annatto seed extract (alkali-processed norbixin, not acid precipitated)

annatto G

CAS: 542-40-5 C24 H28 O4 MW: 380.48396000

Identification

Nameannatto seed extract (alkali-processed norbixin, not acid precipitated)
IUPAC(2E,4E,6E,8E,10E,12E,14E,16E,18E)-4,8,13,17-tetramethylicosa-2,4,6,8,10,12,14,16,18-nonaenedioic acid
CAS Number542-40-5
EINECS208-810-8
FDA UNIISearch
Molecular FormulaC24 H28 O4
Molecular Weight380.48396000

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesEU SANCO
JECFA Food AdditiveAnnatto Extract (Alkali-Processed Norbixin, not Acid Precipitated)
GSFA CodexAnnatto extracts, norbixin-based (160b(ii))
DG SANTE Food Additivesannatto G

Physical Properties

Appearance dark red-brown to red purple powder (est)
Assay 15.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 640.37 °C. @ 760.00 mm Hg (est)
Flash Point 671.00 °F. TCC ( 355.10 °C. ) (est)
logP (o/w) 5.532 (est)
Soluble in alkaline water

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycoloring agents
Recommendation for annatto seed extract (alkali-processed norbixin, not acid precipitated) usage levels up tonot for fragrance use.
Recommendation for annatto seed extract (alkali-processed norbixin, not acid precipitated) flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

