olestra
sucrose polyester
Identification
| Name | olestra |
| CAS Number | 121854-29-3 |
| FDA UNII | 6742Y30KGK |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | GRN 325 |
| FDA Mainterm (SATF) | 121854-29-3 ; OLESTRA |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | used in place of fats and oils |
| Recommendation for olestra usage levels up to | not for fragrance use. |
| Recommendation for olestra flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
sucrose polyester
PubMed:
Intervention to reduce PCBs: learnings from a controlled study of Anniston residents.
PubMed:
Detox diets for toxin elimination and weight management: a critical review of the evidence.
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Vitamin d bioavailability: state of the art.
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Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial.
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Review of the effects of dilution of dietary energy with olestra on energy intake.
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Fat substitutes promote weight gain in rats consuming high-fat diets.
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mu-Opioid receptor stimulation in the nucleus accumbens elevates fatty tastant intake by increasing palatability and suppressing satiety signals.
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Intraperitoneal injections as a possible means of generating varied levels of methylmercury in the eggs of birds in field studies.
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Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations: results from two pilot studies.
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The effect of olestra on the absorption, excretion and storage of 2,2',5,5' tetrachlorobiphenyl; 3,3',4,4' tetrachlorobiphenyl; and perfluorooctanoic acid.
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Fat and sugar flavor preference and acceptance in C57BL/6J and 129 mice: experience attenuates strain differences.
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Olestra is associated with slight reductions in serum carotenoids but does not markedly influence serum fat-soluble vitamin concentrations.
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Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male.
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Daily intake of multivitamins during long-term intake of olestra in men prevents declines in serum vitamins A and E but not carotenoids.
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Dioxin toxicity and chloracne in the Ukraine.
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Dietary fat and obesity: a review of animal, clinical and epidemiological studies.
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Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene.
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A novel, noninvasive method for the measurement of intestinal fat absorption.
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Olestra labeling change.
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Number of days, number of subjects, and sources of variation in longitudinal intervention or crossover feeding trials with multiple days of measurement.
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Consumption of a controlled low-fat diet containing olestra for 9 months improves health risk factors in conjunction with weight loss in obese men: the Ole' Study.
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Olestra: targetless arrow?
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Is olestra consumption associated with changes in dietary intake, serum lipids, and body weight?
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Health risks, past usage, and intention to use weight loss products in normal weight women with high and low body dysphoria.
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Severe gastrointestinal illness associated with olestra ingestion.
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Authors' financial relationships with the food and beverage industry and their published positions on the fat substitute olestra.
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Modifications in cyclosporine (CsA) microemulsion blood concentrations by olestra.
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[Diet therapy in chronic inflammatory bowel disease: results from meta-analysis and randomized controlled trials].
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Intestinal alkaline phosphatase release is not associated with chylomicron formation.
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A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole Study.
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A role for olestra in body weight management.
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Severe 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients.
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Effect on body weight of replacing dietary fat with olestra for two or ten weeks in healthy men and women.
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Additive gastrointestinal effects with concomitant use of olestra and orlistat.
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[Inhibitors of absorption as anti-obesity drugs].
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Randomized, double-blind, placebo-controlled, food allergy challenge to olestra snacks.
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The effect of ingesting olestra-based foods on feeding behavior and energy balance in humans.
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"You ate all that!?": caretaker-child interaction during children's assisted dietary recall interviews.
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Postmarketing surveillance of new food ingredients: results from the program with the fat replacer olestra.
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Postmarketing surveillance of new food ingredients: design and implementation of the program for the fat replacer olestra.
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A brief dietary assessment instrument for assessing target foods, nutrients and eating patterns.
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8:45-90:00. The Influence of a High Fat Meal Compared to an Olestra Meal on Coronary Artery Endothelial Dysfunction by Rubidium (Rb)-82 Positron Emission Tomography (PET) and on Post Prandial Serum Triglycerides.
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Effects of dietary fat, nutrition labels, and repeated consumption on sensory-specific satiety.
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Changes in diet, weight, and serum lipid levels associated with olestra consumption.
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Olestra consumption does not predict serum concentrations of carotenoids and fat-soluble vitamins in free-living humans: early results from the sentinel site of the olestra post-marketing surveillance study.
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Effects of wheat bran and Olestra on objective measures of stool and subjective reports of GI symptoms.
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Caretaker-child interaction during children's 24-hour dietary recalls: who contributes what to the recall record?
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Effects of dietary fibre and olestra on regional apparent viscosity and water content of digesta residue in porcine large intestine.
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Effects of olestra and sorbitol consumption on objective measures of diarrhea: impact of stool viscosity on common gastrointestinal symptoms.
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Olestra consumption is not associated with macular pigment optical density in a cross-sectional volunteer sample in Indianapolis.
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Positive results on tests for steatorrhea in persons consuming olestra potato chips.
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Early adopters of olestra-containing foods: who are they?
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Olestra snacks compared with regular snacks.
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Effect of the moderate consumption of olestra in patients receiving long-term warfarin therapy.
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Olestra formulation and the gastrointestinal tract.
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Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
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Does intraduodenal administration of sucrose polyester (Olestra) cause satiation in humans?
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Vitamin K-supplemented snacks containing olestra: implication for patients taking warfarin.
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Comparison of effects on colonic motility and stool characteristics associated with feeding olestra and wheat bran to ambulatory mini-pigs.
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[Fat substitutes in human diet].
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A non-absorbable dietary fat substitute enhances elimination of persistent lipophilic contaminants in humans.
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Current concepts in the pharmacological management of obesity.
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Gastric emptying of indigestible versus digestible oils and solid fats in normal humans.
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Procter & Gamble responds on olestra.
