alpha-cyclodextrin
alpha-cycloamylase
Identification
| Name | alpha-cyclodextrin |
| CAS Number | 10016-20-3 |
| EINECS | 233-007-4 |
| FDA UNII | Z1LH97KTRM |
| Molecular Formula | C36 H60 O30 |
| Molecular Weight | 972.85020000 |
| MDL Number | MFCD00078207 |
| Beilstein | 79627 |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | GRN 155 |
| JECFA Food Additive | alpha-Cyclodextrin |
| GSFA Codex | Cyclodextrin, alpha- (457) |
| DG SANTE Food Contact Materials | alpha-cyclodextrin |
Physical Properties
| Appearance | white crystalline solid (est) |
| Assay | 98.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 278.00 °C. @ 760.00 mm Hg |
| logP (o/w) | -6.550 (est) |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties
| Odor Description | at 100.00 %. |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-rat LD50 788 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | carrier solvents, encapsulating agent for food additives, flavorings, stabilizers and absorbents |
| Recommendation for alpha-cyclodextrin usage levels up to | not for fragrance use. |
| Recommendation for alpha-cyclodextrin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
alfadex
alfadexum
alpha-
cycloamylase
alpha-
cycloamylose
alpha-
schardinger dextrin
PubMed:
Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice.
PubMed:
The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes.
PubMed:
Encapsulation of shiitake (Lenthinus edodes) flavors by spray drying.
PubMed:
Cyclodextrin encapsulation to prevent the loss of l-menthol and its retention during drying.
PubMed:
Mutations enhance β-cyclodextrin specificity of cyclodextrin glycosyltransferase from Bacillus circulans.
PubMed:
An experimental design based strategy to optimize a capillary electrophoresis method for the separation of 19 polycyclic aromatic hydrocarbons.
PubMed:
Transglycosylation of engineered cyclodextrin glucanotransferases as O-glycoligases.
PubMed:
Engineering a hollow nanocontainer platform with multifunctional molecular machines for tumor-targeted therapy in vitro and in vivo.
PubMed:
Calcium ion contribution to thermostability of cyclodextrin glycosyltransferase is closely related to calcium-binding site CaIII.
PubMed:
Molecular cloning and enzymatic characterization of cyclomaltodextrinase from hyperthermophilic archaeon Thermococcus sp. CL1.
PubMed:
Intravenous topiramate: comparison of pharmacokinetics and safety with the oral formulation in healthy volunteers.
PubMed:
Structure selective complexation of cyclodextrins with five polyphenols investigated by capillary electrokinetic chromatography.
PubMed:
Empirical, thermodynamic and quantum-chemical investigations of inclusion complexation between flavanones and (2-hydroxypropyl)-cyclodextrins.
PubMed:
An investigation into the supramolecular structure, solubility, stability and antioxidant activity of rutin/cyclodextrin inclusion complex.
PubMed:
Production of α-cyclodextrin glycosyltransferase in Bacillus megaterium MS941 by systematic codon usage optimization.
PubMed:
Enhanced mineralization of diuron using a cyclodextrin-based bioremediation technology.
PubMed:
Sorption of ochratoxin A from aqueous solutions using β-cyclodextrin-polyurethane polymer.
PubMed:
In vitro and in vivo characterization of amorphous, nanocrystalline, and crystalline ziprasidone formulations.
PubMed:
Encapsulation of ethylene gas into α-cyclodextrin and characterisation of the inclusion complexes.
PubMed:
[Enhanced storage stability of recombinant enzyme preparation of alpha-CGTase from Paenibacillus macerans by chemical additives].
PubMed:
High-level extracellular production of α-cyclodextrin glycosyltransferase with recombinant Escherichia coli BL21 (DE3).
PubMed:
Extracellular expression and biochemical characterization of alpha-cyclodextrin glycosyltransferase from Paenibacillus macerans.
PubMed:
Effect of alpha-cyclodextrin-cinnamic acid inclusion complexes on populations of Escherichia coli O157:H7 and Salmonella enterica in fruit juices.
PubMed:
Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice.
PubMed:
Mutations of Lysine 47 in cyclodextrin glycosyltransferase from Paenibacillus macerans enhance beta-cyclodextrin specificity.
PubMed:
Delayed supplementation of glycine enhances extracellular secretion of the recombinant alpha-cyclodextrin glycosyltransferase in Escherichia coli.
PubMed:
Calcium leads to further increase in glycine-enhanced extracellular secretion of recombinant alpha-cyclodextrin glycosyltransferase in Escherichia coli.
