annatto seed extract (oil-processed bixin)

annatto D

CAS: 6983-79-5 C25 H30 O4 MW: 394.51090000

Identification

Nameannatto seed extract (oil-processed bixin)
IUPAC(2E,4E,6E,8E,10E,12E,14E,16Z,18E)-20-methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid
CAS Number6983-79-5
EINECS230-248-7
FDA UNIISearch
Molecular FormulaC25 H30 O4
Molecular Weight394.51090000

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesEU SANCO
JECFA Food AdditiveView
GSFA CodexView
DG SANTE Food Additivesannatto D

Physical Properties

Appearance dark red-brown to red-purple oily liquid (est)
Assay 10.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 198.00 °C. @ 760.00 mm Hg
Boiling Point 596.02 °C. @ 760.00 mm Hg (est)
Flash Point 388.00 °F. TCC ( 197.80 °C. ) (est)
logP (o/w) 6.170 (est)
Soluble in acetone
Insoluble in water

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycoloring agents
Recommendation for annatto seed extract (oil-processed bixin) usage levels up tonot for fragrance use.
Recommendation for annatto seed extract (oil-processed bixin) flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

annatto seed

Synonyms

annatto D bixa orellana seed extract (oil-processed bixin) c.i. 75120 (oil-processed bixin) ci 75120 (oil-processed bixin) natural orange 4 (oil-processed bixin) Info: EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS PubMed: Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo. PubMed: Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2. PubMed: De novo transcriptome sequencing in Bixa orellana to identify genes involved in methylerythritol phosphate, carotenoid and bixin biosynthesis. PubMed: Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation. PubMed: Aprotic solvents effect on the UV-visible absorption spectra of bixin. PubMed: DFT and ENDOR Study of Bixin Radical Cations and Neutral Radicals on Silica-Alumina. PubMed: Short communication: norbixin and bixin partitioning in Cheddar cheese and whey. PubMed: Bixin protects hepatocytes against 1,2-dimethylhydrazine-induced genotoxicity but does not suppress DNA damage and pre-neoplastic lesions in the colon of Wistar rats. PubMed: Inhibition of cyclophosphamide-induced oxidative stress in rat brain by polar and non-polar extracts of Annatto (Bixa orellana) seeds. PubMed: Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats. PubMed: Effect of bixin and norbixin on the expression of cytochrome P450 in HepG2 cell line. PubMed: Inhibition of Cholesterol and Polyunsaturated Fatty Acids Oxidation through the Use of Annatto and Bixin in High-Pressure Processed Fish. PubMed: Characterisation and stability evaluation of bixin nanocapsules. PubMed: Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice. PubMed: Induction of liver monooxygenases by annatto and bixin in female rats. PubMed: Bixin action in the healing process of rats mouth wounds. PubMed: The antiatherogenic effect of bixin in hypercholesterolemic rabbits is associated to the improvement of lipid profile and to its antioxidant and anti-inflammatory effects. PubMed: Protective effect of bixin on cisplatin-induced genotoxicity in PC12 cells. PubMed: Effects of thermal denaturation on binding between bixin and whey protein. PubMed: Effects of pH on the molecular binding between β-lactoglobulin and bixin. PubMed: Bixin and norbixin have opposite effects on glycemia, lipidemia, and oxidative stress in streptozotocin-induced diabetic rats. PubMed: A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats. PubMed: Contact sensitizing potential of annatto extract and its two primary color components, cis-bixin and norbixin, in female BALB/c mice. PubMed: Interaction of curcumin and bixin with β-cyclodextrin: complexation methods, stability, and applications in food. PubMed: Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo. PubMed: Annatto constituent cis-bixin has selective antimyeloma effects mediated by oxidative stress and associated with inhibition of thioredoxin and thioredoxin reductase. PubMed: Binding between bixin and whey protein at pH 7.4 studied by spectroscopy and isothermal titration calorimetry. PubMed: Simultaneous extraction and analysis by high performance liquid chromatography coupled to diode array and mass spectrometric detectors of bixin and phenolic compounds from annatto seeds. PubMed: Extraction of an hyperglycaemic principle from the annatto (Bixa orellana), a medicinal plant in the West Indies. PubMed: Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation. PubMed: Studies on application of annatto (Bixa orellena L.) dye formulations in dairy products. PubMed: Time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy analyses of Bixa orellana seeds. PubMed: Toxicity of the hyperglycaemic-inducing extract of the annatto (Bixa orellana) in the dog. PubMed: Evaluation of the clastogenicity and anticlastogenicity of the carotenoid bixin in human lymphocyte cultures. PubMed: Model studies on the photosensitized isomerization of bixin. PubMed: Analysis of binding interaction between the natural apocarotenoid bixin and human serum albumin by circular dichroism and fluorescence spectroscopy. PubMed: Antioxidant action of bixin against cisplatin-induced chromosome aberrations and lipid peroxidation in rats. PubMed: Bixin and norbixin in human plasma: determination and study of the absorption of a single dose of Annatto food color. PubMed: [Analysis of the uncertainty of the easily oxidized substance of the injector by titration]. PubMed: Thermal degradation kinetics of bixin in an aqueous model system. PubMed: Biosynthesis of the food and cosmetic plant pigment bixin (annatto). PubMed: Inhibitory effect of apocarotenoids on the activity of tyrosinase: Multi-spectroscopic and docking studies. PubMed: Next generation sequencing and de novo transcriptome analysis of Costus pictus D. Don, a non-model plant with potent anti-diabetic properties. PubMed: Circular dichroism and absorption spectroscopic data reveal binding of the natural cis-carotenoid bixin to human alpha1-acid