6-methyl quinoline

6-methylquinoline

CAS: 91-62-3 C10 H9 N MW: 143.18873000 animal animal

Identification

Name6-methyl quinoline
IUPAC6-methylquinoline
CAS Number91-62-3
EINECS202-084-6
FDA UNIIK14453I13N
Molecular FormulaC10 H9 N
Molecular Weight143.18873000
MDL NumberMFCD00006804
Nikkaji NumberJ800A
Beilstein0110336
CoE Number2339
XlogP32.60 (est)

Regulatory

JECFA Food Flavoring1302 6-methylquinoline
DG SANTE Food Flavourings14.042 6-methylquinoline
FEMA Number2744
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)91-62-3 ; 6-METHYLQUINOLINE

Physical Properties

Appearance pale yellow to amber brown clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.06000 to 1.06600 @ 25.00 °C., 1.06300 to 1.07100 @ 20.00 °C.
Pounds per Gallon - (est). 8.820 to 8.870
Pounds per Gallon - est. 8.856 to 8.922
Refractive Index 1.61100 to 1.61700 @ 20.00 °C.
Melting Point -22.00 °C. @ 760.00 mm Hg
Boiling Point 259.00 to 261.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.022000 mmHg @ 25.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 2.570
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength high ,
Substantivity 400 hour(s) at 10.00 % in dipropylene glycol
Odor Description at 1.00 % in dipropylene glycol.
Odor sample from International Flavors & Fragrances Inc.
Taste Description sweet animal tonka naphthyl tobacco anisic phenolic

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Human Experience2 % solution: no irritation or sensitization.
Oral/Parenteral Toxicityoral-rat LD50 800 mg/kg
Dermal Toxicityskin-rabbit LD50 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for 6-methyl quinoline usage levels up to1.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.32 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)0.01 (μg/capita/day)
Structure ClassIII
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-
Dairy products, excluding products of category 02.0 (01.0)0.02400
Fats and oils, and fat emulsions (type water-in-oil) (02.0)2.90000
Edible ices, including sherbet and sorbet (03.0)-
Processed fruit (04.1)-
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)2.90000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)5.00000
Bakery wares (07.0)1.50000
Meat and meat products, including poultry and game (08.0)-
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)-
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)1.20000
Foodstuffs intended for particular nutritional uses (13.0)-
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)0.00058
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)-
Ready-to-eat savouries (15.0)-
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)-

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Indukern, S.A. F&F Ingredients Division

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Potential Uses

FR amber FR animal FR balsam FR castoreum FR civet FR earth FR green FR hay new mown hay FR leather FR lilac FR linden flower FR moss FR ocean sea FR tobacco FR tonka bean

Natural Occurrence

tea leaf whiskey

Synonyms

khinaldin 6- methylchinolin 6- methylquinoline paramethylquinolene quinoline, 6-methyl- PubMed: Heterocyclic Aromatic Hydrocarbons Show Estrogenic Activity upon Metabolization in a Recombinant Transactivation Assay. PubMed: Genotoxicity of heterocyclic PAHs in the micronucleus assay with the fish liver cell line RTL-W1. PubMed: Molecules of the quinoline family block tau self-aggregation: implications toward a therapeutic approach for Alzheimer's disease. PubMed: Synthesis and in-vitro antimicrobial activity of secondary and tertiary amines containing 2-chloro-6-methylquinoline moiety. PubMed: 4-Azido-2-chloro-6-methyl-quinoline. PubMed: Novel chalcones derived from 2-chloro-3-formyl-6-methylquinoline. PubMed: Heterocyclic compounds: toxic effects using algae, daphnids, and the Salmonella/microsome test taking methodical quantitative aspects into account. PubMed: Tetra-μ-benzoato-bis-[(6-methyl-quino-line)-copper(II)]. PubMed: Inclusion of quinolines by binaphthol: structures and selectivity. PubMed: Chloride-sensitive fluorescent indicators. PubMed: The formation of 1-hydroxymethylnaphthalene and 6-hydroxymethylquinoline by both oxidative and reductive routes in Cunninghamella elegans. PubMed: Hydroxylation and biodegradation of 6-methylquinoline by pseudomonads in aqueous and nonaqueous immobilized-cell bioreactors. PubMed: The hepatic metabolism of two methylquinolines. PubMed: Uptake and biotransformation of 6,7-dimethylquinoline and 6,8-dimethylquinoline by rainbow trout (Salmo gairdneri). PubMed: Studies on antibiotic biosynthesis by protoplasts and resting cells of Streptomyces echinatus. Part II. Effect of chromophore precursors. PubMed: Directed biosynthesis of novel derivatives of echinomycin. II. Purification and structure elucidation. PubMed: Directed biosynthesis of novel derivatives of echinomycin by Streptomyces echinatus. I. Effect of exogenous analogues of quinoxaline-2-carboxylic acid on the fermentation. PubMed: Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests. PubMed: Carcinogenicities of quinoline derivatives in F344 rats. PubMed: Toxic interaction of mixtures of two coal conversion effluent components (resorcinol and 6-methylquinoline) to Daphnia magna. PubMed: Determination of quinomethionate (6-methylquinoline-2,3-diyldithiocarbonate) residues in crops by in situ fluorometry. PubMed: [Production and purification of quinoline bases. 6. Modified arrangement of 6-methylquinoline-N-oxide in the 4 position]. PubMed: Some derivatives of 6-methylquinoline.