4-methoxysalicylaldehyde

2-hydroxy-4-methoxybenzaldehyde

CAS: 673-22-3 C8 H8 O3 MW: 152.14936000 vanilla

Identification

Name4-methoxysalicylaldehyde
IUPAC2-hydroxy-4-methoxybenzaldehyde
CAS Number673-22-3
EINECS211-604-0
FDA UNII2N395P88LW
Molecular FormulaC8 H8 O3
Molecular Weight152.14936000
MDL NumberMFCD00003327
Nikkaji NumberJ155.609F
Beilstein1072443
XlogP31.50 (est)

Regulatory

FEMA Number4435
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)673-22-3 ; 2-HYDROXY-4-METHOXYBENZALDEHYDE

Physical Properties

Appearance colorless to pale yellow clear solid (est)
Assay 97.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 41.00 to 43.00 °C. @ 760.00 mm Hg
Boiling Point 269.00 to 270.00 °C. @ 760.00 mm Hg, 124.00 °C. @ 12.00 mm Hg
Vapor Pressure 0.004000 mmHg @ 25.00 °C. (est)
Flash Point 235.00 °F. TCC ( 112.78 °C. )
logP (o/w) 2.057 (est)
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Odor Description at 100.00 %.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for 4-methoxysalicylaldehyde usage levels up tonot for fragrance use.
baked goods10.00000
beverages(nonalcoholic)5.00000
beverages(alcoholic)20.00000
breakfast cereal10.00000
cheese-
chewing gum20.00000
condiments / relishes-
confectionery froastings10.00000
egg products-
fats / oils-
fish products-
frozen dairy10.00000
fruit ices-
gelatins / puddings10.00000
granulated sugar-
gravies-
hard candy20.00000
imitation dairy-
instant coffee / tea10.00000
jams / jellies-
meat products-
milk products10.00000
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors100.00000
snack foods-
soft candy10.00000
soups-
sugar substitutes-
sweet sauces10.00000

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Potential Uses

antioxidants FR heliotrope FL vanilla

Natural Occurrence

decalepis hamiltonii periploca sepium walnut black walnut oil

Synonyms

p- anisaldehyde, 2-hydroxy- benzaldehyde, 2-hydroxy-4-methoxy- benzaldehyde,2-hydroxy-4-methoxy- 2- formyl-5-methoxyphenol 2- hydroxy-4-methoxybenzaldehyde 4- hydroxy-4-methoxybenzaldehyde 2- hydroxy-p-anisaldehyde o- hydroxy-p-methoxybenzaldehyde 2- hydroxy-para-anisaldehyde ortho- hydroxy-para-methoxybenzaldehyde salicylaldehyde, 4-methoxy- PubMed: Chemical composition of root aroma of Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter, an endemic and endangered ethnomedicinal plant from Western Ghats, India. PubMed: 7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors. PubMed: Flavoring extracts of Hemidesmus indicus roots and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities. PubMed: Shikimate pathway modulates the elicitor-stimulated accumulation of fragrant 2-hydroxy-4-methoxybenzaldehyde in Hemidesmus indicus roots. PubMed: Essential oils composition of Periploca laevigata Aiton subsp. angustifolia (Labill.) Markgraf (Apocynaceae-Periplocoideae). PubMed: Food protective effects of Periploca sepium oil and its active component against stored food mites. PubMed: Modification of gold nanoparticle loaded on activated carbon with bis(4-methoxysalicylaldehyde)-1,2-phenylenediamine as new sorbent for enrichment of some metal ions. PubMed: Spectral studies of copper(II) complexes of tridentate acylhydrazone ligands with heterocyclic compounds as coligands: X-ray crystal structure of one acylhydrazone copper(II) complex. PubMed: Synthesis and characterization of Mo(VI) complexes derived from ONO donor acylhydrazones. PubMed: Inhibition of Helicobacter pylori growth and its cytotoxicity by 2-hydroxy 4-methoxy benzaldehyde of Decalepis hamiltonii (Wight & Arn); a new functional attribute. PubMed: Antimicrobial and antioxidant activities of the root bark essential oil of Periploca sepium and its main component 2-hydroxy-4-methoxybenzaldehyde. PubMed: A manganese single-chain magnet exhibits a large magnetic coercivity. PubMed: Two thiosemicarbazones derived from salicylaldehyde: very specific hydrogen-bonding interactions of the N-H...S=C type. PubMed: Synthesis, spectral characterization and crystal structure of N-2-hydroxy-4-methoxybenzaldehyde-N'-4-nitrobenzoyl hydrazone and its square planar Cu(II) complex. PubMed: Repellent from traditional Chinese medicine, Periploca sepium Bunge. PubMed: Phenylalanine ammonia-lyase-mediated biosynthesis of 2-hydroxy-4-methoxybenzaldehyde in roots of Hemidesmus indicus. PubMed: Antioxidant property of Decalepis hamiltonii Wight & Arn. PubMed: Isolation of antioxidant compounds from the methanolic extract of the roots of Decalepis hamiltonii (Wight and Arn.). PubMed: Production of 2-hydroxy-4-methoxybenzaldehyde in roots of tissue culture raised and acclimatized plants of Decalepis hamiltonii Wight & Arn., an endangered shrub endemic to Southern India and evaluation of its performance vis-a-vis plants from natural habitat. PubMed: 2-hydroxy-4-isopropylbenzaldehyde, a potent partial tyrosinase inhibitor. PubMed: Determination of 2-hydroxy-4-methoxybenzaldehyde in roots of Decalepis hamiltonii (Wight & Arn.) and Hemidesmus indicus R.Br. PubMed: Essential oil constituents and in vitro antimicrobial activity of Decalepis hamiltonii roots against foodborne pathogens. PubMed: 2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants.