aspartame-acesulfame salt
methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide salt of L-phenylalanyl-2-methyl-L-alpha-aspartic acid
Identification
| Name | aspartame-acesulfame salt |
| IUPAC | (3R)-3-amino-4-[[(2R)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid; 6-methyl-2,2-dioxooxathiazin-4-one |
| CAS Number | 106372-55-8 |
| FDA UNII | IFE6C6BS24 |
| Molecular Formula | C18 H23 O9 N3 S |
| Molecular Weight | 457.46011000 |
Regulatory
| JECFA Food Additive | Aspartame-acesulfame salt |
| GSFA Codex | Aspartame-acesulfame salt (962) |
| DG SANTE Food Additives | aspartame-acesulfame salt |
Physical Properties
| Appearance | white crystalline powder (est) |
| Assay | 63.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 535.80 °C. @ 760.00 mm Hg (est) |
| Flash Point | 532.00 °F. TCC ( 277.80 °C. ) (est) |
| logP (o/w) | 1.108 (est) |
| Soluble in | alcohol, slightly |
Organoleptic Properties
| Taste Description | sweet |
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | sweeteners, flavor enhancers |
| Recommendation for aspartame-acesulfame salt usage levels up to | not for fragrance use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
(3R)-3-
amino-4-[[(2R)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid; 6-methyl-2,2-dioxooxathiazin-4-one
[2-
carboxy-beta-(N-(b-methoxycarbonyl-2-phenyl)ethylcarbamoyl)]ethanaminium-6-methyl-4-oxo-1,2,3-oxathiazin-3-ide-2,2-dioxide
methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide salt of L-phenylalanyl-2-methyl-L-alpha-aspartic acid
6-
methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide salt of laevo-phenylalanyl-2-methyl-laevo-alpha-aspartic acid
PubMed:
Sub-minute method for simultaneous determination of aspartame, cyclamate, acesulfame-K and saccharin in food and pharmaceutical samples by capillary zone electrophoresis.
PubMed:
Assessment of stability of binary sweetener blend (aspartame x acesulfame-K) during storage in whey lemon beverage.
PubMed:
Modified high-density lipoproteins by artificial sweetener, aspartame, and saccharin, showed loss of anti-atherosclerotic activity and toxicity in zebrafish.
PubMed:
Fate of artificial sweeteners in wastewater treatment plants in New York State, U.S.A.
PubMed:
Molecularly imprinted sol-gel nanofibers based solid phase microextraction coupled on-line with high performance liquid chromatography for selective determination of acesulfame.
PubMed:
Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).
PubMed:
Development of low calorie snack food based on intense sweeteners.
PubMed:
Rebaudioside A and Rebaudioside D bitterness do not covary with Acesulfame K bitterness or polymorphisms in TAS2R9 and TAS2R31.
PubMed:
Estimated intake of the sweeteners, acesulfame-K and aspartame, from soft drinks, soft drinks based on mineral waters and nectars for a group of Portuguese teenage students.
PubMed:
Risk assessment of additives through soft drinks and nectars consumption on Portuguese population: a 2010 survey.
PubMed:
High-intensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States.
PubMed:
Non-nutritive sweeteners: no class effect on the glycaemic or appetite responses to ingested glucose.
PubMed:
FTIR determination of Aspartame and Acesulfame-K in tabletop sweeteners.
PubMed:
Advantame sweetener preference in C57BL/6J mice and Sprague-Dawley rats.
PubMed:
Low-calorie sweeteners in food and food supplements on the Italian market.
PubMed:
Effects of three intense sweeteners on fat storage in the C. elegans model.
PubMed:
In vivo cytogenetic studies on blends of aspartame and acesulfame-K.
PubMed:
Effects of artificial sweeteners on the AhR- and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells.
PubMed:
Effect of carbonation on brain processing of sweet stimuli in humans.
PubMed:
Artificial sweeteners: safe or unsafe?
PubMed:
An Equiratio Mixture Model for non-additive components: a case study for aspartame/acesulfame-K mixtures.
PubMed:
[A rapid dialysis method for analysis of artificial sweeteners in food].
PubMed:
Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin.
PubMed:
Estimated intake of the artificial sweeteners acesulfame-K, aspartame, cyclamate and saccharin in a group of Swedish diabetics.
PubMed:
Intake of saccharin, aspartame, acesulfame K and cyclamate in Italian teenagers: present levels and projections.
PubMed:
[The psychophysics of sweet taste. 7. New determination of sweet taste parameters of acesulfame, aspartame, cyclamate, saccharin, glucose and sorbitol].
PubMed:
Effect of sweeteners and hydrocolloids on quality attributes of reduced-calorie carrot juice.
PubMed:
Determination of high-intensity sweeteners in river water and wastewater by solid-phase extraction and liquid chromatography-tandem mass spectrometry.
PubMed:
[Rapid analysis of six sweeteners in wine by dispersive solid-phase extraction and ultra-fast liquid chromatography coupled with tandem mass spectrometry].
PubMed:
Nonnutritive Sweeteners in Breast Milk.
