valeriana officinalis rhizome/root extract

extract of the rhizomes and roots of the valerian, valeriana officinalis l., valerianaceae

CAS: 8057-49-6 fruity fruity

Identification

Namevaleriana officinalis rhizome/root extract
CAS Number8057-49-6
FDA UNIISearch

Regulatory

FEMA Number3099
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)8057-49-6 ; VALERIAN ROOT, EXTRACT (VALERIANA OFFICINALIS L.)
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Food Chemicals Codex Listed No

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Description at 100.00 %.
Taste Description valerian root

Safety Information

Oral/Parenteral Toxicityintraperitoneal-mammal (species unspecified) LD50 975 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

No supplier data available

Potential Uses

None Found

Natural Occurrence

valerian

Synonyms

extract of the rhizomes and roots of the valerian, valeriana officinalis l., valerianaceae valerian rhizome/root extract PubMed: Valerenic Acid Protects Against Physical and Psychological Stress by Reducing the Turnover of Serotonin and Norepinephrine in Mouse Hippocampus-Amygdala Region. PubMed: Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish). PubMed: Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites. PubMed: The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model. PubMed: Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial. PubMed: The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats. PubMed: Three new germacrane-type sesquiterpenes with NGF-potentiating activity from Valeriana officinalis var. latiofolia. PubMed: Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation. PubMed: Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster. PubMed: Valeriana officinalis Dry Plant Extract for Direct Compression: Preparation and Characterization. PubMed: Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors. PubMed: Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). PubMed: Effects of valerian consumption during pregnancy on cortical volume and the levels of zinc and copper in the brain tissue of mouse fetus. PubMed: Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes. PubMed: [Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies]. PubMed: Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study. PubMed: Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice. PubMed: Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors. PubMed: Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia. PubMed: Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. PubMed: Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine. PubMed: In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents. PubMed: Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle. PubMed: A feasibility study of valerian extract for sleep disturbance in person with arthritis. PubMed: Preclinical toxicological assessment of a phytotherapeutic product--CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.). PubMed: Toxicological assessment of P-9801091 plant mixture extract after chronic administration in CBA/HZg mice--a biochemical and histological study. PubMed: Cytoprotective effect of Valeriana officinalis extract on an in vitro experimental model of Parkinson disease. PubMed: A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia. PubMed: Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties. PubMed: Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. PubMed: Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. PubMed: Modulation of postsynaptic potentials in rat cortical neurons by valerian extracts macerated with different alcohols: involvement of adenosine A(1)- and GABA(A)-receptors. PubMed: Interaction of valerian extracts of different polarity with adenosine receptors: identification of isovaltrate as an inverse agonist at A1 receptors. PubMed: NF-kappaB modulators from Valeriana officinalis. PubMed: Effects of aqueous, methanolic and chloroform extracts of rhizome and aerial parts of Valeriana officinalis L. on naloxone-induced jumping in morphine-dependent mice. PubMed: New acylated clionasterol glycosides from Valeriana officinalis. PubMed: A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects. PubMed: Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. PubMed: Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. PubMed: Neuroprotective properties of Valeriana officinalis extracts. PubMed: Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans. PubMed: Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers. PubMed: Analysis of responses to valerian root extract in the feline pulmonary vascular bed. PubMed: Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors. PubMed: (-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis. PubMed: Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia. PubMed: Synergy and other interactions in phytomedicines. PubMed: Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system. PubMed: Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier. PubMed: Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. PubMed: [Effects of Valeriana officinalis L extract on cardiovascular system]. PubMed: Quantifying the effects of mild sedatives. PubMed: [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them].