alpha-acetolactate decarboxylase

CAS: 977164-02-5

Identification

Namealpha-acetolactate decarboxylase
CAS Number977164-02-5
FDA UNIISearch
MDL NumberMFCD00211578

Regulatory

JECFA Food Additivealpha-Acetolactate Decarboxylase from Bacillus brevis expressed in Bacillus subtilis
FDA Mainterm (SATF)977164-02-5 ; ALPHA-ACETOLACTATE DECARBOXYLASE ENZYME PREPARATION FROM BACILLUS SUBTILIS RECOMBINANT
FDA RegulationFDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance brown liquid (est)
Food Chemicals Codex Listed No

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorybrewing of beer and fermentation step of alcohol production
Recommendation for alpha-acetolactate decarboxylase usage levels up tonot for fragrance use.
Recommendation for alpha-acetolactate decarboxylase flavor usage levels up tonot for flavor use.

Chemical sources Association Inc

Exchange of knowledge

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Potential Uses

None Found

Natural Occurrence

bacillus brevis PMC bacillus subtilis PMC

Synonyms

alpha- acetolactate decarboxylase (a-ALDC) enzyme preparation derived from a recombinant Bacillus subtilis alpha- acetolactate decarboxylase enzyme preparation from bacillus subtilis recombinant alpha- acetolactate decarboxylase from bacillus brevis expressed in bacillus subtilis (S)-2- hydroxy-2-methyl-oxobutanoate carboxylase PubMed: Structural and enzymatic characterization of acetolactate decarboxylase from Bacillus subtilis PubMed: Improving the acidic stability of Staphylococcus aureus à-acetolactate decarboxylase in Bacillus subtilis by changing basic residues to acidic residues PubMed: Safety evaluation of the food enzyme acetolactate decarboxylase from a genetically modified Bacillusÿlicheniformis (strain NZYM-JB) PubMed: Structural characterization of an acetolactate decarboxylase from Klebsiella pneumoniae PubMed: Cloning of aldB, which encodes alpha-acetolactate decarboxylase, an exoenzyme from Bacillus brevis PubMed: Structure and catalytic mechanistic insight into Enterobacter aerogenes acetolactate decarboxylase PubMed: Synthetic operon for (R,R)-2,3-butanediol production in Bacillus subtilis and Escherichia coli PubMed: Production of 2,3-dihydroxyisovalerate by Enterobacter cloacae PubMed: Effect of alpha-acetolactate decarboxylase inactivation on alpha-acetolactate and diacetyl production by Lactococcus lactis subsp. lactis biovar diacetylactis PubMed: Acetoin production via unbalanced fermentation in Shewanella oneidensis PubMed: Dual role of alpha-acetolactate decarboxylase in Lactococcus lactis subsp. lactis PubMed: Efficient biochemical production of acetoin from carbon dioxide using Cupriavidus necator H16 PubMed: Establishment and application of multiplexed CRISPR interference system in Bacillus licheniformis PubMed: A simple biosynthetic pathway for 2,3-butanediol production in Thermococcus onnurineus NA1 PubMed: Surface-engineered Saccharomyces cerevisiae displaying à-acetolactate decarboxylase from Acetobacter aceti ssp xylinum PubMed: Enhanced Production of Tetramethylpyrazine in Bacillus licheniformis BL1 through aldC Over-expression and acetaldehyde Supplementation PubMed: Metabolic engineering of Saccharomyces cerevisiae for 2,3-butanediol production PubMed: Acetoin metabolism in bacteria PubMed: Comparative Assessment of Factors Involved in Acetoin Synthesis by Bacillus subtilis 168 PubMed: Regulation of branched-chain amino acid biosynthesis by alpha-acetolactate decarboxylase in Streptococcus thermophilus PubMed: [Alpha-acetolactate decarboxylase from B. licheniformis AS10106: cloning and expression gene in E. coli and S. cerevisiae] PubMed: Metabolic engineering of Parageobacillus thermoglucosidasius for the efficient production of (2R, 3R)-butanediol PubMed: Isobutanol and 2-ketoisovalerate production by Klebsiella pneumoniae via a native pathway PubMed: Structure and mechanism of acetolactate decarboxylase PubMed: N-Acyl-Homoserine Lactone Quorum Sensing Switch from Acidogenesis to Solventogenesis during the Fermentation Process in Serratia marcescens MG1 PubMed: Production of diacetyl by metabolically engineered Enterobacter cloacae PubMed: The transcription factor AlsR binds and regulates the promoter of the alsSD operon responsible for acetoin formation in Bacillus subtilis PubMed: Nucleotide sequence and expression of the Enterobacter aerogenes alpha-acetolactate decarboxylase gene in brewer's yeast PubMed: Engineering Corynebacterium glutamicum for the production of 2,3-butanediol PubMed: Purification and properties of the alpha-acetolactate decarboxylase from Lactococcus lactis subsp. lactis NCDO 2118 PubMed: Selection and properties of alpha-acetolactate decarboxylase-deficient spontaneous mutants of Streptococcus thermophilus PubMed: Toxicological Evaluation of Acetolactate Decarboxylase PubMed: Enhanced production of butanol and acetoin by heterologous expression of an acetolactate decarboxylase in Clostridium acetobutylicum PubMed: [Expression of alpha-acetolactate decarboxylase gene from Bacillus subtilis in Brewer's yeast] PubMed: Electrode-assisted acetoin production in a metabolically engineered Escherichia coli strain PubMed: Purification and characterization of à-acetolactate decarboxylase (ALDC) from newly isolated Lactococcus lactis DX PubMed: Chromosomal Integration and Expression of Two Bacterial alpha-Acetolactate Decarboxylase Genes in Brewer's Yeast PubMed: Bacillus subtilis ccpA gene mutants specifically defective in activation of acetoin biosynthesis PubMed: Construction of a brewer's yeast having alpha-acetolactate decarboxylase gene from Acetobacter aceti ssp. xylinum integrated in the genome PubMed: Cloning and expression of an alpha-acetolactate decarboxylase gene from Streptococcus lactis subsp. diacetylactis in Escherichia coli PubMed: Glucose/citrate cometabolism in Lactococcus lactis subsp. lactis biovar diacetylactis with impaired alpha-acetolactate decarboxylase PubMed: Application of a ribosomal DNA integration vector in the construction of a brewer's yeast having alpha-acetolactate decarboxylase activity PubMed: A thermophilic cell-free cascade enzymatic reaction for acetoin synthesis from pyruvate PubMed: Effect of Respiratory Growth on the Metabolite Production and Stress Robustness of Lactobacillus casei N87 Cultivated in Cheese Whey Permeate Medium PubMed: Industrial Production of 2,3-Butanediol from the Engineered Corynebacterium glutamicum PubMed: Moderate expression of the transcriptional regulator ALsR enhances acetoin production by Bacillus subtilis PubMed: Regulation of the Bacillus subtilis alsS, alsD, and alsR genes involved in post-exponential-phase production of acetoin PubMed: 2-Ketogluconic acid production by Klebsiella pneumoniae CGMCC 1.6366 PubMed: Acetolactate decarboxylase from Aerobacter aerogenes. Purification and properties PubMed: Complete amino acid sequence of alpha-acetolactate decarboxylase from Bacillus brevis PubMed: Anaerobic gene expression in Staphylococcus aureus PubMed: Production of 2,3-butanediol by engineered Saccharomyces cerevisiae PubMed: Effect of ILV6 Deletion and Expression of aldB from Lactobacillus plantarum in Saccharomyces uvarum on Diacetyl Production and Wine Flavor PubMed: Cyanobacterial conversion of carbon dioxide to 2,3-butanediol PubMed: Purification, crystallization and preliminary X-ray crystallographic studies on acetolactate decarboxylase PubMed: Fermentative metabolism of Bacillus subtilis: physiology and regulation of gene expression PubMed: Efficient production of acetoin in Saccharomyces cerevisiae by disruption of 2,3-butanediol dehydrogenase and expression of NADH oxidase PubMed: Purification and characterisation of acetolactate decarboxylase from Leuconostoc lactis NCW1 PubMed: Production of 2-butanol from crude glycerol by a genetically-engineered Klebsiella pneumoniae strain PubMed: The current strategies and parameters for the enhanced microbial production of 2,3-butanediol PubMed: [Isolation and purification of acetolactate synthase and acetolactate decarboxylase from a Lactococcus lactis culture] PubMed: Efficient production of 2,3-butanediol in Saccharomyces cerevisiae by eliminating ethanol and glycerol production and redox rebalancing PubMed: [Gene regulation to lactic acid bacteria for increasing production of flavor