nicotine
Identification
| Name | nicotine |
| IUPAC | 2-(1-methylpyrrolidin-2-yl)pyridine |
| CAS Number | 23950-04-1 |
| FDA UNII | Search |
| Molecular Formula | C10 H14 N2 |
| Molecular Weight | 162.23558000 |
| Nikkaji Number | J38.662F |
| XlogP3 | 1.20 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | unreported-frog LDLo 600 mg/kg |
| Dermal Toxicity | subcutaneous-rat LDLo 320 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for nicotine usage levels up to | not for fragrance use. |
| Recommendation for nicotine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2-(1-
methyl pyrrolidin-2-yl)-pyridine
2-(1-
methylpyrrolidin-2-yl)-pyridine
2-(1-
methylpyrrolidin-2-yl)pyridine
alpha-
nicotine
pyridine, 2-(1-methyl-2-pyrrolidinyl)-
alpha-
pyridyl-alpha-methylpyrrolidine
Info:
Nicotine
PubMed:
Phagocytosis and Inflammation: Exploring the effects of the components of E-cigarette vapor on macrophages.
PubMed:
Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats.
PubMed:
Use of higher-nicotine/tar-yield (regular full-flavor) cigarettes is associated with nicotine dependence and smoking during pregnancy among U.S. women.
PubMed:
Impact of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes.
PubMed:
Mining online e-liquid reviews for opinion polarities about e-liquid features.
PubMed:
Electronic Cigarettes in Germany: Patterns of Use and Perceived Health Improvement.
PubMed:
Consumers' Preferences for Electronic Nicotine Delivery System Product Features: A Structured Content Analysis.
PubMed:
Evidentiary Support in Public Comments to the FDA's Center for Tobacco Products.
PubMed:
A comparative study of electronic cigarette vapor extracts on airway-related cell lines in vitro.
PubMed:
Nicotine, aerosol particles, carbonyls and volatile organic compounds in tobacco- and menthol-flavored e-cigarettes.
PubMed:
Availability, price, and packaging of electronic cigarettes and e-liquids in Guatemala City retailers.
PubMed:
Sales of Nicotine-Containing Electronic Cigarette Products: United States, 2015.
PubMed:
Benzene formation in electronic cigarettes.
PubMed:
Electronic cigarettes and mental illness: Reviewing the evidence for help and harm among those with psychiatric and substance use disorders.
PubMed:
Identifying Topics for E-Cigarette User-Generated Contents: A Case Study From Multiple Social Media Platforms.
PubMed:
A Device-Independent Evaluation of Carbonyl Emissions from Heated Electronic Cigarette Solvents.
PubMed:
A method for classifying user-reported electronic cigarette liquid flavors.
PubMed:
Cytotoxic and Genotoxic Effects of Electronic Cigarette Liquids on Human Mucosal Tissue Cultures of the Oropharynx.
PubMed:
Quit Intentions Moderate Subjective and Physiological Responses to Acute Nicotine Replacement Therapy Administration in Dependent Smokers.
PubMed:
Determination of volatile organic compounds including alcohols in refill fluids and cartridges of electronic cigarettes by headspace solid-phase micro extraction and gas chromatography-mass spectrometry.
PubMed:
Effects of sweet flavorings and nicotine on the appeal and sensory properties of e-cigarettes among young adult vapers: Application of a novel methodology.
PubMed:
Current and Former Smokers' Use of Electronic Cigarettes for Quitting Smoking: An Exploratory Study of Adolescents and Young Adults.
PubMed:
Caffeine Concentrations in Coffee, Tea, Chocolate, and Energy Drink Flavored E-liquids.
PubMed:
"They're Pretty Much Made for Blunts": Product Features That Facilitate Marijuana Use Among Young Adult Cigarillo Users in the United States.
PubMed:
Socioeconomic Disadvantage and Other Risk Factors for Using Higher-Nicotine/Tar-Yield (Regular Full-Flavor) Cigarettes.
PubMed:
Analysis of symptoms and their potential associations with e-liquids' components: a social media study.
PubMed:
[Testing of the composition of e-cigarette liquids - Manufacturer-declared vs. true contents in a selected series of products].
PubMed:
Concentration of Nicotine and Glycols in 27 Electronic Cigarette Formulations.
PubMed:
E-cigarettes, Hookah Pens and Vapes: Adolescent and Young Adult Perceptions of Electronic Nicotine Delivery Systems.
PubMed:
Socially acquired nicotine self-administration with an aversive flavor cue in adolescent female rats.
PubMed:
Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole.
PubMed:
Toxicological assessment of a prototype e-cigaret device and three flavor formulations: a 90-day inhalation study in rats.
PubMed:
Sensory Effects of Menthol and Nicotine in an E-Cigarette.
PubMed:
The effects of alcohol-containing e-cigarettes on young adult smokers.
PubMed:
Real-Time Chemical Analysis of E-Cigarette Aerosols By Means Of Secondary Electrospray Ionization Mass Spectrometry.
PubMed:
Update on flavoring-induced lung disease.
PubMed:
Electronic Cigarette and Electronic Hookah: A Pilot Study Comparing Two Vaping Products.
PubMed:
The effect of potential electronic nicotine delivery system regulations on nicotine product selection.
PubMed:
Use of High-Nicotine/Tar-Yield (Full-Flavor) Cigarettes and Risk for Nicotine Dependence in Nationally Representative Samples of US Smokers.
PubMed:
How Menthol Alters Tobacco-Smoking Behavior: A Biological Perspective.
PubMed:
Flavored Tobacco Products in the United States: A Systematic Review Assessing Use and Attitudes.
PubMed:
Effect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human immortalized BBB endothelial cell line.
PubMed:
Comprehensive chemical characterization of Rapé tobacco products: Nicotine, un-ionized nicotine, tobacco-specific N'-nitrosamines, polycyclic aromatic hydrocarbons, and flavor constituents.
PubMed:
Corrective Taxes and Cigarette Characteristics.
PubMed:
Flavour chemicals in electronic cigarette fluids.
PubMed:
Nicotine concentrations with electronic cigarette use: effects of sex and flavor.
PubMed:
Factors Associated With Electronic Cigarette Users' Device Preferences and Transition From First Generation to Advanced Generation Devices.
PubMed:
Multicomponent analysis of replacement liquids of electronic cigarettes using chromatographic techniques.
PubMed:
Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung.
PubMed:
Chemical Composition and Evaluation of Nicotine, Tobacco Alkaloids, pH, and Selected Flavors in E-Cigarette Cartridges and Refill Solutions.
PubMed:
Custom Mentholation of Commercial Cigarettes for Research Purposes.
PubMed:
The Impact of Flavor Descriptors on Nonsmoking Teens' and Adult Smokers' Interest in Electronic Cigarettes.
PubMed:
E-Cigarette Market Trends in Traditional U.S. Retail Channels, 2012-2013.
PubMed:
Patterns of Longitudinal Transitions in Menthol Use Among US Young Adult Smokers.
PubMed:
Aerosol deposition doses in the human respiratory tree of electronic cigarette smokers.
PubMed:
Toxicological assessment of kretek cigarettes. Part 7: the impact of ingredients added to kretek cigarettes on inhalation toxicity.
PubMed:
Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air.
PubMed:
Identification and Quantification of Several Contaminated Compounds in Replacement Liquids of Electronic Cigarettes by Gas Chromatography-Mass Spectrometry.
PubMed:
Comparative in vitro toxicity profile of electronic and tobacco cigarettes, smokeless tobacco and nicotine replacement therapy products: e-liquids, extracts and collected aerosols.
PubMed:
Comparison of puff topography, toxicant exposure, and subjective effects in low- and high-frequency waterpipe users: a double-blind, placebo-control study.
PubMed:
The association between smokers' perceived importance of the appearance of cigarettes/cigarette packs and smoking sensory experience: a structural equation model.
PubMed:
Evaluation of electronic cigarette liquids and aerosol for the presence of selected inhalation toxins.
PubMed:
Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats.
PubMed:
Investigation of the chemical compositions in tobacco of different origins and maturities at harvest by GC-MS and HPLC-PDA-QTOF-MS.
PubMed:
Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells.
PubMed:
Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?
PubMed:
The role of cocoa as a cigarette additive: opportunities for product regulation.
PubMed:
Direct action and modulating effect of (+)- and (-)-nicotine on ion channels expressed in trigeminal sensory neurons.
PubMed:
Comparison of tobacco-containing and tobacco-free waterpipe products: effects on human alveolar cells.
PubMed:
Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models.
PubMed:
Flavored and nonflavored smokeless tobacco products: rate, pattern of use, and effects.
PubMed:
Youth access, creation, and content of smokeless tobacco ("dip") videos in social media.
PubMed:
Does switching to a tobacco-free waterpipe product reduce toxicant intake? A crossover study comparing CO, NO, PAH, volatile aldehydes, "tar" and nicotine yields.
PubMed:
Electronic cigarettes: effective nicotine delivery after acute administration.
