dextro-camphor

D-camphor

CAS: 464-49-3 C10 H16 O MW: 152.23672000 camphoreous medicinal

Identification

Namedextro-camphor
IUPAC(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
CAS Number464-49-3
EINECS207-355-2
FDA UNIIN20HL7Q941
Molecular FormulaC10 H16 O
Molecular Weight152.23672000
MDL NumberMFCD00064149
Nikkaji NumberJ43.294F
Beilstein2042745
CoE Number140

Regulatory

JECFA Food Flavoring1395 D-camphor
DG SANTE Food Flavourings07.215 D-camphor
FEMA Number2230
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)464-49-3 ; D-CAMPHOR
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance white colorless crystals (est)
Assay 97.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 178.80 °C. @ 760.00 mm Hg
Boiling Point 207.40 °C. @ 760.00 mm Hg
Vapor Pressure 4.000000 mmHg @ 25.00 °C.
Vapor Density 5.24 ( Air = 1 )
Flash Point 148.00 °F. TCC ( 64.44 °C. )
logP (o/w) 3.040
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength high ,
Substantivity 160 hour(s) at 20.00 % in dipropylene glycol
Odor Description
at 10.00 % in dipropylene glycol.
Camphoreous, medicinal, mentholic, with a cooling green nuance
Odor sample from Berje Inc.
Taste Description at 20.00 ppm.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-mouse LD50 1310 mg/kg
Dermal Toxicitysubcutaneous-mouse LDLo 2200 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for dextro-camphor usage levels up to3.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)50.00 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy1.10000
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

Berje Inc.

Where the world comes to its senses

Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.

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BOC Sciences

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ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

View All Website +41 91 695 88 00 marketing@ecsa.ch

Excellentia International

Ingredients by Nature

Exceptional quality and excellence in meeting our customers requirements.

View All Website 732.749.9840 info@excellentiaint.com

Fleurchem, Inc.

Have A Flavorful Day

A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.

View All Website 845-341-2100 info@fleurchem.com

Indukern, S.A. F&F Ingredients Division

Commitment to quality

Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients.

View All Website +34 93 506 91 00 info@indukern.es

Lluch Essence S.L.

A family company dedicated to sales and distribution

Flexibility, availability, price and quality.

View All Website 34 93 379 38 49 web@lluche.com

M&U International LLC

Steady supply & demand

Meeting customers increasing demands at home as well as abroad.

View All Website 908-359-9000 sales@mu-intel.com

Moellhausen S.P.A.

THE CHEMISTRY OF EMOTIONS

Innovation and commitment in the name of excellence.

View All Website +39 039.685.6262

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

PerfumersWorld Ltd.

feeeel... the smell!

The one-stop resource for the creative perfumer.

View All Website +66(0)2-99-800-80 pwenquiries@perfumersworld.com

Prodasynth

PRODUCTEUR PAR ESSENCE

Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry.

View All Website (33) 4 93 09 00 11 info@prodasynth.com

Sigma-Aldrich

Complete Supply Chain

The perfect blend of products and services that bring your creativity to life.

View All Website 800-244-1173 ff@sial.com

SRS Aromatics Ltd

For over 25 years

Bringing flavour and fragrance into your world.

View All Website +44 (0) 1284 704076 info@srsaromatics.co.uk

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

R C Treatt and Co Ltd

Innovative ingredient solutions

World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.

View All Website +1 863 668 9500 enquiries@treatt.com

Ernesto Ventós S.A.

Leaders in essence

We employ our five senses to do our job well.

View All Website +1 856 226 7501 info@ventos.com

WholeChem, LLC

Connecting Innovators To the Building Blocks Of the Universe

Custom manufacturer and distributor of specialty ingredients. We make global local.

