alpha-cyclodextrin

alpha-cycloamylase

CAS: 10016-20-3 C36 H60 O30 MW: 972.85020000

Identification

Namealpha-cyclodextrin
CAS Number10016-20-3
EINECS233-007-4
FDA UNIIZ1LH97KTRM
Molecular FormulaC36 H60 O30
Molecular Weight972.85020000
MDL NumberMFCD00078207
Beilstein79627

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesGRN 155
JECFA Food Additivealpha-Cyclodextrin
GSFA CodexCyclodextrin, alpha- (457)
DG SANTE Food Contact Materialsalpha-cyclodextrin

Physical Properties

Appearance white crystalline solid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 278.00 °C. @ 760.00 mm Hg
logP (o/w) -6.550 (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

Organoleptic Properties

Odor Description at 100.00 %.

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-rat LD50 788 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycarrier solvents, encapsulating agent for food additives, flavorings, stabilizers and absorbents
Recommendation for alpha-cyclodextrin usage levels up tonot for fragrance use.
Recommendation for alpha-cyclodextrin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

alfadex alfadexum alpha- cycloamylase alpha- cycloamylose alpha- schardinger dextrin PubMed: Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice. PubMed: The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes. PubMed: Encapsulation of shiitake (Lenthinus edodes) flavors by spray drying. PubMed: Cyclodextrin encapsulation to prevent the loss of l-menthol and its retention during drying. PubMed: Mutations enhance β-cyclodextrin specificity of cyclodextrin glycosyltransferase from Bacillus circulans. PubMed: An experimental design based strategy to optimize a capillary electrophoresis method for the separation of 19 polycyclic aromatic hydrocarbons. PubMed: Transglycosylation of engineered cyclodextrin glucanotransferases as O-glycoligases. PubMed: Engineering a hollow nanocontainer platform with multifunctional molecular machines for tumor-targeted therapy in vitro and in vivo. PubMed: Calcium ion contribution to thermostability of cyclodextrin glycosyltransferase is closely related to calcium-binding site CaIII. PubMed: Molecular cloning and enzymatic characterization of cyclomaltodextrinase from hyperthermophilic archaeon Thermococcus sp. CL1. PubMed: Intravenous topiramate: comparison of pharmacokinetics and safety with the oral formulation in healthy volunteers. PubMed: Structure selective complexation of cyclodextrins with five polyphenols investigated by capillary electrokinetic chromatography. PubMed: Empirical, thermodynamic and quantum-chemical investigations of inclusion complexation between flavanones and (2-hydroxypropyl)-cyclodextrins. PubMed: An investigation into the supramolecular structure, solubility, stability and antioxidant activity of rutin/cyclodextrin inclusion complex. PubMed: Production of α-cyclodextrin glycosyltransferase in Bacillus megaterium MS941 by systematic codon usage optimization. PubMed: Enhanced mineralization of diuron using a cyclodextrin-based bioremediation technology. PubMed: Sorption of ochratoxin A from aqueous solutions using β-cyclodextrin-polyurethane polymer. PubMed: In vitro and in vivo characterization of amorphous, nanocrystalline, and crystalline ziprasidone formulations. PubMed: Encapsulation of ethylene gas into α-cyclodextrin and characterisation of the inclusion complexes. PubMed: [Enhanced storage stability of recombinant enzyme preparation of alpha-CGTase from Paenibacillus macerans by chemical additives]. PubMed: High-level extracellular production of α-cyclodextrin glycosyltransferase with recombinant Escherichia coli BL21 (DE3). PubMed: Extracellular expression and biochemical characterization of alpha-cyclodextrin glycosyltransferase from Paenibacillus macerans. PubMed: Effect of alpha-cyclodextrin-cinnamic acid inclusion complexes on populations of Escherichia coli O157:H7 and Salmonella enterica in fruit juices. PubMed: Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice. PubMed: Mutations of Lysine 47 in cyclodextrin glycosyltransferase from Paenibacillus macerans enhance beta-cyclodextrin specificity. PubMed: Delayed supplementation of glycine enhances extracellular secretion of the recombinant