PubMed:
Scientific assessment of the use of sugars as cigarette tobacco ingredients: a review of published and other publicly available studies.
PubMed:
Use of the target group index survey to evaluate the cigarette smoking profile in Saudi Arabia.
PubMed:
Effect of ammonia in cigarette tobacco on nicotine absorption in human smokers.
PubMed:
The health effects of menthol cigarettes as compared to non-menthol cigarettes.
PubMed:
Acute effects of waterpipe tobacco smoking: a double-blind, placebo-control study.
PubMed:
Determination of hazardous VOCs and nicotine released from mainstream smoke by the combination of the SPME and GC-MS methods.
PubMed:
The effect of chewing gum flavor on the negative affect associated with tobacco abstinence among dependent cigarette smokers.
PubMed:
Cellular basis for the olfactory response to nicotine.
PubMed:
The effect of chewing gum on self-reported nicotine withdrawal: is it the flavor, the act of chewing, or both?
PubMed:
Comparison of methods for measurement of smoking behavior: mouthpiece-based computerized devices versus direct observation.
PubMed:
Surveillance of moist snuff: total nicotine, moisture, pH, un-ionized nicotine, and tobacco-specific nitrosamines.
PubMed:
A randomized, controlled exposure study in adult smokers of full flavor Marlboro cigarettes switching to Marlboro Lights or Marlboro Ultra Lights cigarettes.
PubMed:
The menthol smoker: tobacco industry research on consumer sensory perception of menthol cigarettes and its role in smoking behavior.
PubMed:
Genotoxicity of 10 cigarette smoke condensates in four test systems: comparisons between assays and condensates.
PubMed:
Internal tobacco industry research on olfactory and trigeminal nerve response to nicotine and other smoke components.
PubMed:
Toxicological evaluation of potassium sorbate added to cigarette tobacco.
PubMed:
Do increases in cigarette prices lead to increases in sales of cigarettes with high tar and nicotine yields?
PubMed:
Determination of 10 carcinogenic polycyclic aromatic hydrocarbons in mainstream cigarette smoke.
PubMed:
Cytotoxicity and gene expression profiles in cell cultures exposed to whole smoke from three types of cigarettes.
PubMed:
Cadmium, lead, and thallium in mainstream tobacco smoke particulate.
PubMed:
Characterization of measured menthol in 48 U.S. cigarette sub-brands.
PubMed:
Toxicological evaluation of glycerin as a cigarette ingredient.
PubMed:
Scope for regulation of cigarette smoke toxicity according to brand differences in published toxicant emissions.
PubMed:
Smoking topography predicts abstinence following treatment with nicotine replacement therapy.
PubMed:
Adolescent and adult rats' aversion to flavors previously paired with nicotine.
PubMed:
Extinguishing the rewarding value of smoke cues: pharmacological and behavioral treatments.
PubMed:
Application, function, and effects of menthol in cigarettes: a survey of tobacco industry documents.
PubMed:
Efficacy of oral transmucosal nicotine lozenge for suppression of withdrawal symptoms in smoking abstinence.
PubMed:
Relationship between FTC 'tar' and urine mutagenicity in smokers of tobacco-burning or Eclipse cigarettes.
PubMed:
Flavor improvement does not increase abuse liability of nicotine chewing gum.
PubMed:
Subjective and discriminative stimulus effects of two de-nicotinized cigarettes with different tar yields.
PubMed:
Acute effects of smoking of cigarettes with different tar content on plasma oxidant/antioxidant status.
PubMed:
Toxicologic evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice.
PubMed:
Indian cigarettes gain popularity, but don't let the flavor fool you.
PubMed:
Glass fiber contamination of cigarette filters: an additional health risk to the smoker?
PubMed:
Preferences for tastes paired with a nicotine antagonist in rats chronically treated with nicotine.
PubMed:
Genetic differences in nicotine-induced conditioned taste aversion.
PubMed:
Comparison of measured and FTC-predicted nicotine uptake in smokers.
PubMed:
Nicotine and addiction. The Brown and Williamson documents.
PubMed:
Rewarding drugs produce taste avoidance, but not taste aversion.
PubMed:
Nicotine polacrilex dose effects: serum nicotine levels and sensory characteristics.
PubMed:
Clinical evaluation of a citric acid inhaler for smoking cessation.
PubMed:
The use of flavor in cigarette substitutes.
PubMed:
Withdrawal from chronic nicotine fails to produce a conditioned taste aversion to saccharin in rats.
PubMed:
Development of a citric acid aerosol as a smoking cessation aid.
PubMed:
Neuromuscular disorder associated with a defect in mitochondrial energy supply.