integerrimine

(15E)-12- hydroxysenecionan-11,16-dione inegerrimine intergerrimine senecionan-11,16-dione, 12-hydroxy-, (15E)- (9CI) senecionin, (15E)-isomer senecionine, (15E)-isomer squalidin squalidine PubMed: UPLC-MS/MS method for determination of selected pyrrolizidine alkaloids in feed. PubMed: Three new monoterpene glucosides from Senecio solidagineus. PubMed: Correction to Metabolomic and Genomic Evidence for Compromised Bile Acid Homeostasis by Senecionine, a Hepatotoxic Pyrrolizidine Alkaloid. PubMed: Toxicity of pyrrolizidine alkaloids to Spodoptera exigua using insect cell lines and injection bioassays. PubMed: Prenatal exposure to integerrimine N-oxide impaired the maternal care and the physical and behavioral development of offspring rats. PubMed: Mass-spectrometry-directed analysis and purification of pyrrolizidine alkaloid cis/trans isomers in Gynura japonica. PubMed: Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid. PubMed: [Determination of five pyrrolizidine alkaloids in honey by liquid chromatography-tandem mass spectrometry]. PubMed: Tusanqi and hepatic sinusoidal obstruction syndrome. PubMed: Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine. PubMed: Development and validation of a rapid multiplex ELISA for pyrrolizidine alkaloids and their N-oxides in honey and feed. PubMed: Assessment of pyrrolizidine alkaloid-induced toxicity in an in vitro screening model. PubMed: Analysis of pyrrolizidine alkaloids and evaluation of some biological activities of Algerian Senecio delphinifolius (Asteraceae). PubMed: The relationship between structurally different pyrrolizidine alkaloids and western flower thrips resistance in F(2) hybrids of Jacobaea vulgaris and Jacobaea aquatica. PubMed: Haematological and immunological effects of repeated dose exposure of rats to integerrimine N-oxide from Senecio brasiliensis. PubMed: [Simultaneous quantitation of adonifoline and senecionine in Senecio herbs by UPLC-MS]. PubMed: Authentication of Senecio scandens and S. vulgaris based on the comprehensive secondary metabolic patterns gained by UPLC-DAD/ESI-MS. PubMed: The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS. PubMed: Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. PubMed: The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury. PubMed: Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa. PubMed: [Ethyl acetate-soluble chemical constituents from whole plants of Senecio chrysanthemoides]. PubMed: Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (lepidoptera). PubMed: Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids. PubMed: Identification of the UDP-glucuronosyltransferase isozyme involved in senecionine glucuronidation in human liver microsomes. PubMed: Pyrrolizidine alkaloids in pollen and pollen products. PubMed: Intracellular glutathione plays important roles in pyrrolizidine alkaloids-induced growth inhibition on hepatocytes. PubMed: Feeding deterrence and detrimental effects of pyrrolizidine alkaloids fed to honey bees (Apis mellifera). PubMed: Simultaneous determination of senecionine, adonifoline and their metabolites in rat serum by UPLC-ESIMS and its application in pharmacokinetic studies. PubMed: Determination of senkirkine and senecionine in Tussilago farfara using microwave-assisted extraction and pressurized hot water extraction with liquid chromatography tandem mass spectrometry. PubMed: Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloid-producing plants of Ethiopia. PubMed: Simultaneous characterization of pyrrolizidine alkaloids and N-oxides in Gynura segetum by liquid chromatography/ion trap mass spectrometry. PubMed: Safety assessment of food and herbal products containing hepatotoxic pyrrolizidine alkaloids: interlaboratory consistency and the importance of N-oxide determination. PubMed: Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes. PubMed: The toxicity of Senecio inaequidens DC. PubMed: Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang). PubMed: Identification and quantification of hepatotoxic pyrrolizidine alkaloids in the Ethiopian medicinal plant Solanecio gigas (Asteraceae). PubMed: Pyrrolizidine alkaloids of the endemic Mexican genus Pittocaulon and assignment of stereoisomeric 1,2-saturated necine bases. PubMed: Determination of pyrrolizidine alkaloids in senecio species by liquid