calcium laevo-5-methyl tetrahydrofolate
calcium L-5-methyltetrahydrofolate
Identification
| Name | calcium laevo-5-methyl tetrahydrofolate |
| IUPAC | calcium (2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate |
| CAS Number | 151533-22-1 |
| FDA UNII | A9R10K3F2F |
| Molecular Formula | C20 H23 Ca N7 O6 |
| Molecular Weight | 497.52551000 |
| MDL Number | MFCD15146358 |
Regulatory
| JECFA Food Additive | Calcium L-5-Methyltetrahydrofolate |
Physical Properties
| Appearance | whit to pale yellow crystalline powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| Soluble in | alkaline solutions |
Organoleptic Properties
| Odor Description | at 100.00 %. |
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | nutrient supplements |
| Recommendation for calcium laevo-5-methyl tetrahydrofolate usage levels up to | not for fragrance use. |
| Recommendation for calcium laevo-5-methyl tetrahydrofolate flavor usage levels up to | not for flavor use. |
American International Chemical, Inc.
Consistent sources
North American supplier for globally sourced ingredients.
BOC Sciences
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Potential Uses
Natural Occurrence
Synonyms
N-{4-[[((6S)-2-
amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl}-L-glutamic acid calcium salt
N-{4-[[((6S)-2-
amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl}-laevo-glutamic acid calcium salt
calcium (2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
calcium L-5-methyl tetrahydrofolate
calcium L-5-methyltetrahydrofolate
calcium laevo-5-methyltetrahydrofolate
calcium N-(4-((((6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate
metafolin
laevo-
methylfolate, calcium
laevo-5-
methyltetrahydrofolic acid calcium salt
nutrifolin
PubMed:
[Metafolin--alternative for folate deficiency supplementation in pregnant women].
PubMed:
Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study.
PubMed:
Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone.
PubMed:
Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics.
PubMed:
Bioequivalence of two leucovorin calcium tablet formulations.