Identification

Nameethyl vanillin
IUPAC3-ethoxy-4-hydroxybenzaldehyde
CAS Number121-32-4
EINECS204-464-7
FDA UNIIYC9ST449YJ
Molecular FormulaC9 H10 O3
Molecular Weight166.17630000
MDL NumberMFCD00006944
Nikkaji NumberJ2.006K
Beilstein1073761
CoE Number108
XlogP31.60 (est)

Regulatory

JECFA Food Flavoring893 ethyl vanillin
DG SANTE Food Flavourings05.019 ethyl vanillin
FEMA Number2464
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)121-32-4 ; ETHYL VANILLIN
FDA RegulationFDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE

Physical Properties

Appearance white to off-white powder (est)
Assay 98.00 to 100.00
Heavey Metals <10.00 ppm
Food Chemicals Codex Listed Yes
Melting Point 76.00 to 78.00 °C. @ 760.00 mm Hg
Boiling Point 285.00 to 294.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Flash Point 293.00 °F. TCC ( 145.00 °C. )
logP (o/w) 1.580
Shelf Life 24.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in chloroform
Insoluble in paraffin oil
Stability cream

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Strength medium ,
Substantivity 400 hour(s) at 20.00 % in dipropylene glycol
Odor Description
at 10.00 % in dipropylene glycol.
Sweet, creamy, vanilla, with a root berry salicylate-like nuance
sweet, vanilla
sweet vanilla intensely sweet vanilla
Odor sample from Berje Inc.
Taste Description
at 50.00 ppm.
sweet, aromatic, caramel

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicitygavage-rat LD50 [sex: M,F] > 2000 mg/kg
Dermal Toxicityskin-rabbit LD50 > 7940 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for ethyl vanillin usage levels up to8.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)5400.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)43000.00 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings140.00000
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

Advanced Biotech. Inc.

Inspired by Nature

A diverse range of products, all meeting our stringent commitment to quality.

View All Website 973-339-6242 info@adv-bio.com

Associate Allied Chemicals

Quality, Service and Values

Our aim is to become a reliable one-stop shop for our customers.

View All Website +91 22 2419 8800 aacipl@aacipl.com

Augustus Oils Ltd

The Premier Supplier

Augustus Oils Ltd, in harmony with nature - to present it at its best...

View All Website +44 (0)1420 590555 essentials@augustus-oils.ltd.uk

Beijing Lys Chemicals Co, LTD.

From Grams to Tons

Fine chemical high-tech company which contains R&D, production, and sales.

View All Website 86-10-68418738 jiayanyong@lyschem.com

Berje Inc.

Where the world comes to its senses

Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.

View All Website 973-748-8980 tlauzurica@berjeinc.com

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

View All Website +41 91 695 88 00 marketing@ecsa.ch

Excellentia International

Ingredients by Nature

Exceptional quality and excellence in meeting our customers requirements.

View All Website 732.749.9840 info@excellentiaint.com

Fleurchem, Inc.

Have A Flavorful Day

A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.

View All Website 845-341-2100 info@fleurchem.com

Foreverest Resources Ltd.

Leading pine based chemicals supplier

Supplying turpentine based and natural/extracted flavor & fragrance ingredients.

View All Website +86 (0)592 5105533 info@foreverest.cn

Global Essence Inc.

Preferred Partner

Accommodate each customers unique needs.

View All Website 001 732 677 1100 info@globalessenceuk.com

Indukern, S.A. F&F Ingredients Division

Commitment to quality

Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients.

View All Website +34 93 506 91 00 info@indukern.es

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

Lluch Essence S.L.

A family company dedicated to sales and distribution

Flexibility, availability, price and quality.

View All Website 34 93 379 38 49 web@lluche.com

M&U International LLC

Steady supply & demand

Meeting customers increasing demands at home as well as abroad.

View All Website 908-359-9000 sales@mu-intel.com

Moellhausen S.P.A.

THE CHEMISTRY OF EMOTIONS

Innovation and commitment in the name of excellence.