chromatography/thermospray-mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy. PubMed: Pyrrolizidine alkaloid level in Senecio bicolor (Wilid.) Tod, ssp. cineraria (DC.) from middle Europe. PubMed: Dynamic pH junction-sweeping capillary electrophoresis for online preconcentration of toxic pyrrolizidine alkaloids in Chinese herbal medicine. PubMed: Do naïve ruminants degrade alkaloids in the rumen? PubMed: Acquisition, transformation and maintenance of plant pyrrolizidine alkaloids by the polyphagous arctiid Grammia geneura. PubMed: Separation and determination of toxic pyrrolizidine alkaloids in traditional Chinese herbal medicines by micellar electrokinetic chromatography with organic modifier. PubMed: Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. PubMed: Frequent gain and loss of pyrrolizidine alkaloids in the evolution of Senecio section Jacobaea (Asteraceae). PubMed: Specific recognition, detoxification and metabolism of pyrrolizidine alkaloids by the polyphagous arctiid Estigmene acrea. PubMed: Direct evidence for membrane transport of host-plant-derived pyrrolizidine alkaloid N-oxides in two leaf beetle genera. PubMed: Comparison of hepatic in vitro metabolism of the pyrrolizidine alkaloid senecionine in sheep and cattle. PubMed: Preventive activity of pyrrolizidine alkaloids from Seneciobrasiliensis (Asteraceae) on gastric and duodenal induced ulcer on mice and rats. PubMed: Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. PubMed: Differential metabolism of the pyrrolizidine alkaloid, senecionine, in Fischer 344 and Sprague-Dawley rats. PubMed: Acquired and partially de novo synthesized pyrrolizidine alkaloids in two polyphagous arctiids and the alkaloid profiles of their larval food-plants. PubMed: Variation in pyrrolizidine alkaloid patterns of Senecio jacobaea. PubMed: Evaporative light scattering detection of pyrrolizidine alkaloids. PubMed: Taste receptors for pyrrolizidine alkaloids in a monophagous caterpillar. PubMed: Pyrrolizidine alkaloids as oviposition stimulants for the cinnabar moth, Tyria jacobaeae. PubMed: Uptake and metabolism of pyrrolizidine alkaloids in Longitarsus flea beetles (Coleoptera: Chrysomelidae) adapted and non-adapted to alkaloid-containing host plants. PubMed: Biochemical strategy of sequestration of pyrrolizidine alkaloids by adults and larvae of chrysomelid leaf beetles. PubMed: Toxicity of Senecio vernalis to laying hens and evaluation of residues in eggs. PubMed: Toxic pyrrolyzidine alkaloids from three mongolian plants. a possible risk for cattle poisoning. PubMed: Pyrrolizidine alkaloid profiles of some Senecio species from Egypt. PubMed: Structure-activity relationships of pyrrolizidine alkaloids in insect chemical defense against the orb-weaving spider Nephila clavipes. PubMed: Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. PubMed: Alkaloids from Senecio aquaticus. PubMed: Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae. PubMed: Induction of micronuclei by alkaloids extracted from Senecio brasiliensis and stored for 23 years. PubMed: Interplant alkaloid variation and Senecio vernalis toxicity in cattle. PubMed: Defensive chemistry of Senecio miser. PubMed: Variability in chemical constituents in Petasites hybridus from Austria. PubMed: SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest). PubMed: Hepatotoxicity associated with pyrrolizidine alkaloid (Crotalaria spp) ingestion in a horse on Easter Island. PubMed: Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids. PubMed: [Veno-occlusive disease after prolonged treatment with senecionine (Hemoluol)]. PubMed: The roles of CYP3A and CYP2B isoforms in hepatic bioactivation and detoxification of the pyrrolizidine alkaloid senecionine in sheep and hamsters. PubMed: Generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine. PubMed: Determination of pyrrolizidine alkaloids in honey from selected sites by solid phase extraction and HPLC-MS. PubMed: The two facies of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insects with acquired plant alkaloids. PubMed: Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. PubMed: Pyrrolizidine alkaloids from Gynura divaricata. PubMed: A competitive enzyme immunoassay for the pyrrolizidine alkaloids of the senecionine type. PubMed: Preparative separation of pyrrolizidine alkaloids by high-speed counter-current chromatography. PubMed: Enzyme-linked immunosorbent