glycyrrhiza glabra rhizome/root extract
extract of the roots and rhizomes of the licorice, glycyrrhiza glabra l., fabaceae
Identification
| Name | glycyrrhiza glabra rhizome/root extract |
| IUPAC | glycyrrhiza glabra rhizome/root extract |
| CAS Number | 84775-66-6 |
| FDA UNII | Search |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | 184.1408 |
| FEMA Number | 2628 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 68916-91-6 ; LICORICE EXTRACT (GLYCYRRHIZA SPP.) |
| FDA Regulation | FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE |
Physical Properties
| Food Chemicals Codex Listed | No |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
Organoleptic Properties
| Odor Description | at 100.00 %. |
| Taste Description | licorice |
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic, flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment | Search |
| baked goods | - |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | - |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | - |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
Horner International
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Potential Uses
Natural Occurrence
Synonyms
extract of the roots and rhizomes of the licorice, glycyrrhiza glabra l., fabaceae
licorice rhizome/root extract
PubMed:
Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa.
PubMed:
Comparative Analysis of Antibacterial Properties and Chemical Composition of Glycyrrhiza glabra L. from Astrakhan Region (Russia) and Calabria Region (Italy).
PubMed:
Evaluation of sodium benzoate and licorice (Glycyrrhiza glabra) root extract as heat-sensitizing additives against Escherichia coli O157:H7 in mildly heated young coconut liquid endosperm.
PubMed:
Enhancement of Hippocampal CA3 Neuronal Dendritic Arborization by Glycyrrhiza glabra root extract Treatment in Wistar Albino Rats.
PubMed:
Qualitative identification of dibenzoylmethane in licorice root (Glycyrrhiza glabra) using gas chromatography-triple quadrupole mass spectrometry.
PubMed:
A Simple Semi-preparative Reversed-phase HPLC/PDA Method for Separation and Quantification of Glycyrrhizin in Nine Samples of Glycyrrhiza glabra Root Collected from Different Geographical Origins.
PubMed:
Liquorice, a unique "guide drug" of traditional Chinese medicine: a review of its role in drug interactions.
PubMed:
Absolute configuration of naturally occurring glabridin.
PubMed:
Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models: An experimental study.
PubMed:
Transdermal microemulsions of Glycyrrhiza glabra L.: characterization, stability and evaluation of antioxidant potential.
PubMed:
Improving the thrombin inhibitory activity of glycyrrhizin, a triterpenic saponin, through a molecular simplification of the carbohydrate moiety.
PubMed:
Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model.
PubMed:
Comparison of three officinal Chinese pharmacopoeia species of Glycyrrhiza based on separation and quantification of triterpene saponins and chemometrics analysis.
PubMed:
Effect of GutGard in the Management of Helicobacter pylori: A Randomized Double Blind Placebo Controlled Study.
PubMed:
Application of Glycyrrhiza glabra root as a novel adsorbent in the removal of toluene vapors: equilibrium, kinetic, and thermodynamic study.
PubMed:
Anti-convulsant action and amelioration of oxidative stress by Glycyrrhiza glabra root extract in pentylenetetrazole- induced seizure in albino rats.
PubMed:
[Genetic effects of root extracts of Glycyrrhiza glabra L. on different test-systems].
PubMed:
In vitro studies on protective effect of Glycyrrhiza glabra root extracts against cadmium-induced genetic and oxidative damage in human lymphocytes.
PubMed:
Treatment of licorice seeds with colchicine: changes in seedling DNA levels and anthocyanin and glycyrrhizic acid contents of derived callus cultures.
PubMed:
Chromolithic method development, validation and system suitability analysis of ultra-sound assisted extraction of glycyrrhizic acid and glycyrrhetinic acid from Glycyrrhiza glabra.
PubMed:
High throughput screening to identify natural human monoamine oxidase B inhibitors.
PubMed:
An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts.
PubMed:
Licorice induced hypokalemia, edema, and thrombocytopenia.
PubMed:
Licochalcone a inhibits lipopolysaccharide-induced inflammatory response in vitro and in vivo.
PubMed:
ISSR and RAPD based evaluation of genetic stability of encapsulated micro shoots of Glycyrrhiza glabra following 6 months of storage.
PubMed:
Glycyrrhizin and long-term histopathologic changes in a murine model of asthma.
PubMed:
Biogeography of symbiotic and other endophytic bacteria isolated from medicinal Glycyrrhiza species in China.
PubMed:
Evaluation of the genotoxic potential of standardized extract of Glycyrrhiza glabra (GutGardâ¢).
PubMed:
Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra).
PubMed:
Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents.
PubMed:
Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats.
PubMed:
Evaluation of the Anticonvulsant Activity of the Leaves of Glycyrrhiza glabra var. glandulifera Grown in Iran, as a Possible Renewable Source for Anticonvulsant Compounds.
PubMed:
Black licorice ingestion: Yet another confounding agent in patients with melena.
PubMed:
Metabolic profiling of roots of liquorice (Glycyrrhiza glabra) from different geographical areas by ESI/MS/MS and determination of major metabolites by LC-ESI/MS and LC-ESI/MS/MS.
PubMed:
Leaves Antimicrobial Activity of Glycyrrhiza glabra L.
PubMed:
Dual inhibitory effect of Glycyrrhiza glabra (GutGardâ¢) on COX and LOX products.
PubMed:
18β-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice.
PubMed:
The effect of licorice drink on the systemic exposure of verapamil in rabbits.
PubMed:
The Effect of Licorice Drink on the Systemic Exposure of Verapamil in Rabbits.
