dextro,laevo-isoleucine
DL-isoleucine
Identification
| Name | dextro,laevo-isoleucine |
| IUPAC | 2-amino-3-methylpentanoic acid |
| CAS Number | 443-79-8 |
| EINECS | 207-139-8 |
| FDA UNII | 5HX0BYT4E3 |
| Molecular Formula | C6 H13 N O2 |
| Molecular Weight | 131.17501000 |
| MDL Number | MFCD00004268 |
| Nikkaji Number | J1.283A |
| Beilstein | 1721790 |
| CoE Number | 10127 |
| XlogP3 | -1.70 (est) |
Regulatory
| JECFA Food Flavoring | 1422 DL-isoleucine |
| DG SANTE Food Flavourings | 17.010 DL-isoleucine |
| FEMA Number | 3295 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 443-79-8 ; DL-ISOLEUCINE |
Physical Properties
| Appearance | white crystalline powder (est) |
| Assay | 98.00 to 100.00 sum of isomers |
| Food Chemicals Codex Listed | Yes |
| Melting Point | 290.00 to 292.00 °C. @ 760.00 mm Hg |
| Boiling Point | 225.00 to 226.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.031000 mmHg @ 25.00 °C. (est) |
| Flash Point | > 230.00 °F. TCC ( > 110.00 °C. ) |
| logP (o/w) | 0.799 (est) |
| Soluble in | water, 2.191e+004 mg/L @ 25 °C (est) |
| Insoluble in | alcohol |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antistatic agents |
Organoleptic Properties
| Odor Strength | none |
| Odor Description | at 100.00 %. |
| Taste Description | bitter |
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | special dietary and nutritional additives |
| Recommendation for dextro,laevo-isoleucine usage levels up to | not for fragrance use. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 5.20 (μg/capita/day) |
| baked goods | - |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | - |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | - |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
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Potential Uses
Natural Occurrence
Synonyms
acetic acid, amino-sec-butyl-
2-
amino-3-methyl pentanoic acid
2-
amino-3-methyl valeric acid
(±)-2-
amino-3-methylpentanoic acid
(±)-erythro-2-
amino-3-methylpentanoic acid
2-
amino-3-methylpentanoic acid
DL-2-
amino-3-methylpentanoic acid
2-
amino-3-methylvaleric acid
DL-2-
amino-3-methylvaleric acid
alpha-
amino-beta-methyl valeric acid
(±)-iso
leucine
dextro,laevo-allo-iso
leucine
dextro,laevo-iso
leucine
DL-allo-iso
leucine
DL-iso
leucine
iso
leucine
pentanoic acid, 2-amino-3-methyl-
valeric acid, 2-amino-3-methyl-
PubMed:
Linear-dichroic infrared spectroscopy - validation and experimental design of the new orientation technique of solid samples as suspension in nematic liquid crystal.
PubMed:
Analysis of the loading and hydroxylation steps in lankamycin biosynthesis in Streptomyces rochei.
PubMed:
Structural relationships in crystals accommodating different stereoisomers of 2-amino-3-methylpentanoic acid.
PubMed:
Stereoconfiguration of anteiso-fatty biosynthesized from DL-isoleucine in rat skin.
PubMed:
Soft agar colony formation of bladder cells during carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine and application to detection of bladder cancer promoters.
PubMed:
Preparation of Tc 99m-Sn-thioglycolic acid-dl-isoleucine (Tc-99m-TGA-ILEU) complex and its comparison with Tl 201-chloride for myocardial imaging.
PubMed:
Anti-inflammatory and analgesic properties of four amino-acids.
PubMed:
Comparative utilization of the alpha-keto and D- and L-alpha-hydroxy analogs of leucine, isoleucine and valine by chicks and rats.
PubMed:
Effect of different concentrations of dl-isoleucine, dl-valine, and dl-alanine on growth and sporulation in Fusarium oxysporum f. udum (Butl.) Sn. et H.
PubMed:
Influence of isoleucine upon quinomycin biosynthesis by Streptomyces sp. 732.
PubMed:
Amino Acid and vitamin requirements of several bacteroides strains.
PubMed:
NUTRITIONAL AND REGULATORY ASPECTS OF SERINE METABOLISM IN ESCHERICHIA COLI.
PubMed:
Nitrogenous compounds in germination and postgerminative development of Bacillus megaterium spores.
PubMed:
THE EFFECT OF dl-METHIONINE, l-CYSTINE, AND dl-ISOLEUCINE ON THE UTILIZATION OF PARENTERALLY ADMINISTERED DOG HEMOGLOBIN : A SUGGESTION FOR DESIGNING THE COMPOSITION OF THE "IDEAL" PROTEIN DIGEST.
PubMed:
PLASMA SUBSTITUTES : HUMAN AND ANIMAL GLOBIN RELATED TO THE PRODUCTION OF HEMOGLOBIN AND PLASMA PROTEIN DOG HEMOGLOBIN UTILIZATION IMPROVED BY METHIONINE BUT NOT BY ISOLEUCINE.
PubMed:
Dog hemoglobin parenterally well utilized to maintain weight and nitrogen balance; utilization improved by dl-methionine but not by dl-isoleucine.
PubMed:
PLASMA PROTEIN PRODUCTION INFLUENCED BY AMINO ACID MIXTURES AND LACK OF ESSENTIAL AMINO ACIDS : A DEFICIENCY STATE RELATED TO UNKNOWN FACTORS.
PubMed:
TOLERANCE TO AMINO ACID MIXTURES AND CASEIN DIGESTS GIVEN INTRAVENOUSLY : GLUTAMIC ACID RESPONSIBLE FOR REACTIONS.
PubMed:
AMINO ACID MIXTURES EFFECTIVE PARENTERALLY FOR LONG CONTINUED PLASMA PROTEIN PRODUCTION. CASEIN DIGESTS COMPARED.