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Demographic, dietary and lifestyle factors differentially explain variability in serum carotenoids and fat-soluble vitamins: baseline results from the sentinel site of the Olestra Post-Marketing Surveillance Study.
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Transient overconsumption of novel foods by deafferentated rats: effects of novel diet composition.
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Gastrointestinal symptoms in 3181 volunteers ingesting snack foods containing olestra or triglycerides. A 6-week randomized, placebo-controlled trial.
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Review article: olestra and its gastrointestinal safety.
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The selling of olestra.
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Olestra Postmarketing Surveillance Study: design and baseline results from the sentinel site.
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Sounding the alarm for misuse of olestra-containing foods in binge-eating disorders.
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Effect of fat-free potato chips with and without nutrition labels on fat and energy intakes.
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Gastrointestinal symptoms following olestra consumption.
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Determination of fat in olestra-containing savory snack products by capillary gas chromatography.
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Effects of 14 d of covert substitution of olestra for conventional fat on spontaneous food intake.
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Poor digestibility of fully hydrogenated soybean oil in rats: a potential benefit of hydrogenated fats and oils.
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Olestra: a new food additive.
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Overview of olestra: a new fat substitute.
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Olestra at the movies.
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Small portions of olestra OK.
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Gastrointestinal symptoms following consumption of olestra or regular triglyceride potato chips: a controlled comparison.
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A randomized, double-blind study of the effect of olestra on disease activity in patients with quiescent inflammatory bowel disease. Olestra in IBD Study Group.
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Review and analysis of the effects of olestra, a dietary fat substitute, on gastrointestinal function and symptoms.
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Randomized, double-blind, placebo-controlled, consumer rechallenge test of Olean salted snacks.
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Comparison of olestra absorption in guinea pigs with normal and compromised gastrointestinal tracts.
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Assessment of the nutritional effects of olestra.
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Olestra, a nonabsorbed, noncaloric replacement for dietary fat: a review.
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Assessment of the nutritional effects of olestra, a nonabsorbed fat replacement: summary.
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An indirect means of assessing potential nutritional effects of dietary olestra in healthy subgroups of the general population.
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Evaluation of the potential for olestra to affect the availability of dietary phytochemicals.
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Olestra ingestion and dietary fat absorption in humans.
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Olestra ingestion and retinyl palmitate absorption in humans.
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Olestra's effect on vitamins D and E in humans can be offset by increasing dietary levels of these vitamins.
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Olestra dose response on fat-soluble and water-soluble nutrients in humans.
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Olestra affects serum concentrations of alpha-tocopherol and carotenoids but not vitamin D or vitamin K status in free-living subjects.
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Nutritional status of pigs fed olestra with and without increased dietary levels of vitamins A and E in long-term studies.
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Olestra's effect on the status of vitamins A, D and E in the pig can be offset by increasing dietary levels of these vitamins.
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Olestra dose response on fat-soluble and water-soluble nutrients in the pig.
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Physical or temporal separation of olestra and vitamins A, E and D intake decreases the effect of olestra on the status of the vitamins in the pig.
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The domestic pig as a model for evaluating olestra's nutritional effects.
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Estimated consumption and eating frequency of olestra from savory snacks using menu census data.
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Assessment of the nutritional effects of olestra, a nonabsorbed fat replacement: introduction and overview.
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From the Miocene to olestra: a historical perspective on fat consumption.
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Olestra: assessing its potential to interact with drugs in the gastrointestinal tract.
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Sensory properties of a nonabsorbable fat substitute did not affect regulation of energy intake.
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Genotoxicity and subchronic toxicity studies with heated olestra.
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Olestra and the FDA.
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Olestra and the FDA.
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Olestra and the FDA.
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Olestra and the FDA.
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Disposition of ingested olestra in weanling mini-pigs.
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Degradation of olestra, a non caloric fat replacer, by microorganisms isolated from activated sludge and other environments.
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Replacement of dietary fat with sucrose polyester: effects on energy intake and appetite control in nonobese males.
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Olestra and the FDA.
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The trials of olestra: is a fat-free lunch too costly?
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Lipid-based fat substitutes.
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The effect of olestra on breath gas production and faecal microbial counts.
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Utilization of hydrolyzed sucrose polyester (olestra) in broiler diets.
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Disposition of ingested olestra in the Fischer 344 rat.
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Chronic toxicity and carcinogenicity of olestra in Swiss CD-1 mice.
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Liquid chromatographic method for determining the percent of olestra in lipid samples.
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A comparison of the effect of olestra and triglyceride on postprandial esophageal acid exposure.
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Olestra, a nondigestible, nonabsorbable fat. Effects on gastrointestinal and colonic transit.
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Effects of olestra, a noncaloric fat substitute, on daily energy and fat intakes in lean men.
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Safety evaluation of olestra, a nonabsorbed, fatlike fat replacement.
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The excretion and characterization of intravenously administered olestra.
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A 20-month olestra feeding study in dogs.
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Serum 25-hydroxyvitamin D concentrations of free-living subjects consuming olestra.
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Analysis of liver tissue for olestra following long-term feeding to rats and monkeys.
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Chronic toxicity and carcinogenicity studies of olestra in Fischer 344 rats.
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Vitamin K status of free-living subjects consuming olestra.
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Olestra and potential role of a nonabsorbable lipid in the diets of children.
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Effects of partial replacement of dietary fat by olestra on dietary cholesterol absorption in man.
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The effect of olestra on systemic levels of oral contraceptives.
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A 91-day feeding study in rats with heated olestra/vegetable oil blends.
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Evaluation of olestra in short-term genotoxicity assays.
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FYI: more news about Olestra.
PubMed:
Influence of absorbable and nonabsorbable lipids and lipidlike substances on drug bioavailability.