glabratic acid
4-(2,4-dihydroxy-6-methylbenzoyloxy)-2-hydroxy-6-methylbenzoic acid
Identification
| Name | glabratic acid |
| IUPAC | 4-(2,4-dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoic acid |
| CAS Number | 480-56-8 |
| FDA UNII | D0M65TKS0F |
| Molecular Formula | C16 H14 O7 |
| Molecular Weight | 318.28198000 |
| MDL Number | MFCD00210524 |
| Nikkaji Number | J13.181D |
| Beilstein | 2172778 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 557.10 °C. @ 760.00 mm Hg (est) |
| Flash Point | 407.00 °F. TCC ( 208.30 °C. ) (est) |
| logP (o/w) | 4.390 (est) |
| Soluble in | water, 16.08 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intravenous-mouse LD > 200 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for glabratic acid usage levels up to | not for fragrance use. |
| Recommendation for glabratic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzoic acid, 4-[(2,4-dihydroxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-
4-
carboxy-3-hydroxy-5-methyl phenyl 2,4-dihydroxy-6-methyl benzoate
2,4-
dihydroxy-6-methyl benzoic acid 4-carboxy-3-hydroxy-5-methyl phenyl ester
4-(2,4-
dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoic acid
4-[(2,4-
dihydroxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methylbenzoic acid
4-(2,4-
dihydroxy-6-methylbenzoyloxy)-2-hydroxy-6-methylbenzoic acid
lecanoric acid
lecanoricacid
PubMed:
Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells.
PubMed:
Potential of Lichen Compounds as Antidiabetic Agents with Antioxidative Properties: A Review.
PubMed:
Lichen secondary metabolites affect growth of Physcomitrella patens by allelopathy.
PubMed:
Phytochemical study and antioxidant, antimicrobial and anticancer activities of Melanelia subaurifera and Melanelia fuliginosa lichens.
PubMed:
Lichen acids may be used as a potential drug for cancer therapy; by inhibiting mitochondrial thioredoxin reductase purified from rat lung.
PubMed:
Atranorin and lecanoric acid antagonize TCDD-induced xenobiotic response element-driven activity, but not xenobiotic response element-independent activity.
PubMed:
Protective effects of isolecanoric acid on neurodegenerative in vitro models.
PubMed:
A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster.
PubMed:
Growth promoting effects of some lichen metabolites on probiotic bacteria.
PubMed:
Qualitative and spatial metabolite profiling of lichens by a LC-MS approach combined with optimised extraction.
PubMed:
[Study on the chemical constituents of two lichen plants from Meng Mountain].
PubMed:
Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans.
PubMed:
Antioxidant activity of some lichen metabolites.
PubMed:
Characterisation of phenols and antioxidant and hypolipidaemic activities of Lethariella cladonioides.
PubMed:
Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation.
PubMed:
The In vitro antioxidant properties of chinese highland lichens.
PubMed:
Molecular structural studies of lichen substances with antimicrobial, antiproliferative, and cytotoxic effects from Parmelia subrudecta.
PubMed:
In vitro antitumour activity of orsellinates.
PubMed:
Lichen metabolites modulate hydrogen peroxide and nitric oxide in mouse macrophages.
PubMed:
Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.
PubMed:
PTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica.
PubMed:
Radical-scavenging activity of orsellinates.
PubMed:
Metabolites from the Lichen Ochrolechia parella growing under two different heliotropic conditions.
PubMed:
Cytotoxic activity of orsellinates.
PubMed:
A study of the genetic variability of Rhizoplaca chrysoleuca using DNA sequences and secondary metabolic substances.
PubMed:
[Studies on chemical constituents of Umbilicaria esculenta (Miyoshi) minks].
PubMed:
Phenolic constituents from the lichen Parmotrema stuppeum (Nyl.) Hale and their antioxidant activity.
PubMed:
Lichen biodeterioration of the Convento de la Peregrina, Sahagún, Spain.
PubMed:
Destruction of lichen chemical defenses by a fungal.
PubMed:
Inhibition of tumor promotion by a lecanoric acid analogue.
PubMed:
Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues.
PubMed:
Isolation of lecanoric acid, an inhibitor of histidine decarboxylase from a fungus.
PubMed:
[On the occurrence of erythrine and lecanoric acid in some Dinaria species. 51. On the lichen contents].
PubMed:
Biosynthesis of lichen depsides, lecanoric acid and atranorin.