5'-inosinic acid
inosine-5'-monophosphoric acid
Identification
| Name | 5'-inosinic acid |
| CAS Number | 131-99-7 |
| FDA UNII | TAO7US05G5 |
| Molecular Formula | C10 H13 N4 O8 P |
| Molecular Weight | 348.20897200 |
| MDL Number | MFCD00066754 |
| Nikkaji Number | J9.493E |
| Beilstein | 0630517 |
| XlogP3 | -3.70 (est) |
Regulatory
| JECFA Food Additive | 5'-Inosinic Acid |
| GSFA Codex | Inosinic acid (630) |
| DG SANTE Food Additives | 5'-inosinic acid |
Physical Properties
| Appearance | white crystalline powder (est) |
| Assay | 97.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 851.37 °C. @ 760.00 mm Hg (est) |
| Flash Point | 876.00 °F. TCC ( 468.70 °C. ) (est) |
| logP (o/w) | -3.707 (est) |
| Soluble in | water, 5921 mg/L @ 25 °C (est) |
Organoleptic Properties
| Odor Description | at 100.00 %. |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 16000 mg/kg |
| Dermal Toxicity | subcutaneous-rat LD50 3900 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavor enhancers |
| Recommendation for 5'-inosinic acid usage levels up to | not for fragrance use. |
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Potential Uses
Natural Occurrence
Synonyms
[(2R,3S,4R,5R)-3,4-
dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
inosine-5'-monophosphoric acid
Google Patents:
Production of 5'-inosinic acid by fermentation
PubMed:
Enzymatic production of 5'-inosinic acid by a newly synthesised acid phosphatase/phosphotransferase.
Google Patents:
Microorganism producing 5'-inosinic acid and process for producing 5'-inosinic acid using the same
PubMed:
Improving the pyrophosphate-inosine phosphotransferase activity of Escherichia blattae acid phosphatase by sequential site-directed mutagenesis.
PubMed:
Surface imprinting polymers for the recognition of nucleotides.
PubMed:
Phase I dose-escalation pharmacokinetics of AZT-P-ddI (IVX-E-59) in patients with human immunodeficiency virus.
PubMed:
Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1.
PubMed:
Nucleotide dimers suppress HIV expression in vitro.
PubMed:
[Effect of antibiotics on 5'-inosinic acid biosynthesis by a Brevibacterium ammoniagenes mutant].
PubMed:
[Adenine effect on the biosynthesis of 5'-inosinic acid by the mutant Brevibacterium ammoniagenes 225-5].
PubMed:
[Effect of medium components on the metabolism of Brevibacterium ammoniagenes-producer of 5'-inosinic acid].
PubMed:
Inhibition of ribonucleotide reductase activity and nucleic acid synthesis in tumor cells by the dialdehyde derivatives of inosine (NSC 118994) and inosinic acid.
PubMed:
[Study of inosine transformation into 5'-inosinic acid by the culture of Pseudomonas trifoli].
PubMed:
Production of nucleic acid-related substances by fermentation processes. 33. Accumulation of inosine by a mutant of Brevibacterium ammoniagenes.
PubMed:
Production of nucleic acid-related substances by fermentative processes. 28. Accumulation of 5' inosinic acid by a manganese-insensitive mutant of Brevibacterium ammoniagenes.
PubMed:
Unbalanced growth death due to depletion of Mn2+ in Brevibacterium ammoniagenes.
PubMed:
Production of nucleic acid-related substances by fermentative processes. XIX. Accumulation of 5'-inosinic acid by a mutant of Brevibacterium ammoniagenes.
PubMed:
REMOVAL OF INTERFERING NUCLEOTIDES FROM BRAIN EXTRACTS CONTAINING SUBSTANCE P. EFFECT OF DRUGS ON BRAIN CONCENTRATIONS OF SUBSTANCE P.