pogostone
4H-pyran-4-one, 2-hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-
Identification
| Name | pogostone |
| IUPAC | 4-hydroxy-6-methyl-3-(4-methylpentanoyl)pyran-2-one |
| CAS Number | 23800-56-8 |
| FDA UNII | Search |
| Molecular Formula | C12 H16 O4 |
| Molecular Weight | 224.25632000 |
| Nikkaji Number | J19.811K |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 381.50 °C. @ 760.00 mm Hg (est) |
| Flash Point | 294.00 °F. TCC ( 145.30 °C. ) (est) |
| logP (o/w) | 0.750 (est) |
| Soluble in | water, 2749 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for pogostone usage levels up to | not for fragrance use. |
| Recommendation for pogostone flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
4-
hydroxy-6-methyl-3-(4-methylpentanoyl)pyran-2-one
2-
hydroxy-6-methyl-3-(4-methylpentanoyl)pyran-4-one
4H-
pyran-4-one, 2-hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-
PubMed:
Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats.
PubMed:
In vitro and in vivo antibacterial activity of Pogostone.
PubMed:
Pogostone suppresses proinflammatory mediator production and protects against endotoxic shock in mice.
PubMed:
Identification of two chemotypes of Pogostemon cablin (Blanco) Benth. through DNA barcodes.
PubMed:
A gas chromatography-mass spectrometry method for the determination of pogostone in canine plasma and its application to a pharmacokinetic study.
PubMed:
Characterisation of the metabolism of pogostone in vitro and in vivo using liquid chromatography with mass spectrometry.
PubMed:
[Study on constituents of the aerial parts of Pogostemon cablin].
PubMed:
Evaluation of the antibacterial activity of patchouli oil.
PubMed:
Preliminary antibacterial evaluation of the chemical compositions in Herba pogostemonis oil.
PubMed:
Insecticidal activity of pogostone against Spodoptera litura and Spodoptera exigua (Lepidoptera: Noctuidae).
PubMed:
LC-MS/MS determination of pogostone in rat plasma and its application in pharmacokinetic studies.
PubMed:
Analysis of Pogostemon cablin from pharmaceutical research to market performances.
PubMed:
Synthesis and antimicrobial evaluation of pogostone and its analogues.
PubMed:
Anti-Candida albicans activity and pharmacokinetics of pogostone isolated from Pogostemonis Herba.
PubMed:
Composition of the essential oil of Pogostemon travancoricus var. travancoricus.
PubMed:
Acaricidal activity of DHEMH, derived from patchouli oil, against house dust mite, Dermatophagoides farinae.
PubMed:
PREPARATIVE ISOLATION AND PURIFICATION OF FIVE FLAVONOIDS FROM POGOSTEMON CABLIN BENTH BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY AND PREPARATIVE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY.
PubMed:
[Identification method with significant specificity of volatile oil of Pogostemon cablin].
PubMed:
GC-MS fingerprint of Pogostemon cablin in China.
PubMed:
[Re-study on characteristic fingerprint of volatile oil from Herba Pogostemonis by GC].
PubMed:
[Investigation on the influential factors of the volatile oil and main constituent content in Pogostemon cablin].
PubMed:
[Study on purification technology of patchouly oil with molecular distillation].
PubMed:
[Two chemotypes of Pogostemon cablin and influence of region of cultivation and harvesting time on volatile oil composition].
PubMed:
[Constituents analysis on volatile oil of Pogostemon cablin from different collection time cultivated in Hainan].
PubMed:
[DNA profiling of Pogostemon cablin chemotypes differing in essential oil composition].
PubMed:
[GC-MS analysis of volatile oil of herba Pogostemonis collected from Gaoyao county].
PubMed:
[Chemical constituents of Pogostemon cablin (Blanco) Benth].
PubMed:
Studies of the antibacterial activity of plant extracts and their constituents against periodontopathic bacteria.