magnolol
[1,1'-biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-
Identification
| Name | magnolol |
| CAS Number | 528-43-8 |
| FDA UNII | 001E35HGVF |
| Molecular Formula | C18 H18 O2 |
| Molecular Weight | 266.33986000 |
| MDL Number | MFCD00016658 |
| Nikkaji Number | J277.749E |
Regulatory
| JECFA Food Flavoring | 2023 magnolol |
| FEMA Number | 4559 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 528-43-8 ; MAGNOLOL |
Physical Properties
| Appearance | white crystalline powder (est) |
| Assay | 92.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 101.00 to 104.00 °C. @ 760.00 mm Hg |
| Boiling Point | 398.00 to 400.00 °C. @ 760.00 mm Hg |
| Flash Point | 364.00 °F. TCC ( 184.44 °C. ) |
| logP (o/w) | 4.502 (est) |
| Shelf Life | 12.00 month(s) or longer if stored properly. |
| Storage | refrigerate in tightly sealed containers. |
| Soluble in | alcohol, slightly |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antioxidants |
Organoleptic Properties
| Odor Description | bitter |
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | oral-mouse LD50 2200 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic and flavor agents |
| Recommendation for magnolol usage levels up to | not for fragrance use. |
| Structure Class | III |
| baked goods | - |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | 2000.00000 |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | 2000.00000 |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
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Potential Uses
Natural Occurrence
Synonyms
4-
allyl-2-(5-allyl-2-hydroxyphenyl) phenol
2,2'-
bichavicol
[1,1'-
biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-
[1,1'-
biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-
dehydrodichavicol
5,5'-
di-2-propenyl-[1,1'-biphenyl]-2,2'-diol
5,5'-
di(prop-2-en-1-yl)biphenyl-2,2'-diol
5,5'-
diallyl-[1,1'-biphenyl]-2,2'-diol
5,5'-
diallyl-2,2'-biphenyl diol
5,5'-
diallyl-2,2'-biphenyldiol
5,5'-
diallyl-2,2'-dihydroxybiphenyl
5,5'-
diallyl-biphenyl-2,2'-diol
5,5'-
diallylbiphenyl-2,2'-diol
2,2'-
dihydroxy-5,5'-diallyl biphenyl
2,2'-
dihydroxy-5,5'-diallylbiphenyl
2-(2-
hydroxy-5-prop-2-enyl phenyl)-4-prop-2-enyl phenol
2-(2-
hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
magnolia bark extract
magonila bark P.E.
mangolol
PubMed:
Active ingredients from natural botanicals in the treatment of obesity.
PubMed:
Polyethylene glycol-based ultrasound-assisted extraction of magnolol and honokiol from Cortex Magnoliae Officinalis.
PubMed:
Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.
PubMed:
Natural and natural-like phenolic inhibitors of type B trichothecene in vitro production by the wheat (Triticum sp.) pathogen Fusarium culmorum.
PubMed:
Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice.
PubMed:
Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression.
PubMed:
Neuroprotective effects of neolignans isolated from Magnoliae Cortex against glutamate-induced apoptotic stimuli in HT22 cells.
PubMed:
P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo.
PubMed:
Effect of magnolol on the function of osteoblastic MC3T3-E1 cells.
PubMed:
Magnolol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity through activation of mitochondrial function.
PubMed:
Antidepressant-like effect of magnolol on BDNF up-regulation and serotonergic system activity in unpredictable chronic mild stress treated rats.
PubMed:
Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDP-glucuronosyltransferase isoforms.
PubMed:
Hydrophobic ionic liquid-based ultrasound-assisted extraction of magnolol and honokiol from cortex Magnoliae officinalis.
PubMed:
Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice.
PubMed:
Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1.
PubMed:
Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
PubMed:
Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells.
PubMed:
Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells.
PubMed:
Anti-clastogenic effect of magnolol on benzo(a)pyrene-induced clastogenicity in mice.
PubMed:
Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor.
PubMed:
Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract.
PubMed:
[Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].
PubMed:
Cytotoxic neolignans: an SAR study.
PubMed:
Magnolia virginiana Neolignan compounds as chemical barriers to swallowtail butterfly host use.