sodium taurocholate

taurocholic acid sodium salt

CAS: 145-42-6 C26 H44 N Na O7 S MW: 537.69284928

Identification

Namesodium taurocholate
IUPAC2-[4-[(3R,7R,12S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonate
CAS Number145-42-6
EINECS205-653-7
FDA UNIIM6N3TH81NO
Molecular FormulaC26 H44 N Na O7 S
Molecular Weight537.69284928
MDL NumberMFCD00013050
Beilstein3901620

Regulatory

FDA Mainterm (SATF)145-42-6 ; SODIUM TAUROCHOLATE

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) 0.051 (est)
Soluble in water, 2.731e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral Toxicityintravenous-rabbit LDLo 110 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryspecial dietary and nutritional additives
Recommendation for sodium taurocholate usage levels up tonot for fragrance use.
Recommendation for sodium taurocholate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

mono sodium 2-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)ethanesulfonate taurocholic acid sodium salt 2-[4-[(3R,7R,12S)-3,7,12- trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonate PubMed: Fucoxanthin Derivatives: Synthesis and their Chemical Properties. PubMed: Milk Phospholipids Enhance Lymphatic Absorption of Dietary Sphingomyelin in Lymph-Cannulated Rats. PubMed: Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats. PubMed: Functional role of oppA encoding an oligopeptide-binding protein from Lactobacillus salivarius Ren in bile tolerance. PubMed: Effect of substituent pattern and molecular weight of cellulose ethers on interactions with different bile salts. PubMed: Non-selective and selective enrichment media for the recovery of Clostridium difficile from chopped beef. PubMed: In Vitro Study of Potentially Probiotic lactic Acid Bacteria Strains Isolated From Traditional Dairy Products. PubMed: Functional role of tlyC1 encoding a hemolysin-like protein from Bifidobacterium longum BBMN68 in bile tolerance. PubMed: Bile acids are nutrient signaling hormones. PubMed: Characterization, phylogenetic affiliation and probiotic properties of high cell density Lactobacillus strains recovered from silage. PubMed: Isolation and characterization of antifungal compound from Lactobacillus plantarum KCC-10 from forage silage with potential beneficial properties. PubMed: Structure-activity relationship for FDA approved drugs as inhibitors of the human sodium taurocholate cotransporting polypeptide (NTCP). PubMed: Factors affecting adhesion of lactic acid bacteria to Caco-2 cells and inhibitory effect on infection of Salmonella typhimurium. PubMed: Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers. PubMed: Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. PubMed: Cj1136 is required for lipooligosaccharide biosynthesis, hyperinvasion, and chick colonization by Campylobacter jejuni. PubMed: Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys. PubMed: Clostridium difficile from healthy food animals: optimized isolation and prevalence. PubMed: Effect of food components and dosing times on the oral pharmacokinetics of nifedipine in rats. PubMed: Bile salt deconjugation and cholesterol removal from media by Lactobacillus strains used as probiotics in chickens. PubMed: Detection of Vibrio parahaemolyticus in tropical shellfish by SYBR green real-time PCR and evaluation of three enrichment media. PubMed: Improved isolation and detection of pathogenic Vibrio parahaemolyticus from seafood using a new enrichment broth. PubMed: In vitro evaluation of the dissolution behaviour of itraconazole in bio-relevant media. PubMed: Review article: The function and regulation of proteins involved in bile salt biosynthesis and transport. PubMed: Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms. PubMed: Enhanced lutein bioavailability by lyso-phosphatidylcholine in rats. PubMed: Phospholipids affect the intestinal absorption of carotenoids in mice. PubMed: The effect of antibiotic and probiotic combination therapy on secondary pancreatic infections and oxidative stress parameters in experimental acute necrotizing pancreatitis. PubMed: Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice. PubMed: A physicochemical investigation of two phosphatidylcholine/bile salt interfaces: implications for lipase activation. PubMed: Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. PubMed: pH-dependent interaction of fumonisin B1 with cholesterol: physicochemical and molecular modeling studies at the air-water interface. PubMed: Lysophosphatidylcholine enhances carotenoid uptake from mixed micelles by Caco-2 human intestinal cells. PubMed: Effect of vagotomy on acute pancreatitis in rats. PubMed: Effect of human milk fortifier on the immunodetection and molecular mass profile of transforming growth factor-alpha. PubMed: Role of duodenal reflux in nonglandular gastric ulcer disease of the mature horse. PubMed: Effect of peanut oil and randomized peanut oil on cholesterol and oleic acid absorption, transport, and distribution in the lymph of the rat. PubMed: A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine. PubMed: Estimation of the increase in solubility of drugs as a function of bile salt concentration. PubMed: Stability of emulsions stabilised by two physiological surfactants: L-alpha-phosphatidylcholine and sodium taurocholate. PubMed: Studies on the mechanism of intestinal passage of the food comutagen harman, in the rabbit. PubMed: Jejunal mucosal injury and restitution: role of hydrolytic products of food digestion. PubMed: Hydrolysis of pyridoxine-5'-beta-D-glucoside by a broad-specificity beta-glucosidase from mammalian tissues. PubMed: Parenteral nutrition: short term effects on hepatic clearance of sodium taurocholate and indocyanine green. PubMed: Effect of cholecystokinin-octapeptide on total parenteral nutrition-induced changes in hepatic bile secretion and composition in the rat. PubMed: Postprandial release of neurotensin-like immunoreactivity and its mechanism. PubMed: Enhancing effect of bile and bile acid on stomach tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. PubMed: Action of ethanol on gastrin release in the dog. PubMed: Effect of fat retention on the rachitogenic effect of rye fed to broiler chicks. PubMed: Bile production in fasted and fed primates.