PubMed:
Mutations at subsite -3 in cyclodextrin glycosyltransferase from Paenibacillus macerans enhancing alpha-cyclodextrin specificity.
PubMed:
Kinetics of molecular encapsulation of 1-methylcyclopropene into alpha-cyclodextrin.
PubMed:
Release of 1-methylcyclopropene from heat-pressed polymer films.
PubMed:
Changes in the catalytic properties of Pyrococcus furiosus thermostable amylase by mutagenesis of the substrate binding sites.
PubMed:
Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys.
PubMed:
Biochemical and structural features of a novel cyclodextrinase from cow rumen metagenome.
PubMed:
Stereoisomeric distribution of 3-mercaptohexan-1-ol and 3-mercaptohexyl acetate in dry and sweet white wines made from Vitis vinifera (Var. Sauvignon Blanc and Semillon).
PubMed:
Retention of a European pear aroma model mixture using different types of saccharides.
PubMed:
Cyclodextrin (CD) complexes of cholesterol--their potential use in reducing dietary cholesterol intake.
PubMed:
The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats.
PubMed:
Evaluation of certain food additives.
PubMed:
The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes.
PubMed:
Enzymatic analysis of an amylolytic enzyme from the hyperthermophilic archaeon Pyrococcus furiosus reveals its novel catalytic properties as both an alpha-amylase and a cyclodextrin-hydrolyzing enzyme.
PubMed:
Disposition of 14C-alpha-cyclodextrin in germ-free and conventional rats.
PubMed:
Safety evaluation of an alpha-cyclodextrin glycosyltranferase preparation.
PubMed:
Embryotoxicity and teratogenicity study with alpha-cyclodextrin in rabbits.
PubMed:
Embryotoxicity and teratogenicity study with alpha-cyclodextrin in rats.
PubMed:
Subchronic (13-week) oral toxicity study of alpha-cyclodextrin in dogs.
PubMed:
Encapsulation of shiitake (Lenthinus edodes) flavors by spray drying.
PubMed:
Paenibacillus stellifer sp. nov., a cyclodextrin-producing species isolated from paperboard.
PubMed:
Evaluation of certain food additives and contaminants.
PubMed:
Green-leaf-derived C6-aroma compounds with potent antibacterial action that act on both Gram-negative and Gram-positive bacteria.
PubMed:
Inclusion complex of conjugated linoleic acid (CLA) with cyclodextrins.
PubMed:
Enantioseparation of chiral thiobarbiturates using cyclodextrin-modified capillary electrophoresis.
PubMed:
Hydrolytic action of alpha-amylase on high-amylose starch of low molecular mass.
PubMed:
Enantiomeric purity and odor characteristics of 2- and 3-acetoxy-1, 8-cineoles in the rhizomes of Alpinia galanga willd.
PubMed:
Cloning and sequencing of a cyclodextrin glycosyltransferase gene from Brevibacillus brevis CD162 and its expression in Escherichia coli.
PubMed:
Crystal structure of recombinant soybean beta-amylase complexed with beta-cyclodextrin.
PubMed:
Comparison of the binding of beta-cyclodextrin and alpha- and gamma-cyclodextrins with pullulanase from Klebsiella pneumoniae as studied by equilibrium and kinetic fluorometry.
PubMed:
Two sulfhydryl groups near the active site of soybean beta-amylase.
PubMed:
Affinity purification of beta-amylases originating from plant using cyclomaltohexaose-immobilized Sepharose 6B in the presence of ammonium sulfate.
PubMed:
Evidence for beta-galactosidase catalyzed hydrolysis of paranitrophenyl-beta-D-galactopyranoside anchored in cyclodextrins.
PubMed:
Expression and mutation of soybean beta-amylase in Escherichia coli.
PubMed:
Interaction between pullulanase from Klebsiella pneumoniae and cyclodextrins.
PubMed:
Effect of some constituents of chicken egg yolk lipoprotein on the growth and IgM production of human-human hybridoma cells and other human-derived cells.
PubMed:
Three-dimensional structure of soybean beta-amylase determined at 3.0 A resolution: preliminary chain tracing of the complex with alpha-cyclodextrin.
PubMed:
Affinity labeling of a subsite of Taka-amylase A by the fluorescent reagent o-phthalaldehyde.
PubMed:
Repeating use of Chalara paradoxa amylase by alpha-cyclodextrin affinity column.