metabolite] PubMed: Characterization and regulation of the 2,3-butanediol pathway in Serratia marcescens PubMed: Ca2+-citrate uptake and metabolism in Lactobacillus casei ATCC 334 PubMed: Cloning and expression of the gene encoding alpha-acetolactate decarboxylase from Acetobacter aceti ssp. xylinum in brewer's yeast PubMed: Mechanism of 2,3-butanediol stereoisomer formation in Klebsiella pneumoniae PubMed: Reconstruction of an acetogenic 2,3-butanediol pathway involving a novel NADPH-dependent primary-secondary alcohol dehydrogenase PubMed: Characterization of acetoin production in a budC gene disrupted mutant of Serratia marcescens G12 PubMed: Identification of acetoin reductases involved in 2,3-butanediol pathway in Klebsiella oxytoca PubMed: Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241 PubMed: Transcriptional and translational regulation of alpha-acetolactate decarboxylase of Lactococcus lactis subsp. lactis PubMed: Selection of an endogenous 2,3-butanediol pathway in Escherichia coli by fermentative redox balance PubMed: Metabolic engineering of Zymomonas mobilis for 2,3-butanediol production from lignocellulosic biomass sugars PubMed: Hydroxy-pentanones production by Bacillus sp. H15-1 and its complete genome sequence PubMed: Enhanced production of 2,3-butanediol by overexpressing acetolactate synthase and acetoin reductase in Klebsiella pneumoniae PubMed: Diacetyl and alpha-acetolactate overproduction by Lactococcus lactis subsp. lactis biovar diacetylactis mutants that are deficient in alpha-acetolactate decarboxylase and have a low lactate dehydro PubMed: Efficient production of 2,3-butanediol by recombinant Saccharomyces cerevisiae through modulation of gene expression by cocktail ë-integration PubMed: Enhanced 2,3-butanediol production in recombinant Klebsiella pneumoniae via overexpression of synthesis-related genes PubMed: Metabolic engineering of acetoin and meso-2, 3-butanediol biosynthesis in E. coli PubMed: Enhancement of acetoin production in Candida glabrata by in silico-aided metabolic engineering PubMed: The LysR-type transcriptional regulator (LTTR) AlsR indirectly regulates expression of the Bacillus subtilis bdhA gene encoding 2,3-butanediol dehydrogenase PubMed: A central role for carbon-overflow pathways in the modulation of bacterial cell death PubMed: Disruption of the alsSD operon of Enterococcus faecalis impairs growth on pyruvate at low pH PubMed: Genetic manipulation of the pathway for diacetyl metabolism in Lactococcus lactis PubMed: Metabolic engineering of a Saccharomyces cerevisiae strain capable of simultaneously utilizing glucose and galactose to produce enantiopure (2R,3R)-butanediol PubMed: Improved performances and control of beer fermentation using encapsulated alpha-acetolactate decarboxylase and modeling PubMed: Thermophilic fermentation of acetoin and 2,3-butanediol by a novel Geobacillus strain PubMed: The influence of budA deletion on glucose metabolism related in 2,3-butanediol production by Klebsiella pneumoniae PubMed: Characterization of CidR-mediated regulation in Bacillus anthracis reveals a previously undetected role of S-layer proteins as murein hydrolases PubMed: Volatile organic compounds profile during milk fermentation by Lactobacillus pentosus and correlations between volatiles flavor and carbohydrate metabolism PubMed: Simultaneous production of butanol and acetoin by metabolically engineered Clostridium acetobutylicum PubMed: Promoters inducible by aromatic amino acids and ?-aminobutyrate (GABA) for metabolic engineering applications in Saccharomyces cerevisiae PubMed: The regulation of 2,3-butanediol synthesis in Klebsiella pneumoniae as revealed by gene over-expressions and metabolic flux analysis PubMed: Cloning and sequencing of the gene encoding alpha-acetolactate decarboxylase from Leuconostoc oenos PubMed: Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation PubMed: Stereospecificity of Corynebacterium glutamicum 2,3-butanediol dehydrogenase and implications for the stereochemical purity of bioproduced 2,3-butanediol PubMed: Bio-molecular characterisation of indigenous Oenococcus oeni strains from Negroamaro wine PubMed: Synthesis of 2,3-butanediol by Synechocystis sp. PCC6803 via heterologous expression of a catabolic pathway from lactic acid- and enterobacteria PubMed: Synthetic 2,3-butanediol pathway integrated using Tn7-tool and powered via elimination of sporulation and acetate production in acetogen biocatalyst PubMed: Influence of blocking of 2,3-butanediol pathway on glycerol metabolism for 1,3-propanediol production by Klebsiella oxytoca PubMed: An efficient method using Gluconacetobacter europaeus to reduce an unfavorable flavor compound, acetoin, in rice vinegar production PubMed: The production of D-acetoin by a transgenic Escherichia coli PubMed: Synthesis of pure meso-2,3-butanediol from crude glycerol using an engineered metabolic pathway in Escherichia coli PubMed: Expression of Recombinant alpha-Acetolactate Decarboxylase and Its Characterization PubMed: A general method for selection of alpha-acetolactate decarboxylase-deficient Lactococcus lactis mutants to improve diacetyl formation PubMed: Identification of up-regulated genes of Bacillus amyloliquefaciens B55 during the early stage of direct surface contact with rice R109 root PubMed: Increased 2,3-butanediol production by changing codon usages in Escherichia coli PubMed: High-yield production of (R)-acetoin in Saccharomyces cerevisiae by deleting genes for NAD(P)H-dependent ketone reductases producing meso-2,3-butanediol and 2,3-dimethylglycerate PubMed: Use of a modified alcohol dehydrogenase, ADH1, promoter in construction of diacetyl non-producing brewer's yeast PubMed: Lactococcus lactis as a cell factory for high-level diacetyl production PubMed: Recombinant brewer's yeast strains suitable for accelerated brewing PubMed: A simple method to generate chromosomal mutations in Lactobacillus plantarum strain TF103 to eliminate undesired fermentation products PubMed: Complete sequences of four plasmids of Lactococcus lactis subsp. cremoris SK11 reveal extensive adaptation to the dairy environment PubMed: Monitoring the acetohydroxy acid synthase reaction and related carboligations by circular dichroism spectroscopy PubMed: Metabolic operons in Lactococci PubMed: Evaluation of certain food additives. Fifty-first report of the Joint FAO/WHO Expert Committee on Food Additives PubMed: Identification of the transcriptional activator controlling the butanediol fermentation pathway in Klebsiella terrigena PubMed: Cloning, sequence and expression of a linear plasmid-based and a chromosomal homolog of chloroacetaldehyde dehydrogenase-encoding genes in Xanthobacter autotrophicus GJ10 PubMed: Identification of genes negatively regulated by Fis: Fis and RpoS comodulate growth-phase-dependent gene expression in Escherichia coli PubMed: Development of industrial-medium-required elimination of the 2,3-butanediol fermentation pathway to maintain ethanol yield in an ethanologenic strain of Klebsiella oxytoca PubMed: Imbalance of leucine flux in Lactococcus lactis and its use for the isolation of diacetyl-overproducing strains PubMed: Characterization of the genes of the 2,3-butanediol operons from Klebsiella terrigena and Enterobacter aerogenes PubMed: [Construction of a set of secreting expression vectors for Saccharomyces cerevisiea] PubMed: Identification of conserved promoter elements for aldB and isozyme specific residues in aldolase B PubMed: [Effects of knockout of 2,3-butanediol synthesis key enzyme genes on 1,3-propandediol production in Klebsiella pneumoniae] PubMed: Evaluation of certain food additives and contaminants. Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives PubMed: A simple method to generate chromosomal mutations in Lactobacillus plantarum strain TF103 to eliminate undesired fermentation products PubMed: Diacetyl production mechanism by a strain of Lactococcus lactis spp. lactis bv. diacetylactis. Study of alpha-acetolactic acid extracellular accumulation under anaerobiosis PubMed: Development and Use of a Screening Procedure for Production of (alpha)-Acetolactate by Lactococcus lactis subsp. lactis biovar diacetylactis Strains PubMed: [Integration and expression of beta-endoglucanase I from Trichoderma reesei in brewing yeast]