View All Website +39 039.685.6262

OQEMA

With a focus on providing the highest level of service

OQEMA has established itself at the forefront of the global chemical industry.

View All Website +1 973 886 3778 fandf@oqema.co.uk

Pell Wall Perfumes

Hand-made fragrances

Pell Wall maintains a broad palette of ingredients & in order to keep stocks fresh & the options wide we also sell from our own stock.

View All Website +44 (0) 20 3745 0887 https://pellwall.com/contact-us/

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

PerfumersWorld Ltd.

feeeel... the smell!

The one-stop resource for the creative perfumer.

View All Website +66(0)2-99-800-80 pwenquiries@perfumersworld.com

Prodasynth

PRODUCTEUR PAR ESSENCE

Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry.

View All Website (33) 4 93 09 00 11 info@prodasynth.com

Sigma-Aldrich

Complete Supply Chain

The perfect blend of products and services that bring your creativity to life.

View All Website 800-244-1173 ff@sial.com

Soda Aromatic Co., Ltd.

Depth of Experience

We guarantees product safety and quality.

View All Website +81-3-5645-7347 aromachemicals@soda.toray.co.jp

SRS Aromatics Ltd

For over 25 years

Bringing flavour and fragrance into your world.

View All Website +44 (0) 1284 704076 info@srsaromatics.co.uk

Sunaux International

Buy With Confidence

We have industry leading processes and procedures to ensure nothing but the most reliable product.

View All Website 0512-57995626 johnjft@sunaux.com

Synerzine, Inc.

Innovation. Customization. Aroma Ingredients.

Synerzine is a leading supplier of flavor and fragrance ingredients.

View All Website (404) 524-6744 info@synerzine.com

Taytonn ASCC Pte Ltd

Supplying Asia Pacific

We fully understand the demands of the F&F industry and we endeavour to supply quality products, with ready availability and a personalised service.

View All Website + 65 - 6861 8113 info@taytonnascc.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

The Good Scents Company

Fragrance Creators

For your fragrance creations.

View All Website 414-764-2659 goodscnt@thegoodscentscompany.com

The John D. Walsh Company, Inc

Suppliers Since 1942

Supplying the fragrance and flavor industry with high quality products.

View All Website 973-962-1400 info@johndwalsh.com

The Lermond Company

Your Sourcing Resource

The Lermond family has been sourcing raw materials for the flavor and fragrance industry for nearly 7 decades.

View All Website 201-896-3300 info@lermond.com

R C Treatt and Co Ltd

Innovative ingredient solutions

World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.

View All Website +1 863 668 9500 enquiries@treatt.com

Qingdao Free Trade Zone United International Co Ltd

Quality Products

A partner in your supply chain solution.

View All Website +86-532-83893699 info@unitedint.com

Ernesto Ventós S.A.

Leaders in essence

We employ our five senses to do our job well.

View All Website +1 856 226 7501 info@ventos.com

Vigon International

Passion for Simplicity

Manufacturer and supplier of high quality flavor and fragrance ingredients.

View All Website 570-476-6300 sales@vigon.com

WholeChem, LLC

Connecting Innovators To the Building Blocks Of the Universe

Custom manufacturer and distributor of specialty ingredients. We make global local.

View All Website +1 (262) 995.8668 info@wholechem.com

Zanos Ltd.

Distributor of Speciality Chemicals and Natural Ingredients

Sourcing and supplying quality aroma chemicals and prestige natural ingredients for the flavour and fragrance industry.

