calcium cyclamate dihydrate
cyclohexyl sulfamic acid calcium salt (2:1) dihydrate
Identification
| Name | calcium cyclamate dihydrate |
| IUPAC | calcium N-cyclohexylsulfamate dihydrate |
| CAS Number | 5897-16-5 |
| FDA UNII | OK71859Z12 |
| Molecular Formula | C12 H28 Ca N2 O8 S2 |
| Molecular Weight | 432.57076000 |
Regulatory
| JECFA Food Additive | Calcium Cyclamate |
| GSFA Codex | Calcium cyclamate (952(ii)) |
| FDA Mainterm (SATF) | 5897-16-5 ; CALCIUM CYCLAMATE--PROHIBITED |
| FDA Regulation | FDA PART 189 -- SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD |
Physical Properties
| Appearance | white crystals (est) |
| Assay | 98.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | 0.979 (est) |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intravenous-rabbit LD50 125 mg/kg |
| Dermal Toxicity | subcutaneous-rat LD50 100 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for calcium cyclamate dihydrate usage levels up to | not for fragrance use. |
| Recommendation for calcium cyclamate dihydrate flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
calcium cyclohexane sulfamate dihydrate (1:2)
calcium cyclohexyl sulfamate dihydrate (1:2)
calcium N-cyclohexylsulfamate dihydrate
cyclamate calcium dihydrate
cyclohexane sulfamic acid calcium salt (2:1) dihydrate
cyclohexyl sulfamic acid calcium salt (2:1) dihydrate
PubMed:
The metabolism of cyclamate to cyclohexylamine in humans during long-term administration.
PubMed:
Effects of a saccharin and cyclamate mixture on rat embryos.
PubMed:
Taste qualities of solutions preferred by hamsters.
PubMed:
Gustatory neural coding in the monkey cortex: the quality of sweetness.
PubMed:
The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers.
PubMed:
Assessment of the genotoxicity of calcium cyclamate and cyclohexylamine.
PubMed:
Myocardial effects of calcium cyclamate in the BIO F1D Alexander Syrian golden hamster.
PubMed:
No evidence found for induction of dominant lethal mutations and heritable translocations in male mice by calcium cyclamate.
PubMed:
Caffeine intensifies taste of certain sweeteners: role of adenosine receptor.
PubMed:
Sensory evaluation of soft drinks with various sweeteners.
PubMed:
Cytogenetic effects of cyclamates.
PubMed:
The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays.
PubMed:
Effects of cyclamate calcium on the immune response in rabbits.
PubMed:
Chemical induction of sperm abnormalities in mice.
PubMed:
A toxicity method with calcium cyclamate for chronic carcinogenesis experiments.
PubMed:
Cytogenetic studies on calcium cyclamate in Meriones unguiculatus (gerbil) in vivo.
PubMed:
In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine.
PubMed:
Aspartylphenylalanine methyl ester: a low-calorie sweetener.
PubMed:
Effect of maternal calcium cyclamate intake on cellular development in the young rat.
PubMed:
Calcium cyclamate and renal tubular acidosis.
PubMed:
Photosensitive dermatitis and renal tubular acidosis after ingestion of calcium cyclamate.
PubMed:
Sugar substitute, sodium and calcium cyclamate.
PubMed:
Myocardial lesions: a reassessment of the toxicology of calcium cyclamate.
PubMed:
Cytogenetic effects of cyclamates on human cells in vitro.
PubMed:
[Effects on rat's intestinal mucosa of prolonged calcium cyclamate administration].
PubMed:
Feeding and reproduction of rats fed calcium cyclamate.
PubMed:
NEW and nonofficial remedies: cyclamate calcium.