grandisin

furan, tetrahydro-3,4-dimethyl-2,5-bis(3,4,5-trimethoxyphenyl)-, (2alpha,3beta,4alpha,5beta)-(-)-

CAS: 53250-50-3 C24 H32 O7 MW: 432.51344000

Identification

Namegrandisin
IUPAC(2S,3S,4S)-3,4-dimethyl-2,5-bis(3,4,5-trimethoxyphenyl)oxolane
CAS Number53250-50-3
FDA UNIISearch
Molecular FormulaC24 H32 O7
Molecular Weight432.51344000

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 521.07 °C. @ 760.00 mm Hg (est)
Flash Point 399.00 °F. TCC ( 203.70 °C. ) (est)
logP (o/w) 3.358 (est)
Soluble in water, 0.6513 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for grandisin usage levels up tonot for fragrance use.
Recommendation for grandisin flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

cryptocarya crassinervia

Synonyms

(2S,3S,4S)-3,4- dimethyl-2,5-bis(3,4,5-trimethoxyphenyl)oxolane furan, tetrahydro-3,4-dimethyl-2,5-bis(3,4,5-trimethoxyphenyl)-, (2alpha,3beta,4alpha,5beta)-(-)- (2alpha,3beta,4alpha,5beta)-(-)- tetrahydro-3,4-dimethyl-2,5-bis(3,4,5-trimethoxyphenyl) furan PubMed: In vitro metabolism of grandisin, a lignan with anti-chagasic activity. PubMed: In vitro metabolism study of the promising anticancer agent the lignan (-)-grandisin. PubMed: Secondary metabolites from the phloem of Piper solmsianum (Piperaceae) in the honeydew of Edessa meditabunda. PubMed: Chemoprotective effect of the tetrahydrofuran lignan grandisin in the in-vivo rodent micronucleus assay. PubMed: In vitro basal cytotoxicity assay applied to estimate acute oral systemic toxicity of grandisin and its major metabolite. PubMed: Cytotoxicity and antiangiogenic activity of grandisin. PubMed: Antinociceptive and antiinflammatory activities of grandisin extracted from Virola surinamensis. PubMed: Larvicidal activity of grandisin against Aedes aegypti. PubMed: Disruption of Chrysomya megacephala growth caused by lignan grandisin. PubMed: Three new compounds from Kadsura longipedunculata. PubMed: Metabolism of (-)-grandisin from Piper solmsianum in Coleoptera and Lepidoptera species. PubMed: Synthesis and trypanocidal activity of 1,4-bis-(3,4,5-trimethoxy-phenyl)-1,4-butanediol and 1,4-bis-(3,4-dimethoxyphenyl)-1,4-butanediol. PubMed: Arylfurans as potential trypanosoma cruzi trypanothione reductase inhibitors. PubMed: Trypanocidal tetrahydrofuran lignans from inflorescences of Piper solmsianum. PubMed: Antimalarial compounds from Rhaphidophora decursiva. PubMed: Phenylpropanoids and tetrahydrofuran lignans from Piper solmsianum. PubMed: Infraspecific variation of sulfur-containing bisamides from Aglaia leptantha. PubMed: (-)-Grandisin form Cryptocarya crassinervia. PubMed: [Neolignans from Piper polysyphorum C.DC].