annatto seed

Synonyms

annatto G bixa orellana seed extract (alkali-processed norbixin, not acid precipitated) c.i. 75120 (alkali-processed norbixin, not acid precipitated) ci 75120 (alkali-processed norbixin, not acid precipitated) natural orange 4 (alkali-processed norbixin, not acid precipitated) Info: EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS PubMed: Gum arabic and Fe²⁺ synergistically improve the heat and acid stability of norbixin at pH 3.0-5.0. PubMed: Studies on interaction of norbixin with DNA: multispectroscopic and in silico analysis. PubMed: Short communication: norbixin and bixin partitioning in Cheddar cheese and whey. PubMed: Short communication: Development of a novel method for the extraction of norbixin from whey and its subsequent quantification via high performance liquid chromatography. PubMed: Inhibition of cyclophosphamide-induced oxidative stress in rat brain by polar and non-polar extracts of Annatto (Bixa orellana) seeds. PubMed: Probing the binding between norbixin and dairy proteins by spectroscopy methods. PubMed: Effect of bixin and norbixin on the expression of cytochrome P450 in HepG2 cell line. PubMed: A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats. PubMed: Prooxidant activity of norbixin in model of acute gastric ulcer induced by ethanol in rats. PubMed: Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo. PubMed: Raman spectroscopic determination of norbixin and tartrazine in sugar. PubMed: Characteristics of activated carbon and carbon nanotubes as adsorbents to remove annatto (norbixin) in cheese whey. PubMed: Bixin and norbixin have opposite effects on glycemia, lipidemia, and oxidative stress in streptozotocin-induced diabetic rats. PubMed: Contact sensitizing potential of annatto extract and its two primary color components, cis-bixin and norbixin, in female BALB/c mice. PubMed: Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo. PubMed: Norbixin ingestion did not induce any detectable DNA breakage in liver and kidney but caused a considerable impairment in plasma glucose levels of rats and mice. PubMed: Digestive stability and transport of norbixin, a 24-carbon carotenoid, across monolayers of Caco-2 cells. PubMed: Effect of temperature and concentration on benzoyl peroxide bleaching efficacy and benzoic acid levels in whey protein concentrate. PubMed: Toxicity of the hyperglycaemic-inducing extract of the annatto (Bixa orellana) in the dog. PubMed: Induction of liver monooxygenases by annatto and bixin in female rats. PubMed: Extraction of an hyperglycaemic principle from the annatto (Bixa orellana), a medicinal plant in the West Indies. PubMed: Decolorization of Cheddar cheese whey by activated carbon. PubMed: Antigenotoxic and antimutagenic potential of an annatto pigment (norbixin) against oxidative stress. PubMed: Biochemical behaviour of norbixin during in vitro DNA damage induced by reactive oxygen species. PubMed: Time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy analyses of Bixa orellana seeds. PubMed: Inhibitory effect of apocarotenoids on the activity of tyrosinase: Multi-spectroscopic and docking studies. PubMed: A synergistic effect of Cu(2+) and norbixin on DNA damage. PubMed: Bixin and norbixin in human plasma: determination and study of the absorption of a single dose of Annatto food color. PubMed: Generalized and rapid supramolecular solvent-based sample treatment for the determination of annatto in food. PubMed: Hypoglycaemic activity of Bixa orellana extract in the dog. PubMed: Cold enzymatic bleaching of fluid whey. PubMed: Determination of bixin and norbixin in meat using liquid chromatography and photodiode array detection. PubMed: [Detection of the annatto dye norbixin/bixin in cheese using derivative spectroscopy and high performance liquid chromatography (HPLC)]. PubMed: Alternative bleaching methods for Cheddar cheese whey. PubMed: Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats. PubMed: High-performance liquid chromatographic separation of carminic acid, alpha- and beta-bixin, and alpha- and beta-norbixin, and the determination of carminic acid in foods. PubMed: The use of lactoperoxidase for the bleaching of fluid whey. PubMed: Effect of bleaching permeate from microfiltered skim milk on 80% serum protein concentrate. PubMed: Effect of temperature and bleaching agent on bleaching of liquid Cheddar whey. PubMed: The effect of microfiltration on color, flavor, and functionality of 80% whey protein concentrate. PubMed: Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice. PubMed: Sensory and Functionality Differences of Whey Protein Isolate Bleached by Hydrogen or Benzoyl Peroxide. PubMed: Influence of bleaching on flavor of 34% whey protein concentrate and residual benzoic acid concentration in dried whey proteins. PubMed: Short communication: The influence of solids concentration and bleaching agent on bleaching efficacy and flavor of sweet whey powder. PubMed: Influence of storage, heat treatment, and solids composition on the bleaching of whey with hydrogen peroxide. PubMed: Development of carotenoid storage cells in Bixa orellana L. seed arils. PubMed: Characterizing endogenous and exogenous peroxidase activity for bleaching of fluid whey and retentate. PubMed: Evaluation of certain food additives and contaminants. PubMed: Determination of annatto in high-fat dairy products, margarine and hard candy by solvent extraction followed by high-performance liquid chromatography. PubMed: Next generation sequencing and de novo transcriptome analysis of Costus pictus D. Don, a non-model plant with potent anti-diabetic properties. PubMed: Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation. PubMed: Bioautography and chemical characterization of antimicrobial compound(s) in commercial water-soluble annatto extracts. PubMed: The effect of starter culture and annatto on the flavor and functionality of whey protein concentrate. PubMed: Effect of bleaching whey on sensory and functional properties of 80% whey protein concentrate. PubMed: Method development and analysis of retail foods for annatto food colouring material. PubMed: The effect of bleaching agent on the flavor of liquid whey and whey protein concentrate. PubMed: Carotenoids and β-cyclodextrin inclusion complexes: Raman spectroscopy and theoretical investigation. PubMed: In vitro scavenging capacity of annatto seed extracts against reactive oxygen and nitrogen species. PubMed: Neuron-glial cell communication in the traumatic stress-induced immunomodulation. PubMed: Effect of natural pigments on the oxidative stability of sausages stored under refrigeration. PubMed: Evaluation of the clastogenicity and anticlastogenicity of the carotenoid bixin in human lymphocyte cultures. PubMed: Novel method for the determination of added annatto colour in extruded corn snack products. PubMed: Annatto constituent cis-bixin has selective antimyeloma effects mediated by oxidative stress and associated with inhibition of thioredoxin and thioredoxin reductase. PubMed: Invited review: Annatto usage and bleaching in dairy foods. PubMed: Reactive oxygen species mediate lethality induced by far-UV in Escherichia coli cells. PubMed: Biosynthesis of the food and cosmetic plant pigment bixin (annatto). PubMed: Analysis of annatto (Bixa orellana) food coloring formulations. 2. Determination of aromatic hydrocarbon thermal degradation products by gas chromatography. PubMed: Characterization of the principal colouring components of annatto using high performance liquid chromatography with photodiode-array detection. PubMed: Partial replacement of nitrite by annatto as a colour additive in sausage. PubMed: Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion. PubMed: Chitosan microspheres containing the natural urucum pigment.