrane scrambling by gedunin.
PubMed:
Evaluation of a fluorescence-based method for antibabesial drug screening.
PubMed:
Review on pharmacological and toxicologyical effects of oleum azadirachti oil.
PubMed:
Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves.
PubMed:
The therapeutic properties of Carapa guianensis.
PubMed:
Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis.
PubMed:
Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation.
PubMed:
Antiplasmodial activity of the andiroba (Carapa guianensis Aubl., Meliaceae) oil and its limonoid-rich fraction.
PubMed:
Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum.
PubMed:
Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT-dependent Extraction of Ceramides from the Endoplasmic Reticulum.
PubMed:
The limonoids and their antitobacco mosaic virus (TMV) activities from Munronia unifoliolata Oliv.
PubMed:
Querying genomic databases: refining the connectivity map.
PubMed:
The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-κB and MAPK pathways.
PubMed:
Effect of triterpenoids and limonoids isolated from Cabralea canjerana and Carapa guianensis (Meliaceae) against Spodoptera frugiperda (J. E. Smith).
PubMed:
Antimalarial activity in Xylocarpus granatum (Koen).
PubMed:
Rings D-seco and B,D-seco tetranortriterpenoids from root bark of Entandrophragma angolense.
PubMed:
Limonoids from seeds of Thai Xylocarpus moluccensis.
PubMed:
Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.
PubMed:
Gedunin and photogedunin of Xylocarpus granatum possess antifilarial activity against human lymphatic filarial parasite Brugia malayi in experimental rodent host.
PubMed:
Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).
PubMed:
Evaluation of effect of triterpenes and limonoids on cell growth, cell cycle and apoptosis in human tumor cell line.
PubMed:
A systematic protocol for the characterization of Hsp90 modulators.
PubMed:
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
PubMed:
Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica.
PubMed:
Limonoids from the leaves of Cipadessa baccifera.
PubMed:
Deoxygedunin, a natural product with potent neurotrophic activity in mice.
PubMed:
7-Deacetyl-gedunin.
PubMed:
Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats.
PubMed:
Gedunin, a novel natural substance, inhibits ovarian cancer cell proliferation.
PubMed:
Granatumins A-G, limonoids from the seeds of a Krishna mangrove, Xylocarpus granatum.
PubMed:
Identification of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress induced injury.
PubMed:
Effects of limonoids from Cipadessa fruticosa on fall armyworm.
PubMed:
Susceptibility of Aedes aegypti and Culex quinquefasciatus Larvae to gedunin-related limonoids.
PubMed:
6α-Acetoxy-gedunin.
PubMed:
Isolation of limonoids from seeds of Carapa guianensis Aublet (Meliaceae) by high-speed countercurrent chromatography.
PubMed:
Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships.
PubMed:
Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae).
PubMed:
Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro.
PubMed:
Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi.
PubMed:
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.
PubMed:
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.
PubMed:
Hydroxylated gedunin derivatives from Cedrela sinensis.
PubMed:
Inhibition of allergen-induced eosinophil recruitment by natural tetranortriterpenoids is mediated by the suppression of IL-5, CCL11/eotaxin and NFkappaB activation.
PubMed:
The toxicity and behavioural effects of neem limonoids on Cnaphalocrocis medinalis (Guenée), the rice leaffolder.
PubMed:
Effect of neem limonoids on lactate dehydrogenase (LDH) of the rice leaffolder, Cnaphalocrocis medinalis (Guenée) (Insecta: Lepidoptera: Pyralidae).
PubMed:
Insect growth regulatory effects of some extracts and sterols from Myrtillocactus geometrizans (Cactaceae) against Spodoptera frugiperda and Tenebrio molitor.
PubMed:
Effects of neem limonoids on the malaria vector Anopheles stephensi Liston (Diptera: Culicidae).
PubMed:
Insect growth inhibition by tocotrienols and hydroquinones from Roldana barba-johannis.
PubMed:
Antioxidant and insect growth regulatory activities of stilbenes and extracts from Yucca periculosa.
PubMed:
6beta-hydroxygedunin from Azadirachta indica. Its potentiation effects with some non-azadirachtin limonoids in neem against lepidopteran larvae.
PubMed:
Traditionally-used antimalarials from the Meliaceae.
PubMed:
Three new tetranortriterpenoids from neem seed oil.
PubMed:
Acetylcholinesterase and insect growth inhibitory activities of Gutierrezia microcephala on fall armyworm Spodoptera frugiperda J.E. Smith.
PubMed:
Growth inhibitory effects on fall armyworm Spodoptera frugiperda of some limonoids isolated from Cedrela spp. (Meliaceae).
PubMed:
Delevoyin C, a tetranortriterpenoid from Entandrophragma delevoyi.
PubMed:
In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae).
PubMed:
Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives.
PubMed:
Constituents of Azadirachta indica: isolation and structure elucidation of a new antibacterial tetranortriterpenoid, mahmoodin, and a new protolimonoid, naheedin.
PubMed:
Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica.
PubMed:
Potential antimalarial candidates from African plants: and in vitro approach using Plasmodium falciparum.