View All Website +1 (262) 995.8668 info@wholechem.com

Potential Uses

FR basil oil replacer FL/FR camphor tree bark FR cologne disinfectants FR floral FR lavandin FR lavender FL/FR lavender spike lavender FR nutmeg FR orange blossom FL/FR pennyroyal FR pine FR rosemary FR sage FR sassafras FR woody

Natural Occurrence

anise seed oil apple custard apple plant basil leaf oil basil oil basil plant basil shoot oil bay laurel leaf oil bay laurel plant camphor oil cardamom fruit cardamom seed carrot seed cayenne fruit cinnamomum camphora nees. cinnamon ceylon cinnamon bark oil cinnamon ceylon cinnamon leaf cinnamon ceylon cinnamon oil cinnamon ceylon cinnamon plant cinnamon ceylon cinnamon root bark cinnamon ceylon cinnamon stem bark coriander fruit coriander oil coriander seed oil dill root fennel seed ginger rhizome ginger rhizome oil hyssop flower hyssop leaf hyssop leaf oil hyssop oil lavandula spica lovage root mugwort plant nutmeg seed nutmeg seed oil oregano plant oregano shoot pepper black pepper fruit pepper black pepper seed rosemary rosemary leaf rosemary leaf oil rosemary oil rosemary plant rosemary sap rosemary shoot rosemary shoot oil saffron stigma saffron stigma sage sage leaf sage leaf oil sage oil sage oil dalmatian @ 9.60% Data sage pericarp oil sassafras officinale savory summer savory plant savory winter savory plant sunflower flower tarragon leaf oil tarragon oil tarragon shoot thyme plant turmeric rhizome turmeric rhizome oil turmeric tuber wormwood wild wormwood plant

