ferrous lactate
ferrous L-lactate
Identification
| Name | ferrous lactate |
| EINECS | 227-608-0 |
| FDA UNII | 5JU4C2L5A0 |
| Molecular Formula | C6 H12 Fe O6 |
| Molecular Weight | 236.00184000 |
| Nikkaji Number | J3.081C |
| Beilstein | 6099658 |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | 184.1311 |
| JECFA Food Additive | Ferrous Lactate |
| GSFA Codex | Ferrous lactate (585) |
| DG SANTE Food Additives | ferrous lactate |
| FDA Mainterm (SATF) | 5905-52-2 ; FERROUS LACTATE |
| FDA Regulation | FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE |
Physical Properties
| Appearance | greenish white to green crystalline powder (est) |
| Assay | 96.00 to 100.00 |
| Heavey Metals | >0.002%, Pb <5 ppm |
| Water Content | 12% - 14% |
| Food Chemicals Codex Listed | No |
| Boiling Point | 227.00 to 228.00 °C. @ 760.00 mm Hg (est) |
| PH Number | 5.00 to 6.00 |
| Vapor Pressure | 0.015000 mmHg @ 25.00 °C. (est) |
| Flash Point | 230.00 °F. TCC ( 109.90 °C. ) (est) |
| logP (o/w) | -0.698 (est) |
| Shelf Life | 36.00 month(s) or longer if stored properly. |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
| Insoluble in | alcohol |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
Organoleptic Properties
| Taste Description | mild sweet metallic |
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | oral-mouse LD50 147 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | nutrient supplements |
| Recommendation for ferrous lactate usage levels up to | not for fragrance use. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 73.00 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI) | 6400 (μg/person/day) |
| baked goods | - |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | 10.00000 |
| chewing gum | - |
| condiments / relishes | 20.00000 |
| confectionery froastings | - |
| egg products | 10.00000 |
| fats / oils | 10.00000 |
| fish products | 10.00000 |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | 20.00000 |
| hard candy | - |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | 20.00000 |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | 20.00000 |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | 20.00000 |
| snack foods | 20.00000 |
| soft candy | - |
| soups | 20.00000 |
| sugar substitutes | - |
| sweet sauces | - |
| Dairy products, excluding products of category 02.0 (01.0) | - |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0) | - |
| Edible ices, including sherbet and sorbet (03.0) | - |
| Processed fruit (04.1) | - |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2) | - |
| Confectionery (05.0) | - |
| Chewing gum (05.3) | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0) | - |
| Bakery wares (07.0) | - |
| Meat and meat products, including poultry and game (08.0) | 42.00000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0) | - |
| Eggs and egg products (10.0) | - |
| Sweeteners, including honey (11.0) | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0) | 42.00000 |
| Foodstuffs intended for particular nutritional uses (13.0) | - |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1) | - |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2) | - |
| Ready-to-eat savouries (15.0) | - |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0) | - |
American International Chemical, Inc.
Consistent sources
North American supplier for globally sourced ingredients.
BOC Sciences
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Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Glentham Life Sciences Ltd
The Chemical, Biochemical & Research Essentials Supplier
Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.
Penta International Corporation
Chemistry innovation
At Penta, our products and services help businesses do business better.
Potential Uses
Natural Occurrence
Synonyms
ferrous L-lactate
ferrous lactate gluconate (EZ-iron)
ferrous lactate hydrate
ferrouslactate
(T-4)-bis((2S)-2-(
hydroxy-kappaO)propanoato-kappaO)-iron
2-
hydroxypropanoate; iron(+2) cation
2-
hydroxypropanoate; iron(2+)
2-
hydroxypropanoic acid iron(2+) salt (2:1)
2-
hydroxypropanoic acid; iron
iron dilactate
iron(2+) 2-hydroxypropanoate (2:1)
iron(2+) bis(2-hydroxypropanoate)
iron(2+) lactate
iron(2+) lactate (2:1)
iron(2+) lactate, (2:1)
iron(II) lactate
iron(II) lactate hydrate
(S)-bis(
lactato-O1,O2)iron
lactic acid iron(2+) salt (2:1)
propanoic acid, 2-hydroxy-, iron(2+) salt (2:1)
propanoic acid, 2-hydroxy-, iron(2+) salt (2:1) (9CI)
Info:
EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed:
The Effect of Iron and Fat in a Diet Containing Green Tea Extract (Camellia sinensis) on the Antioxidant Capacity of Some Organs and the mRNA Expression of Specific Genes in Mice.
Leffingwell & Associates:
Flavor Properties of FEMA GRAS List 25 flavor chemicals
PubMed:
Effects of mineral content of bovine drinking water: does iron content affect milk quality?
PubMed:
Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows.
PubMed:
Preference and drinking behavior of lactating dairy cows offered water with different concentrations, valences, and sources of iron.
PubMed:
[Effects of recombinant human lactoferrin on improving the iron status of IDA rats].
