Identification

Namediethyl sebacate
IUPACdiethyl decanedioate
CAS Number110-40-7
EINECS203-764-5
FDA UNIII41B9FJK6V
Molecular FormulaC14 H26 O4
Molecular Weight258.35802000
MDL NumberMFCD00009219
Nikkaji NumberJ5.519K
Beilstein1790779
CoE Number623

Regulatory

JECFA Food Flavoring624 diethyl sebacate
DG SANTE Food Flavourings09.475 diethyl sebacate
FEMA Number2376
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)110-40-7 ; DIETHYL SEBACATE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.96000 to 0.96500 @ 25.00 °C.
Pounds per Gallon - (est). 7.988 to 8.030
Refractive Index 1.43500 to 1.43800 @ 20.00 °C.
Melting Point 1.00 to 4.00 °C. @ 760.00 mm Hg
Boiling Point 302.00 to 305.00 °C. @ 760.00 mm Hg, 151.00 to 153.00 °C. @ 3.00 mm Hg
Acid Value 1.00 max. KOH/g
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 3.920 (est)
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Strength medium
Substantivity 164 hour(s) at 100.00 %
Odor Description
at 100.00 %.
mild melon fruity quince wine
Odor sample from Elan Inc.
Taste Description
melon fruity winey cognac cilantro
melon fruity winey cognac cilantro

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Human Experience4 % solution: no irritation or sensitization.
Oral/Parenteral Toxicitygavage-rat LD50 [sex: M,F] 14470 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for diethyl sebacate usage levels up to10.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)120.00 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum2.70000
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings3.20000
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

FR banana FR currant emollients FR melon FR peach FR pineapple plasticisers FR raspberry skin conditioning solvents

Natural Occurrence

not found in nature

Synonyms

decane dioic acid diethyl ester decanedioic acid diethyl ester decanedioic acid, diethyl ester diethyl 1,10-decane dioate diethyl 1,10-decanedioate diethyl 1,8-octane dicarboxylate diethyl 1,8-octanedicarboxylate diethyl decane dioate diethyl decane-1,10-dioate diethyl decanedioate diethyl sebacate FCC ethyl decane dioate ethyl sebacate nikkol DES-SP sebacic acid diethyl ester sebacic acid, diethyl ester PubMed: Exploring the Solid State Properties of Enzymatic Poly(amine-co-ester) Terpolymers to Expand their Applications in Gene Transfection. PubMed: Development and evaluation of a tacrolimus cream formulation using a binary solvent system. PubMed: Micelles of enzymatically synthesized PEG-poly(amine-co-ester) block copolymers as pH-responsive nanocarriers for docetaxel delivery. PubMed: Enzyme-catalyzed synthesis of aliphatic-aromatic oligoamides. PubMed: Sebacic and succinic acid derived plasticised PVC for the inhibition of biofouling in its initial stages. PubMed: Potentially important nighttime heterogeneous chemistry: NO3 with aldehydes and N2O5 with alcohols. PubMed: Reactive uptake kinetics of NO3 on multicomponent and multiphase organic mixtures containing unsaturated and saturated organics. PubMed: Reactive uptake studies of NO3 and N2O5 on alkenoic acid, alkanoate, and polyalcohol substrates to probe nighttime aerosol chemistry. PubMed: Discovery of synergistic permeation enhancers for oral drug delivery. PubMed: A systematic selection of the non-aqueous phase in a bacterial two liquid phase bioreactor treating alpha-pinene. PubMed: Allergic contact dermatitis due to diethyl sebacate in a hand cream. PubMed: Biodegradation of phenol at low temperature using two-phase partitioning bioreactors. PubMed: Skin permeation of lidocaine from crystal suspended oily formulations. PubMed: Effects of accelerators on mobility of 14C-2,4-dichlorophenoxy butyric acid in plant cuticles depends on type and concentration of accelerator. PubMed: Sorption in reconstituted waxes of homologous series of alcohol ethoxylates and n-alkyl esters and their effects on the mobility of 2,4-dichlorophenoxybutyric acid. PubMed: Contact dermatitis due to lanoconazole, cetyl alcohol and diethyl sebacate in lanoconazole cream. PubMed: Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin. PubMed: Calcium chloride penetrates plant cuticles via aqueous pores. PubMed: Allergic contact dermatitis from diethyl sebacate in lanoconazole cream. PubMed: Contact dermatitis due to diethyl sebacate. PubMed: Allergic contact dermatitis due to diethyl sebacate. PubMed: Effect of vehicles on diclofenac permeation across excised rat skin. PubMed: Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by dinitrofluorobenzene. PubMed: Allergic contact dermatitis from ethyl sebacate. PubMed: In vivo activity and metabolic fate of 2-(2,3,3-triiodoallyl)tetrazole (ME1401), a novel antifungal agent. PubMed: Effects of penetration enhancers on percutaneous absorption of nifedipine. Comparison between Deet and Azone. PubMed: Enhancement of transdermal delivery by superfluous thermodynamic potential. II. In vitro-in vivo correlation of percutaneous nifedipine transport. PubMed: Contact dermatitis due to diethyl sebacate.