isoginkgetin
5,5'',7,7''-tetrahydroxy-4',4'''-dimethoxy-3''',8-biflavone
Identification
| Name | isoginkgetin |
| IUPAC | 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one |
| CAS Number | 548-19-6 |
| FDA UNII | Search |
| Molecular Formula | C32 H22 O10 |
| Molecular Weight | 566.51934000 |
| MDL Number | MCFD00597035 |
| Nikkaji Number | J11.548G |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 843.60 °C. @ 760.00 mm Hg (est) |
| Flash Point | 536.00 °F. TCC ( 280.20 °C. ) (est) |
| logP (o/w) | 5.240 (est) |
| Soluble in | water, 0.002419 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for isoginkgetin usage levels up to | not for fragrance use. |
| Recommendation for isoginkgetin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
4H-1-
benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-
3''',8-
biflavone, 5,5'',7,7''-tetrahydroxy-4',4'''-dimethoxy-
8-[5-(5,7-
dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
8-[5-(5,7-
dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
4',4'''-
dimethylamentoflavone
5,5'',7,7''-
tetrahydroxy-4',4'''-dimethoxy-3''',8-biflavone
PubMed:
Two new nonacosanetriols from Ginkgo biloba sarcotesta.
PubMed:
Biflavonoids from Caper (Capparis spinosa L.) fruits and their effects in inhibiting NF-kappa B activation.
PubMed:
Short-circuiting RNA splicing.
PubMed:
Inhibition of arachidonate release from rat peritoneal macrophage by biflavonoids.
PubMed:
The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.
PubMed:
Evaluation of proinflammatory cytokine pathway inhibitors for p38 MAPK inhibitory potential.
PubMed:
Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase.
PubMed:
New constituent from Podocarpus macrophyllus var. macrophyllus shows anti-tyrosinase effect and regulates tyrosinase-related proteins and mRNA in human epidermal melanocytes.
PubMed:
In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves.
PubMed:
Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression.
PubMed:
Osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana.
PubMed:
Comparative antiplasmodial, leishmanicidal and antitrypanosomal activities of several biflavonoids.
PubMed:
Biflavones from Chamaecyparis obtusa.
PubMed:
Biflavone glucosides from Ginkgo biloba yellow leaves.
PubMed:
Neuroprotective effects of naturally occurring biflavonoids.
PubMed:
Investigation of the free radical scavenging activity of Ginkgo biloba L. leaves.
PubMed:
Effects of Ginkgetin from Ginkgo biloba Leaves on cyclooxygenases and in vivo skin inflammation.
PubMed:
Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes.
PubMed:
Effect of biflavones of Ginkgo biloba against UVB-induced cytotoxicity in vitro.
PubMed:
Inhibition of cAMP-phosphodiesterase by biflavones of Ginkgo biloba in rat adipose tissue.
PubMed:
Effects of flavonoids of Ginkgo biloba on proliferation of human skin fibroblast.
PubMed:
Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids.
PubMed:
HPLC Separation and Quantitative Determination of Biflavones in Leaves from Ginkgo biloba.