PubMed:
Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma.
PubMed:
Antidyslipidaemic activity of Glycyrrhiza glabra in high fructose diet induced dsyslipidaemic Syrian golden hamsters.
PubMed:
Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway.
PubMed:
A rapid screening method for prenylated flavonoids with ultra-high-performance liquid chromatography/electrospray ionisation mass spectrometry in licorice root extracts.
PubMed:
Hepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrine.
PubMed:
Evaluation of antioxidant and anti-atherogenic properties of Glycyrrhiza glabra root using in vitro models.
PubMed:
[Cloning and characterization of cDNA encoding Psammosilene tunicoides squalene synthase].
PubMed:
Isoliquiritigenin, a flavonoid from licorice, plays a dual role in regulating gastrointestinal motility in vitro and in vivo.
PubMed:
In vitro effects of glycyrrhetinic acid on the growth of clinical isolates of Candida albicans.
PubMed:
Anti-proliferative effect of licochalcone A on vascular smooth muscle cells.
PubMed:
Glycyrrhizin reduces secondary inflammatory process after spinal cord compression injury in mice.
PubMed:
Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice.
PubMed:
Isoliquiritigenin, a flavonoid from licorice, relaxes guinea-pig tracheal smooth muscle in vitro and in vivo: role of cGMP/PKG pathway.
PubMed:
Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of Glycyrrhiza glabra root.
PubMed:
Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra.
PubMed:
Chemoprofile and bioactivities of Taverniera cuneifolia (Roth) Arn.: a wild relative and possible substitute of Glycyrrhiza glabra L.
PubMed:
Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra.
PubMed:
Hypocholesterolaemic and antioxidant effects of Glycyrrhiza glabra (Linn) in rats.
PubMed:
Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats.
PubMed:
Simultaneous HPLC analysis, with isocratic elution, of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products.
PubMed:
Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells.
PubMed:
Effect of licorice root on peripheral blood indexes upon vibration exposure.
PubMed:
Separation and analysis of glycyrrhizin, 18beta-glycyrrhetic acid and 18alpha-glycyrrhetic acid in liquorice roots by means of capillary zone electrophoresis.
PubMed:
Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts.
PubMed:
Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice.
PubMed:
[Effects of nutrient solution concentration on inorganic and glycyrrhizin contents of Glycyrrhiza glabra Linn].
PubMed:
Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells.
PubMed:
Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra.
PubMed:
Isoliquiritigenin inhibits the growth of prostate cancer.
PubMed:
Chemical modification of glycyrrhizic acid as a route to new bioactive compounds for medicine.
PubMed:
Antioxidant effect of licorice root on blood catalase activity in vibration stress.
PubMed:
Protection of DNA and microsomal membranes in vitro by Glycyrrhiza glabra L. against gamma irradiation.
PubMed:
Immunological studies of Revitonil, a phytopharmaceutical containing Echinacea purpurea and Glycyrrhiza glabra root extract.
PubMed:
[Comparative study of Glycyrrhiza glabra L. and Glycyrrhiza echinata L. of different origin. Medicinal plant polysaccharides III].
PubMed:
Flavonoid constituents from Glycyrrhiza glabra hairy root cultures.
PubMed:
Antioxidant activity of parapharmaceutics containing natural inhibitors of free radical processes.
PubMed:
Biosynthesis of the dimethylallyl moiety of glabrol in Glycyrrhiza glabra hairy root cultures via a non-mevalonate pathway.
PubMed:
Antimicrobial flavonoids from Glycyrrhiza glabra hairy root cultures.
PubMed:
Activation of macrophages by crude polysaccharide fractions obtained from shoots of Glycyrrhiza glabra and hairy roots of Glycyrrhiza uralensis in vitro.
PubMed:
[Polysaccharides of Glycyrrhiza glabra L. and Glycyrrhiza echinata L. Medicinal plants II].
PubMed:
Seasonal variation of glycyrrhizin and isoliquiritigenin glycosides in the root of Glycyrrhiza glabra L.
PubMed:
Structural aspects of the inhibitory effect of glabridin on LDL oxidation.
PubMed:
The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation.
PubMed:
Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation.
PubMed:
Inhibition of human complement by beta-glycyrrhetinic acid.
PubMed:
Distribution Pattern of Saponins in Different Organs of Glycyrrhiza glabra.
PubMed:
A further contribution to the triterpenoid constituents of Glycyrrhiza glabra L.
PubMed:
Triterpenoid biosynthesis in tissue cultures of Glycyrrhiza glabra var. glandulifera.
PubMed:
Biotransformation of 18 beta-glycyrrhetinic acid by cell suspension cultures of Glycyrrhiza glabra.
PubMed:
Examination of triterpenoids produced by callus and cell suspension cultures of Glycyrrhiza glabra.
PubMed:
[Identification of some flavonic aglycones in root extracts of Glycyrrhiza glabra L].
PubMed:
Isolation of two new flavonoids from the root of Glycyrrhiza glabra var. typica.
PubMed:
[Differences between the root and rhizome of Ural licorice (Glycyrrhiza uralensis Fisch.) and those of smooth licorice (Glycyrrhiza glabra L.)].
PubMed:
[Liquiritoside, flavonoside from root of licorice, Glycyrrhiza glabra L].
PubMed:
Evaluation of the genotoxic potential of standardized extract of Glycyrrhiza glabra (GutGardâ¢).
PubMed:
Exploring the possible metabolism mediated interaction of Glycyrrhiza glabra extract with CYP3A4 and CYP2D6.
PubMed:
Memory enhancing activity of Glycyrrhiza glabra in mice.