alpha-acetolactate decarboxylase
Identification
| Name | alpha-acetolactate decarboxylase |
| CAS Number | 977164-02-5 |
| FDA UNII | Search |
| MDL Number | MFCD00211578 |
Regulatory
| JECFA Food Additive | alpha-Acetolactate Decarboxylase from Bacillus brevis expressed in Bacillus subtilis |
| FDA Mainterm (SATF) | 977164-02-5 ; ALPHA-ACETOLACTATE DECARBOXYLASE ENZYME PREPARATION FROM BACILLUS SUBTILIS RECOMBINANT |
| FDA Regulation | FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Appearance | brown liquid (est) |
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | brewing of beer and fermentation step of alcohol production |
| Recommendation for alpha-acetolactate decarboxylase usage levels up to | not for fragrance use. |
| Recommendation for alpha-acetolactate decarboxylase flavor usage levels up to | not for flavor use. |
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Exchange of knowledge
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Potential Uses
Natural Occurrence
Synonyms
alpha-
acetolactate decarboxylase (a-ALDC) enzyme preparation derived from a recombinant Bacillus subtilis
alpha-
acetolactate decarboxylase enzyme preparation from bacillus subtilis recombinant
alpha-
acetolactate decarboxylase from bacillus brevis expressed in bacillus subtilis
(S)-2-
hydroxy-2-methyl-oxobutanoate carboxylase
PubMed:
Structural and enzymatic characterization of acetolactate decarboxylase from Bacillus subtilis
PubMed:
Improving the acidic stability of Staphylococcus aureus à-acetolactate decarboxylase in Bacillus subtilis by changing basic residues to acidic residues
PubMed:
Safety evaluation of the food enzyme acetolactate decarboxylase from a genetically modified Bacillusÿlicheniformis (strain NZYM-JB)
PubMed:
Structural characterization of an acetolactate decarboxylase from Klebsiella pneumoniae
PubMed:
Cloning of aldB, which encodes alpha-acetolactate decarboxylase, an exoenzyme from Bacillus brevis
PubMed:
Structure and catalytic mechanistic insight into Enterobacter aerogenes acetolactate decarboxylase
PubMed:
Synthetic operon for (R,R)-2,3-butanediol production in Bacillus subtilis and Escherichia coli
PubMed:
Production of 2,3-dihydroxyisovalerate by Enterobacter cloacae
PubMed:
Effect of alpha-acetolactate decarboxylase inactivation on alpha-acetolactate and diacetyl production by Lactococcus lactis subsp. lactis biovar diacetylactis
PubMed:
Acetoin production via unbalanced fermentation in Shewanella oneidensis
PubMed:
Dual role of alpha-acetolactate decarboxylase in Lactococcus lactis subsp. lactis
PubMed:
Efficient biochemical production of acetoin from carbon dioxide using Cupriavidus necator H16
PubMed:
Establishment and application of multiplexed CRISPR interference system in Bacillus licheniformis
PubMed:
A simple biosynthetic pathway for 2,3-butanediol production in Thermococcus onnurineus NA1
PubMed:
Surface-engineered Saccharomyces cerevisiae displaying à-acetolactate decarboxylase from Acetobacter aceti ssp xylinum
PubMed:
Enhanced Production of Tetramethylpyrazine in Bacillus licheniformis BL1 through aldC Over-expression and acetaldehyde Supplementation
PubMed:
Metabolic engineering of Saccharomyces cerevisiae for 2,3-butanediol production
PubMed:
Acetoin metabolism in bacteria
PubMed:
Comparative Assessment of Factors Involved in Acetoin Synthesis by Bacillus subtilis 168
PubMed:
Regulation of branched-chain amino acid biosynthesis by alpha-acetolactate decarboxylase in Streptococcus thermophilus
PubMed:
[Alpha-acetolactate decarboxylase from B. licheniformis AS10106: cloning and expression gene in E. coli and S. cerevisiae]
PubMed:
Metabolic engineering of Parageobacillus thermoglucosidasius for the efficient production of (2R, 3R)-butanediol
PubMed:
Isobutanol and 2-ketoisovalerate production by Klebsiella pneumoniae via a native pathway
PubMed:
Structure and mechanism of acetolactate decarboxylase
PubMed:
N-Acyl-Homoserine Lactone Quorum Sensing Switch from Acidogenesis to Solventogenesis during the Fermentation Process in Serratia marcescens MG1
PubMed:
Production of diacetyl by metabolically engineered Enterobacter cloacae
PubMed:
The transcription factor AlsR binds and regulates the promoter of the alsSD operon responsible for acetoin formation in Bacillus subtilis
PubMed:
Nucleotide sequence and expression of the Enterobacter aerogenes alpha-acetolactate decarboxylase gene in brewer's yeast
PubMed:
Engineering Corynebacterium glutamicum for the production of 2,3-butanediol
PubMed:
Purification and properties of the alpha-acetolactate decarboxylase from Lactococcus lactis subsp. lactis NCDO 2118
PubMed:
Selection and properties of alpha-acetolactate decarboxylase-deficient spontaneous mutants of Streptococcus thermophilus
PubMed:
Toxicological Evaluation of Acetolactate Decarboxylase
PubMed:
Enhanced production of butanol and acetoin by heterologous expression of an acetolactate decarboxylase in Clostridium acetobutylicum
PubMed:
[Expression of alpha-acetolactate decarboxylase gene from Bacillus subtilis in Brewer's yeast]
PubMed:
Electrode-assisted acetoin production in a metabolically engineered Escherichia coli strain
PubMed:
Purification and characterization of à-acetolactate decarboxylase (ALDC) from newly isolated Lactococcus lactis DX
PubMed:
Chromosomal Integration and Expression of Two Bacterial alpha-Acetolactate Decarboxylase Genes in Brewer's Yeast
PubMed:
Bacillus subtilis ccpA gene mutants specifically defective in activation of acetoin biosynthesis
PubMed:
Construction of a brewer's yeast having alpha-acetolactate decarboxylase gene from Acetobacter aceti ssp. xylinum integrated in the genome
PubMed:
Cloning and expression of an alpha-acetolactate decarboxylase gene from Streptococcus lactis subsp. diacetylactis in Escherichia coli
PubMed:
Glucose/citrate cometabolism in Lactococcus lactis subsp. lactis biovar diacetylactis with impaired alpha-acetolactate decarboxylase
PubMed:
Application of a ribosomal DNA integration vector in the construction of a brewer's yeast having alpha-acetolactate decarboxylase activity
PubMed:
A thermophilic cell-free cascade enzymatic reaction for acetoin synthesis from pyruvate
PubMed:
Effect of Respiratory Growth on the Metabolite Production and Stress Robustness of Lactobacillus casei N87 Cultivated in Cheese Whey Permeate Medium
PubMed:
Industrial Production of 2,3-Butanediol from the Engineered Corynebacterium glutamicum
PubMed:
Moderate expression of the transcriptional regulator ALsR enhances acetoin production by Bacillus subtilis
PubMed:
Regulation of the Bacillus subtilis alsS, alsD, and alsR genes involved in post-exponential-phase production of acetoin
PubMed:
2-Ketogluconic acid production by Klebsiella pneumoniae CGMCC 1.6366
PubMed:
Acetolactate decarboxylase from Aerobacter aerogenes. Purification and properties
PubMed:
Complete amino acid sequence of alpha-acetolactate decarboxylase from Bacillus brevis
PubMed:
Anaerobic gene expression in Staphylococcus aureus
PubMed:
Production of 2,3-butanediol by engineered Saccharomyces cerevisiae
PubMed:
Effect of ILV6 Deletion and Expression of aldB from Lactobacillus plantarum in Saccharomyces uvarum on Diacetyl Production and Wine Flavor
PubMed:
Cyanobacterial conversion of carbon dioxide to 2,3-butanediol
PubMed:
Purification, crystallization and preliminary X-ray crystallographic studies on acetolactate decarboxylase
PubMed:
Fermentative metabolism of Bacillus subtilis: physiology and regulation of gene expression
PubMed:
Efficient production of acetoin in Saccharomyces cerevisiae by disruption of 2,3-butanediol dehydrogenase and expression of NADH oxidase
PubMed:
Purification and characterisation of acetolactate decarboxylase from Leuconostoc lactis NCW1
PubMed:
Production of 2-butanol from crude glycerol by a genetically-engineered Klebsiella pneumoniae strain
PubMed:
The current strategies and parameters for the enhanced microbial production of 2,3-butanediol
PubMed:
[Isolation and purification of acetolactate synthase and acetolactate decarboxylase from a Lactococcus lactis culture]
PubMed:
Efficient production of 2,3-butanediol in Saccharomyces cerevisiae by eliminating ethanol and glycerol production and redox rebalancing
PubMed:
[Gene regulation to lactic acid bacteria for increasing production of flavor metabolite]
PubMed:
Characterization and regulation of the 2,3-butanediol pathway in Serratia marcescens
PubMed:
Ca2+-citrate uptake and metabolism in Lactobacillus casei ATCC 334
PubMed:
Cloning and expression of the gene encoding alpha-acetolactate decarboxylase from Acetobacter aceti ssp. xylinum in brewer's yeast
PubMed:
Mechanism of 2,3-butanediol stereoisomer formation in Klebsiella pneumoniae
PubMed:
Reconstruction of an acetogenic 2,3-butanediol pathway involving a novel NADPH-dependent primary-secondary alcohol dehydrogenase
PubMed:
Characterization of acetoin production in a budC gene disrupted mutant of Serratia marcescens G12
PubMed:
Identification of acetoin reductases involved in 2,3-butanediol pathway in Klebsiella oxytoca
PubMed:
Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241
PubMed:
Transcriptional and translational regulation of alpha-acetolactate decarboxylase of Lactococcus lactis subsp. lactis
PubMed:
Selection of an endogenous 2,3-butanediol pathway in Escherichia coli by fermentative redox balance
PubMed:
Metabolic engineering of Zymomonas mobilis for 2,3-butanediol production from lignocellulosic biomass sugars
PubMed:
Hydroxy-pentanones production by Bacillus sp. H15-1 and its complete genome sequence
PubMed:
Enhanced production of 2,3-butanediol by overexpressing acetolactate synthase and acetoin reductase in Klebsiella pneumoniae
PubMed:
Diacetyl and alpha-acetolactate overproduction by Lactococcus lactis subsp. lactis biovar diacetylactis mutants that are deficient in alpha-acetolactate decarboxylase and have a low lactate dehydro
PubMed:
Efficient production of 2,3-butanediol by recombinant Saccharomyces cerevisiae through modulation of gene expression by cocktail ë-integration
PubMed:
Enhanced 2,3-butanediol production in recombinant Klebsiella pneumoniae via overexpression of synthesis-related genes
PubMed:
Metabolic engineering of acetoin and meso-2, 3-butanediol biosynthesis in E. coli
PubMed:
Enhancement of acetoin production in Candida glabrata by in silico-aided metabolic engineering
PubMed:
The LysR-type transcriptional regulator (LTTR) AlsR indirectly regulates expression of the Bacillus subtilis bdhA gene encoding 2,3-butanediol dehydrogenase
PubMed:
A central role for carbon-overflow pathways in the modulation of bacterial cell death
PubMed:
Disruption of the alsSD operon of Enterococcus faecalis impairs growth on pyruvate at low pH
PubMed:
Genetic manipulation of the pathway for diacetyl metabolism in Lactococcus lactis
PubMed:
Metabolic engineering of a Saccharomyces cerevisiae strain capable of simultaneously utilizing glucose and galactose to produce enantiopure (2R,3R)-butanediol
PubMed:
Improved performances and control of beer fermentation using encapsulated alpha-acetolactate decarboxylase and modeling
PubMed:
Thermophilic fermentation of acetoin and 2,3-butanediol by a novel Geobacillus strain
PubMed:
The influence of budA deletion on glucose metabolism related in 2,3-butanediol production by Klebsiella pneumoniae
PubMed:
Characterization of CidR-mediated regulation in Bacillus anthracis reveals a previously undetected role of S-layer proteins as murein hydrolases
PubMed:
Volatile organic compounds profile during milk fermentation by Lactobacillus pentosus and correlations between volatiles flavor and carbohydrate metabolism
PubMed:
Simultaneous production of butanol and acetoin by metabolically engineered Clostridium acetobutylicum
PubMed:
Promoters inducible by aromatic amino acids and ?-aminobutyrate (GABA) for metabolic engineering applications in Saccharomyces cerevisiae
PubMed:
The regulation of 2,3-butanediol synthesis in Klebsiella pneumoniae as revealed by gene over-expressions and metabolic flux analysis
PubMed:
Cloning and sequencing of the gene encoding alpha-acetolactate decarboxylase from Leuconostoc oenos
PubMed:
Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation
PubMed:
Stereospecificity of Corynebacterium glutamicum 2,3-butanediol dehydrogenase and implications for the stereochemical purity of bioproduced 2,3-butanediol
PubMed:
Bio-molecular characterisation of indigenous Oenococcus oeni strains from Negroamaro wine
PubMed:
