ferrous ascorbate

iron(2+) di-L-ascorbate

CAS: 24808-52-4 C12 H16 Fe O12 +2 MW: 408.09492000

Identification

Nameferrous ascorbate
CAS Number24808-52-4
EINECS246-469-7
FDA UNIIDI3477D0PI
Molecular FormulaC12 H16 Fe O12 +2
Molecular Weight408.09492000
MDL NumberMFCD00137682

Regulatory

FDA/DG SANTE Petitions, Reviews, Notices184.1307a
FDA Mainterm (SATF)24808-52-4 ; FERROUS ASCORBATE
FDA RegulationFDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE

Physical Properties

Food Chemicals Codex Listed No
Boiling Point 415.80 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000000 mmHg @ 25.00 °C. (est)
Flash Point 357.00 °F. TCC ( 180.40 °C. ) (est)
logP (o/w) -2.653 (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynutrient supplements
Recommendation for ferrous ascorbate usage levels up tonot for fragrance use.
Recommendation for ferrous ascorbate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

L- ascorbic acid iron(2+) salt (2:1) laevo- ascorbic acid iron(2+) salt (2:1) (2R)-2-[(1S)-1,2- dihydroxyethyl]-4,5-dihydroxyfuran-3-one; iron(2+) ferrous cevitamate iron(2+) di-L-ascorbate iron(2+) di-laevo-ascorbate iron(II) ascorbate PubMed: Efficacy and safety of ferrous asparto glycinate in the management of iron deficiency anaemia in pregnant women. PubMed: Different iron sources to study the physiology and biochemistry of iron metabolism in marine micro-algae. PubMed: Is a 40 % absorption of iron from a ferrous ascorbate reference dose appropriate to assess iron absorption independent of iron status? PubMed: Iron deficiency anemia in pregnancy: intravenous versus oral route. PubMed: Bioavailability of stabilised ferrous gluconate with glycine in fresh cheese matrix: a novel iron compound for food fortification. PubMed: Treatment of iron deficiency anemia in children: a comparative study of ferrous ascorbate and colloidal iron. PubMed: Evaluation of efficacy and tolerability of RB Tone forte tablet in the treatment of pregnancy anaemia. PubMed: Antiurolithic effect of berberine is mediated through multiple pathways. PubMed: Salicylic acid protects against chronic L-DOPA-induced 6-OHDA generation in experimental model of parkinsonism. PubMed: Cooperative functions of manganese and thiol redox system against oxidative stress in human spermatozoa. PubMed: Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents. PubMed: Iron absorption and iron status are reduced after Roux-en-Y gastric bypass. PubMed: Antioxidant-mediated protective effect of potato peel extract in erythrocytes against oxidative damage. PubMed: Iron chelators and free radical scavengers in naturally occurring polyhydroxylated 1,4-naphthoquinones. PubMed: Effect of ferrous sulphate and ascorbic acid on motility, viability and lipid peroxidation of crossbred cattle bull spermatozoa. PubMed: Oxidative stress alters membrane sulfhydryl status, lipid and phospholipid contents of crossbred cattle bull spermatozoa. PubMed: Phytochemical analysis of Achyranthes aspera and its activity on sesame oil induced lipid peroxidation. PubMed: Persistent anemia after Roux-en-Y gastric bypass. PubMed: Inhibition of iron uptake from iron salts and chelates by divalent metal cations in intestinal epithelial cells. PubMed: Echinochrome, a naturally occurring iron chelator and free radical scavenger in artificial and natural membrane systems. PubMed: Breast milk fractions solubilize Fe(III) and enhance iron flux across Caco-2 cells. PubMed: Role of some trace metal ions in placental membrane lipid peroxidation. PubMed: Bioavailability of iron bis-glycinate chelate in water. PubMed: Hypocholesterolemic and hypolipidemic activity of some novel morpholine derivatives with antioxidant activity. PubMed: Effect of genetically modified, low-phytic acid maize on absorption of iron from tortillas. PubMed: [Effect of altitude on iron absorption]. PubMed: Microencapsulated ferrous sulfate to fortify cow milk: absorption and distribution in mice. PubMed: Bioavailability, absorption mechanism, and toxicity of microencapsulated iron (I) sulfate: studies in mice. PubMed: A comparison of the hydroxyl radical scavenging properties of the shark bile steroid 5 beta-scymnol and plant pycnogenols. PubMed: Milk inhibits and ascorbic acid favors ferrous bis-glycine chelate bioavailability in humans. PubMed: Ferrous-ascorbate complexes as carriers of nitric