assay detection of pyrrolizidine alkaloids: immunogens based on quaternary pyrrolizidinium salts. PubMed: Pyrrolizidine alkaloids of three species of senecio in British Columbia. PubMed: A cytochrome P4502B form is the major bioactivation enzyme for the pyrrolizidine alkaloid senecionine in guinea pig. PubMed: Analysis of pyrrolizidine alkaloids: a competitive enzyme-linked immunoassay (ELISA) for the quantitative determination of some toxic pyrrolizidine alkaloids. PubMed: The effect of spironolactone treatment on the cytochrome P450-mediated metabolism of the pyrrolizidine alkaloid senecionine by hepatic microsomes from rats and guinea pigs. PubMed: Hepatotoxic pyrrolizidine alkaloids in the Mexican medicinal plant Packera candidissima (Asteraceae: Senecioneae). PubMed: Differing embryotoxic effects of senecionine and senecionine-N-oxide on the chick embryo. PubMed: Structural influences on pyrrolizidine alkaloid-induced cytopathology. PubMed: Pyrrolizidine alkaloids from Senecio leucanthemifolius and Senecio rodriguezii. PubMed: Microsomal formation of a pyrrolic alcohol glutathione conjugate of the pyrrolizidine alkaloid senecionine. PubMed: Hydrolysis of pyrrolizidine alkaloids by guinea pig hepatic carboxylesterases. PubMed: Detection of sulphur-conjugated pyrrolic metabolites in blood and fresh or fixed liver tissue from rats given a variety of toxic pyrrolizidine alkaloids. PubMed: Pyrrolizidine alkaloids from Werneria nubigena. PubMed: Pyrrolizidine alkaloids from Melampyrum pratense. PubMed: Sequestration of ingested [(14)C]senecionineN-oxide in the exocrine defensive secretions of chrysomelid beetles. PubMed: DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: structure-activity relationships. PubMed: Flavin-containing monooxygenase: a major detoxifying enzyme for the pyrrolizidine alkaloid senecionine in guinea pig tissues. PubMed: Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver. PubMed: Mechanisms for pyrrolizidine alkaloid activation and detoxification. PubMed: Excretion and blood radioactivity levels following [14C]senecionine administration in the rat. PubMed: N-acetylcysteine-conjugated pyrrole identified in rat urine following administration of two pyrrolizidine alkaloids, monocrotaline and senecionine. PubMed: The effect of the pyrrolizidine alkaloid integerrimine on the chromosomes of mouse bone marrow cells. PubMed: Honeydew analysis for detecting phloem transport of plant natural products : Implications for host-plant resistance to sap-sucking insects. PubMed: [Studies on the alkaloids of Gynura segetum (Lour.) Merr]. PubMed: Pyrrolizidine alkaloids in Senecio vulgaris L. growing in Iceland. PubMed: Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver. PubMed: The role of flavin-containing monooxygenase in the N-oxidation of the pyrrolizidine alkaloid senecionine. PubMed: Human embryotoxicity of pyrrolizidine-containing drugs. PubMed: Effects of the pyrrolizidine alkaloid senecionine and the alkenals trans-4-OH-hexenal and trans-2-hexenal on intracellular calcium compartmentation in isolated hepatocytes. PubMed: Sites of synthesis, translocation and accumulation of pyrrolizidine alkaloid N-oxides in Senecio vulgaris L. PubMed: Alkaloid N-oxides as transport and vacuolar storage compounds of pyrrolizidine alkaloids in Senecio vulgaris L. PubMed: Metabolic links between the biosynthesis of pyrrolizidine alkaloids and polyamines in root cultures of Senecio vulgaris. PubMed: Macrocyclic pyrrolizidine alkaloids from Senecio anonymus. Separation of a complex alkaloid extract using droplet counter-current chromatography. PubMed: Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris. PubMed: Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry. PubMed: Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea. PubMed: Livestock poisoning in South America by species of the Senecio plant. PubMed: Species differences in the hepatic microsomal metabolism of the pyrrolizidine alkaloid senecionine. PubMed: Alkaloid patterns and biosynthetic capacity of root cultures from some pyrrolizidine alkaloid producing Senecio species. PubMed: Lipid peroxidation and cellular damage caused by the pyrrolizidine alkaloid senecionine, the alkenal trans-4-hydroxy-2-hexenal, and related alkenals. PubMed: Toxic actions of senaetnine, a new pyrrolizidine-type alkaloid, in rats. PubMed: Microsomal metabolism