2H-1-benzopyran-2-one, 8-[[(2S)-3,3-dimethyloxiranyl]methyl]-7-methoxy-

CAS: 23971-42-8 C15 H16 O4 MW: 260.28932000

Identification

Namemeranzin
IUPAC8-[[(2S)-3,3-dimethyloxiran-2-yl]methyl]-7-methoxychromen-2-one
CAS Number23971-42-8
FDA UNIISearch
Molecular FormulaC15 H16 O4
Molecular Weight260.28932000
MDL NumberMFCD02683834
Nikkaji NumberJ11.626B

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 414.78 °C. @ 760.00 mm Hg (est)
Flash Point 366.00 °F. TCC ( 185.30 °C. ) (est)
logP (o/w) 1.920 (est)
Soluble in water, 137.2 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for meranzin usage levels up tonot for fragrance use.
Recommendation for meranzin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

orange fruit

Synonyms

2H-1- benzopyran-2-one, 8-[[(2S)-3,3-dimethyloxiranyl]methyl]-7-methoxy- 8-[[(2S)-3,3- dimethyloxiran-2-yl]methyl]-7-methoxychromen-2-one PubMed: Searching the cytochrome p450 enzymes for the metabolism of meranzin hydrate: a prospective antidepressant originating from chaihu-shugan-san. PubMed: Comparison of Chemical Profiling and Antioxidant Activities of Fruits, Leaves, Branches, and Flowers of Citrus grandis 'Tomentosa'. PubMed: [Chemical studies on roots of Ficus hirta]. PubMed: Comparison between the pharmacokinetics of meranzin hydrate in a rat model of chronic depression and in controls following the oral administration of Chaihu-Shugan-San. PubMed: Analysis of major constituents in Fructus aurantii-Magnolia bark decoction by UPLC-PDA. PubMed: [Determination of the active constituents in aurantii fructus from Jiangxi province at different harvest time by HPLC]. PubMed: Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae. PubMed: Meranzin hydrate exhibits anti-depressive and prokinetic-like effects through regulation of the shared α2-adrenoceptor in the brain-gut axis of rats in the forced swimming test. PubMed: Multidimensional liquid chromatography for the determination of chiral coumarins and furocoumarins in Citrus essential oils. PubMed: The involvement of AMPA-ERK1/2-BDNF pathway in the mechanism of new antidepressant action of prokinetic meranzin hydrate. PubMed: Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS. PubMed: Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia. PubMed: Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells. PubMed: Meranzin hydrate induces similar effect to Fructus Aurantii on intestinal motility through activation of H1 histamine receptors. PubMed: Meranzin hydrate from Muraya paniculata. PubMed: Two new coumarins from Murraya paniculata. PubMed: Reverse pharmacognosy: identifying biological properties for plants by means of their molecule constituents: application to meranzin. PubMed: Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa. PubMed: Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker. PubMed: A new bicoumarin from the leaves and stems of Triphasia trifolia. PubMed: HPLC comparison of supercritical fluid extraction and solvent extraction of coumarins from the peel of Citrus maxima fruit. PubMed: [Structure determination of the constituents from Citrus grandis Osbeck].