glycoprotein. PubMed: Generalized and rapid supramolecular solvent-based sample treatment for the determination of annatto in food. PubMed: Hypoglycaemic activity of Bixa orellana extract in the dog. PubMed: ToF-SIMS characterization of thermal modifications of bixin from Bixa orellana fruit. PubMed: Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity. PubMed: Detection of bixin, lycopene, canthaxanthin, and beta-apo-8'-carotenal in products derived from red pepper. PubMed: The coupled reactions between methyl linoleate and bixin or tocopherol during oxidation by lipoxidase. PubMed: Determination of bixin and norbixin in meat using liquid chromatography and photodiode array detection. PubMed: Norbixin ingestion did not induce any detectable DNA breakage in liver and kidney but caused a considerable impairment in plasma glucose levels of rats and mice. PubMed: [Detection of the annatto dye norbixin/bixin in cheese using derivative spectroscopy and high performance liquid chromatography (HPLC)]. PubMed: Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity. PubMed: High-performance liquid chromatographic separation of carminic acid, alpha- and beta-bixin, and alpha- and beta-norbixin, and the determination of carminic acid in foods. PubMed: Characterization of bixin by LC-MS and LC-NMR. PubMed: In vitro scavenging capacity of annatto seed extracts against reactive oxygen and nitrogen species. PubMed: Identification and expression pattern of a new carotenoid cleavage dioxygenase gene member from Bixa orellana. PubMed: Characteristic Parameters of MTF of the Retina-Brain System. PubMed: Energized state of mitochondria as revealed by the spectral change of bound bixin. PubMed: Spectral changes of bixin upon interaction with respiring rat liver mitochondria. PubMed: The induced reaction between methyl linoleate and bixin during oxidation by lipoxidase. PubMed: THE PREPARATION OF BIXIN. PubMed: Development of carotenoid storage cells in Bixa orellana L. seed arils. PubMed: RNA-Seq analysis and annotation of a draft blueberry genome assembly identifies candidate genes involved in fruit ripening, biosynthesis of bioactive compounds, and stage-specific alternative splicing. PubMed: Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells. PubMed: Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein. PubMed: Evaluation of certain food additives and contaminants. PubMed: Optical characterization in annatto and commercial colorific. PubMed: Determination of annatto in high-fat dairy products, margarine and hard candy by solvent extraction followed by high-performance liquid chromatography. PubMed: Method development and analysis of retail foods for annatto food colouring material. PubMed: Effect of annatto seed and coriander leaves as natural antioxidants in fish meatballs during frozen storage. PubMed: Effect of carotenoids on the respiratory burst of rat peritoneal macrophages. PubMed: Unraveling new genes associated with seed development and metabolism in Bixa orellana L. by expressed sequence tag (EST) analysis. PubMed: Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. PubMed: Invited review: Annatto usage and bleaching in dairy foods. PubMed: Capillary NMR detection in separation science. PubMed: Evaluation of the developmental toxicity of annatto in the rat. PubMed: Suppressive effect of carotenoids on the luminol dependent chemiluminescence of the stimulated rat macrophages. PubMed: Effect of dietary supplementation with carotenoids on xenobiotic metabolizing enzymes in the liver, lung, kidney and small intestine of the rat. PubMed: Antigenotoxic and antimutagenic potential of an annatto pigment (norbixin) against oxidative stress. PubMed: Analysis of annatto (Bixa orellana) food coloring formulations. 2. Determination of aromatic hydrocarbon thermal degradation products by gas chromatography. PubMed: Effects of Singlet Oxygen Quenchers and pH on the Bacterially Induced Hypersensitive Reaction in Tobacco Suspension Cell Cultures. PubMed: Cellular toxicity of elsinochrome phytotoxins produced by the pathogenic fungus, Elsinoë fawcettii causing citrus scab. PubMed: Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. PubMed: Absence of carcinogenic and anticarcinogenic effects of annatto in the rat liver medium-term assay. PubMed: Subacute toxicity assessment of annatto in rat. PubMed: Novel method for the determination of added annatto colour in extruded corn snack products. PubMed: Dietary supplementation with a natural carotenoid mixture decreases oxidative stress. PubMed: Effect of natural food colorings on immunoglobulin production in vitro by rat spleen lymphocytes. PubMed: Diverse carotenoids protect against chemically induced neoplastic transformation. PubMed: [Determination of the pigmenting carotenoids in feeds and premixes for laying hens and broilers (author's transl)]. PubMed: Isolation and purification of RNA from tissues rich in polyphenols, polysaccharides, and pigments of annatto (Bixa orellana L.). PubMed: Chitosan microspheres containing the natural urucum pigment. PubMed: To dye or not to dye: biochemistry of annatto unveiled. PubMed: FT-IR study of some seco- and apocarotenoids. PubMed: Modified atmosphere packaged cheddar cheese shreds: influence of fluorescent light exposure and gas type on color and production of volatile compounds. PubMed: In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids. PubMed: Retinoic acid and beta-carotene inhibit fibronectin synthesis and release by fibroblasts; antagonism to phorbol ester. PubMed: Characterization of the principal colouring components of annatto using high performance liquid chromatography with photodiode-array detection. PubMed: Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties. PubMed: Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers. PubMed: [Analysis of the seed Bixa orellana, L. (annatto) and the waste generated in the extraction of its pigments]. PubMed: Controlled release of metformin hydrochloride and repaglinide from sandwiched osmotic pump tablet.