clivorine

(8?,12S,13S,14Z)-12- acetoxy-4-methyl-11,16-dioxo-14,21-didehydrosenecionan-4-ium-8-olate senecionanium, 12-(acetyloxy)-14,15,20,21-tetradehydro-15,20-dihydro-8-hydroxy-4-methyl-11,16-dioxo-, (8-xi,12-beta,14-Z)- PubMed: Differential induction of apoptosis and autophagy by pyrrolizidine alkaloid clivorine in human hepatoma Huh-7.5 cells and its toxic implication. PubMed: Clivorine, an otonecine pyrrolizidine alkaloid from Ligularia species, impairs neuronal differentiation via NGF-induced signaling pathway in cultured PC12 cells. PubMed: The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity. PubMed: Quercetin prevents pyrrolizidine alkaloid clivorine-induced liver injury in mice by elevating body defense capacity. PubMed: Assessment of pyrrolizidine alkaloid-induced toxicity in an in vitro screening model. PubMed: Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity. PubMed: The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury. PubMed: Pyrrolizidine alkaloid clivorine induced oxidative injury on primary cultured rat hepatocytes. PubMed: Pyrrolizidine alkaloid clivorine-induced oxidative stress injury in human normal liver L-02 cells. PubMed: Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity. PubMed: Protection of epidermal growth factor against clivorine-induced mitochondrial-mediated apoptosis in hepatocytes. PubMed: Protection of S-adenosyl methionine against the toxicity of clivorine on hepatocytes. PubMed: Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes. PubMed: Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine. PubMed: The toxic effect of pyrrolizidine alkaloid clivorine on the human embryonic kidney 293 cells and its primary mechanism. PubMed: Intracellular glutathione plays important roles in pyrrolizidine alkaloid clivorine-induced toxicity on L-02 hepatocytes. PubMed: In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors. PubMed: Deacetylclivorine: a gender-selective metabolite of clivorine formed in female Sprague-Dawley rat liver microsomes. PubMed: Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine. PubMed: Pyrrolizidine alkaloid clivorine induces apoptosis in human normal liver L-02 cells and reduces the expression of p53 protein. PubMed: Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook. PubMed: Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat. PubMed: Pyrrolizidine alkaloid clivorine inhibits human normal liver L-02 cells growth and activates p38 mitogen-activated protein kinase in L-02 cells. PubMed: Species differences in the in vitro metabolic activation of the hepatotoxic pyrrolizidine alkaloid clivorine. PubMed: Simultaneous analysis of clivorine and its four microsomal metabolites by high-performance liquid chromatography. PubMed: Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid. PubMed: Characterization of two structural forms of otonecine-type pyrrolizidine alkaloids from Ligularia hodgsonii by NMR spectroscopy. PubMed: Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid. PubMed: A quantitative investigation of the transannular amine-ketone (N...C=O) interaction in medium-sized heterocycles. PubMed: Genotoxicity of a variety of pyrrolizidine alkaloids in the hepatocyte primary culture-DNA repair test using rat, mouse, and hamster hepatocytes. PubMed: CArcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata. PubMed: Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test.