alpha-cyclodextrin glycosyltransferase in Escherichia coli. PubMed: Calcium leads to further increase in glycine-enhanced extracellular secretion of recombinant alpha-cyclodextrin glycosyltransferase in Escherichia coli. PubMed: Mutations at subsite -3 in cyclodextrin glycosyltransferase from Paenibacillus macerans enhancing alpha-cyclodextrin specificity. PubMed: Kinetics of molecular encapsulation of 1-methylcyclopropene into alpha-cyclodextrin. PubMed: Release of 1-methylcyclopropene from heat-pressed polymer films. PubMed: Changes in the catalytic properties of Pyrococcus furiosus thermostable amylase by mutagenesis of the substrate binding sites. PubMed: Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys. PubMed: Biochemical and structural features of a novel cyclodextrinase from cow rumen metagenome. PubMed: Stereoisomeric distribution of 3-mercaptohexan-1-ol and 3-mercaptohexyl acetate in dry and sweet white wines made from Vitis vinifera (Var. Sauvignon Blanc and Semillon). PubMed: Retention of a European pear aroma model mixture using different types of saccharides. PubMed: Cyclodextrin (CD) complexes of cholesterol--their potential use in reducing dietary cholesterol intake. PubMed: The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats. PubMed: Evaluation of certain food additives. PubMed: The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes. PubMed: Enzymatic analysis of an amylolytic enzyme from the hyperthermophilic archaeon Pyrococcus furiosus reveals its novel catalytic properties as both an alpha-amylase and a cyclodextrin-hydrolyzing enzyme. PubMed: Disposition of 14C-alpha-cyclodextrin in germ-free and conventional rats. PubMed: Safety evaluation of an alpha-cyclodextrin glycosyltranferase preparation. PubMed: Embryotoxicity and teratogenicity study with alpha-cyclodextrin in rabbits. PubMed: Embryotoxicity and teratogenicity study with alpha-cyclodextrin in rats. PubMed: Subchronic (13-week) oral toxicity study of alpha-cyclodextrin in dogs. PubMed: Encapsulation of shiitake (Lenthinus edodes) flavors by spray drying. PubMed: Paenibacillus stellifer sp. nov., a cyclodextrin-producing species isolated from paperboard. PubMed: Evaluation of certain food additives and contaminants. PubMed: Green-leaf-derived C6-aroma compounds with potent antibacterial action that act on both Gram-negative and Gram-positive bacteria. PubMed: Inclusion complex of conjugated linoleic acid (CLA) with cyclodextrins. PubMed: Enantioseparation of chiral thiobarbiturates using cyclodextrin-modified capillary electrophoresis. PubMed: Hydrolytic action of alpha-amylase on high-amylose starch of low molecular mass. PubMed: Enantiomeric purity and odor characteristics of 2- and 3-acetoxy-1, 8-cineoles in the rhizomes of Alpinia galanga willd. PubMed: Cloning and sequencing of a cyclodextrin glycosyltransferase gene from Brevibacillus brevis CD162 and its expression in Escherichia coli. PubMed: Crystal structure of recombinant soybean beta-amylase complexed with beta-cyclodextrin. PubMed: Comparison of the binding of beta-cyclodextrin and alpha- and gamma-cyclodextrins with pullulanase from Klebsiella pneumoniae as studied by equilibrium and kinetic fluorometry. PubMed: Two sulfhydryl groups near the active site of soybean beta-amylase. PubMed: Affinity purification of beta-amylases originating from plant using cyclomaltohexaose-immobilized Sepharose 6B in the presence of ammonium sulfate. PubMed: Evidence for beta-galactosidase catalyzed hydrolysis of paranitrophenyl-beta-D-galactopyranoside anchored in cyclodextrins. PubMed: Expression and mutation of soybean beta-amylase in Escherichia coli. PubMed: Interaction between pullulanase from Klebsiella pneumoniae and cyclodextrins. PubMed: Effect of some constituents of chicken egg yolk lipoprotein on the growth and IgM production of human-human hybridoma cells and other human-derived cells. PubMed: Three-dimensional structure of soybean beta-amylase determined at 3.0 A resolution: preliminary chain tracing of the complex with alpha-cyclodextrin. PubMed: Affinity labeling of a subsite of Taka-amylase A by the fluorescent reagent o-phthalaldehyde. PubMed: Repeating use of Chalara paradoxa amylase by alpha-cyclodextrin affinity column.