Synonyms

bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-, (1R,4R)- bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R,4R)- (+)- bornan-2-one (+)-2- bornanone (1R)- * (+)-2- bornanone D-2- bornanone dextro-2- bornanone D-2- camphanone dextro-2- camphanone (+)- camphor (1R,4R)-(+)- camphor (1R)- camphor (1R)- * (+)- camphor (1R)-(+)- camphor (R)- camphor (R)-(+)- camphor D- camphor D-(+)- camphor D-formosa camphor D-laurel camphor dextro-(+)- camphor dextro-formosa camphor dextro-laurel camphor japanese camphor camphor (gum) powder USP camphor (gum) powder, technical camphor flake USP24 camphor gum camphor gum natural camphor gum synthetic camphor powder camphor powder natural camphor powder natural USP/FCC camphor powder synthetic camphor-D natural camphor, (1R,4R)-(+)- D- gum camphor dextro- gum camphor (R)-1,7,7- trimethyl bicyclo(2.2.1)-2-heptanone (1R)-1,7,7- trimethyl bicyclo(2.2.1)heptan-2-one 2-keto-1,7,7- trimethyl norcamphane (R)-1,7,7- trimethylbicyclo(2.2.1)-2-heptanone (1R,4R)-1,7,7- trimethylbicyclo(2.2.1)heptan-2-one (1R)-1,7,7- trimethylbicyclo(2.2.1)heptan-2-one (1R,4R)-1,7,7- trimethylbicyclo[2.2.1]heptan-2-one (1R,4R)-1,7,7- trimethylnorbornan-2-one 2-keto-1,7,7- trimethylnorcamphane PubMed: Total synthesis of chiriquitoxin, an analogue of tetrodotoxin isolated from the skin of a dart frog. PubMed: Hot-spot residues in the cytochrome P450cam-putidaredoxin binding interface. PubMed: Optically pure, monodisperse cis-oligodiacetylenes: aggregation- induced chirality enhancement. PubMed: [About flavouring substances and flavouring preparations regulation in the field of manufacturing of flavourings and foodstuffs]. PubMed: Reaction of an "invisible" frustrated N/B Lewis pair with dihydrogen. PubMed: Nona-coordinated chiral Eu(III) complexes with stereoselective ligand-ligand noncovalent interactions for enhanced circularly polarized luminescence. PubMed: Desymmetrization of cyclohexadienones viad-camphor-derived triazolium salt catalyzed intramolecular Stetter reaction. PubMed: In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum. PubMed: Spectroscopic evidence for the unusual stereochemical configuration of an endosome-specific lipid. PubMed: Analysis of volatile compositions of Magnolia biondii pamp by steam distillation and headspace solid phase micro-extraction. PubMed: Formation of repressor-inducer-operator ternary complex: negative cooperativity of d-camphor binding to CamR. PubMed: Topological and experimental approach to the pressure-temperature-composition phase diagram of the binary enantiomer system d- and l-camphor. PubMed: Changing the substrate specificity of P450cam towards diphenylmethane by semi-rational enzyme engineering. PubMed: Breeding and identification of novel koji molds with high activity of acid protease by genome recombination between Aspergillus oryzae and Aspergillus niger. PubMed: Improvement of the embryonic stem cell test endpoint analysis by use of field potential detection. PubMed: Preparation of functionalized cyclic enol phosphates by halogen-magnesium exchange and directed deprotonation reactions. PubMed: Circularly polarized luminescence of Eu(III) complexes with point- and axis-chiral ligands dependent on coordination structures. PubMed: Highly enantioselective intramolecular Michael reactions by D-camphor-derived triazolium salts. PubMed: Resolution of planar chiral cationic (eta6-arene)tricarbonylmanganese complexes. PubMed: Biotransformations of (+/-)-geosmin by terpene-degrading bacteria. PubMed: D-camphor-crataegus berry extract combination increases blood pressure and cognitive functioning in the elderly - a randomized, placebo controlled double blind study. PubMed: Skin disposition of d-camphor and l-menthol alone and together. PubMed: Tetraaquabis(D-camphor-10-sulfonato)calcium(II). PubMed: A role of the heme-7-propionate side chain in cytochrome P450cam as a gate for regulating the access of water molecules to the substrate-binding site. PubMed: Diamagnetic lanthanide tris beta-diketonates as organic-soluble chiral NMR shift reagents. PubMed: D-Camphor-derived triazolium salts for catalytic intramolecular crossed aldehyde-ketone benzoin reactions. PubMed: Hexaaqua-magnesium(II) bis-(d-camphor-10-sulfonate). PubMed: Polyploid formation between Aspergillus niger and Trichoderma viride for enhanced citric acid production from cellulose. PubMed: Preparation of highly conductive, self-assembled gold/polyaniline nanocables and polyaniline nanotubes. PubMed: Expression, crystallization and preliminary diffraction studies of the Pseudomonas putida cytochrome P450cam operon repressor CamR. PubMed: [Efficacy and safety of a herbal drug containing hawthorn berries and D-camphor in hypotension and orthostatic circulatory disorders/results of a retrospective epidemiologic cohort study]. PubMed: A randomized trial of Korodin Herz-Kreislauf-Tropfen as add-on treatment in older patients with orthostatic hypotension. PubMed: Detection of a high-barrier conformational change in the active site of cytochrome P450cam upon binding of putidaredoxin. PubMed: L358P mutation on cytochrome P450cam simulates structural changes upon putidaredoxin binding: the structural changes trigger electron transfer to oxy-P450cam from electron donors. PubMed: Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam. PubMed: Discriminative power of an assay for automated in vitro screening of teratogens. PubMed: NMR study on the structural changes of cytochrome P450cam upon the complex formation with putidaredoxin. Functional significance of the putidaredoxin-induced