byakangelicin
7H-furo(3,2-g)(1)benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-, (R)-
Identification
| Name | byakangelicin |
| IUPAC | 9-[(2R)-2,3-dihydroxy-3-methylbutoxy]-4-methoxyfuro[3,2-g]chromen-7-one |
| CAS Number | 482-25-7 |
| FDA UNII | LE80Z850I1 |
| Molecular Formula | C17 H18 O7 |
| Molecular Weight | 334.32486000 |
| MDL Number | MFCD00468051 |
| Nikkaji Number | J14.808C |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 421.7 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for byakangelicin usage levels up to | not for fragrance use. |
| Recommendation for byakangelicin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
byak-angelicin
(R)-9-(2,3-
dihydroxy-3-methylbutoxy)-4-methoxy-7H-furo(3,2-g)(1)benzopyran-7-one
9-[(2R)-2,3-
dihydroxy-3-methylbutoxy]-4-methoxyfuro[3,2-g]chromen-7-one
7H-
furo(3,2-g)(1)benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-, (R)-
PubMed:
Spectrum Effect Relationship and Component Knock-Out in Angelica Dahurica Radix by High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer.
PubMed:
Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation.
PubMed:
Simultaneous determination and pharmacokinetics of sixteen Angelicae dahurica coumarins in vivo by LC-ESI-MS/MS following oral delivery in rats.
PubMed:
[Chemical constituents from polarity part in roots of Angelica dahurica var. formosana cv. Chuanbaizhi].
PubMed:
[Chemical constituents from lipophilic parts in roots of Angelica dahurica var. formosana cv. Chuanbaizhi].
PubMed:
[Quantitative determination of three active ingredients for quality evaluation of Angelica dahurica].
PubMed:
Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio.
PubMed:
[Chemical constituents of Angelica nitida roots].
PubMed:
Simultaneous determination of 13 chemical marker compounds in Gwakhyangjeonggi-san, a herbal formula, with validated analytical methods.
PubMed:
Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery.
PubMed:
Identification of the absorbed constituents after oral administration of Yuanhu Zhitong prescription extract and its pharmacokinetic study by rapid resolution liquid chromatography/quadrupole time-of-flight.
PubMed:
Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation.
PubMed:
[Study on the coumarin glucosides of Angelica dahurica].
PubMed:
[A new natural product from root of Angelica dahurica cv. Qibaizhi].
PubMed:
Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells.
PubMed:
[Study on absorption ingredients of yuanhuzhitong pill by everted intestinal sac method].
PubMed:
Sodium desoxycholate-assisted capillary electrochromatography with methacrylate ester-based monolithic column on fast separation and determination of coumarin analogs in Angelica dahurica extract.
PubMed:
Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry.
PubMed:
Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.
PubMed:
An efficient strategy based on MAE, HPLC-DAD-ESI-MS/MS and 2D-prep-HPLC-DAD for the rapid extraction, separation, identification and purification of five active coumarin components from Radix Angelicae Dahuricae.
PubMed:
beta-secretase inhibitory effects of furanocoumarins from the root of Angelica dahurica.
PubMed:
Supercritical fluid extraction for identification and determination of volatile metabolites from Angelica dahurica by GC-MS.
PubMed:
[Studies on chemical constituents of the roots of Angelica pubescens].
PubMed:
[Studies on chemical constituents from fruits of Paliurus ramosissimus].
PubMed:
Separation and quantitative analysis of coumarin compounds from Angelica dahurica (Fisch. ex Hoffm) Benth. et Hook. f by pressurized capillary electrochromatography.
PubMed:
Agents protecting against sepsis from the roots of Angelica dahurica.
PubMed:
[Studies on quality standards of radix Angelicae dahuricae].
PubMed:
Antioxidative activity of furanocoumarins isolated from Angelicae dahuricae.
PubMed:
Identification of new urinary metabolites of byakangelicin, a component of Angelicae dahuricae Radix, in rats.
PubMed:
Constituents of Peucedanum zenkeri seeds and their antimicrobial effects.
PubMed:
Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production.
PubMed:
[Studies on chemical constituents of Peucedanum medium Dunn var. garcile Dunn ex Shan at Sheh].
PubMed:
Crystal structure of byakangelicin (C17H18O7).
PubMed:
Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells.
PubMed:
Minor furocoumarins of Murraya koenigii.
PubMed:
Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica.
PubMed:
Effect of byakangelicin, an aldose reductase inhibitor, on galactosemic cataracts, the polyol contents and Na(+), K(+)ATPase activity in sciatic nerves of strepto-zotocin-induced diabetic rats.
PubMed:
Histamine-release effectors from Angelica dahurica var. dahurica root.
PubMed:
Studies on the antitumor-promoting activity of naturally occurring substances. II. Inhibition of tumor-promoter-enhanced phospholipid metabolism by umbelliferous materials.
PubMed:
Endocrinological studies on plant products. 8. Inhibitory effect of byakangelicin on and presence of sulphydryl group in pregnant mare's serum gonadotropin.
PubMed:
Endocrinological studies on plant products: VII. Further evidences on the presence of sulphydryl group in human chorionic gonadotropin and mechanism of action of byakangelicin.
PubMed:
Effect of byakangelicin on placental gonadotropins.
PubMed:
Endocrinological studies on plant products: V. Effect of byakangelicin on female sex hormones & on fertility of rats.