aspartame-acesulfame salt

methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide salt of L-phenylalanyl-2-methyl-L-alpha-aspartic acid

CAS: 106372-55-8 C18 H23 O9 N3 S MW: 457.46011000 sweet

Identification

Nameaspartame-acesulfame salt
IUPAC(3R)-3-amino-4-[[(2R)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid; 6-methyl-2,2-dioxooxathiazin-4-one
CAS Number106372-55-8
FDA UNIIIFE6C6BS24
Molecular FormulaC18 H23 O9 N3 S
Molecular Weight457.46011000

Regulatory

JECFA Food AdditiveAspartame-acesulfame salt
GSFA CodexAspartame-acesulfame salt (962)
DG SANTE Food Additivesaspartame-acesulfame salt

Physical Properties

Appearance white crystalline powder (est)
Assay 63.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 535.80 °C. @ 760.00 mm Hg (est)
Flash Point 532.00 °F. TCC ( 277.80 °C. ) (est)
logP (o/w) 1.108 (est)
Soluble in alcohol, slightly

Organoleptic Properties

Taste Description sweet

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysweeteners, flavor enhancers
Recommendation for aspartame-acesulfame salt usage levels up tonot for fragrance use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

(3R)-3- amino-4-[[(2R)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid; 6-methyl-2,2-dioxooxathiazin-4-one [2- carboxy-beta-(N-(b-methoxycarbonyl-2-phenyl)ethylcarbamoyl)]ethanaminium-6-methyl-4-oxo-1,2,3-oxathiazin-3-ide-2,2-dioxide methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide salt of L-phenylalanyl-2-methyl-L-alpha-aspartic acid 6- methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide salt of laevo-phenylalanyl-2-methyl-laevo-alpha-aspartic acid PubMed: Sub-minute method for simultaneous determination of aspartame, cyclamate, acesulfame-K and saccharin in food and pharmaceutical samples by capillary zone electrophoresis. PubMed: Assessment of stability of binary sweetener blend (aspartame x acesulfame-K) during storage in whey lemon beverage. PubMed: Modified high-density lipoproteins by artificial sweetener, aspartame, and saccharin, showed loss of anti-atherosclerotic activity and toxicity in zebrafish. PubMed: Fate of artificial sweeteners in wastewater treatment plants in New York State, U.S.A. PubMed: Molecularly imprinted sol-gel nanofibers based solid phase microextraction coupled on-line with high performance liquid chromatography for selective determination of acesulfame. PubMed: Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). PubMed: Development of low calorie snack food based on intense sweeteners. PubMed: Rebaudioside A and Rebaudioside D bitterness do not covary with Acesulfame K bitterness or polymorphisms in TAS2R9 and TAS2R31. PubMed: Estimated intake of the sweeteners, acesulfame-K and aspartame, from soft drinks, soft drinks based on mineral waters and nectars for a group of Portuguese teenage students. PubMed: Risk assessment of additives through soft drinks and nectars consumption on Portuguese population: a 2010 survey. 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PubMed: Determination of eight artificial sweeteners and common Stevia rebaudiana glycosides in non-alcoholic and alcoholic beverages by reversed-phase liquid chromatography coupled with tandem mass spectrometry. PubMed: The effect of five artificial sweeteners on Caco-2, HT-29 and HEK-293 cells. PubMed: [Consumption of carbonated beverages with nonnutritive sweeteners in Latin American university students]. PubMed: Effects of artificial sweeteners on body weight, food and drink intake. PubMed: Role of nitrification in the biodegradation of selected artificial sweetening agents in biological wastewater treatment process. PubMed: Artificial sweeteners - a review. PubMed: Improved powder mix quality with Twinsweet. PubMed: Responses of single chorda tympani taste fibers of the calf (Bos taurus). PubMed: [The use of low-calorie sweeteners]. PubMed: Rate of atherosclerosis progression in ApoE-/- mice long after discontinuation of cola beverage drinking. PubMed: Selective continuous monitoring and analysis of mixtures of acesulfame-K, cyclamate, and saccharin in artificial sweetener tablets, diet soft drinks, yogurts, and wines using filter-supported bilayer lipid membranes. PubMed: Bitterness prediction of H1-antihistamines and prediction of masking effects of artificial sweeteners using an electronic tongue. PubMed: Qualitative and quantitative control of carbonated cola beverages using ¹H NMR spectroscopy. PubMed: [Simultaneous determination of five synthetic sweeteners in food by solid phase extraction-high performance liquid chromatography-evaporative light scattering detection]. PubMed: [Modification of fasting blood glucose in adults with diabetes mellitus type 2 after regular soda and diet soda intake in the State of Querétaro, Mexico]. PubMed: Estimation of the dietary intake of 13 priority additives in France, Italy, the UK and Ireland as part of the FACET project. PubMed: [Simultaneous determination of twelve sweeteners and nine preservatives in foods by solid-phase extraction and LC-MS/MS]. PubMed: Estimated intake of intense sweeteners from non-alcoholic beverages in Denmark. PubMed: Intake of intense sweeteners in Germany. PubMed: Application of dispersive solid-phase extraction and ultra-fast liquid chromatography-tandem quadrupole mass spectrometry in food additive residue analysis of red wine. PubMed: Reaction kinetics and efficiencies for the hydroxyl and sulfate radical based oxidation of artificial sweeteners in water. PubMed: Effects of intense sweeteners on hunger, food intake, and body weight: a review. PubMed: Evaluation of certain food additives and contaminants. PubMed: Enhancement of rat bladder contraction by artificial sweeteners via increased extracellular Ca2+ influx. PubMed: Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water. 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PubMed: Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT). PubMed: Analysis of nine food additives in red wine by ion-suppression reversed-phase high-performance liquid chromatography using trifluoroacetic acid and ammonium acetate as ion-suppressors. PubMed: The content of high-intensity sweeteners in different categories of foods available on the Polish market. PubMed: Retention behaviour of some high-intensity sweeteners on different SPE sorbents. PubMed: Acidogenicity of high-intensity sweeteners and polyols. PubMed: [Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry]. PubMed: Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010. 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PubMed: The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets. PubMed: Sweet taste in the calf: III. Behavioral responses to sweeteners. PubMed: Behavioral study in the gray mouse lemur (Microcebus murinus) using compounds considered sweet by humans. PubMed: The capsaicin receptor participates in artificial sweetener aversion. PubMed: Adaptation of sweeteners in water and in tannic acid solutions. PubMed: Bitterness of sweeteners as a function of concentration. PubMed: Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. PubMed: Simultaneous determination of sweeteners and preservatives in preserved fruits by micellar electrokinetic capillary chromatography. PubMed: Reverse phase liquid chromatographic determination of some food additives. PubMed: [Simultaneous determination of artificial sweeteners in beverage by ultra performance liquid chromatography]. 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PubMed: Simultaneous determination of antioxidants, preservatives and sweeteners permitted as additives in food by mixed micellar electrokinetic chromatography. PubMed: Effect of chewing gums on plaque pH after a sucrose challenge. PubMed: Micellar electrokinetic capillary chromatographic determination of artificial sweeteners in low-Joule soft drinks and other foods. PubMed: Gustatory neural coding in the monkey cortex: the quality of sweetness. PubMed: Review of present and future use of nonnutritive sweeteners. PubMed: The metabolism of intense sweeteners. PubMed: Direct simultaneous determination of eight sweeteners in foods by capillary isotachophoresis. PubMed: Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners. PubMed: [Simultaneous determination of various food additives by high performance liquid chromatography]. 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