PubMed:
Hematite nanoparticles larger than 90 nm show no sign of toxicity in terms of lactate dehydrogenase release, nitric oxide generation, apoptosis, and comet assay in murine alveolar macrophages and human lung epithelial cells.
PubMed:
Durable cofactor immobilization in sol-gel bio-composite thin films for reagentless biosensors and bioreactors using dehydrogenases.
PubMed:
Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and HâOâ.
PubMed:
Inactivation of astrocytic glutamine synthetase by hydrogen peroxide requires iron.
PubMed:
[Comparative characteristic of lactate dehydrogenase properties from the white muscles and liver of goldfish (Carassius auratus L.)].
PubMed:
Modification of the chiral selectivity of D-glucose oxidase and L-lactate oxidase in a collagen matrix.
PubMed:
[Effects of dinitrosyl iron complex with glutathione and its components on ischemic rat heart during reperfusion].
PubMed:
Estrogen reduces iron-mediated brain edema and neuronal death.
PubMed:
The soluble nickel component of residual oil fly ash alters pulmonary host defense in rats.
PubMed:
The fabrication and characterization of dicalcium phosphate dihydrate-modified magnetic nanoparticles and their performance in hyperthermia processes in vitro.
PubMed:
The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage.
PubMed:
Screening and formulation of chemoattractant coatings for artificial reef structures.
PubMed:
Superparamagnetic iron oxide nanoparticles encapsulated in biodegradable thermosensitive polymeric micelles: toward a targeted nanomedicine suitable for image-guided drug delivery.
PubMed:
Anaphylaxis to oral iron salts. desensitization protocol for tolerance induction.
PubMed:
The case/Renal failure after percutaneous closure of a perivalvular leak.
PubMed:
Growth and activity of Bulgarian yogurt starter culture in iron-fortified milk.
PubMed:
Cytotoxicity of a newly synthesized nitroxide derivative of 4-ferrocenecarboxyl-2,2,6,6-tetramethylpiperidine-1-oxyl in high metastatic lung tumor cells.
PubMed:
An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation.
PubMed:
Fortification of soy sauce using various iron sources: sensory acceptability and shelf stability.
PubMed:
Development of fortified dried broken rice as a complementary food.
PubMed:
Propolis protects human spermatozoa from DNA damage caused by benzo[a]pyrene and exogenous reactive oxygen species.
PubMed:
[Improving of the rat brain neurons and PC12 neuronal cells survival by gangliosides under oxidative stress].
PubMed:
In vitro evaluation of iron solubility and dialyzability of various iron fortificants and of iron-fortified milk products targeted for infants and toddlers.
PubMed:
Local prevention of oxidative stress in the intestinal epithelium of the rat by adhesive liposomes of superoxide dismutase and tempamine.
PubMed:
Iron absorption by human subjects from different iron fortification compounds added to Thai fish sauce.
PubMed:
p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.
PubMed:
Iron availability of a fortified processed wheat cereal: a comparison of fourteen iron forms using an in vitro digestion/human colonic adenocarcinoma (CaCo-2) cell model.
PubMed:
In vitro iron availability from iron-fortified whole-grain wheat flour.
PubMed:
Effect of iron lactate overloading on adenine nucleotide levels and adenosine 3'-monophosphate forming enzyme in rat liver and spleen.
PubMed:
Combating iodine and iron deficiencies through the double fortification of fish sauce, mixed fish sauce, and salt brine.
PubMed:
Iron toxicity in organotypic cultures of hippocampal slices: role of reactive oxygen species.
PubMed:
Magnetometric evaluation of cadmium oxide-induced toxicity to pulmonary alveolar macrophages of Syrian golden hamsters.
PubMed:
Abundance and phylogenetic affiliation of iron reducers in activated sludge as assessed by fluorescence in situ hybridization and microautoradiography.
PubMed:
[Effects of supplementing calcium, iron and zinc on the fetus development and growth during pregnancy].
PubMed:
[Effects of supplementing of calcium, iron and zinc on women's health during pregnancy].
PubMed:
Iron lactate-induced osteopenia in male Sprague-Dawley rats.
PubMed:
Effects of 2-butoxyethanol on hepatic oxidative damage.
PubMed:
The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status.
PubMed:
Expression of glutathione-S-transferase isozyme in the SY5Y neuroblastoma cell line increases resistance to oxidative stress.
PubMed:
Hemoglobin increases endothelin-1 in endothelial cells by decreasing nitric oxide.
PubMed:
Effects of hemoglobin on heme oxygenase gene expression and viability of cultured smooth muscle cells.
PubMed:
Changes in free and esterified cholesterol: hallmarks of acute renal tubular injury and acquired cytoresistance.
PubMed:
Polyene antibiotics: relative degrees of in vitro cytotoxicity and potential effects on tubule phospholipid and ceramide content.
PubMed:
NT2 neurons, a classical model for Alzheimer's disease, are highly susceptible to oxidative stress.