View All Website +44 (0) 1565 755899 sales@zanos.co.uk

Potential Uses

FR acacia FR acorn FR allspice FR almond blossom FR amber FR apple FR apple green apple FR apricot FR azalea FR baby powder FR balsam FR banana FL barley FR bay rum FR bayberry FL/FR carob bean locust bean FL/FR benzoin absolute replacer FR blackberry FR blueberry FR bouquet FR bread baked bread FR bubble gum FL butter rum FR butterscotch FR cabreuva wood FL cake FL candy FL cappuccino FL caramel FR carnation FR cassia FR cassia blossom FR castoreum FR cedar FR cedarwood FR cherry blossom FL chocolate cocoa FR christmas FR clove FR clove blossom FR coconut FR coffee FR colonia FL cookie FR cotton candy FR country meadow FR crabapple blossom FR cream FL cream ice cream FL custard FR date FL egg nog FR elder berry FR elder flower FR fagonia FL/FR fenugreek FR fig FR fir balsam FR floral FR flouve FR flouve blossom FR frangipani plumeria fruit dried fruit FR gardenia FR genet FR gingerbread FR gooseberry FR graham cracker FL/FR guaiacwood FR gurjun balsam FR habuba FR hawthorn FR hay new mown hay FR heliotrope FR hibiscus FR honeysuckle FR hyacinth FR hydrangea FR incense FL jackfruit FR kewda FR labdanum FR licorice FR lilac FR lychee FR malt FR mango flower FR maple FL/FR marigold FL marshmallow FR melon FL milk malted milk FR mint FL molasses FR moss FR musk FR myrtle oil replacer FR opoponax FR orange blossom FR oriental FR papaya FR passion blossom FR passion fruit FR peach blossom FR pear FR pear blossom FR peru balsam FR petunia FR plum FR plum blossom FR plum blossom FR poppy red poppy FR powder FL praline FR prune FR pumpkin pie FR raisin FR raspberry FR raspberry black raspberry FR redwood FR root beer FR rose dog rose FR rose moss rose FL rum butter FR sandalwood FL sarsaparilla FR sassafras FR scented stock FL soda cream soda FR spice FR stephanotis straw FR strawberry FR sweet pea tabu FR tobacco FR toffee FR tolu balsam FR tonka bean FL/FR valerian FR vanilla FR violet FR wallflower FR woody FR wormseed oil replacer FR zibeline

