stevioside

steviol glycosides

CAS: 57817-89-7 C38 H60 O18 MW: 804.88180000 sweet

Identification

Namestevioside
CAS Number57817-89-7
EINECS260-975-5
FDA UNII0YON5MXJ9P
Molecular FormulaC38 H60 O18
Molecular Weight804.88180000
MDL NumberMFCD00079561
Beilstein0077427

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesGRN 395
JECFA Food AdditiveSteviol glycosides
GSFA CodexSteviol glycosides (960)
DG SANTE Food Additivessteviol glycosides
FEMA Number4763
FDANo longer provide for the use of these seven synthetic flavoring substances

Physical Properties

Appearance white to pale yellow powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 198.00 °C. @ 760.00 mm Hg
Boiling Point 464.50 °C. @ 760.00 mm Hg (est)
Flash Point 480.00 °F. TCC ( 248.80 °C. ) (est)
logP (o/w) 4.440 (est)
Soluble in water, 166.9 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Taste Description sweet

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysweeteners, flavor enhancers
Recommendation for stevioside usage levels up tonot for fragrance use.
baked goods40.00000
beverages(nonalcoholic)25.00000
beverages(alcoholic)25.00000
breakfast cereal40.00000
cheese-
chewing gum200.00000
condiments / relishes15.00000
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy40.00000
fruit ices25.00000
gelatins / puddings40.00000
granulated sugar-
gravies15.00000
hard candy40.00000
imitation dairy40.00000
instant coffee / tea25.00000
jams / jellies-
meat products10.00000
milk products40.00000
nut products-
other grains-
poultry-
processed fruits25.00000
processed vegetables25.00000
reconstituted vegetables-
seasonings / flavors25.00000
snack foods20.00000
soft candy40.00000
soups10.00000
sugar substitutes-
sweet sauces25.00000

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Jiangyin Healthway International Trade Co., Ltd

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O'Laughlin Industries Inc.

Manufacturer of chemicals and ingredients used in flavors, fragrances, food, beverages and cosmetics

Leading the Flavor and Fragrance Industry since 1980.

