meranzin hydrate
2H-1-benzopyran-2-one, 8-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-
Identification
| Name | meranzin hydrate |
| IUPAC | 8-(2,3-dihydroxy-3-methylbutyl)-7-methoxychromen-2-one |
| CAS Number | 5875-49-0 |
| FDA UNII | Search |
| Molecular Formula | C15 H18 O5 |
| Molecular Weight | 278.30446000 |
| MDL Number | MFCD18974714 |
| Nikkaji Number | J445.062K |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 500.50 °C. @ 760.00 mm Hg (est) |
| Flash Point | 371.00 °F. TCC ( 188.30 °C. ) (est) |
| logP (o/w) | 0.610 (est) |
| Soluble in | water, 1049 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for meranzin hydrate usage levels up to | not for fragrance use. |
| Recommendation for meranzin hydrate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2H-1-
benzopyran-2-one, 8-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-
8-(2,3-
dihydroxy-3-methyl-butyl)-7-methoxy-chromen-2-one
8-(2,3-
dihydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
8-(2,3-
dihydroxy-3-methylbutyl)-7-methoxychromen-2-one
PubMed:
Searching the cytochrome p450 enzymes for the metabolism of meranzin hydrate: a prospective antidepressant originating from chaihu-shugan-san.
PubMed:
Comparison of Chemical Profiling and Antioxidant Activities of Fruits, Leaves, Branches, and Flowers of Citrus grandis 'Tomentosa'.
PubMed:
[Chemical studies on roots of Ficus hirta].
PubMed:
Comparison between the pharmacokinetics of meranzin hydrate in a rat model of chronic depression and in controls following the oral administration of Chaihu-Shugan-San.
PubMed:
Analysis of major constituents in Fructus aurantii-Magnolia bark decoction by UPLC-PDA.
PubMed:
[Determination of the active constituents in aurantii fructus from Jiangxi province at different harvest time by HPLC].
PubMed:
Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae.
PubMed:
Meranzin hydrate exhibits anti-depressive and prokinetic-like effects through regulation of the shared α2-adrenoceptor in the brain-gut axis of rats in the forced swimming test.
PubMed:
The involvement of AMPA-ERK1/2-BDNF pathway in the mechanism of new antidepressant action of prokinetic meranzin hydrate.
PubMed:
Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS.
PubMed:
Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia.
PubMed:
Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells.
PubMed:
Meranzin hydrate induces similar effect to Fructus Aurantii on intestinal motility through activation of H1 histamine receptors.
PubMed:
Meranzin hydrate from Muraya paniculata.
PubMed:
Two new coumarins from Murraya paniculata.
PubMed:
Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa.
PubMed:
Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker.
PubMed:
A new bicoumarin from the leaves and stems of Triphasia trifolia.
PubMed:
HPLC comparison of supercritical fluid extraction and solvent extraction of coumarins from the peel of Citrus maxima fruit.
PubMed:
[Structure determination of the constituents from Citrus grandis Osbeck].