Natural Occurrence

not found in nature

Synonyms

bourbonal ethavan ethovan 3- ethoxy protocatechualdehyde 2- ethoxy-4-formyl phenol 3- ethoxy-4-hydroxy-benzaldehyde 3- ethoxy-4-hydroxybenzaldehyde 3- ethoxy-4-oxidanyl-benzaldehyde 3- ethoxyprotocatechualdehyde ethyl protal ethyl protocatechualdehyde-3-ethyl ether ethyl protocatechuic aldehyde ethyl vanillin 10% dpg ethyl vanillin FCC ethyl vanillin N.F. ethyl vanillin NF ethyl vanillin synthetic ethylprotal ethylprotocatechualdehyde-3-ethyl ether ethylprotocatechuic aldehyde ethylvanillin 4- hydroxy-3-ethoxybenzaldehyde protocatechuic aldehyde ethyl ether quantrovanil rhodiarome rhodiascent vanillin, ethyl- vanirome PubMed: Determination of flavor enhancers in milk powder by one-step sample preparation and two-dimensional liquid chromatography. J-Stage: Antioxidant Properties of Ethyl Vanillin in Vitro and in Vivo PubMed: Laccase catalyzed synthesis of iodinated phenolic compounds with antifungal activity. PubMed: A vanillin derivative causes mitochondrial dysfunction and triggers oxidative stress in Cryptococcus neoformans. PubMed: Determination of vanillin, ethyl vanillin, and coumarin in infant formula by liquid chromatography-quadrupole linear ion trap mass spectrometry. PubMed: The missense of smell: functional variability in the human odorant receptor repertoire. PubMed: Oxidative decarboxylation of mandelic acid derivative by recombinant Escherichia coli: a novel method of ethyl vanillin synthesis. PubMed: A systematic approach for optimizing the robustness of pulse sequence elements with respect to couplings, offsets, and B1-field inhomogeneities (COB). PubMed: Phenolic compounds in particles of mainstream waterpipe smoke. PubMed: Thermal tolerance and survival of Cronobacter sakazakii in powdered infant formula supplemented with vanillin, ethyl vanillin, and vanillic acid. PubMed: Effect of vanillin and ethyl vanillin on cytochrome P450 activity in vitro and in vivo. PubMed: Molecularly imprinted photonic hydrogels as colorimetric sensors for rapid and label-free detection of vanillin. PubMed: Effect of vanillin, ethyl vanillin, and vanillic acid on the growth and heat resistance of Cronobacter species. PubMed: Antioxidant properties of ethyl vanillin in vitro and in vivo. PubMed: Differential presence of anthropogenic compounds dissolved in the marine waters of Puget Sound, WA and Barkley Sound, BC. PubMed: Simultaneous spectrophotometric kinetic determination of four flavor enhancers in foods with the aid of chemometrics. PubMed: A comprehensive evaluation of the toxicology of cigarette ingredients: aromatic carbonyl compounds. PubMed: Synthesis and anticancer activity of some novel tetralin-6-yl-pyrazoline, 2-thioxopyrimidine, 2-oxopyridine, 2-thioxo-pyridine and 2-iminopyridine derivatives. PubMed: [Studies on the chemical constituents of marine sponge Iotrochota sp]. PubMed: Conformational equilibria in vanillin and ethylvanillin. PubMed: Assessment of the anti-angiogenic, anti-inflammatory and antinociceptive properties of ethyl vanillin. PubMed: Microencapsulation of flavors in carnauba wax. PubMed: Fast single run of vanilla fingerprint markers on microfluidic-electrochemistry chip for confirmation of common frauds. PubMed: Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. PubMed: Rapid method for the determination of coumarin, vanillin, and ethyl vanillin in vanilla extract by reversed-phase liquid chromatography with ultraviolet detection. PubMed: Dihydroagarofuranoid sesquiterpenes, a lignan derivative, a benzenoid, and antitubercular constituents from the stem of Microtropis japonica. PubMed: Competitive and noncompetitive odorant interactions in the early neural coding of odorant mixtures. PubMed: 3-Eth-oxy-4-hydroxy-benzaldehyde. PubMed: Synthesis and non-aqueous medium titrations of some new 4-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives. PubMed: Rapid sample screening method for authenticity controlling vanilla flavors using a CE microchip approach with electrochemical detection. PubMed: Optical recording of the intrinsic signal from the human olfactory cleft. PubMed: Determination of coumarin, vanillin, and ethyl vanillin in vanilla extract products: liquid chromatography mass spectrometry method development and validation studies. PubMed: Electrophysiological and behavioral responses to chocolate volatiles in both sexes of the pyralid moths Ephestia cautella and Plodia interpunctella. PubMed: Qualitative determination of false-positive effects in the acetylcholinesterase assay using thin layer chromatography. PubMed: Optimum methamphetamine profiling with sample preparation by solid-phase microextraction. PubMed: Identification of impurities and statistical classification of methamphetamine tablets (Ya-Ba) seized in Thailand. PubMed: Human potency predictions for aldehydes using the local lymph node assay. PubMed: Liquid chromatographic determination of vanillin and related aromatic compounds. PubMed: Odor response properties of rat olfactory receptor neurons. PubMed: Identification of coumarin as the sensitizer in a patient sensitive to her own perfume but negative to the fragrance mix. PubMed: Odorants selectively activate distinct G protein subtypes in olfactory cilia. PubMed: Specificity of signal molecules in the activation of Agrobacterium virulence gene expression. PubMed: Determination of coumarin as an adulterant in vanilla flavoring products by high-performance liquid chromatography. PubMed: Identification of urinary 3-ethoxy-4-hydroxybenzoic and 3-ethoxy-4-hydroxymandelic acids after dietary intake of ethyl vanillin. PubMed: Immediate reactions to balsam of Peru, cassia oil and ethyl vanillin. PubMed: Determination of vanillin and ethyl vanillin in food products. PubMed: [On the polarographic and oscillopolarographic determination of the semicarbazones of vanillin and ethyl vanillin (IV)]. PubMed: Anti-tuberculosis agents derived from 3-ethoxy-4-hydroxybenzaldehyde. PubMed: [Differential subject for the correction of vanillin and ethyl vanillin].