oxide. PubMed: Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice. PubMed: Bioavailability and stability of microencapsulated ferrous sulfate in fluid milk: studies in mice. PubMed: [Results of preoperative autotransfusion with ferrous ascorbate prophylaxis in orthopedic surgery patients]. PubMed: Effects of iron replenishment on iron, calcium, phosphorus and magnesium metabolism in iron-deficient rats. PubMed: Effects of membrane peroxidation on [3H]acetylcholine release in rat cerebral cortical synaptosomes. PubMed: Rate of 59Fe uptake into brain and cerebrospinal fluid and the influence thereon of antibodies against the transferrin receptor. PubMed: Inhibitory effect of phosphatidylserine on iron-dependent lipid peroxidation. PubMed: Bioavailability and the mechanisms of intestinal absorption of iron from ferrous ascorbate and ferric polymaltose in experimental animals. PubMed: Mechanisms of transport of nontransferrin-bound iron in basolateral and canalicular rat liver plasma membrane vesicles. PubMed: [Oral iron therapy. Bioavailability and therapeutic effectiveness of ferrous iron in effervescent tablets in posthemorrhagic iron deficiency anemia]. PubMed: Lipid peroxidation of human granulocytes (PMN) and monocytes by iron complexes. PubMed: Haemoglobin-fortified cereal: an alternative weaning food with high iron bioavailability. PubMed: Studies on Fe complexes produced by yeast. IV. Mechanism of Fe transport from an Fe(II)-oligosaccharide complex across the mucosal membrane of the rat intestine. PubMed: Effect of iron on polymorphonuclear granulocyte phagocytic capacity: role of oxidation state and effect of ascorbic acid. PubMed: Lipid peroxidation of rabbit small intestinal microvillus membrane vesicles by iron complexes. PubMed: Intervention in free radical mediated hepatotoxicity and lipid peroxidation by indole-3-carbinol. PubMed: Relationship between absorption of inorganic and food iron in field studies. PubMed: Long-term consumption of beef extended with soy protein by children, women and men: III. Iron absorption by adult men. PubMed: Failure of transferrin to enhance iron absorption in achlorhydric human subjects. PubMed: Complex stability of ferrous ascorbate in aqueous solution and its significance for iron absorption. PubMed: Anaerobic iron uptake by Escherichia coli. PubMed: Mucosal uptake, mucosal transfer and retention of a therapeutic dose of iron. PubMed: Studies on the binding of iron by rabbit intestinal microvillus membranes. PubMed: Evidence for a defective mitochondrial membrane in 1,2-dimethylhydrazine-induced colon adenocarcinoma in rat: enhanced lipid peroxidation potential in vitro. PubMed: A preliminary simulated iron fortification trial in South Indian preschool children. PubMed: Ageing of Neurospora crassa. VIII. Lethality and mutagenicity of ferrous ions, ascorbic acid, and malondialdehyde. PubMed: The measurement of food iron absorption in man. A methodological study on the measurement of dietary non-haem-Fe absorption when the subjects have a free choice of food items. PubMed: Sodium iron NaFeEDTA as an iron fortification compound in Central America. Absorption studies. PubMed: An animal model to study iron availability from human diets. PubMed: Iron absorption from Southeast Asian diets. II. Role of various factors that might explain low absorption. PubMed: Patterns of food iron absorption in iron-deficient white and indian subjects and in venesected haemochromatotic patients. PubMed: Iron absorption from Southeast Asian rice-based meals. PubMed: Iron absorption from food and from ferrous ascorbate. A study in normal subjects, patients with peptic ulcer and patients after partial gastrectomy. PubMed: Iron absorption from ferrous ascorbate in normal male subjects and in patients 3-6 years after antrectomy with gastroduodenostomy. PubMed: [Orbital scintigraphy using ferrous ascorbate labelled with technetium 99 m. Value in the diagnosis of intraorbital expansive tumors]. PubMed: A scintiscan study of renal form and function using technetium-labelled ferrous ascorbate. PubMed: [Labeled ferrous ascorbate. II. Study of renal uptake]. PubMed: [Labelled ferrous ascorbate. I. Value in renal scintography]. PubMed: [Morphological and functional renal studies using scintigraphy with technetium ferrous ascorbate]. PubMed: [Hydroxylation of 11-desoxycorticosterone by oxygen ion-ferrous ascorbate model system].