View All Website (973) 376-4600 olcorphk@hkstar.com

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Potential Uses

None Found

Natural Occurrence

stevia rebaudiana

Synonyms

steviol glycoside steviol glycosides steviosin Google Patents: Composition and process for modifying or enhancing flavors PubMed: Large-scale profiling of diterpenoid glycosides from Stevia rebaudiana using ultrahigh performance liquid chromatography/tandem mass spectrometry. Google Patents: Glucosylated steviol glycoside as a flavor modifier PubMed: Tandem mass spectrometric fragmentation patterns of known and new steviol glycosides with structure proposals. PubMed: Stevioside inhibits inflammation and apoptosis by regulating TLR2 and TLR2-related proteins in S. aureus-infected mouse mammary epithelial cells. PubMed: Synergistic Foaming and Surface Properties of a Weakly Interacting Mixture of Soy Glycinin and Biosurfactant Stevioside. PubMed: High-performance thin-layer chromatography analysis of steviol glycosides in Stevia formulations and sugar-free food products, and benchmarking with (ultra) high-performance liquid chromatography. PubMed: Transglycosylation specificity of glycosyl donors in transglycosylation of stevioside catalysed by cyclodextrin glucanotransferase. PubMed: Adsorption characteristics of rebaudioside A and stevioside on cross-linked poly(styrene-co-divinylbenzene) macroporous resins functionalized with chloromethyl, amino and phenylboronic acid groups. PubMed: Genetic signature of differential sensitivity to stevioside in the Italian population. PubMed: Use of just-about-right scales and penalty analysis to determine appropriate concentrations of stevia sweeteners for vanilla yogurt. PubMed: Fast methodology of analysing major steviol glycosides from Stevia rebaudiana leaves. PubMed: Methylerythritol and mevalonate pathway contributions to biosynthesis of mono-, sesqui-, and diterpenes in glandular trichomes and leaves of Stevia rebaudiana Bertoni. PubMed: Development and validation of a reversed-phase high-performance liquid chromatography method for routine identification and purity assessment of high-purity steviol glycoside sweeteners. PubMed: Steviol glucuronidation and its potential interaction with UDP-glucuronosyltransferase 2B7 substrates. PubMed: Use of the modified Gompertz equation to assess the Stevia rebaudiana Bertoni antilisterial kinetics. PubMed: The influence of stevia glycosides on the growth of Lactobacillus reuteri strains. PubMed: Utilisation of steviol glycosides from Stevia rebaudiana (Bertoni) by lactobacilli and bifidobacteria in in vitro conditions. PubMed: Efficient regeneration for enhanced steviol glycosides production in Stevia rebaudiana (Bertoni). PubMed: Quantitation of sweet steviol glycosides by means of a HILIC-MS/MS-SIDA approach. PubMed: Biotransformation of stevioside by Leuconostoc citreum SK24.002 alternansucrase acceptor reaction. PubMed: Classification of stevia sweeteners in soft drinks using liquid chromatography and time-of-flight mass spectrometry. PubMed: Ecotoxicity of artificial sweeteners and stevioside. PubMed: [The use of low-calorie sweeteners]. PubMed: [Simultaneous determination of twelve sweeteners and nine preservatives in foods by solid-phase extraction and LC-MS/MS]. PubMed: Assessment of Korean consumer exposure to sodium saccharin, aspartame and stevioside. PubMed: Determination of six steviol glycosides of Stevia rebaudiana (Bertoni) from different geographical origin by LC-ESI-MS/MS. PubMed: Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells. PubMed: Effects of salt stress on the growth, physiological responses, and glycoside contents of Stevia rebaudiana Bertoni. PubMed: Enhanced physical and oxidative stabilities of soy protein-based emulsions by incorporation of a water-soluble stevioside-resveratrol complex. PubMed: Genetic and metabolic diversity in Stevia rebaudiana using RAPD and HPTLC analysis. PubMed: Simultaneous analysis of steviol and steviol glycosides by liquid chromatography with ultraviolet detection on a mixed-mode column: application to Stevia plant material and Stevia-containing dietary supplements. PubMed: Transglycosylation of stevioside to improve the edulcorant quality by lower substitution using cornstarch hydrolyzate and CGTase. PubMed: Sweeteners from plants--with emphasis on Stevia rebaudiana (Bertoni) and Siraitia grosvenorii (Swingle). PubMed: Stevia rebaudiana Bertoni as a source of bioactive compounds: the effect of harvest time, experimental site and crop age on steviol glycoside content and antioxidant properties. PubMed: Absolute quantitation of stevioside and rebaudioside A in commercial standards by quantitative NMR. PubMed: Steviol glycoside safety: is the genotoxicity database sufficient? PubMed: Analysis of nine food additives in red wine by ion-suppression reversed-phase high-performance liquid chromatography using trifluoroacetic acid and ammonium acetate as ion-suppressors. PubMed: Simultaneous determination of steviol and steviol glycosides by liquid chromatography-mass spectrometry. PubMed: Application of dispersive solid-phase extraction and ultra-fast liquid chromatography-tandem quadrupole mass spectrometry in food additive residue analysis of red wine. PubMed: Stability of steviol glycosides in several food matrices. PubMed: "Extraction and safety of stevioside"; response to the article "Stevia rebaudiana Bertoni, source of a high potency natural sweetener: a comprehensive review on the biochemical, nutritional and functional aspects". PubMed: Steviol glycosides from Stevia: biosynthesis pathway review and their application in foods and medicine. PubMed: Human psychometric and taste receptor responses to steviol glycosides. PubMed: Mass production of rubusoside using a novel stevioside-specific β-glucosidase from Aspergillus aculeatus. PubMed: Stevioside enhances satellite cell activation by inhibiting of NF-κB signaling pathway in regenerating muscle after cardiotoxin-induced injury. PubMed: [Influences of ion-suppressors on retention behaviors of nine food additives in reversed-phase high performance liquid chromatographic separation]. PubMed: The leaves of Stevia rebaudiana (Bertoni), their constituents and the analyses thereof: a review. PubMed: Functional food and diabetes: a natural way in diabetes prevention? PubMed: Synthesis of ent-kaurane diterpene monoglycosides. PubMed: Enzyme-assisted extraction of bioactives from plants. PubMed: Preparative separation and purification of rebaudioside a from steviol glycosides using mixed-mode macroporous adsorption resins. PubMed: Downstream processing of stevioside and its potential applications. PubMed: Evaluation of certain food additive and contaminants. PubMed: Tandem mass spectrometric fragmentation patterns of known and new steviol glycosides with structure proposals. PubMed: Identification and quantification of major steviol glycosides in Stevia rebaudiana purified extracts by 1H NMR spectroscopy. PubMed: Long-term feeding effects of stevioside sweetener on some toxicological parameters of growing male rats. PubMed: Investigations on the stability of stevioside and rebaudioside a in soft drinks. PubMed: The food additives inulin and stevioside counteract oxidative stress. PubMed: Employing ultra high pressure liquid chromatography as the second dimension in a comprehensive two-dimensional system for analysis of Stevia rebaudiana extracts. PubMed: Stevia and saccharin preferences in rats and mice. PubMed: Evaluation of certain food additives. PubMed: Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice. PubMed: Stevia (Stevia rebaudiana) a bio-sweetener: a review. PubMed: Stimulatory effect of stevioside on peripheral mu opioid receptors in animals. PubMed: Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS. PubMed: Photostability of rebaudioside A and stevioside in beverages. PubMed: Comparative toxicokinetics and metabolism of rebaudioside A, stevioside, and steviol in rats. PubMed: A critical review of the genetic toxicity of steviol and steviol glycosides. PubMed: Pharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men. PubMed: Overview: the history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages. PubMed: The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure. PubMed: Evaluation of certain food additives and contaminants. PubMed: Microbial hydrolysis of steviol glycosides. PubMed: The use of a sweetener substitution method to predict dietary exposures for the intense sweetener rebaudioside A. PubMed: Specific immunomodulatory and secretory activities of stevioside and steviol in intestinal cells. PubMed: Immune up regulatory response of a non-caloric natural sweetener, stevioside. PubMed: Re: Analysis of genotoxic potentiality of stevioside by comet assay. PubMed: Comments to the paper by Nunes et al. (2007), Analysis of genotoxic potentiality of stevioside by comet assay, Food and Chemical Toxicology 45 (2007) 662-666. PubMed: The diterpene glycoside, rebaudioside A, does not improve glycemic control or affect blood pressure after eight weeks treatment in the Goto-Kakizaki rat. PubMed: Steviol glycoside biosynthesis. PubMed: Analysis of genotoxic potentiality of stevioside by comet assay. PubMed: Biological effects of stevioside on the survival of Escherichia coli strains and plasmid DNA. PubMed: Spatial organisation of four enzymes from Stevia rebaudiana that are involved in steviol glycoside synthesis. PubMed: Identification of steviol glucuronide in human urine. PubMed: Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. PubMed: Daily intake assessment of saccharin, stevioside, D-sorbitol and aspartame from various processed foods in Korea. PubMed: Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats. PubMed: Evaluation of certain food additives. PubMed: Preventive effects of a soy-based diet supplemented with stevioside on the development of the metabolic syndrome and type 2 diabetes in Zucker diabetic fatty rats. PubMed: [Analysis of nine kinds of sweeteners in foods by LC/MS]. PubMed: Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. PubMed: Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana. PubMed: [Simultaneous determination of stevioside, rebaudioside A and glycyrrhizic acid in foods by HPLC]. PubMed: Steviol quantification at the picomole level by high-performance liquid chromatography. PubMed: Antihyperglycemic effects of stevioside in type 2 diabetic subjects. PubMed: Stevioside. PubMed: Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. PubMed: Metabolism of stevioside in pigs and intestinal absorption characteristics of stevioside, rebaudioside A and steviol. PubMed: Effect of stevioside and steviol on the developing broiler embryos. PubMed: Metabolism of stevioside by chickens. PubMed: In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. PubMed: Leaf Ests from Stevia rebaudiana: a resource for gene discovery in diterpene synthesis. PubMed: Analysis of sweet diterpene glycosides from Stevia rebaudiana: improved HPLC method. PubMed: Evaluation of certain food additives. Fifty-first report of the Joint FAO/WHO Expert Committee on Food Additives. PubMed: Measurement of the relative sweetness of stevia extract, aspartame and cyclamate/saccharin blend as compared to sucrose at different concentrations. PubMed: Assessment of the carcinogenicity of stevioside in F344 rats. PubMed: Pharmacokinetic studies of 131I-stevioside and its metabolites. PubMed: Chronic oral toxicity and carcinogenicity study of stevioside in rats. PubMed: Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A. PubMed: [Subchronic oral toxicity study of stevioside in F344 rats]. PubMed: Determination of seven artificial sweeteners in diet food preparations by reverse-phase liquid chromatography with absorbance detection. PubMed: Diterpenoid sweeteners. Synthesis and sensory evaluation of stevioside analogues with improved organoleptic properties. PubMed: Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.