psoromic acid
11H-dibenzo(b,e)(1,4)dioxepin-6-carboxylic acid, 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-
Identification
| Name | psoromic acid |
| IUPAC | 10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid |
| CAS Number | 7299-11-8 |
| FDA UNII | Search |
| Molecular Formula | C18 H14 O8 |
| Molecular Weight | 358.30318000 |
| MDL Number | MFCD00046941 |
| Nikkaji Number | J14.291C |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 641.70 °C. @ 760.00 mm Hg (est) |
| Flash Point | 459.00 °F. TCC ( 237.00 °C. ) (est) |
| logP (o/w) | 2.970 (est) |
| Soluble in | water, 1.228 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intravenous-mouse LD50 12 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 200 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for psoromic acid usage levels up to | not for fragrance use. |
| Recommendation for psoromic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
11H-
dibenzo(b,e)(1,4)dioxepin-6-carboxylic acid, 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-
4-
formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo(b,e)(1,4)dioxepin-6-carboxylic acid
10-
formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid
parellic acid
PubMed:
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.
PubMed:
Antioxidative and cardiovascular-protective activities of metabolite usnic acid and psoromic acid produced by lichen species Usnea complanata under submerged fermentation.
PubMed:
Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase.
PubMed:
Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.
PubMed:
Cytotoxic and apoptotic effects on hepatocytes of secondary metabolites obtained from lichens.
PubMed:
[Pharmacological studies on psoromic acid, a constituent of lichens].