PubMed:
Ubiquitous Detection of Artificial Sweeteners and Iodinated X-ray Contrast Media in Aquatic Environmental and Wastewater Treatment Plant Samples from Vietnam, The Philippines, and Myanmar.
PubMed:
Addition of sucralose enhances the release of satiety hormones in combination with pea protein.
PubMed:
Emission of artificial sweeteners, select pharmaceuticals, and personal care products through sewage sludge from wastewater treatment plants in Korea.
PubMed:
Dietary intake of non-nutritive sweeteners in type 1 diabetes mellitus children.
PubMed:
Dietary intake of artificial sweeteners by the Belgian population.
PubMed:
Determination of aspartame by ion chromatography with electrochemical integrated amperometric detection.
PubMed:
Simultaneous determination of sweeteners in beverages by LC-MS/MS.
PubMed:
Review of the nutritional benefits and risks related to intense sweeteners.
PubMed:
Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides.
PubMed:
[Influences of ion-suppressors on retention behaviors of nine food additives in reversed-phase high performance liquid chromatographic separation].
PubMed:
Occurrence of seven artificial sweeteners in the aquatic environment and precipitation of Tianjin, China.
PubMed:
[Simultaneous determination of various aseptics and sweeteners in milk and dairy products].
PubMed:
Determination of artificial sweeteners by capillary electrophoresis with contactless conductivity detection optimized by hydrodynamic pumping.
PubMed:
Nonnutritive sweeteners are not supernormal stimuli.
PubMed:
Determination of eight artificial sweeteners and common Stevia rebaudiana glycosides in non-alcoholic and alcoholic beverages by reversed-phase liquid chromatography coupled with tandem mass spectrometry.
PubMed:
The effect of five artificial sweeteners on Caco-2, HT-29 and HEK-293 cells.
PubMed:
[Consumption of carbonated beverages with nonnutritive sweeteners in Latin American university students].
PubMed:
Effects of artificial sweeteners on body weight, food and drink intake.
PubMed:
Role of nitrification in the biodegradation of selected artificial sweetening agents in biological wastewater treatment process.
PubMed:
Artificial sweeteners - a review.
PubMed:
Improved powder mix quality with Twinsweet.
PubMed:
Responses of single chorda tympani taste fibers of the calf (Bos taurus).
PubMed:
[The use of low-calorie sweeteners].
PubMed:
Rate of atherosclerosis progression in ApoE-/- mice long after discontinuation of cola beverage drinking.
PubMed:
Selective continuous monitoring and analysis of mixtures of acesulfame-K, cyclamate, and saccharin in artificial sweetener tablets, diet soft drinks, yogurts, and wines using filter-supported bilayer lipid membranes.
PubMed:
Bitterness prediction of H1-antihistamines and prediction of masking effects of artificial sweeteners using an electronic tongue.
PubMed:
Qualitative and quantitative control of carbonated cola beverages using ¹H NMR spectroscopy.
PubMed:
[Simultaneous determination of five synthetic sweeteners in food by solid phase extraction-high performance liquid chromatography-evaporative light scattering detection].
PubMed:
[Modification of fasting blood glucose in adults with diabetes mellitus type 2 after regular soda and diet soda intake in the State of Querétaro, Mexico].
PubMed:
Estimation of the dietary intake of 13 priority additives in France, Italy, the UK and Ireland as part of the FACET project.
PubMed:
[Simultaneous determination of twelve sweeteners and nine preservatives in foods by solid-phase extraction and LC-MS/MS].
PubMed:
Estimated intake of intense sweeteners from non-alcoholic beverages in Denmark.
PubMed:
Intake of intense sweeteners in Germany.
PubMed:
Application of dispersive solid-phase extraction and ultra-fast liquid chromatography-tandem quadrupole mass spectrometry in food additive residue analysis of red wine.
PubMed:
Reaction kinetics and efficiencies for the hydroxyl and sulfate radical based oxidation of artificial sweeteners in water.
PubMed:
Effects of intense sweeteners on hunger, food intake, and body weight: a review.
PubMed:
Evaluation of certain food additives and contaminants.
PubMed:
Enhancement of rat bladder contraction by artificial sweeteners via increased extracellular Ca2+ influx.
PubMed:
Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water.
PubMed:
Sweetener/sweetness-induced changes in flavor perception and flavor release of fruity and green character in beverages.
PubMed:
Estimated intake of intense sweeteners from non-alcoholic beverages in Denmark, 2005.
PubMed:
Analysis of multiple sweeteners and their degradation products in lassi by HPLC and HPTLC plates.
PubMed:
Artificial sweeteners--a recently recognized class of emerging environmental contaminants: a review.
PubMed:
Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners.
PubMed:
Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets.
PubMed:
Separation and simultaneous determination of four artificial sweeteners in food and beverages by ion chromatography.
PubMed:
Adherence of Streptococcus mutans to smooth surfaces in the presence of artificial sweeteners.
PubMed:
Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT).
PubMed:
Analysis of nine food additives in red wine by ion-suppression reversed-phase high-performance liquid chromatography using trifluoroacetic acid and ammonium acetate as ion-suppressors.
