para-menthane-3,8-diol
2-(2-hydroxypropan-2-yl)-5-methylcyclohexan-1-ol
Identification
| Name | para-menthane-3,8-diol |
| IUPAC | 2-(2-hydroxypropan-2-yl)-5-methylcyclohexan-1-ol |
| CAS Number | 42822-86-6 |
| EINECS | 255-953-7 |
| FDA UNII | 6T6Z1Z1NC4 |
| Molecular Formula | C10 H20 O2 |
| Molecular Weight | 172.26780000 |
| MDL Number | MFCD00191551 |
| Nikkaji Number | J309.978D |
| Beilstein | 2552262 |
Regulatory
| JECFA Food Flavoring | 1416 p-menthane-3,8-diol |
| DG SANTE Food Flavourings | 02.246 p-menthane-3,8-diol |
| FEMA Number | 4053 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 42822-86-6 ; P-MENTHANE-3,8-DIOL |
Physical Properties
| Appearance | white crystals (est) |
| Assay | 99.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.97600 to 0.98200 @ 25.00 °C. |
| Pounds per Gallon - (est). | 8.121 to 8.171 |
| Melting Point | 34.00 to 35.00 °C. @ 760.00 mm Hg |
| Boiling Point | 266.00 to 268.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.001000 mmHg @ 25.00 °C. (est) |
| Flash Point | 248.00 °F. TCC ( 120.00 °C. ) |
| logP (o/w) | 1.374 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | hair conditioning |
Organoleptic Properties
| Odor Description | at 10.00 % in dipropylene glycol. |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment | Search |
| Recommendation for para-menthane-3,8-diol usage levels up to | 5.0000 % in the fragrance concentrate. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 39.00 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA) | 18.00 (μg/capita/day) |
| Structure Class | I |
| baked goods | 100.00000 |
| beverages(nonalcoholic) | 48.00000 |
| beverages(alcoholic) | 40.00000 |
| breakfast cereal | 20.00000 |
| cheese | 50.00000 |
| chewing gum | 1500.00000 |
| condiments / relishes | 50.00000 |
| confectionery froastings | 200.00000 |
| egg products | - |
| fats / oils | 100.00000 |
| fish products | - |
| frozen dairy | 5.00000 |
| fruit ices | 5.00000 |
| gelatins / puddings | 150.00000 |
| granulated sugar | 5.00000 |
| gravies | 35.00000 |
| hard candy | 500.00000 |
| imitation dairy | 75.00000 |
| instant coffee / tea | 25.00000 |
| jams / jellies | 150.00000 |
| meat products | - |
| milk products | 75.00000 |
| nut products | 15.00000 |
| other grains | - |
| poultry | - |
| processed fruits | 20.00000 |
| processed vegetables | 20.00000 |
| reconstituted vegetables | 20.00000 |
| seasonings / flavors | 15.00000 |
| snack foods | 15.00000 |
| soft candy | 500.00000 |
| soups | 15.00000 |
| sugar substitutes | - |
| sweet sauces | 25.00000 |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Chemical sources Association Inc
Exchange of knowledge
Need This Item for Flavor? You can contact the Chemical Sources Association.
Foreverest Resources Ltd.
Leading pine based chemicals supplier
Supplying turpentine based and natural/extracted flavor & fragrance ingredients.
Potential Uses
Natural Occurrence
Synonyms
citriodiol
coolact 38D (Takasago)
cubebaol
cyclohexanemethanol, 2-hydroxy-a,a,4-trimethyl-
cyclohexanol, 2-(2-hydroxy-2-propyl)-5-methyl-
2-(1-
hydroxy-1-methyl ethyl)-5-methyl cyclohexanol
2-(1-
hydroxy-1-methylethyl)-5-methylcyclohexanol
1-
hydroxy-2-(1-methyl-1-hydroxyethyl)-5-methyl cyclohexane
2-
hydroxy-a,a,4-trimethylcyclohexane methanol
2-(2-
hydroxypropan-2-yl)-5-methylcyclohexan-1-ol
2-(2-
hydroxypropan-2-yl)-5-methylcyclohexanol
(1alpha,3beta,4beta)-p-
menthan-3,8-diol
(1alpha,3beta,4beta)-para-
menthan-3,8-diol
p-
menthan-3,8-diol
para-
menthan-3,8-diol
(1alpha,3beta,4beta)-p-
menthane-3,8-diol
(1alpha,3beta,4beta)-para-
menthane-3,8-diol
p-
menthane-3,8-diol
menthoglycol
iso
pulegol hydrate
PubMed:
Assessing the efficacy of candidate mosquito repellents against the background of an attractive source that mimics a human host.
