valeriana officinalis rhizome/root extract
extract of the rhizomes and roots of the valerian, valeriana officinalis l., valerianaceae
Identification
| Name | valeriana officinalis rhizome/root extract |
| CAS Number | 8057-49-6 |
| FDA UNII | Search |
Regulatory
| FEMA Number | 3099 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 8057-49-6 ; VALERIAN ROOT, EXTRACT (VALERIANA OFFICINALIS L.) |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Food Chemicals Codex Listed | No |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | fragrance |
Organoleptic Properties
| Odor Description | at 100.00 %. |
| Taste Description | valerian root |
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mammal (species unspecified) LD50 975 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic, flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment | Search |
| baked goods | - |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | - |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | - |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
extract of the rhizomes and roots of the valerian, valeriana officinalis l., valerianaceae
valerian rhizome/root extract
PubMed:
Valerenic Acid Protects Against Physical and Psychological Stress by Reducing the Turnover of Serotonin and Norepinephrine in Mouse Hippocampus-Amygdala Region.
PubMed:
Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish).
PubMed:
Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites.
PubMed:
The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model.
PubMed:
Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial.
PubMed:
The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats.
PubMed:
Three new germacrane-type sesquiterpenes with NGF-potentiating activity from Valeriana officinalis var. latiofolia.
PubMed:
Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation.
PubMed:
Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster.
PubMed:
Valeriana officinalis Dry Plant Extract for Direct Compression: Preparation and Characterization.
PubMed:
Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors.
PubMed:
Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis).
PubMed:
Effects of valerian consumption during pregnancy on cortical volume and the levels of zinc and copper in the brain tissue of mouse fetus.
PubMed:
Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes.
PubMed:
[Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies].
PubMed:
Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study.
PubMed:
Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.
PubMed:
Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors.
PubMed:
Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia.
PubMed:
Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats.
PubMed:
Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine.
PubMed:
In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents.
PubMed:
Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle.
PubMed:
A feasibility study of valerian extract for sleep disturbance in person with arthritis.
PubMed:
Preclinical toxicological assessment of a phytotherapeutic product--CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.).
PubMed:
Toxicological assessment of P-9801091 plant mixture extract after chronic administration in CBA/HZg mice--a biochemical and histological study.
PubMed:
Cytoprotective effect of Valeriana officinalis extract on an in vitro experimental model of Parkinson disease.
PubMed:
A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia.
PubMed:
Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties.
PubMed:
Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid.
PubMed:
Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.
PubMed:
Modulation of postsynaptic potentials in rat cortical neurons by valerian extracts macerated with different alcohols: involvement of adenosine A(1)- and GABA(A)-receptors.
PubMed:
Interaction of valerian extracts of different polarity with adenosine receptors: identification of isovaltrate as an inverse agonist at A1 receptors.
PubMed:
NF-kappaB modulators from Valeriana officinalis.
PubMed:
Effects of aqueous, methanolic and chloroform extracts of rhizome and aerial parts of Valeriana officinalis L. on naloxone-induced jumping in morphine-dependent mice.
PubMed:
New acylated clionasterol glycosides from Valeriana officinalis.
PubMed:
A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects.
PubMed:
Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
PubMed:
Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers.
PubMed:
Neuroprotective properties of Valeriana officinalis extracts.
PubMed:
Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans.
PubMed:
Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers.
PubMed:
Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
PubMed:
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.
PubMed:
(-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis.
PubMed:
Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia.
PubMed:
Synergy and other interactions in phytomedicines.
PubMed:
Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system.
PubMed:
Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier.
PubMed:
Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man.
PubMed:
[Effects of Valeriana officinalis L extract on cardiovascular system].
PubMed:
Quantifying the effects of mild sedatives.
PubMed:
[Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them].