seselin
2H,8H-benzo(1,2-b:3,4-b')dipyran-2-one, 8,8-dimethyl-
Identification
| Name | seselin |
| IUPAC | 8,8-dimethylpyrano[2,3-f]chromen-2-one |
| CAS Number | 523-59-1 |
| FDA UNII | 5634E8957P |
| Molecular Formula | C14 H12 O3 |
| Molecular Weight | 228.24724000 |
| MDL Number | MFCD01018179 |
| Nikkaji Number | J11.874E |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 60.34 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for seselin usage levels up to | not for fragrance use. |
| Recommendation for seselin flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
2H,8H-
benzo(1,2-b:3,4-b')dipyran-2-one, 8,8-dimethyl-
8,8-
dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-2-one
8,8-
dimethylpyrano[2,3-f]chromen-2-one
PubMed:
Isolation of seselin from Clausena anisata (Rutaceae) leaves and its effects on the feeding and development of Lucilia cuprina larvae may explain its use in ethnoveterinary medicine.
PubMed:
Antithrombotic activity of a newly synthesized coumarin derivative 3-(5-hydroxy-2,2-dimethyl-chroman-6-yl)-N-{2-[3-(5-hydroxy-2,2-dimethyl-chroman-6-yl)-propionylamino]-ethyl}-propionamide.
PubMed:
Biological activities of Indian celery, Seseli diffusum (Roxb. ex Sm.) Sant. & Wagh.
PubMed:
Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark.
PubMed:
6-Butyryl-5-hy-droxy-4-phenyl-seselin.
PubMed:
Isolation of xanthyletin, an inhibitor of ants' symbiotic fungus, by high-speed counter-current chromatography.
PubMed:
Botanical origin of Indian celery seed (fruit).
PubMed:
[Synthesis and antinociceptive activity of seselin derivatives].
PubMed:
Seselin from Plumbago zeylanica inhibits phytohemagglutinin (PHA)-stimulated cell proliferation in human peripheral blood mononuclear cells.
PubMed:
Antinociceptive activity of the pyranocoumarin seselin in mice.
PubMed:
Natural and synthetic 2,2-dimethylpyranocoumarins with antibacterial activity.
PubMed:
Synthesis and evaluation of the antioxidant and antiinflammatory activities of some benzo[l]khellactone derivatives and analogues.
PubMed:
Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica.
PubMed:
Antiproliferative effect of isopentenylated coumarins on several cancer cell lines.
PubMed:
Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model.
PubMed:
Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series.
PubMed:
Anti-AIDS agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs.
PubMed:
Biological activity of some coumarins from Sri Lankan Rutaceae.
PubMed:
Identification of eight coumarins occurring with psoralen, xanthotoxin, and bergapten on leaf surfaces.
PubMed:
Pharmacological activities of the prenylcoumarins, developed from folk usage as a medicine of Peucedanum japonicum THUNB.
PubMed:
Studies on the anti-tumor-promoting activity of naturally occurring substances. IV. Pd-II [(+)anomalin, (+)praeruptorin B], a seselin-type coumarin, inhibits the promotion of skin tumor formation by 12-O-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated mice.
PubMed:
Plant antitumor agents, 21. Flavones, coumarins, and an alkaloid from Sargentia greggii.
PubMed:
Calcium antagonist-like actions of coumarins isolated from "Qian-Hu" on anaphylactic mediator release from mast cell induced by concanavalin A.
PubMed:
Effects of Seselin and Coumarin on Growth, Indoleacetic Acid Oxidase, and Peroxidase, with Special Reference to Cucumber (Cucumis sativa L.) Radicles.
PubMed:
[Therapeutic possibilities of a seselin in the treatment of some heart diseases].