Synthesis of 2,3-butanediol by Synechocystis sp. PCC6803 via heterologous expression of a catabolic pathway from lactic acid- and enterobacteria
PubMed:
Synthetic 2,3-butanediol pathway integrated using Tn7-tool and powered via elimination of sporulation and acetate production in acetogen biocatalyst
PubMed:
Influence of blocking of 2,3-butanediol pathway on glycerol metabolism for 1,3-propanediol production by Klebsiella oxytoca
PubMed:
An efficient method using Gluconacetobacter europaeus to reduce an unfavorable flavor compound, acetoin, in rice vinegar production
PubMed:
The production of D-acetoin by a transgenic Escherichia coli
PubMed:
Synthesis of pure meso-2,3-butanediol from crude glycerol using an engineered metabolic pathway in Escherichia coli
PubMed:
Expression of Recombinant alpha-Acetolactate Decarboxylase and Its Characterization
PubMed:
A general method for selection of alpha-acetolactate decarboxylase-deficient Lactococcus lactis mutants to improve diacetyl formation
PubMed:
Identification of up-regulated genes of Bacillus amyloliquefaciens B55 during the early stage of direct surface contact with rice R109 root
PubMed:
Increased 2,3-butanediol production by changing codon usages in Escherichia coli
PubMed:
High-yield production of (R)-acetoin in Saccharomyces cerevisiae by deleting genes for NAD(P)H-dependent ketone reductases producing meso-2,3-butanediol and 2,3-dimethylglycerate
PubMed:
Use of a modified alcohol dehydrogenase, ADH1, promoter in construction of diacetyl non-producing brewer's yeast
PubMed:
Lactococcus lactis as a cell factory for high-level diacetyl production
PubMed:
Recombinant brewer's yeast strains suitable for accelerated brewing
PubMed:
A simple method to generate chromosomal mutations in Lactobacillus plantarum strain TF103 to eliminate undesired fermentation products
PubMed:
Complete sequences of four plasmids of Lactococcus lactis subsp. cremoris SK11 reveal extensive adaptation to the dairy environment
PubMed:
Monitoring the acetohydroxy acid synthase reaction and related carboligations by circular dichroism spectroscopy
PubMed:
Metabolic operons in Lactococci
PubMed:
Evaluation of certain food additives. Fifty-first report of the Joint FAO/WHO Expert Committee on Food Additives
PubMed:
Identification of the transcriptional activator controlling the butanediol fermentation pathway in Klebsiella terrigena
PubMed:
Cloning, sequence and expression of a linear plasmid-based and a chromosomal homolog of chloroacetaldehyde dehydrogenase-encoding genes in Xanthobacter autotrophicus GJ10
PubMed:
Identification of genes negatively regulated by Fis: Fis and RpoS comodulate growth-phase-dependent gene expression in Escherichia coli
PubMed:
Development of industrial-medium-required elimination of the 2,3-butanediol fermentation pathway to maintain ethanol yield in an ethanologenic strain of Klebsiella oxytoca
PubMed:
Imbalance of leucine flux in Lactococcus lactis and its use for the isolation of diacetyl-overproducing strains
PubMed:
Characterization of the genes of the 2,3-butanediol operons from Klebsiella terrigena and Enterobacter aerogenes
PubMed:
[Construction of a set of secreting expression vectors for Saccharomyces cerevisiea]
PubMed:
Identification of conserved promoter elements for aldB and isozyme specific residues in aldolase B
PubMed:
[Effects of knockout of 2,3-butanediol synthesis key enzyme genes on 1,3-propandediol production in Klebsiella pneumoniae]
PubMed:
Evaluation of certain food additives and contaminants. Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives
PubMed:
A simple method to generate chromosomal mutations in Lactobacillus plantarum strain TF103 to eliminate undesired fermentation products
PubMed:
Diacetyl production mechanism by a strain of Lactococcus lactis spp. lactis bv. diacetylactis. Study of alpha-acetolactic acid extracellular accumulation under anaerobiosis
PubMed:
Development and Use of a Screening Procedure for Production of (alpha)-Acetolactate by Lactococcus lactis subsp. lactis biovar diacetylactis Strains
PubMed:
[Integration and expression of beta-endoglucanase I from Trichoderma reesei in brewing yeast]