PubMed:
Effect of bioactive tannoid principles of Emblica officinalis on iron-induced hepatic toxicity in rats.
PubMed:
Chloroacetonitrile-induced toxicity and oxidative stress in rat gastric epithelial cells.
PubMed:
Effects of TNF-alpha and IL-1beta on iron metabolism by A549 cells and influence on cytotoxicity.
PubMed:
Eosinophilic gastroenterocolitis in iron lactate-overloaded rats.
PubMed:
Iron-ethanol synergism and pathological liver transformation.
PubMed:
Iron-mediated cardiotoxicity develops independently of extracellular hydroxyl radicals in isolated rat hearts.
PubMed:
The labile iron pool in hepatocytes: prooxidant-induced increase in free iron precedes oxidative cell injury.
PubMed:
Secretion and increase of intracellular CuZn superoxide dismutase content in human neuroblastoma SK-N-BE cells subjected to oxidative stress.
PubMed:
An ethanol-extract of Ampelopsis brevipedunculata (Vitaceae) berries decreases ferrous iron-stimulated hepatocyte injury in culture.
PubMed:
Determination of water in ferrous lactate by near infrared reflectance spectroscopy with a fibre-optic probe.
PubMed:
Ethanol-induced cell death by lipid peroxidation in PC12 cells.
PubMed:
Effects of iron chelates on the transferrin-free culture of rat dermal fibroblasts through active oxygen generation.
PubMed:
Effect of oxidative stress by iron on 4-hydroxynonenal formation and proliferative activity in hepatomas of different degrees of differentiation.
PubMed:
Characterization of ion interference in gossypol consumption.
PubMed:
Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice.
PubMed:
A comparison of oral and intravenous iron supplementation in preterm infants receiving recombinant erythropoietin.
PubMed:
Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes.
PubMed:
Changes in antioxidative activities induced by Fe (II) and Fe (III) in cultured Vero cells.
PubMed:
Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats.
PubMed:
Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation.
PubMed:
Dual effect of lipid peroxidation on the membrane order of retinal cells in culture.
PubMed:
Direct detection of ascorbyl radical in experimental brain injury: microdialysis and an electron spin resonance spectroscopic study.
PubMed:
Free-radical mediated toxicity in whole rat brain reaggregate cultures is prevented by alpha-tocopherol.
PubMed:
Prevention of lipid peroxidation does not prevent oxidant-induced myocardial contractile dysfunction.
PubMed:
Superoxide scavenging activity in leukocytes and absence of cellular toxicity of a series of coumarins.
PubMed:
K(+)-linked release of oxidized glutathione induced by tert-butyl hydroperoxide in perfused rat liver is independent of lipid peroxidation and cell death.
PubMed:
Role of iron and glutathione redox cycle in acetaminophen-induced cytotoxicity to cultured rat hepatocytes.
PubMed:
Postischemic inhibition of cerebral cortex pyruvate dehydrogenase.
PubMed:
Role of hydroxyl radicals in the activation of human platelets.
PubMed:
Protection of the rat jejunal mucosa against oxidative injury by cationized superoxide dismutase.
PubMed:
Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells.
PubMed:
The use of cyclic voltammetry for the evaluation of oxidative damage in biological samples.
PubMed:
The effect of changes in iron redox state on the activity of enzymes sensitive to modification of SH groups.
PubMed:
Inorganic iron effects on in vitro hypoxic proximal renal tubular cell injury.
PubMed:
Iron availability and free radical induced injury in the isolated ischaemic/reperfused rat heart.
PubMed:
Cytophotometric assay of cytochrome oxidase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase activities in human peroxidized spermatozoa.
PubMed:
Ferrous iron dependent nitric oxide production in nitrate reducing cultures of Escherichia coli.
PubMed:
Effect of oxygen free radicals and lipid peroxides on cardiac isoenzymes.
PubMed:
An EPR study of the interactions between heme and flavin in yeast flavocytochrome b2.
PubMed:
[A multicomponent additive intended for preparing infant milk mixtures enriched with essential and protective factors].
PubMed:
On the therapeutic effects of trivalent and divalent iron in iron deficiency anaemia.
PubMed:
Lipid peroxidation in isolated rat hepatocytes measured by ethane and n-pentane formation.
PubMed:
Reduction of ferric iron by L-lactate and DL-glycerol-3-phosphate in membrane preparations from Staphylococcus aureus and interactions with the nitrate reductase system.
PubMed:
Circadian variations of certain blood components currently investigated.
PubMed:
Suppressive effects of metal salts on leukocyte and fibroblastic function.
PubMed:
The effect of pH on the stability of solutions of liver fraction I, N.F.X in the presence of ferrous lactate and ferrous gluconate.
PubMed:
[Ferrous lactate as an oral iron preparation for therapeutic use].
PubMed:
[Rationalization of ferrous lactate industry].