4-amino-5,6-dimethyl thieno(2,3-d)pyrimidin-2(1H)-one
4-amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one
Identification
| Name | 4-amino-5,6-dimethyl thieno(2,3-d)pyrimidin-2(1H)-one |
| IUPAC | 4-amino-5,6-dimethyl-1H-thieno[2,3-d]pyrimidin-2-one |
| CAS Number | 121746-18-7 |
| FDA UNII | 2VLS8HFV5E |
| Molecular Formula | C8 H9 N3 O S |
| Molecular Weight | 195.24493000 |
| Nikkaji Number | J3.032.337H |
Regulatory
| DG SANTE Food Flavourings | 16.116 4-amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one |
| FEMA Number | 4669 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 121746-18-7 ; 4-AMINO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-2(1H)-ONE |
Physical Properties
| Assay | 98.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | 0.907 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
| Similar Items | note |
Organoleptic Properties
| Taste Description | sweet |
Safety Information
| Oral/Parenteral Toxicity | gavage-rat LD50 [sex: M] No LD50 obtained Substance tested up to 50 mg/kg without any effect. |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavor modifiers |
| Recommendation for 4-amino-5,6-dimethyl thieno(2,3-d)pyrimidin-2(1H)-one usage levels up to | not for fragrance use. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 0.00 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI) | 3600 (μg/person/day) |
| Threshold of Concern | 90 (μg/person/day) |
| Structure Class | III |
| baked goods | 5.00000 |
| beverages(nonalcoholic) | 7.50000 |
| beverages(alcoholic) | 7.50000 |
| breakfast cereal | 10.00000 |
| cheese | - |
| chewing gum | 10.00000 |
| condiments / relishes | 10.00000 |
| confectionery froastings | 10.00000 |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | 7.50000 |
| fruit ices | 7.50000 |
| gelatins / puddings | 5.00000 |
| granulated sugar | - |
| gravies | - |
| hard candy | 10.00000 |
| imitation dairy | 7.50000 |
| instant coffee / tea | 7.50000 |
| jams / jellies | 10.00000 |
| meat products | - |
| milk products | 7.50000 |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | 5.00000 |
| snack foods | 5.00000 |
| soft candy | 10.00000 |
| soups | - |
| sugar substitutes | 300.00000 |
| sweet sauces | 10.00000 |
| Dairy products, excluding products of category 02.0 (01.0) | 6.40000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0) | - |
| Edible ices, including sherbet and sorbet (03.0) | 6.40000 |
| Processed fruit (04.1) | - |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2) | - |
| Confectionery (05.0) | 8.50000 |
| Chewing gum (05.3) | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0) | 8.50000 |
| Bakery wares (07.0) | 4.00000 |
| Meat and meat products, including poultry and game (08.0) | - |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0) | - |
| Eggs and egg products (10.0) | - |
| Sweeteners, including honey (11.0) | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0) | - |
| Foodstuffs intended for particular nutritional uses (13.0) | 8.50000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1) | 6.40000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2) | 6.40000 |
| Ready-to-eat savouries (15.0) | - |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0) | 6.40000 |
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Exchange of knowledge
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Potential Uses
Natural Occurrence
Synonyms
4-
amino-5,6-dimethyl-1H-thieno[2,3-d]pyrimidin-2-one
4-
amino-5,6-dimethylthieno(2,3-d)pyrimidin-2(1H)-one
4-
amino-5,6-dimethylthieno[2,3-d]pyrimidin-2(1H)-one
Google Patents:
Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US Patents:
7,928,111 - Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
WIPO Patents:
SWEETENER COMPOSITIONS AND METHODS OF MAKING THEM
Leffingwell & Associates:
Flavor Properties of FEMA GRAS List 25 flavor chemicals