of pyrrolizidine alkaloids: N-oxidation of seneciphylline and senecionine. PubMed: [Solvent extraction and isolation of alkaloids A and B from Senecio fuberi]. PubMed: Metabolism and toxicity of anacrotine, a pyrrolizidine alkaloid, in rats. PubMed: Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and the alkenal trans-4-OH-2-hexenal. PubMed: Microsomal metabolism of pyrrolizidine alkaloids from Senecio jacobaea. Isolation and quantification of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine and N-oxides by high performance liquid chromatography. PubMed: Genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids, a possible alkenal metabolite of the alkaloids, and related alkenals. PubMed: Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro. PubMed: Selective uptake of pyrrolizidine N-oxides by cell suspension cultures from pyrrolizidine alkaloid producing plants. PubMed: The formation of 6,7-dihydro-7-hydroxy-1-hydroxy-methyl-5H-pyrrolizine, a metabolite of pyrrolizidine alkaloids. PubMed: Method for determination of pyrrolizidine alkaloids and their metabolites by high-performance liquid chromatography. PubMed: Determination of pyrrolizidine alkaloids in Senecio inaequidens D.C. by capillary gas chromatography. PubMed: In vivo covalent binding of trans-4-hydroxy-2-hexenal to rat liver macromolecules. PubMed: Comparative cytopathology of primary rat hepatocyte cultures exposed to aflatoxin B1, acetaminophen, and other hepatotoxins. PubMed: trans-4-Hydroxy-2-hexenal: a reactive metabolite from the macrocyclic pyrrolizidine alkaloid senecionine. PubMed: Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine. PubMed: Genotoxicity of a variety of pyrrolizidine alkaloids in the hepatocyte primary culture-DNA repair test using rat, mouse, and hamster hepatocytes. PubMed: In vivo covalent binding of retronecine-labelled [3H]seneciphylline and [3H]senecionine to DNA of rat liver, lung and kidney. PubMed: Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. PubMed: Senecionine from Gynura segetum. PubMed: New guaianolides from Centaurea kandavanensis. PubMed: Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes. PubMed: Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro. PubMed: Transfer of [3H]pyrrolizidine alkaloids from Senecio vulgaris L. and metabolites into rat milk and tissues. PubMed: Comparison of the toxicities of Senecio jacobaea, Senecio vulgaris and Senecio glabellus in rats. PubMed: A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro. PubMed: Covalent binding of two pyrrolizidine alkaloids, senecionine and seneciphylline, to hepatic macromolecules and their distribution, excretion, and transfer into milk of lactating mice. PubMed: Carcinogenic and mutagenic activity of an alkaloidal extract of Senecio nemorensis ssp. fuchsii. PubMed: Alkaloids from Senecio aegyptius and S. desfontainei. PubMed: Metabolism, cytotoxicity, and genotoxicity of the pyrrolizidine alkaloid senecionine in primary cultures of rat hepatocytes. PubMed: Effects of the pyrrolizidine alkaloids senecionine, retrorsine and seneciphylline on aminopyrine N-demethylase activity on the rat liver S-10 fraction. PubMed: [On the gas-chromatographical determination of the pyrrolizidine alkaloids of some Senecio-species]. PubMed: [Spasmolytic properties of pyrrolizidine alkaloids]. PubMed: Pyrrolizidine alkaloids: their occurrence in honey from tansy ragwort (Senecio jacobaea L.) PubMed: Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure. PubMed: Senecionine, Seneciphylline, Jacobine and Otosenine from Senecio cineraria. PubMed: Pyrrolizidine alkaloid biosynthesis. Relative rates of incorporation of the isomers of isoleucine into the necic acid component of senecionine. PubMed: [Various biochemical changes in the rat liver following acute senecionine poisoning. I. Changes in content of reduced glutathione, plasma proteins and bilirubin]. PubMed: Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum. PubMed: Pharmacological properties of integerrimine, an alkaloid isolated from Crotalaria brevifolia. PubMed: Tumor inhibitors. XXII. Senecionine and senecionine N-oxide, the active principles of Senecio triangularis. PubMed: The action of alloxan, senecionine, sulfadiazine, and thiouracil in the hamster. PubMed: The effects of senecionine on the monkey. PubMed: Effects of senecionine on the hamster and monkey.