[1,1'-biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-

CAS: 528-43-8 C18 H18 O2 MW: 266.33986000

Identification

Namemagnolol
CAS Number528-43-8
FDA UNII001E35HGVF
Molecular FormulaC18 H18 O2
Molecular Weight266.33986000
MDL NumberMFCD00016658
Nikkaji NumberJ277.749E

Regulatory

JECFA Food Flavoring2023 magnolol
FEMA Number4559
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)528-43-8 ; MAGNOLOL

Physical Properties

Appearance white crystalline powder (est)
Assay 92.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 101.00 to 104.00 °C. @ 760.00 mm Hg
Boiling Point 398.00 to 400.00 °C. @ 760.00 mm Hg
Flash Point 364.00 °F. TCC ( 184.44 °C. )
logP (o/w) 4.502 (est)
Shelf Life 12.00 month(s) or longer if stored properly.
Storage refrigerate in tightly sealed containers.
Soluble in alcohol, slightly

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

Organoleptic Properties

Odor Description bitter

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-mouse LD50 2200 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic and flavor agents
Recommendation for magnolol usage levels up tonot for fragrance use.
Structure ClassIII
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum2000.00000
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy2000.00000
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

None Found

Natural Occurrence

magnolia officinalis

Synonyms

4- allyl-2-(5-allyl-2-hydroxyphenyl) phenol 2,2'- bichavicol [1,1'- biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl- [1,1'- biphenyl]-2,2'-diol, 5,5'-di-2-propenyl- dehydrodichavicol 5,5'- di-2-propenyl-[1,1'-biphenyl]-2,2'-diol 5,5'- di(prop-2-en-1-yl)biphenyl-2,2'-diol 5,5'- diallyl-[1,1'-biphenyl]-2,2'-diol 5,5'- diallyl-2,2'-biphenyl diol 5,5'- diallyl-2,2'-biphenyldiol 5,5'- diallyl-2,2'-dihydroxybiphenyl 5,5'- diallyl-biphenyl-2,2'-diol 5,5'- diallylbiphenyl-2,2'-diol 2,2'- dihydroxy-5,5'-diallyl biphenyl 2,2'- dihydroxy-5,5'-diallylbiphenyl 2-(2- hydroxy-5-prop-2-enyl phenyl)-4-prop-2-enyl phenol 2-(2- hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol magnolia bark extract magonila bark P.E. mangolol PubMed: Active ingredients from natural botanicals in the treatment of obesity. PubMed: Polyethylene glycol-based ultrasound-assisted extraction of magnolol and honokiol from Cortex Magnoliae Officinalis. PubMed: Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. PubMed: Natural and natural-like phenolic inhibitors of type B trichothecene in vitro production by the wheat (Triticum sp.) pathogen Fusarium culmorum. PubMed: Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice. PubMed: Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression. PubMed: Neuroprotective effects of neolignans isolated from Magnoliae Cortex against glutamate-induced apoptotic stimuli in HT22 cells. PubMed: P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo. PubMed: Effect of magnolol on the function of osteoblastic MC3T3-E1 cells. PubMed: Magnolol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity through activation of mitochondrial function. PubMed: Antidepressant-like effect of magnolol on BDNF up-regulation and serotonergic system activity in unpredictable chronic mild stress treated rats. PubMed: Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDP-glucuronosyltransferase isoforms. PubMed: Hydrophobic ionic liquid-based ultrasound-assisted extraction of magnolol and honokiol from cortex Magnoliae officinalis. PubMed: Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice. PubMed: Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1. PubMed: Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. PubMed: Signaling pathway for TNF-alpha-induced MMP-9 expression: mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells. PubMed: Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells. PubMed: Anti-clastogenic effect of magnolol on benzo(a)pyrene-induced clastogenicity in mice. PubMed: Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor. PubMed: Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract. PubMed: [Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design]. PubMed: Cytotoxic neolignans: an SAR study. PubMed: Magnolia virginiana Neolignan compounds as chemical barriers to swallowtail butterfly host use.