PubMed:
The content of high-intensity sweeteners in different categories of foods available on the Polish market.
PubMed:
Retention behaviour of some high-intensity sweeteners on different SPE sorbents.
PubMed:
Acidogenicity of high-intensity sweeteners and polyols.
PubMed:
[Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry].
PubMed:
Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010.
PubMed:
Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection.
PubMed:
Detection of food additives by voltammetry at the liquid-liquid interface.
PubMed:
Artificial sweeteners--do they bear a carcinogenic risk?
PubMed:
Modified apolipoprotein (apo) A-I by artificial sweetener causes severe premature cellular senescence and atherosclerosis with impairment of functional and structural properties of apoA-I in lipid-free and lipid-bound state.
PubMed:
Oral zinc sulfate solutions inhibit sweet taste perception.
PubMed:
Acceptable daily intake and the regulation of intense sweeteners.
PubMed:
Uncoupling sweet taste and calories: comparison of the effects of glucose and three intense sweeteners on hunger and food intake.
PubMed:
Frozen yogurt with added inulin and isomalt.
PubMed:
Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS.
PubMed:
The intake of intense sweeteners - an update review.
PubMed:
[Analysis of nine kinds of sweeteners in foods by LC/MS].
PubMed:
Whole nerve chorda tympani responses to sweeteners in C57BL/6ByJ and 129P3/J mice.
PubMed:
Calculation of the intake of three intense sweeteners in young insulin-dependent diabetics.
PubMed:
Solution properties and sweetness response of selected bulk and intense sweeteners.
PubMed:
[Simultaneous determination of six synthetic sweeteners in food by high performance liquid chromatography-tandem mass spectrometry].
PubMed:
Reducing added sugar intake in Norway by replacing sugar sweetened beverages with beverages containing intense sweeteners - a risk benefit assessment.
PubMed:
Physical properties and bioactive constituents of powdered mixtures and drinks prepared with cocoa and various sweeteners.
PubMed:
An electronic tongue: evaluation of the masking efficacy of sweetening and/or flavoring agents on the bitter taste of epinephrine.
PubMed:
The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets.
PubMed:
Sweet taste in the calf: III. Behavioral responses to sweeteners.
PubMed:
Behavioral study in the gray mouse lemur (Microcebus murinus) using compounds considered sweet by humans.
PubMed:
The capsaicin receptor participates in artificial sweetener aversion.
PubMed:
Adaptation of sweeteners in water and in tannic acid solutions.
PubMed:
Bitterness of sweeteners as a function of concentration.
PubMed:
Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors.
PubMed:
Simultaneous determination of sweeteners and preservatives in preserved fruits by micellar electrokinetic capillary chromatography.
PubMed:
Reverse phase liquid chromatographic determination of some food additives.
PubMed:
[Simultaneous determination of artificial sweeteners in beverage by ultra performance liquid chromatography].
PubMed:
Determination of nine intense sweeteners in foodstuffs by high-performance liquid chromatography and evaporative light-scattering detection: interlaboratory study.
PubMed:
Simultaneous determination of antioxidants, preservatives and sweetener additives in food and cosmetics by flow injection analysis coupled to a monolithic column.
PubMed:
Simultaneous determination of nine intense sweeteners in foodstuffs by high performance liquid chromatography and evaporative light scattering detection--development and single-laboratory validation.
PubMed:
Dietary estimated intake of intense sweeteners by Italian teenagers. Present levels and projections derived from the INRAN-RM-2001 food survey.
PubMed:
Fluoride concentration and pH of iced tea products.
PubMed:
Sweetener preference of C57BL/6ByJ and 129P3/J mice.
PubMed:
Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay.
PubMed:
Effect of temperature, pH, and ions on sweet taste.
PubMed:
Simultaneous determination of antioxidants, preservatives and sweeteners permitted as additives in food by mixed micellar electrokinetic chromatography.
PubMed:
Effect of chewing gums on plaque pH after a sucrose challenge.
PubMed:
Micellar electrokinetic capillary chromatographic determination of artificial sweeteners in low-Joule soft drinks and other foods.
PubMed:
Gustatory neural coding in the monkey cortex: the quality of sweetness.
PubMed:
Review of present and future use of nonnutritive sweeteners.
PubMed:
The metabolism of intense sweeteners.
PubMed:
Direct simultaneous determination of eight sweeteners in foods by capillary isotachophoresis.
PubMed:
Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners.
PubMed:
[Simultaneous determination of various food additives by high performance liquid chromatography].
PubMed:
Simultaneous determination of artificial sweeteners, preservatives, caffeine, theobromine and theophylline in food and pharmaceutical preparations by ion chromatography.
PubMed:
Selective inhibition of sweetness by the sodium salt of +/-2-(4-methoxyphenoxy)propanoic acid.
PubMed:
Effects of sweetness and energy in drinks on food intake following exercise.
PubMed:
Noncariogenic intense natural sweeteners.
PubMed:
Investigation of synergism in binary mixtures of sweeteners.