PubMed:
A push-pull system to reduce house entry of malaria mosquitoes.
PubMed:
The efficacy of repellents against Aedes, Anopheles, Culex and Ixodes spp. - a literature review.
PubMed:
[Field efficacy of repellent formulation containing para-menthane-3,8-diol and lemongrass against Culicoides pachymerus (Diptera: Ceratopogonidae) in Colombia].
PubMed:
Efficacy testing of several Ixodes ricinus tick repellents: different results with different assays.
PubMed:
Repellents and acaricides as personal protection measures in the prevention of tick-borne diseases.
PubMed:
Efficacy of DEET and non-DEET-based insect repellents against bites of Simulium damnosum vectors of onchocerciasis.
PubMed:
[Studies on anti-tumor metastatic constituents from Lindera glauca].
PubMed:
Metabolism of (+)- and (-)-menthols by CYP2A6 in human liver microsomes.
PubMed:
Patent literature on mosquito repellent inventions which contain plant essential oils--a review.
PubMed:
[Personal protection measures against blood-sucking insects and ticks].
PubMed:
Efficacy and safety of catnip (Nepeta cataria) as a novel filth fly repellent.
PubMed:
Dihydronepetalactones deter feeding activity by mosquitoes, stable flies, and deer ticks.
PubMed:
Percutaneous absorption of an insect repellent p-menthane-3,8-DIOL: a model for human dermal absorption.
PubMed:
Effective insect repellent formulation in both surfactantless and classical microemulsions with a long-lasting protection for human beings.
PubMed:
Acaricidal effects of Corymbia citriodora oil containing para-menthane-3,8-diol against nymphs of Ixodes ricinus (Acari: Ixodidae).
PubMed:
Repellency of MyggA Natural spray (para-menthane-3,8-diol) and RB86 (neem oil) against the tick Ixodes ricinus (Acari: Ixodidae) in the field in east-central Sweden.
PubMed:
PMD, a registered botanical mosquito repellent with deet-like efficacy.
PubMed:
Repellency of oils of lemon eucalyptus, geranium, and lavender and the mosquito repellent MyggA natural to Ixodes ricinus (Acari: Ixodidae) in the laboratory and field.
PubMed:
Efficacy of repellent products against caged and free flying Anopheles stephensi mosquitoes.
PubMed:
[Extraction and determination of volatile constituents in leaves of Eucalyptus citriodora].
PubMed:
Laboratory and field tests of the effectiveness of the lemon-eucalyptus extract, Citridiol, as a repellent against land leeches of the genus Haemadipsa (Haemadipsidae).
PubMed:
Laboratory evaluation of mosquito repellents against Aedes albopictus, Culex nigripalpus, and Ochierotatus triseriatus (Diptera: Culicidae).
PubMed:
Enhancement effect of p-menthane-3,8-diol on in vitro permeation of antipyrine and indomethacin through Yucatan micropig skin.
PubMed:
Repellency of IR3535, KBR3023, para-menthane-3,8-diol, and deet to black salt marsh mosquitoes (Diptera: Culicidae) in the Everglades National Park.
PubMed:
Repellent activities of stereoisomers of p-menthane-3,8-diols against Anopheles gambiae (Diptera: Culicidae).
PubMed:
Efficacy of three insect repellents against the malaria vector Anopheles arabiensis.
PubMed:
Evaluation of a eucalyptus-based repellent against Anopheles spp. in Tanzania.
PubMed:
Studies on the metabolism of l-menthol in rats.