structural changes. PubMed: Dose-response related efficacy in orthostatic hypotension of a fixed combination of D-camphor and an extract from fresh crataegus berries and the contribution of the single components. PubMed: A delicate balance of energetics. Subtleties associated with alpha-ketol-based bridge migration to afford 9-keto-10beta-p-methoxybenzyloxytaxanes. PubMed: Optical cell with a temperature-control unit for a vacuum-ultraviolet circular dichroism spectrophotometer. PubMed: Camphor-Crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension. PubMed: Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods. PubMed: Energetic stabilization of d-camphor via weak neutral currents. PubMed: Adrenodoxin-cytochrome P450scc interaction as revealed by EPR spectroscopy: comparison with the putidaredoxin-cytochrome P450cam system. PubMed: Putidaredoxin-cytochrome P450cam interaction. PubMed: X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: roles of Thr252 and water in the active center. PubMed: Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site. PubMed: In vitro transcriptional analysis of the cytochrome P-450cam hydroxylase operon. PubMed: Construction and application of MCBL plate for facilitation of chromosome recombination in fungi. PubMed: Putidaredoxin-cytochrome p450cam interaction. Spin state of the heme iron modulates putidaredoxin structure. PubMed: Reproductive toxicity studies of D-camphor in rats and rabbits. PubMed: Preparation of Enantiomerically Enriched (2R,3R)- or (2S,3S)-trans-2,3-Diaryloxiranes via Camphor-Derived Sulfonium Ylides. PubMed: NMR studies of recombinant cytochrome P450cam mutants. PubMed: Purification and characterization of a cam repressor (CamR) for the cytochrome P-450cam hydroxylase operon on the Pseudomonas putida CAM plasmid. PubMed: Substrate interactions in cytochrome P-450: correlation between carbon-13 nuclear magnetic resonance chemical shifts and C-O vibrational frequencies. PubMed: Thermodynamic aspects of the CO-binding reaction to cytochrome P-450cam. Relevance with their biological significance and structure. PubMed: Heterologous expression of the cytochrome P450cam hydroxylase operon and the repressor gene of Pseudomonas putida in Escherichia coli. PubMed: High-pressure flash photolysis study of hemoprotein: effects of substrate analogues on the recombination of carbon monoxide to cytochrome P450CAM. PubMed: Significant contribution of arginine-112 and its positive charge of Pseudomonas putida cytochrome P-450cam in the electron transport from putidaredoxin. PubMed: Spectral intermediate in the reaction of ferrous cytochrome P450cam with superoxide anion. PubMed: Putative functions of phenylalanine-350 of Pseudomonas putida cytochrome P-450cam. PubMed: Transcription of the cam operon and camR genes in Pseudomonas putida PpG1. PubMed: Development of bacterial cytochrome P-450(cam) (cytochrome m) production. PubMed: [d-Camphor reference standard (Control 911) and dl-Camphor Reference Standard (Control 911) of the National Institute of Hygienic Sciences]. PubMed: Observation of the O-O stretching Raman band for cytochrome P-450cam under catalytic conditions. PubMed: Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. PubMed: [d-Camphor Reference Standard (Control 901) and dl-Camphor Reference Standard (Control 901) of National Institute of Hygienic Sciences]. PubMed: Cloning and nucleotide sequences of NADH-putidaredoxin reductase gene (camA) and putidaredoxin gene (camB) involved in cytochrome P-450cam hydroxylase of Pseudomonas putida. PubMed: Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation. PubMed: Theoretical study of the product specificity in the hydroxylation of camphor, norcamphor, 5,5-difluorocamphor, and pericyclocamphanone by cytochrome P-450cam. PubMed: Oxime-metabolizing activity of liver aldehyde oxidase. PubMed: [D-camphor-beta-sulfonic acid as an ion-pair reagent for the determination of biogenic amines and their metabolites in the rat brain by reverse phase high performance liquid chromatography]. PubMed: Anticonvulsant properties of spirohydantoins derived from optical isomers of camphor. PubMed: [Central depressant effect of l-tetrahydroberberine-d-camphor sulfonate (THB-CS). Electroencephalographic study]. PubMed: High-pressure investigations of cytochrome P-450 spin and substrate binding equilibria. PubMed: Novel reactivity of cytochrome P-450-CAM. Methyl hydroxylation of 5,5-difluorocamphor. PubMed: Regioselectivity in the cytochromes P-450: control by protein constraints and by chemical reactivities. PubMed: Proton coupling in the ligand-binding reaction of ferric cytochrome P-450 from Pseudomonas putida. PubMed: Sequential cold-sensitive mutations in Aspergillus fumigatus. II. Analysis by the parasexual cycle. PubMed: Cytochrome P-450cam and putidaredoxin interaction during electron transfer. PubMed: Magnetic circular dichroism of Pseudomonas putida cytochrome P-450 in near infrared region. PubMed: Growth inhibition of Vibrio cholerae by d-camphor. PubMed: Inhibition of oxidative metabolism in Escherichia coli by d-camphor and restoration of oxidase activity by quinones. PubMed: Growth inhibition of Escherichia coli strain 82-r by d-camphor. PubMed: Proton magnetic resonance reveals high-spin iron (II) in ferrous cytochrome P450 cam from Pseudomonas putida. PubMed: Induction specificity and catabolite repression of the early enzymes in camphor degradation by Pseudomonas putida. PubMed: Approximation of rotational strengths from molar rotation data and generation of rotatory dispersion curves for d-camphor-10-sulfonate.